The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy
Open accessAbstract
Cluster of differentiation (CD)8+ T cells exist as naive, central memory, and effector memory subsets, and any of these populations can be genetically engineered into tumor-reactive effector cells for adoptive immunotherapy. However, the optimal subset from which to derive effector CD8+ T cells for patient treatments is controversial and understudied. We investigated human CD8+ T cells and found that naive cells were not only the most abundant subset but also the population most capable of in vitro expansion and T-cell receptor transgene expression. Despite increased expansion, naive-derived cells displayed minimal effector differentiation, a quality associated with greater efficacy after cell infusion. Similarly, the markers of terminal differentiation, killer cell lectin-like receptor G1 and CD57, were expressed at lower levels in cells of naive origin. Finally, naive-derived effector cells expressed higher CD27 and retained longer telomeres, characteristics that suggest greater proliferative potential and that have been linked to greater efficacy in clinical trials. Thus, these data suggest that naive cells resist terminal differentiation, or “exhaustion,” maintain high replicative potential, and therefore may be the superior subset for use in adoptive immunotherapy.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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“Despite their increased expansion (Figure 3A-C), effector cells from naïve progenitors (TEFF ) expressed lower levels of CD45RO than effector cells from central memory (TEFF ) or effector memory (TEFF ) progenitors (Figure 2A).(29) CCR7 was retained by TEFF N cells, but it was mostly lost by TEFF CM (Figure 4A).”
BackgroundCancer regression in patients after transfer of genetically engineered lymphocytes
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Self-citationWnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
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Self-citationControl of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin
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Self-citationAdoptive immunotherapy for cancer: harnessing the T cell response
Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688
Self-citationDendritic-Cell-Based Therapeutic Cancer Vaccines
Palucka, K., & Banchereau, J. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.004 · Cited by 869
Clinical manufacturing of CAR T cells: foundation of a promising therapy
Wang, X., & Rivière, I. (2016) · Molecular Therapy - Oncolytics · doi:10.1038/mto.2016.15 · Cited by 637
Locke, F. L., Rossi, J. M., Neelapu, S. S., Jacobson, C. A., Miklos, D. B., Ghobadi, A., Oluwole, O. O., Reagan, P. M., Lekakis, L. J., Lin, Y., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002394 · Cited by 489
Metadata
- Authors
- Hinrichs, C. S., Borman, Z. A., Gattinoni, L., Yu, Z., Burns, W. R., Huang, J., Klebanoff, C. A., Johnson, L. A., Kerkar, S. P., Yang, S., Muranski, P., Palmer, D. C., Scott, C. D., Morgan, R. A., Robbins, P. F., Rosenberg, S. A., & Restifo, N. P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-01-20
- Volume
- 117
- Issue
- 3
- Pages
- 808-814
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1975962380
- Cited by
- 307
- References
- 51
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Hinrichs, C. S., Borman, Z. A., Gattinoni, L., Yu, Z., Burns, W. R., Huang, J., Klebanoff, C. A., Johnson, L. A., Kerkar, S. P., Yang, S., Muranski, P., Palmer, D. C., Scott, C. D., Morgan, R. A., Robbins, P. F., Rosenberg, S. A., & Restifo, N. P. (2011). Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy. Blood. https://doi.org/10.1182/blood-2010-05-286286
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
