Cited by 377Hematopoietic Stem Cell TransplantationBlood disorders and treatmentsMesenchymal stem cell research

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A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

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Cho, Rebecca H., Sieburg, Hans B., Muller-Sieburg, Christa E.·2008·Blood

DOI 10.1182/blood-2007-11-123547PMC PMC2424153

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Abstract

Whether hematopoietic stem cells (HSCs) change with aging has been controversial. Previously, we showed that the HSC compartment in young mice consists of distinct subsets, each with predetermined self-renewal and differentiation behavior. Three classes of HSCs can be distinguished based on their differentiation programs: lymphoid biased, balanced, and myeloid biased. We now show that aging causes a marked shift in the representation of these HSC subsets. A clonal analysis of repopulating HSCs demonstrates that lymphoid-biased HSCs are lost and long-lived myeloid-biased HSCs accumulate in the aged. Myeloid-biased HSCs from young and aged sources behave similarly in all aspects tested. This indicates that aging does not change individual HSCs. Rather, aging changes the clonal composition of the HSC compartment. We show further that genetic factors contribute to the age-related changes of the HSC subsets. In comparison with B6 mice, aged D2 mice show a more pronounced shift toward myeloid-biased HSCs with a corresponding reduction in the number of both T- and B-cell precursors. This suggests that low levels of lymphocytes in the blood can be a marker for HSC aging. The loss of lymphoid-biased HSCs may contribute to the impaired immune response to infectious diseases and cancers in the aged.

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Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · cited 1×
“For example, aged HSCs may have a reduced ability to home to the bone marrow (BM),(5,6) an altered cell surface phenotype,(5,7) may cycle more rapidly,(5) produce more myeloid cells,(5-8) and have a different gene expression program than their young counterparts.(9,10) HSCs from aged environments may have slightly les…”
Background
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106
The aging of hematopoietic stem cells
Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A., & Weissman, I. L. (1996) · Nature Medicine · doi:10.1038/nm0996-1011 · Cited by 853
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Chambers, S. M., Shaw, C. A., Gatza, C. E., Fisk, C. J., Donehower, L. A., & Goodell, M. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050201 · Cited by 806
Age-Associated Characteristics of Murine Hematopoietic Stem Cells
Sudo, K., Ema, H., Morita, Y., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1273 · Cited by 722
Long-Term Propagation of Distinct Hematopoietic Differentiation Programs In Vivo
Dykstra, B. J., Kent, D. G., Bowie, M. B., McCaffrey, L., Hamilton, M. J., Lyons, K., Lee, S.-J., Brinkman, R. R., & Eaves, C. J. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.015 · Cited by 632
Clonal and systemic analysis of long-term hematopoiesis in the mouse.Preprint
Jordan, C. T., & Lemischka, I. R. (1990) · Genes & Development · doi:10.1101/gad.4.2.220 · Cited by 550
DNA repair is limiting for haematopoietic stem cells during ageing
Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.
Szilvassy, S. J., Humphries, R. K., Lansdorp, P. M., Eaves, A. C., & Eaves, C. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8736 · Cited by 450

Show all 62 references

Research works printed but not linked: 2

Graf, 2007, Two lineages of hematopoietic stem cells identified by differences in lineage priming. [Abstract.], Exp Hematol, 35
Lichtman, 2001, Hamatology in the Aged

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Berent-Maoz, B., Montecino‐Rodriguez, E., & Dorshkind, K. A. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.006 · Cited by 25
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Arif, T., Qiu, J., Khademian, H., Lohithakshan, A., Menon, A., Menon, V., Slavinsky, M., Batignes, M., Miao, L., Sebra, R., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.012 · Cited by 25
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Stem cells and aging: a chicken-or-the-egg issue?
Smith, J. A., & Daniel, R. (2012) · Europe PMC (PubMed Central) · Cited by 23
Telomere, DNA damage, and oxidative stress in stem cell aging
Zhang, J., & Ju, Z. (2010) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20190 · Cited by 25
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Cui, Z., Wei, H., Goding, C. R., & Cui, R. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122240 · Cited by 21
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Beyret, E., Martínez‐Redondo, P., Platero-Luengo, A., & Belmonte, J. C. I. (2018) · Circulation Research · doi:10.1161/circresaha.117.311866 · Cited by 22
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Zohar, K., Averbuch, D., Shahaf, G. L., Zisman‐Rozen, S., Golan, K., Itkin, T., Lapidot, T., Mehr, R., & Melamed, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100999 · Cited by 21
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Nogalska, A., Eerdeng, J., Akre, S., Vergel-Rodriguez, M., Lee, Y., Bramlett, C. S., Chowdhury, A. Y., Wang, B., Cess, C. G., Finley, S. D., et al. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01225-y · Cited by 20
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Gong, X., Shen, H., Guo, L., Huang, C., Su, T., Wang, H., Feng, S., Yang, S., Huo, F., Liu, H., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00337-9 · Cited by 20
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Waraky, A., Östlund, A., Nilsson, T., Weichenhan, D., Lutsik, P., Bähr, M., Hey, J., Tunalı, G., Adamsson, J., Jacobsson, S., et al. (2023) · Haematologica · doi:10.3324/haematol.2022.282255 · Cited by 20
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Rožman, P. J. (2018) · GeroScience · doi:10.1007/s11357-018-0027-x · Cited by 20
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Jiang, R., Lu, Z., Wang, C., Xiao, J., Liu, Q., Xu, X., Shi, J., Shen, J., Zhu, X., Gong, P., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp5239 · Cited by 19
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Jurecic, R. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-24108-7_10 · Cited by 22
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Choudry, F., & Frontini, M. (2015) · Stem Cells International · doi:10.1155/2016/5797521 · Cited by 19

Authors: Cho, R. H., Sieburg, H. B., & Muller-Sieburg, C. E.
Affiliations: Sidney Kimmel Cancer Center (US)
Sidney Kimmel Cancer Center, San Diego, CA
Venue: Blood
Publisher: American Society of Hematology
Published: 2008-06-15
Volume: 111
Issue: 12
Pages: 5553-5561
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2007-11-123547
PMC: PMC2424153
OpenAlex: W1974139477
Cited by: 377
References: 62
Citations by year: 2026: 14 · 2025: 22 · 2024: 23 · 2023: 27 · 2022: 18 · 2021: 19 · 2020: 26 · 2019: 22 · 2018: 16 · 2017: 19 · 2016: 24 · 2015: 20 · 2014: 22 · 2013: 31 · 2012: 23
FWCI: 11.04
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Miami
National Institutes of Health
National Institute on Aging (R01AG023197, AG023197)
National Institute of Diabetes and Digestive and Kidney Diseases (DK048015, R01DK048015, R56DK048015)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: hematopoietic stem cells, aging, clonal composition, self-renewal, clonal analysis, T cell precursors, B cell precursors, genetic factors, C57BL/6 mice, immunosenescence
MeSH terms: Aging, Animals, B-Lymphocytes, Blood, Clone Cells, Genetic Markers, Hematopoietic Stem Cells, Lymphocytes, Mice, Inbred Strains, Mice, Transgenic, T-Lymphocytes, Thymus Gland, Cellular Senescence, Cell Lineage, Mice, Congenic, Myeloid Cells, Mice

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A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

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