The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Beyond the increasing complexity of the immunomodulatory HLA-G molecule
Abstract
Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.
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“HLA-G interacts with natural killer cells as part of the innate immune system and is primarily expressed in placental tissues as part of immune tolerance during pregnancy (Carosella et al, 2008).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Carosella et al, 2008
Citations
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Metadata
- Authors
- Carosella, E. D., Favier, B., Rouas-Freiss, N., Moreau, P., & LeMaoult, J.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- CEA, I2BM, Service de Recherches en Hemato-Immunologie, Paris, France
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-05-15
- Volume
- 111
- Issue
- 10
- Pages
- 4862-4870
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1979253523
- Cited by
- 348
- References
- 94
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 16 · 2021: 12 · 2020: 17 · 2019: 17 · 2018: 13 · 2017: 10 · 2016: 25 · 2015: 31 · 2014: 27 · 2013: 21 · 2012: 32
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- HLA-G, immunomodulation, non-classical MHC class I, maternal-fetal immune tolerance, transplantation, autoimmunity, tumor immunology, hematologic malignancies
- MeSH terms
- Female, HLA Antigens, Humans, Immune System, Immunologic Factors, Killer Cells, Natural, Male, Pregnancy, Receptors, Immunologic, Histocompatibility Antigens Class I, Hematologic Neoplasms, HLA-G Antigens
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