Cited by 216Hematopoietic Stem Cell TransplantationT-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

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Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

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Rossi, Simona W., Jeker, Lukas T., Ueno, Tomoo, Kuse, Sachiyo, Keller, Marcel P., Zuklys, Saulius, Gudkov, Andrei V., Takahama, Yousuke, Krenger, Werner, Blazar, Bruce R., Holländer, Georg A.·2007·Blood

DOI 10.1182/blood-2006-10-049767PMC PMC1874572

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Abstract

The systemic administration of keratinocyte growth factor (KGF) enhances T-cell lymphopoiesis in normal mice and mice that received a bone marrow transplant. KGF exerts protection to thymic stromal cells from cytoablative conditioning and graft-versus-host disease–induced injury. However, little is known regarding KGF's molecular and cellular mechanisms of action on thymic stromal cells. Here, we report that KGF induces in vivo a transient expansion of both mature and immature thymic epithelial cells (TECs) and promotes the differentiation of the latter type of cells. The increased TEC numbers return within 2 weeks to normal values and the microenvironment displays a normal architectural organization. Stromal changes initiate an expansion of immature thymocytes and permit regular T-cell development at an increased rate and for an extended period of time. KGF signaling in TECs activates both the p53 and NF-κB pathways and results in the transcription of several target genes necessary for TEC function and T-cell development, including bone morphogenetic protein 2 (BMP2), BMP4, Wnt5b, and Wnt10b. Signaling via the canonical BMP pathway is critical for the KGF effects. Taken together, these data provide new insights into the mechanism(s) of action of exogenous KGF on TEC function and thymopoiesis.

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The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
Cellular signaling by fibroblast growth factor receptors
Eswarakumar, V. P., Lax, I., & Schlessinger, J. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.01.001 · Cited by 1,923
Bone Morphogenetic Proteins
Chen, D., Zhao, M., & Mundy, G. R. (2004) · Growth Factors · doi:10.1080/08977190412331279890 · Cited by 1,921
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Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Fibroblast growth factors, their receptors and signaling
Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332
A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., & Gudkov, A. V. (1999) · Science · doi:10.1126/science.285.5434.1733 · Cited by 1,270
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Mackall, C. L., Fleisher, T. A., Brown, M. R., Andrich, M. P., Chen, C. C., Feuerstein, I. M., Horowitz, M. E., Magrath, I. T., Shad, A. T., Steinberg, S. M., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320303 · Cited by 1,026
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Kouhara, H., Hadari, Y., Spivak-Kroizman, T., Schilling, J., Bar-Sagi, D., Lax, I., & Schlessinger, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80252-4 · Cited by 908
NF-κB as a Therapeutic Target in Multiple Myeloma
Hideshima, T., Chauhan, D., Richardson, P. G. G., Mitsiades, C. S., Mitsiades, N., Hayashi, T., Munshi, N. C., Dang, L., Castro, A. C., Palombella, V. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200360200 · Cited by 899
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Douek, D. C., Vescio, R. A., Betts, M. R., Brenchley, J. M., Hill, B. J., Zhang, L., Berenson, J. R., Collins, R. H., & Koup, R. A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02293-5 · Cited by 579

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Bruinsma, M., van Soest, P. L., Leenen, P. J. M., Lambrecht, B. N., Cupedo, T., Löwenberg, B., Cornelissen, J. J., & Braakman, E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7424 · Cited by 22
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Authors: Rossi, S. W., Jeker, L. T., Ueno, T., Kuse, S., Keller, M. P., Zuklys, S., Gudkov, A. V., Takahama, Y., Krenger, W., Blazar, B. R., & Holländer, G. A.
Affiliations: University of Basel (CH)
Tokushima University (JP)
Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel and The University Children's Hospital (UKBB), Basel, Switzerland;
Cleveland Clinic (US)
University of Minnesota (US)
ORCID: Rossi, Simona W.
Jeker, Lukas T.
Keller, Marcel P.
Gudkov, Andrei V.
Takahama, Yousuke
Blazar, Bruce R.
Venue: Blood
Publisher: American Society of Hematology
Published: 2007-01-09
Volume: 109
Issue: 9
Pages: 3803-3811
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2006-10-049767
PMC: PMC1874572
OpenAlex: W2012330112
Cited by: 215
References: 78
Citations by year: 2026: 10 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 1 · 2017: 7 · 2016: 14 · 2015: 6 · 2014: 8 · 2013: 15 · 2012: 13
FWCI: 12.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Dana Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (68310, 3100-68310.02)
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL073794)
National Institute of Allergy and Infectious Diseases (R01 AI 1057477)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: keratinocyte growth factor, thymic epithelial cells, T cell development, thymopoiesis, thymic stromal cells, bone marrow transplantation, graft-versus-host disease, p53 pathway, NF-κB signaling, BMP signaling, Wnt signaling, thymocyte proliferation
MeSH terms: Animals, Cell Differentiation, Epithelial Cells, Female, T-Lymphocytes, Thymus Gland, Signal Transduction, Tumor Suppressor Protein p53, NF-kappa B, Bone Morphogenetic Proteins, Lymphopoiesis, Cell Proliferation, Mice, Fibroblast Growth Factor 7

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Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

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