The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
Open accessAbstract
The systemic administration of keratinocyte growth factor (KGF) enhances T-cell lymphopoiesis in normal mice and mice that received a bone marrow transplant. KGF exerts protection to thymic stromal cells from cytoablative conditioning and graft-versus-host disease–induced injury. However, little is known regarding KGF's molecular and cellular mechanisms of action on thymic stromal cells. Here, we report that KGF induces in vivo a transient expansion of both mature and immature thymic epithelial cells (TECs) and promotes the differentiation of the latter type of cells. The increased TEC numbers return within 2 weeks to normal values and the microenvironment displays a normal architectural organization. Stromal changes initiate an expansion of immature thymocytes and permit regular T-cell development at an increased rate and for an extended period of time. KGF signaling in TECs activates both the p53 and NF-κB pathways and results in the transcription of several target genes necessary for TEC function and T-cell development, including bone morphogenetic protein 2 (BMP2), BMP4, Wnt5b, and Wnt10b. Signaling via the canonical BMP pathway is critical for the KGF effects. Taken together, these data provide new insights into the mechanism(s) of action of exogenous KGF on TEC function and thymopoiesis.
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“A third category, typified by fibroblast growth factor 7 (Fgf7; also referred to as keratinocyte growth factor), binds to receptors expressed on thymic stromal cells but not thymocytes.[23][24][25]”
From Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a (2012) · cites this paper as [25]
In the citing paper
“FGF7 is particularly remarkable because its administration to old mice results in a renewal of the thymic microenvironment, increased numbers of ETPs, and a restoration of thymus cellularity to levels observed in the young (106, 107).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [107]
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“Fgf7 is known to stimulate the secretion of various cytokines by thymic epithelial cells.25”
From Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a (2012) · cites this paper as [25]
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Self-citationAge, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy
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NF-κB as a Therapeutic Target in Multiple Myeloma
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Metadata
- Authors
- Rossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., & Holländer, G. A.
- Affiliations
- University of Basel (CH)
- Tokushima University (JP)
- Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland;
- Cleveland Clinic (US)
- University of Minnesota (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-01-09
- Volume
- 109
- Issue
- 9
- Pages
- 3803-3811
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC1874572
- OpenAlex
- W2012330112
- Cited by
- 215
- References
- 78
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 1 · 2017: 7 · 2016: 14 · 2015: 6 · 2014: 8 · 2013: 15 · 2012: 13
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Dana Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (68310, 3100-68310.02)
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL073794)
- National Institute of Allergy and Infectious Diseases (R01 AI 1057477)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- keratinocyte growth factor, thymic epithelial cells, T cell development, thymopoiesis, thymic stromal cells, bone marrow transplantation, graft-versus-host disease, p53 pathway, NF-κB signaling, BMP signaling, Wnt signaling, thymocyte proliferation
- MeSH terms
- Animals, Cell Differentiation, Epithelial Cells, Female, T-Lymphocytes, Thymus Gland, Signal Transduction, Tumor Suppressor Protein p53, NF-kappa B, Bone Morphogenetic Proteins, Lymphopoiesis, Cell Proliferation, Mice, Fibroblast Growth Factor 7
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