The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
Abstract
The studies concerning clinical implications of TET2 mutation in patients with primary acute myeloid leukemia (AML) are scarce. We analyzed TET2 mutation in 486 adult patients with primary AML. TET2 mutation occurred in 13.2% of our patients and was closely associated with older age, higher white blood cell and blast counts, lower platelet numbers, normal karyotype, intermediate-risk cytogenetics, isolated trisomy 8, NPM1 mutation, and ASXL1 mutation but mutually exclusive with IDH mutation. TET2 mutation is an unfavorable prognostic factor in patients with intermediate-risk cytogenetics, and its negative impact was further enhanced when the mutation was combined with FLT3-ITD, NPM1-wild, or unfavorable genotypes (other than NPM1+/FLT3-ITD− or CEBPA+). A scoring system integrating TET2 mutation with FLT3-ITD, NPM1, and CEBPA mutations could well separate AML patients with intermediate-risk cytogenetics into 4 groups with different prognoses (P < .0001). Sequential analysis revealed that TET2 mutation detected at diagnosis was frequently lost at relapse; rarely, the mutation was acquired at relapse in those without TET2 mutation at diagnosis. In conclusion, TET2 mutation is associated with poor prognosis in AML patients with intermediate-risk cytogenetics, especially when it is combined with other adverse molecular markers. TET2 mutation appeared to be unstable during disease evolution.
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Cites
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Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766
Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Diverio, D., Colombo, E., Santucci, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041974 · Cited by 1,892
Mutation in TET2 in Myeloid Cancers
Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776
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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
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Clonal hematopoiesis: Mutation-specific adaptation to environmental change
Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.05.006 · Cited by 129
Reprogramming the epigenome with vitamin C
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TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
Li, Y., Xue, M., Deng, X., Dong, L., Nguyen, L. X. T., Ren, L., Han, L., Li, C., Xue, J., Zhao, Z., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.07.001 · Cited by 110
Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias
Olson, T. L., Cheon, H., Xing, J. C., Olson, K. C., Paila, U., Hamele, C. E., Neelamraju, Y., Shemo, B. C., Schmachtenberg, M., Sundararaman, S. K., et al. (2021) · Blood · doi:10.1182/blood.2020005831 · Cited by 65
Yang, Y.-T., Chiu, Y.-C., Kao, C.-J., Hou, H.-A., Lin, C.-C., Tsai, C.-H., Tseng, M.-H., Chou, W.-C., & Tien, H.-F. (2018) · Blood Cancer Journal · doi:10.1038/s41408-018-0115-2 · Cited by 32
Self-citation
Metadata
- Authors
- Chou, W.-C., Chou, S.-C., Liu, C.-Y., Chen, C.-Y., Hou, H.-A., Kuo, Y.-Y., Lee, M.-C., Ko, B.-S., Tang, J.-L., Yao, M., Tsay, W., Wu, S.-J., Huang, S.-Y., Hsu, S.-C., Chen, Y.-C., Chang, Y.-C., Kuo, Y.-Y., Kuo, K.-T., Lee, F.-Y., Liu, M.-C., Liu, C.-W., Tseng, M.-H., Huang, C.-F., & Tien, H.-F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-10-06
- Volume
- 118
- Issue
- 14
- Pages
- 3803-3810
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2051293191
- Cited by
- 322
- References
- 4
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- closed
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