Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

Kwissa, Marcin; Nakaya, Helder I.; Oluoch, Herold; Pulendran, Bali

doi:10.1182/blood-2011-10-388579

Cited by 132Immune Response and InflammationImmunotherapy and Immune ResponsesImmune responses and vaccinations

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

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Kwissa, Marcin, Nakaya, Helder I., Oluoch, Herold, Pulendran, Bali·2012·Blood

DOI 10.1182/blood-2011-10-388579PMC PMC3311246

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Abstract

TLR ligands (TLR-Ls) represent novel vaccine adjuvants, but their immunologic effects in humans remain poorly defined in vivo. In the present study, we analyzed the innate responses stimulated by different TLR-Ls in rhesus macaques. MPL (TLR4-L), R-848 (TLR7/8-L), or cytosine-phosphate-guanine oligodeoxynucleotide (TLR9-L) induced a rapid and robust expansion of blood neutrophils, with a concomitant reduction in PBMCs. Furthermore, all TLR-Ls induced rapid (3-8 hours) expansion of CD14+ monocytes, but only TLR7/8-L and TLR9-L mobilized the CD14+CD16+ and CD14dimCD16++ monocytes, and only TLR7/8-L and TLR9-L induced activation of myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs), production of IP-10 and type-I IFN, and expression of type-I IFN–related and chemokine genes in the blood. In the draining lymph nodes (LNs), consistent with the effects in blood, all TLR-Ls induced expansion of CD14+ monocytes, but only TLR7/8-L and TLR9-L expanded the activated CD14+CD16+ cells. TLR4-L and TLR9-L differentially induced the expansion of mDCs and pDCs (1-3 days), but did not activate DCs. In contrast, TLR7/8-L did not induce DC expansion, but did activate mDCs. Finally, both TLR9-L and TLR7/8-L induced the expression of genes related to chemokines and type-I IFNs in LNs. Thus different TLR-Ls mediate distinct signatures of early innate responses both locally and systemically.

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Experiments in non-human primates suggest that elicited cytokine profiles depend on the nature of the TLR ligand.
“Experiments in non-human primates suggest that elicited cytokine profiles are dependent on the nature of the TLR ligand”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Kwissa et al., 2012

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Guide for the Care and Use of Laboratory Animals: Eighth Edition
(2011) · doi:10.17226/12910 · Cited by 16,199 · see citing works
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works
Neutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,045 · see citing works
Guide for the care and use of laboratory animals
(1997) · Choice Reviews Online · doi:10.5860/choice.34-3310 · Cited by 2,930 · see citing works
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,517 · see citing works
Nomenclature of monocytes and dendritic cells in blood
Ziegler‐Heitbrock, L., Ancuța, P., Crowe, S. M., Dalod, M., Grau, V., Hart, D. N. J., Leenen, P. J. M., Liu, Y.-J., MacPherson, G. G., Randolph, G. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-258558 · Cited by 2,436 · see citing works
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964 · see citing works
Vaccine Adjuvants: Putting Innate Immunity to Work
Coffman, R. L., Sher, A., & Seder, R. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.002 · Cited by 1,927 · see citing works
Neutrophils, from marrow to microbes.
Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,550 · see citing works
Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial
Paavonen, J. A., Jenkins, D., Bosch, F. X., Naud, P., Salmerón, J., Wheeler, C. M., Chow, S., Apter, D. L., Kitchener, H. C., Castellsagué, X., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60946-5 · Cited by 1,313 · see citing works
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
Cros, J. F., Cagnard, N., Woollard, K. J., Patey, N., Zhang, S., Sénéchal, B., Puel, A., Biswas, S. K., Moshous, D., Pïcard, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.012 · Cited by 1,251 · see citing works
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
Querec, T. D., Akondy, R. S., Lee, E. K., Cao, W., Nakaya, H. I., Teuwen, D. E., Pirani, A. M., Gernert, K. M., Deng, J., Marzolf, B., et al. (2008) · Nature Immunology · doi:10.1038/ni.1688 · Cited by 1,123 · see citing works
Self-citation
Monocyte-Mediated Defense Against Microbial Pathogens
Serbina, N. V., Jia, T., Hohl, T. M., & Pamer, E. G. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090326 · Cited by 1,116 · see citing works
Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets
Wong, K. L., Tai, J. J.-Y., Wong, W. C., Han, H., Sem, X., Yeap, W., Kourilsky, P., & Wong, S. C. (2011) · Blood · doi:10.1182/blood-2010-12-326355 · Cited by 1,111 · see citing works
Immunological mechanisms of vaccination
Pulendran, B., & Ahmed, R. (2011) · Nature Immunology · doi:10.1038/ni.2039 · Cited by 1,085 · see citing works
Self-citation
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Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J., Dunbar, P. R., Wadley, R. B., Jeet, V., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092140 · Cited by 1,019 · see citing works
Programming the magnitude and persistence of antibody responses with innate immunity
Kasturi, S. P., Skountzou, I., Albrecht, R. A., Koutsonanos, D., Tang, H., Nakaya, H. I., Ravindran, R., Stewart, S. M., Alam, M. S., Kwissa, M., et al. (2011) · Nature · doi:10.1038/nature09737 · Cited by 970 · see citing works
Self-citation
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Mackay, F., & Schneider, P. (2009) · Nature reviews. Immunology · doi:10.1038/nri2572 · Cited by 939 · see citing works
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Mata‐Haro, V., Cekic, C., Martin, M., Chilton, P. M., Casella, C. R., & Mitchell, T. C. (2007) · Science · doi:10.1126/science.1138963 · Cited by 901 · see citing works
CpG DNA as a vaccine adjuvant
Bode, C., Zhao, G., Steinhagen, F., Kinjo, T., & Klinman, D. M. (2011) · Expert Review of Vaccines · doi:10.1586/erv.10.174 · Cited by 895 · see citing works
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Bachem, A., Güttler, S., Hartung, E., Ebstein, F., Schaefer, M., Tannert, A., Salama, A., Movassaghi, K., Opitz, C., Mages, H. W., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100348 · Cited by 821 · see citing works
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Nakaya, H. I., Wrammert, J., Lee, E. K., Racioppi, L., Marie-Kunze, S., Haining, W. N., Means, A. R., Kasturi, S. P., Khan, N., Li, G., et al. (2011) · Nature Immunology · doi:10.1038/ni.2067 · Cited by 812 · see citing works
Self-citation
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Didierlaurent, A. M., Morel, S., Lockman, L., Giannini, S. L., Bisteau, M., Carlsen, H., Kielland, A., Vosters, O., Vanderheyde, N., Schiavetti, F., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901474 · Cited by 757 · see citing works
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Ingersoll, M. A., Spanbroek, R., Lottaz, C., Gautier, E. L., Frankenberger, M., Hoffmann, R. F. G., Lang, R., Haniffa, M. A., Collin, M. P., Tacke, F., et al. (2009) · Blood · doi:10.1182/blood-2009-07-235028 · Cited by 731 · see citing works
New horizons in adjuvants for vaccine development
Reed, S. G., Bertholet, S., Coler, R. N., & Friede, M. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.09.006 · Cited by 678 · see citing works
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Zawada, A. M., Rogacev, K. S., Rotter, B., Winter, P., Marell, R.-R., Fliser, D., & Heine, G. H. (2011) · Blood · doi:10.1182/blood-2011-01-326827 · Cited by 562 · see citing works
New horizons in adjuvants for vaccine development
Reed, S. G., Tomai, M. A., & Gale, M. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.08.008 · Cited by 555 · see citing works
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Querec, T. D., Bennouna, S., Alkan, S., Laouar, Y., Gorden, K. B., Flavell, R. A., Akira, S., Ahmed, R., & Pulendran, B. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051720 · Cited by 552 · see citing works
Self-citation
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Mosca, F., Tritto, E., Muzzi, A., Monaci, E., Bagnoli, F., Iavarone, C., O’Hagan, D. T., Rappuoli, R., & Gregorio, E. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804699105 · Cited by 492 · see citing works
New adjuvants for human vaccines
Mbow, M. L., Gregorio, E. D., Valiante, N. M., & Rappuoli, R. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.04.004 · Cited by 408 · see citing works
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Garçon, N., & Mechelen, M. V. V. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.29 · Cited by 321 · see citing works
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Coler, R. N., Bertholet, S., Moutaftsi, M., Guderian, J. A., Windish, H. P., Baldwin, S. L., Laughlin, E. M., Duthie, M. S., Fox, C. B., Carter, D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016333 · Cited by 313 · see citing works
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates
Wille-Reece, U., Flynn, B. J., Loré, K., Koup, R. A., Miles, A. P., Saul, A. J., Kedl, R. M., Mattapallil, J. J., Weiss, W. R., Roederer, M., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052433 · Cited by 275 · see citing works
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Steinman, R. M. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.001 · Cited by 268 · see citing works
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Seo, S., Kwon, H.-J., Ko, H.-J., Byun, Y.-H., Seong, B. L., Uematsu, S., Akira, S., & Kweon, M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001304 · Cited by 211 · see citing works
Mechanism of action of licensed vaccine adjuvants
Tritto, E., Mosca, F., & Gregorio, E. D. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.084 · Cited by 211 · see citing works
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Wille-Reece, U., Wu, C. Y., Flynn, B. J., Kedl, R. M., & Seder, R. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7676 · Cited by 185 · see citing works
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets
Kastenmüller, K., Wille-Reece, U., Lindsay, R. W. B., Trager, L., Darrah, P. A., Flynn, B. J., Becker, M. R., Udey, M. C., Clausen, B. E., Igyártó, B. Z., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45416 · Cited by 165 · see citing works
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MF59 adjuvant: the best insurance against influenza strain diversity
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Wiley, S. R., Raman, V. S., Desbien, A. L., Bailor, H. R., Bhardwaj, R., Shakri, A. R., Reed, S. G., Chitnis, C. E., & Carter, D. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002135 · Cited by 97 · see citing works
Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus
Kwissa, M., Amara, R. R., Robinson, H. L., Moss, B., Alkan, Ş. Ş., Jabbar, A., Villinger, F. J., & Pulendran, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071211 · Cited by 90 · see citing works
Self-citation
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Crane, M. J., Hokeness-Antonelli, K. L., & Salazar‐Mather, T. P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900205 · Cited by 83 · see citing works
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Bogunovic, D., Manches, O., Godefroy, E., Yewdall, A. W., Gallois, A., Salazar, A. Μ., Marie, I., Levy, D. E., & Bhardwaj, N. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3988 · Cited by 55 · see citing works
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Tomai, M. A., & Vasilakos, J. P. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.26 · Cited by 46 · see citing works
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Francica, J. R., Zak, D. E., Linde, C., Siena, E., Johnson, C. D., Juraska, M., Yates, N. L., Gunn, B. M., Gregorio, E. D., Flynn, B. J., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017011411 · Cited by 91 · see citing works
Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants
Ong, G. H., Lian, B. S. X., Kawasaki, T., & Kawai, T. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.745016 · Cited by 95 · see citing works
CD16+ monocytes control T-cell subset development in immune thrombocytopenia
Zhong, H., Bao, W., Li, X., Miller, A., Seery, C., Haq, N., Bussel, J. B., & Yazdanbakhsh, K. (2012) · Blood · doi:10.1182/blood-2012-06-434605 · Cited by 90 · see citing works
Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques
Moody, M. A., Santra, S., Vandergrift, N., Sutherland, L. L., Gurley, T. C., Drinker, M. S., Allen, A. A., Xia, S.-M., Meyerhoff, R. R., Parks, R., et al. (2014) · Journal of Virology · doi:10.1128/jvi.03309-13 · Cited by 90 · see citing works
Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization
Francica, J. R., Sheng, Z., Zhang, Z., Nishimura, Y., Shingai, M., Ramesh, A., Keele, B. F., Schmidt, S. D., Flynn, B. J., Darko, S. W., et al. (2015) · Nature Communications · doi:10.1038/ncomms7565 · Cited by 88 · see citing works
Resiquimod, a topical drug for viral skin lesions and skin cancer
Meyer, T., Surber, C., French, L. E., & Stockfleth, E. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.749236 · Cited by 85 · see citing works
Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques
Kasturi, S. P., Kozlowski, P. A., Nakaya, H. I., Bürger, M. C., Russo, P., Pham, M., Kovalenkov, Y. O., Silveira, E. L. V., Havenar‐Daughton, C., Burton, S. L., et al. (2016) · Journal of Virology · doi:10.1128/jvi.01844-16 · Cited by 83 · see citing works
Self-citation
Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacy
Siefert, A. L., Caplan, M. J., & Fahmy, T. M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.039 · Cited by 77 · see citing works
TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25
Thompson, E. A., Ols, S., Miura, K., Rausch, K. M., Narum, D. L., Spångberg, M., Juraska, M., Wille-Reece, U., Weiner, A. J., Howard, R. F., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120692 · Cited by 73 · see citing works
Modulation of Innate Immune Responses via Covalently Linked TLR Agonists
Tom, J. K., Dotsey, E. Y., Wong, H. Y., Stutts, L., Moore, T., Davies, D. H., Felgner, P. L., & Esser-Kahn, A. P. (2015) · ACS Central Science · doi:10.1021/acscentsci.5b00274 · Cited by 69 · see citing works
Molecular signatures of vaccine adjuvants
Olafsdottir, T. A., Lindqvist, M., & Harandi, A. M. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.04.099 · Cited by 67 · see citing works
The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes
Dowling, D. J., Tan, Z. W., Prokopowicz, Z. M., Palmer, C. D., Matthews, M.-A. H., Dietsch, G. N., Hershberg, R. M., & Levy, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058164 · Cited by 66 · see citing works
Plasticity of monocyte development and monocyte fates
Trzebanski, S., & Jung, S. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.07.007 · Cited by 65 · see citing works
Role of Vaginal Mucosa, Host Immunity and Microbiota in Vulvovaginal Candidiasis
Balakrishnan, S., Yamang, H., Lorenz, M., Chew, S.-Y., & Than, L. (2022) · Pathogens · doi:10.3390/pathogens11060618 · Cited by 64 · see citing works
Dendritic cell immunotherapy
Sabado, R. L., & Bhardwaj, N. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12125 · Cited by 58 · see citing works
IL-12 from endogenous cDC1, and not vaccine DC, is required for Th1 induction
Ashour, D., Arampatzi, P., Pavlović, V., Förstner, K. U., Kaisho, T., Beilhack, A., Erhard, F., & Lutz, M. B. (2020) · JCI Insight · doi:10.1172/jci.insight.135143 · Cited by 58 · see citing works
Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection
Hernandez, A., Patil, N. K., Stothers, C. L., Luan, L., McBride, M. A., Owen, A. M., Burelbach, K. R., Williams, D. L., Sherwood, E. R., & Bohannon, J. K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104502 · Cited by 58 · see citing works
Brucella Dysregulates Monocytes and Inhibits Macrophage Polarization through LC3-Dependent Autophagy
Wang, Y., Li, Y., Li, H., Song, H., Zhai, N., Lou, L., Wang, F., Zhang, K., Bao, W., Jin, X., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00691 · Cited by 56 · see citing works
Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system
Cheng, L., Zhang, Z., Li, G., Li, F., Wang, L., Zhang, L., Zurawski, S., Zurawski, G., Lévy, Y., & Su, L. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.09.052 · Cited by 53 · see citing works
Immunomodulatory activity and control of Salmonella Enteritidis colonization in the intestinal tract of chickens by Lactobacillus based probiotic
Filho, R. A. C. P., Díaz, S. J. A., Fernando, F. S., Yung-Fu, C., Filho, R. L. A., & Berchieri, Â. (2015) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2015.06.006 · Cited by 54 · see citing works
A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice
Lee, A. W. Q., Scott, M. K. D., Wimmers, F., Arunachalam, P. S., Luo, W., Fox, C. B., Tomai, M. A., Khatri, P., & Pulendran, B. (2022) · Nature Communications · doi:10.1038/s41467-022-28197-9 · Cited by 52 · see citing works
Self-citation
Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant
Francica, J. R., Lynn, G. M., Laga, R., Joyce, M. G., Ruckwardt, T. J., Morabito, K. M., Chen, M., Chaudhuri, R., Zhang, B., Sastry, M., et al. (2016) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6b00370 · Cited by 50 · see citing works
Human decidual macrophages and NK cells differentially express Toll-like receptors and display distinct cytokine profiles upon TLR stimulation
Duriez, M., Quillay, H., Madec, Y., Costa, H. E., Cannou, C., Marlin, R., de Truchis, C., Rahmati, M., Barré‐Sinoussi, F., Nugeyre, M.-T., et al. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00316 · Cited by 49 · see citing works
Macrophage- and Neutrophil-Derived TNF-α Instructs Skin Langerhans Cells To Prime Antiviral Immune Responses
Épaulard, O., Adam, L., Poux, C., Zurawski, G., Salabert, N., Rosenbaum, P., Dereuddre‐Bosquet, N., Zurawski, S., Flamar, A.-L., Oh, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303339 · Cited by 44 · see citing works
Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12
Koker, S. D., Hoecke, L. V., Beuckelaer, A. D., Roose, K., Deswarte, K., Willart, M. A. M., Bogaert, P., Naessens, T., Geest, B. G. D., Saelens, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06236-6 · Cited by 44 · see citing works
Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses
Tomalka, J. A., Suthar, M. S., Deeks, S. G., & Sékaly, R. (2022) · Nature Immunology · doi:10.1038/s41590-022-01130-4 · Cited by 45 · see citing works
A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses
Pryke, K. M., Abraham, J., Sali, T. M., Gall, B., Archer, I., Liu, A., Bambina, S., Baird, J. R., Gough, M., Chakhtoura, M., et al. (2017) · mBio · doi:10.1128/mbio.00452-17 · Cited by 43 · see citing works
Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic study
Thauvin, C., Widmer, J., Mottas, I., Hočevar, S., Allémann, É., Bourquin, C., & Delié, F. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.04.007 · Cited by 41 · see citing works
Nucleic acids presenting polymer nanomaterials as vaccine adjuvants
Comberlato, A., Paloja, K., & Bastings, M. M. C. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01222b · Cited by 39 · see citing works
Reprint of: Monocyte subsets in man and other species
Ziegler-Heitbrock, L. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.06.008 · Cited by 40 · see citing works
A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses
Lenart, K., Hellgren, F., Ols, S., Yan, X., Cagigi, A., Cerveira, R. A., Winge, I. P., Hanczak, J., Mueller, S. O., Jasny, E., et al. (2022) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.10.001 · Cited by 39 · see citing works
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response
Palgen, J., Tchitchek, N., Elhmouzi‐Younes, J., Delandre, S., Namet, I., Rosenbaum, P., Dereuddre‐Bosquet, N., Martinon, F., Cosma, A., Lévy, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21222-2 · Cited by 38 · see citing works
Impact of T h 1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques
Verma, A., Schmidt, B., Elizaldi, S. R., Nguyen, N. K., Walter, K. A., Beck, Z., Trinh, H. V., Dinasarapu, A. R., Lakshmanappa, Y. S., Rane, N. N., et al. (2019) · Journal of Virology · doi:10.1128/jvi.01737-19 · Cited by 38 · see citing works
Sex differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE)
Jiang, W., & Gilkeson, G. S. (2014) · Journal of Immunotherapy Applications · doi:10.7243/2055-2394-1-1 · Cited by 37 · see citing works
Mucosal Vaccine Approaches for Prevention of HIV and SIV Transmission
Kozlowski, P. A., & Aldovini, A. (2018) · Current Immunology Reviews · doi:10.2174/1573395514666180605092054 · Cited by 37 · see citing works
Poly(I:C) Potentiates T Cell Immunity to a Dendritic Cell Targeted HIV-Multiepitope Vaccine
Apostólico, J. D. S., Lunardelli, V. A. S., Yamamoto, M. M., Cunha‐Neto, E., Boscardin, S. B., & Rosa, D. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00843 · Cited by 37 · see citing works
Non-human primates as a model for understanding the mechanism of action of toll-like receptor-based vaccine adjuvants
Thompson, E. A., & Loré, K. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.06.006 · Cited by 35 · see citing works
Control of Heterologous Simian Immunodeficiency Virus SIV smE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques
Singh, S., Ramírez-Salazar, E. G., Doueiri, R., Valentin, A., Rosati, M., Hu, X., Keele, B. F., Shen, X., Tomaras, G. D., Ferrari, G., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00281-18 · Cited by 35 · see citing works
Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures
Oh, D., Dowling, D. J., Ahmed, S., Choi, H., Brightman, S. E., Bergelson, I., Berger, S. T., Sauld, J. F. K., Pettengill, M. A., Kho, A. T., et al. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.055541 · Cited by 34 · see citing works
The Lymphatic Immune Response Induced by the Adjuvant AS01: A Comparison of Intramuscular and Subcutaneous Immunization Routes
Neeland, M. R., Shi, W., Collignon, C., Taubenheim, N., Meeusen, E. N. T., Didierlaurent, A. M., & de Veer, M. J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600817 · Cited by 34 · see citing works
Fast and furious: The neutrophil and its armamentarium in health and disease
Metzemaekers, M., Malengier‐Devlies, B., Gouwy, M., Somer, L. D., Cunha, F. Q., Opdenakker, G., & Proost, P. (2023) · Medicinal Research Reviews · doi:10.1002/med.21958 · Cited by 29 · see citing works
Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans
Hellgren, F., Rosdahl, A., Cerveira, R. A., Lenart, K., Ols, S., Gwon, Y.-D., Kurt, S., Delis, A. M., Joas, G., Evander, M., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.175401 · Cited by 32 · see citing works
Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor β
Alamino, V. A., Mascanfroni, I. D., Montesinos, M. M., Gigena, N., Donadío, A. C., Blidner, A. G., Milotich, S. I., Cheng, S.-Y., Masini-Repiso, A. M., Rabinovich, G. A., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-1875 · Cited by 31 · see citing works
Saponin nanoparticle adjuvants incorporating Toll-like receptor agonists drive distinct immune signatures and potent vaccine responses
Ou, B. S., Baillet, J., Interrante, M. V. F., Adamska, J., Zhou, X.-T., Saouaf, O. M., Yan, J., Klich, J., Jons, C., Meany, E. L., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn7187 · Cited by 24 · see citing works
Self-citation
Activation of Toll-Like Receptors Differentially Modulates Inflammation in the Human Reproductive Tract: Preliminary Findings
Benjelloun, F., Quillay, H., Cannou, C., Marlin, R., Madec, Y., Fernandez, H., Chrétien, F. C., Grand, R. L., Barré‐Sinoussi, F., Nugeyre, M.-T., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01655 · Cited by 30 · see citing works
High‐ and low‐molecular‐weight chitosan act as adjuvants during single‐dose influenza A virus protein vaccination through distinct mechanisms
Lampe, A. T., Farris, E., Brown, D. M., & Pannier, A. K. (2020) · Biotechnology and Bioengineering · doi:10.1002/bit.27647 · Cited by 28 · see citing works
An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly
Bell, M. R., & Kutzler, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114175 · Cited by 29 · see citing works
A Multiantigenic DNA Vaccine That Induces Broad Hepatitis C Virus-Specific T-Cell Responses in Mice
Gummow, J., Li, Y., Yu, W., Garrod, T. J., Wijesundara, D. K., Brennan, A. J., Mullick, R., Voskoboinik, I., Grubor‐Bauk, B., & Gowans, E. J. (2015) · Journal of Virology · doi:10.1128/jvi.00803-15 · Cited by 28 · see citing works
Routing dependent immune responses after experimental R848-adjuvated vaccination
van Aalst, S., Jansen, M. A. A., Ludwig, I. S., van der Zee, R., van Eden, W., & Broere, F. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.01.077 · Cited by 27 · see citing works
Regulation of the maturation of human monocytes into immunosuppressive macrophages
Bayık, D., Tross, D., Haile, L. A., Verthelyi, D. I., & Klinman, D. M. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017011221 · Cited by 27 · see citing works
A TLR5 Agonist Enhances CD8+ T Cell-Mediated Graft-versus-Tumor Effect without Exacerbating Graft-versus-Host Disease
Ding, X., Bian, G., Leigh, N. D., Qiu, J., McCarthy, P. L., Liu, H., Aygun‐Sunar, S., Burdelya, L. G., Gudkov, A. V., & Cao, X. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201206 · Cited by 25 · see citing works
Progress towards Adjuvant Development: Focus on Antiviral Therapy
Brai, A., Poggialini, F., Pasqualini, C., Trivisani, C. I., Vagaggini, C., & Dreassi, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119225 · Cited by 25 · see citing works
Intradermal injection of an anti‐Langerin‐HIVGag fusion vaccine targets epidermal Langerhans cells in nonhuman primates and can be tracked in vivo
Salabert, N., Todorova, B., Martinon, F., Boisgard, R., Zurawski, G., Zurawski, S., Dereuddre‐Bosquet, N., Cosma, A., Kortulewski, T., Banchereau, J., et al. (2015) · European Journal of Immunology · doi:10.1002/eji.201545465 · Cited by 23 · see citing works
Host‐ and pathogen‐derived adjuvant coatings on protein nanoparticle vaccines
Chang, T. Z., Diambou, I., Kim, J. R., Wang, B., & Champion, J. A. (2016) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10052 · Cited by 24 · see citing works
Dendritic Cell Vaccines
Sabado, R. L., Meseck, M. L., & Bhardwaj, N. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3387-7_44 · Cited by 23 · see citing works
Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy
Emami, M. R., Espinoza, A., Young, C., Ma, F.-Y., Farahat, P. K., Felgner, P., Chamberlain, J., Xu, X.-M., Pyle, A., Pellegrini, M., et al. (2023) · Molecular Therapy: Methods & Clinical Development · doi:10.1016/j.omtm.2023.06.002 · Cited by 20 · see citing works
In Vivo Effect of Innate Immune Response Modulating Impurities on the Skin Milieu Using a Macaque Model: Impact on Product Immunogenicity
Haile, L. A., Puig, M., Polumuri, S. K., Ascher, J., & Verthelyi, D. I. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.11.001 · Cited by 22 · see citing works
Adjuvantation of an Influenza Hemagglutinin Antigen with TLR4 and NOD2 Agonists Encapsulated in Poly(D,L-Lactide-Co-Glycolide) Nanoparticles Enhances Immunogenicity and Protection against Lethal Influenza Virus Infection in Mice
Ильдарович, Т. А., Dzharullaeva, A. S., Erokhova, A. S., Zemskaya, A., Balyasin, M. V., Ozharovskaia, T. A., Zubkova, O. V., Shevlyagina, N. V., Zhukhovitsky, V. G., Тимофеевна, Ф. И., et al. (2020) · Vaccines · doi:10.3390/vaccines8030519 · Cited by 22 · see citing works
Adjuvants
McElrath, M. J. (2017) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000365 · Cited by 21 · see citing works
Adjuvant‐mediated enhancement of the immune response to HIV vaccines
Ratnapriya, S., Perez‐Greene, E., Schifanella, L., & Herschhorn, A. (2021) · FEBS Journal · doi:10.1111/febs.15814 · Cited by 22 · see citing works
Host-pathogen protein-nucleic acid interactions: A comprehensive review
Jain, A., Mittal, S., Tripathi, L. P., Nussinov, R., & Ahmad, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.001 · Cited by 21 · see citing works
Monocyte subset distribution is associated with mortality in critically ill patients
Krychtiuk, K. A., Lenz, M. W., Koller, L., Honeder, M. C., Wutzlhofer, L. M., Zhang, C., Chi, L., Maurer, G., Niessner, A., Huber, K., et al. (2016) · Thrombosis and Haemostasis · doi:10.1160/th16-05-0405 · Cited by 21 · see citing works
Homologous prime-boost with Zika virus envelope protein and poly (I:C) induces robust specific humoral and cellular immune responses
Amaral, M. P., Apostólico, J. D. S., Tomita, N., Coirada, F. C., Lunardelli, V. A. S., Fernandes, E. R., Souza, H. F. S., Astray, R. M., Boscardin, S. B., & Rosa, D. S. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.03.037 · Cited by 20 · see citing works
Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation
Martinez-Murillo, P., Sundling, C., O'Dell, S. J., Mascola, J. R., Wyatt, R. T., & Hedestam, G. B. K. (2015) · Scientific Reports · doi:10.1038/srep08925 · Cited by 19 · see citing works
Design of Multi-Epitope Vaccine for Staphylococcus saprophyticus: Pan-Genome and Reverse Vaccinology Approach
Yousaf, M., Ullah, A., Sarosh, N., Abbasi, S. W., Ismail, S., Bibi, S., Hasan, M. M., Albadrani, G. M., Nouh, N. A. T., Abdulhakim, J. A., et al. (2022) · Vaccines · doi:10.3390/vaccines10081192 · Cited by 19 · see citing works
Programmed polymersomes with spatio-temporal delivery of antigen and dual-adjuvants for efficient dendritic cells-based cancer immunotherapy
Wang, H., Yang, X., Hu, C., Huang, C., Wang, H., Zhu, D., & Zhang, L. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.02.022 · Cited by 18 · see citing works
Molecular and Cellular Dynamics in the Skin, the Lymph Nodes, and the Blood of the Immune Response to Intradermal Injection of Modified Vaccinia Ankara Vaccine
Rosenbaum, P., Tchitchek, N., Joly, C., Stimmer, L., Hocini, H., Dereuddre‐Bosquet, N., Beignon, A., Chapon, C., Lévy, Y., Grand, R. L., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00870 · Cited by 17 · see citing works
The Influence of Geographical Origin, Age, Sex, and Animal Husbandry on the Spontaneous Histopathology of Laboratory Cynomolgus Macaques ( Macaca Fascicularis ): A Contemporary Global and Multisite Review of Historical Control Data
Chamanza, R., Naylor, S. W., Gregori, M., Boyle, M., Bacares, M. E. P., Drevon-Gaillot, E., Romeike, A., Courtney, C. L., Johnson, K. A., Turner, J. C., et al. (2022) · Toxicologic Pathology · doi:10.1177/01926233221096424 · Cited by 17 · see citing works
Hematologic reference intervals in C ynomolgus ( M acaca fascicularis) monkeys
Bourgès-Abella, N. H., Geffré, A., Moureaux, E., Vincenti, M., Braun, J. P., & Trumel, C. (2013) · Journal of Medical Primatology · doi:10.1111/jmp.12077 · Cited by 17 · see citing works
Induction of innate immune signatures following polyepitope protein-glycoprotein B-TLR4&9 agonist immunization generates multifunctional CMV-specific cellular and humoral immunity
Dasari, V., Smith, C., Schuessler, A., Zhong, J., & Khanna, R. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.27675 · Cited by 16 · see citing works
Toll‐like receptor 4 signaling in hematopoietic‐lineage cells contributes to the enhanced activity of the human vaccine adjuvant AS01
Maele, L. V., Fougeron, D., Cayet, D., Chalon, A., Piccioli, D., Collignon, C., Sirard, J., & Didierlaurent, A. M. (2019) · European Journal of Immunology · doi:10.1002/eji.201948234 · Cited by 14 · see citing works
Molecular signatures for vaccine development
Maertzdorf, J., Kaufmann, S. H. E., & Weiner, J. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.075 · Cited by 14 · see citing works
An Antigen-Free, Plasmacytoid Dendritic Cell–Targeting Immunotherapy To Bolster Memory CD8+ T Cells in Nonhuman Primates
Masuta, Y., Yamamoto, T., Natsume‐Kitatani, Y., Kanuma, T., Moriishi, E., Kobiyama, K., Mizuguchi, K., Yasutomi, Y., & Ishii, K. J. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701183 · Cited by 13 · see citing works
Transcriptional profiling technology for studying vaccine responses: An untapped goldmine
Flanagan, K. L., Noho‐Konteh, F., Ghazal, P., & Dickinson, P. (2013) · Methods · doi:10.1016/j.ymeth.2013.03.032 · Cited by 12 · see citing works
Biological Response Modifier in Cancer Immunotherapy
Liu, R., Luo, F., Liu, X., Wang, L., Yang, J., Deng, Y., Huang, E., Qian, J., Lu, Z., Jiang, X., et al. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7555-7_2 · Cited by 12 · see citing works
Challenges related to the immunogenicity of parenteral recombinant proteins: Underlying mechanisms and new approaches to overcome it
Faraji, F., Karjoo, Z., Moghaddam, M. V., Heidari, S., Emameh, R. Z., & Falak, R. (2018) · International Reviews of Immunology · doi:10.1080/08830185.2018.1471139 · Cited by 12 · see citing works
Diminished HIV Infection of Target CD4+ T Cells in a Toll-Like Receptor 4 Stimulated in vitro Model
Cromarty, R. T., Sigal, A., Liebenberg, L. J. P., McKinnon, L. R., Karim, S. S. A., Passmore, J.-A. S., & Archary, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01705 · Cited by 11 · see citing works
Targeting a Neutralizing Epitope of HIV Envelope Gp120 by Immune Complex Vaccine
Kumar, R., & Visciano, M. L. (2012) · Journal of AIDS & Clinical Research · doi:10.4172/2155-6113.s8-002 · Cited by 10 · see citing works

The TLR3 ligand polyI:C induces liver injury and systemic inflammation in vivo by acting as an alternative pathway complement activator
Zhang, X., Kimura, Y., Miwa, T., & Song, W. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.08.030
Expression and function of toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates
Ketloy, C., Ruxrungtham, K., & Pichyangkul, S. (2007) · doi:10.58837/chula.the.2007.2119
Toll-like receptor ligands differentially activate human innate immune system and distinctively enhance antigen-specific T cell response to vaccination in humanized mice (VAC4P.1105)
Cheng, L., Zhang, Z., Zurawski, S., Zurawski, G., Lévy, Y., & Su, L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.194.supp.72.10
Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system
Cheng, L., Zhang, Z., Li, G., Li, F., Wang, L., Zhang, L., Zurawski, S., Zurawski, G., Lévy, Y., & Su, L. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.09.052 · Cited by 53 · see citing works
Comparison of the TLR7 and TLR9 innate immune signaling pathways in african green monkeys and rhesus macaques
Cox, K. S., Wang, I., Nefedov, A., Zhang, X. D., Dubey, S. A., Bett, A. J., Casimiro, D., Mandl, J. N., & Feinberg, M. B. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.203.8

Authors: Kwissa, M., Nakaya, H. I., Oluoch, H., & Pulendran, B.
Affiliations: Emory University (US)
Emory National Primate Research Center (US)
ORCID: Nakaya, Helder I.
Pulendran, Bali
Venue: Blood
Publisher: American Society of Hematology
Published: 2012-03-01
Volume: 119
Issue: 9
Pages: 2044-2055
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2011-10-388579
PMC: PMC3311246
OpenAlex: W2034484954
Cited by: 132
References: 53
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 15 · 2021: 3 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 14 · 2016: 16 · 2015: 16 · 2014: 15 · 2013: 9 · 2012: 4
FWCI: 6.13
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Blood (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (U19AI096187, 1P01AI096187-01, U19AI057266)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: TLR ligands, vaccine adjuvants, innate immune response, rhesus monkeys, MPL, R848, CpG oligodeoxynucleotides, TLR4, TLR7/8, TLR9, monocyte mobilization, myeloid dendritic cells, plasmacytoid dendritic cells, type I interferon, CXCL10, chemokines, draining lymph nodes
MeSH terms: Adjuvants, Immunologic, Animals, Dendritic Cells, Gene Expression Regulation, Humans, Imidazoles, Immunity, Innate, Injections, Intradermal, Leukocytes, Mononuclear, Ligands, Lymph Nodes, Macaca mulatta, Monocytes, Neutrophils, Oligodeoxyribonucleotides, Transcription, Genetic, Inflammation Mediators, Gene Expression Profiling, Toll-Like Receptors

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Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

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