The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization
Open accessAbstract
Thymus seeding by T-lymphoid progenitor cells is a prerequisite for T-cell development. However, molecules guiding thymus colonization and their roles before and after thymus vascularization are unclear. Here we show that mice doubly deficient for chemokine receptors CCR7 and CCR9 were defective specifically in fetal thymus colonization before, but not after, thymus vascularization. The defective prevascular fetal thymus colonization was followed by selective loss of the first wave of T-cell development generating epidermal Vγ3+ γδ T cells. Unexpectedly, CCL21, a CCR7 ligand, was expressed not by Foxn1-dependent thymic primordium but by Gcm2-dependent parathyroid primordium, whereas CCL25, a CCR9 ligand, was predominantly expressed by Foxn1-dependent thymic primordium, revealing the role of the adjacent parathyroid in guiding fetal thymus colonization. These results indicate coordination between Gcm2-dependent parathyroid and Foxn1-dependent thymic primordia in establishing CCL21/CCR7- and CCL25/CCR9-mediated chemokine guidance essential for prevascular fetal thymus colonization.
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Cites
Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L. (1990) · Cell · doi:10.1016/0092-8674(90)90262-d · Cited by 583
Sharp, L. L., Jameson, J. M., Cauvi, G., & Havran, W. L. (2005) · Nature Immunology · doi:10.1038/ni1152 · Cited by 273
Prethymic T‐cell development defined by the expression of paired immunoglobulin‐like receptors
Masuda, K., Kubagawa, H., Ikawa, T., Chen, C., Kakugawa, K., Hattori, M., Kageyama, R., Cooper, M. D., Minato, N., Katsura, Y., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600878 · Cited by 79
Cited by
Dual nature of the adaptive immune system in lampreys
Guo, P., Hirano, M., Herrin, B. R., Li, J., Yu, C., Sadlonova, A., & Cooper, M. D. (2009) · Nature · doi:10.1038/nature08068 · Cited by 336
Decision checkpoints in the thymus
Carpenter, A. C., & Bosselut, R. (2010) · Nature Immunology · doi:10.1038/ni.1887 · Cited by 306
Mechanisms of thymus organogenesis and morphogenesis
Gordon, J., & Manley, N. R. (2011) · Development · doi:10.1242/dev.059998 · Cited by 293
Self-citationRossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., et al. (2007) · Blood · doi:10.1182/blood-2006-10-049767 · Cited by 215
Self-citationSignal integration and crosstalk during thymocyte migration and emigration
Love, P. E., & Bhandoola, A. (2011) · Nature Reviews Immunology · doi:10.1038/nri2989 · Cited by 213
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Metadata
- Authors
- Liu, C., Saito, F., Liu, Z., Lei, Y., Uehara, S., Love, P., Lipp, M., Kondo, S., Manley, N., & Takahama, Y.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-10-15
- Volume
- 108
- Issue
- 8
- Pages
- 2531-2539
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1989160727
- Cited by
- 196
- References
- 3
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, C., Saito, F., Liu, Z., Lei, Y., Uehara, S., Love, P., Lipp, M., Kondo, S., Manley, N., & Takahama, Y. (2006). Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood. https://doi.org/10.1182/blood-2006-05-024190
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