Thymic involution and immune reconstitution.
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Chronic thymus involution associated with aging results in less efficient T-cell development and decreased emigration of naïve T cells to the periphery. Thymic decline in the aged is linked to increased morbidity and mortality in a wide range of clinical settings. Negative consequences of these effects on global health make it of paramount importance to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan. There is growing evidence that thymus tissue is plastic and that the involution process might be therapeutically halted or reversed. We present here progress on the exploitation of thymosuppressive and thymostimulatory pathways using factors such as keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic thymus restoration and peripheral immune reconstitution in adults.
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Thymic involution reduces naive T-cell production and is thought to contribute to impaired immunity in the elderly.
“Involution of the thymus results in reduced production of naive T cells, and this in turn is thought to contribute to impaired immunity in the elderly.”
From Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a (2012) · cites this paper as [4]
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Fibroblast growth factor 21: a regulator of metabolic disease and health span
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- Authors
- Lynch, H. E., Goldberg, G. L., Chidgey, A., Van den Brink, M. R. M., Boyd, R., & Sempowski, G. D.
- Affiliations
- Duke University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Monash University (AU)
- Corresponding author
- Sempowski, Gregory D.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 30
- Issue
- 7
- Pages
- 366-373
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC2750859
- OpenAlex
- W2018311782
- Cited by
- 522
- References
- 84
- Citations by year
- 2026: 34 · 2025: 36 · 2024: 24 · 2023: 27 · 2022: 17 · 2021: 35 · 2020: 45 · 2019: 28 · 2018: 29 · 2017: 34 · 2016: 29 · 2015: 32 · 2014: 24 · 2013: 39 · 2012: 34
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01-AG25150, R01AG025150)
- National Heart, Lung, and Blood Institute (R01HL069929)
- National Cancer Institute (P01 CA33049, P01CA033049, R01CA107096, P30CA008748)
- National Institute of Allergy and Infectious Diseases (R01AI080455, UC6AI058607)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Keywords
- thymic involution, thymus aging, immune reconstitution, T cell development, thymus regeneration, keratinocyte growth factor, IL-7
- MeSH terms
- Aging, Animals, Humans, Gonadal Steroid Hormones, Thymus Gland, Interleukin-7, T-Lymphocyte Subsets, Cytokines, Fibroblast Growth Factor 7
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