Cited by 348Reproductive System and PregnancyImmune Cell Function and InteractionImmunotherapy and Immune Responses

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Beyond the increasing complexity of the immunomodulatory HLA-G molecule

Carosella, Edgardo D., Favier, Benoit, Rouas-Freiss, Nathalie, Moreau, Philippe, LeMaoult, Joel·2008·Blood

DOI 10.1182/blood-2007-12-127662

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Abstract

Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.

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Authors: Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J.
Affiliations: Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
CEA, I2BM, Service de Recherches en Hemato-Immunologie, Paris, France
ORCID: Carosella, Edgardo D.
Moreau, Philippe
Venue: Blood
Publisher: American Society of Hematology
Published: 2008-05-15
Volume: 111
Issue: 10
Pages: 4862-4870
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2007-12-127662
OpenAlex: W1979253523
Cited by: 348
References: 94
Citations by year: 2026: 3 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 16 · 2021: 12 · 2020: 17 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 25 · 2015: 31 · 2014: 27 · 2013: 21 · 2012: 32
FWCI: 2.16
Type: journal article
Language: en
Open access: closed
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: HLA-G, immunomodulation, non-classical MHC class I, maternal-fetal immune tolerance, transplantation, autoimmunity, tumor immunology, hematologic malignancies
MeSH terms: Female, HLA Antigens, Humans, Immune System, Immunologic Factors, Killer Cells, Natural, Male, Pregnancy, Receptors, Immunologic, Histocompatibility Antigens Class I, Hematologic Neoplasms, HLA-G Antigens

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Beyond the increasing complexity of the immunomodulatory HLA-G molecule

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