The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate
Abstract
Programmed cell death is vital for a number of pathophysiologic settings. Apoptotic cells are rapidly engulfed by phagocytes (ie, macrophages), which in turn acquire an anti-inflammatory phenotype known as alternative activation or the M2-type. Here we show that interaction of apoptotic cells with macrophages attenuates cell death pathways in the latter. Protection of human macrophages required phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2), and Ca2+ signaling, and correlated with Bcl-XL and Bcl-2 up-regulation as well as Ser136-Bad phosphorylation. Unexpectedly, neither phagocytosis nor binding of apoptotic debris to the phagocyte was necessary to induce protection. Surprisingly, apoptotic cells released sphingosine-1-phosphate (S1P), mainly derived from sphingosine kinase 2, as a survival messenger. This points to an active role of apoptotic cells in preventing cell destruction in their neighborhood, with implications for innate immunity and inflammation.
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Cites
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Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
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“5,6 Along this phenotype switch, a proinflammatory mediator profile (eg, tumor necrosis factor- [TNF- ] or nitric oxide) changes to an immunosuppressive one, characterized by, for example, interleukin-10 (IL-10), transforming growth- 1 (TGF1), or prostaglandin E2.(7-9) Recent studies showed protection from apoptosis i…”
BackgroundImmunosuppressive effects of apoptotic cells
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Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967
Cited by
The alliance of sphingosine-1-phosphate and its receptors in immunity
Rivera, J., Proia, R. L., & Olivera, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2400 · Cited by 616
Kadl, A., Meher, A. K., Sharma, P. R., Lee, M. Y., Doran, A. C., Johnstone, S. R., Elliott, M. R., Gruber, F., Han, J., Chen, W., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.215715 · Cited by 573
Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
Elliott, M. R., Koster, K. M., & Murphy, P. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601520 · Cited by 440
Expression analysis of G Protein-Coupled Receptors in mouse macrophages
Lattin, J. E., Schroder, K., Su, A. I., Walker, J. R., Zhang, J., Wiltshire, T., Saijo, K., Glass, C. K., Hume, D. A., Kellie, S., et al. (2008) · Immunome Research · doi:10.1186/1745-7580-4-5 · Cited by 438
Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis
Larson-Casey, J. L., Deshane, J. S., Ryan, A. J., Thannickal, V. J., & Carter, A. B. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.001 · Cited by 428
Metadata
- Authors
- Weigert, A., Johann, A. M., von Knethen, A., Schmidt, H., Geisslinger, G., & Brüne, B.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-09-01
- Volume
- 108
- Issue
- 5
- Pages
- 1635-1642
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2067130711
- Cited by
- 173
- References
- 6
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weigert, A., Johann, A. M., von Knethen, A., Schmidt, H., Geisslinger, G., & Brüne, B. (2006). Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood. https://doi.org/10.1182/blood-2006-04-014852
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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