The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Open accessAbstract
Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are largely unknown. In the present study, we examined the dynamics and functions of diverse monocyte/macrophage phenotypes during the sequential stages of skin repair. By combining the analysis of a new CCR2-eGFP reporter mouse model with conditional mouse mutants defective in myeloid cell-restricted CCR2 signaling or VEGF-A synthesis, we show herein that among the large number of inflammatory CCR2(+)Ly6C(+) macrophages that dominate the early stage of repair, only a small fraction strongly expresses VEGF-A that has nonredundant functions for the induction of vascular sprouts. The switch of macrophage-derived VEGF-A during the early stage of tissue growth toward epidermal-derived VEGF-A during the late stage of tissue maturation was critical to achieving physiologic tissue vascularization and healing progression. The results of the present study provide new mechanistic insights into CCR2-mediated recruitment of blood monocyte subsets into damaged tissue, the dynamics and functional consequences of macrophage plasticity during the sequential repair phases, and the complementary role of macrophage-derived VEGF-A in coordinating effective tissue growth and vascularization in the context of tissue-resident wound cells. Our findings may be relevant for novel monocyte-based therapies to promote tissue vascularization.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recent studies have shown that Mp phenotypes change over the different phases of tissue repair and that the sequential appearance of these phenotypes may be required for efficient repair (11,14,29,49,50).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,349
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874
Inflammation in Wound Repair: Molecular and Cellular Mechanisms
Eming, S. A., Krieg, T., & Davidson, J. M. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700701 · Cited by 2,429
Self-citation
Cited by
Sorted by citations
Items 401–500 of 534
Macrophage Proangiogenic VEGF-A Is Required for Inflammatory Arteriogenesis During Vascular Injury
Sharma, S., Pierce, J., Neverson, J., Khan, R., Lee, C. F., Uppuluri, S., Parry, C., Amelotte, E., Butler, C. A., Sellke, F. W., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13040828 · Cited by 4
“While maladaptive inflammation has been associated with worsening outcomes in patients with PAD [9,10], there has been increasing appreciation for the role of early inflammatory macrophages in orchestrating new vessel growth and maturation [11,12].”
Li, S., Yin, X., Ren, W., Zheng, J., Li, S., Zhi, K., & Gao, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144342 · Cited by 5
Zhou, C., Lei, F., Mittermaier, M., Ksander, B. R., Dana, R., Dohlman, C. H., Vavvas, D. G., Chodosh, J., & Paschalis, E. I. (2023) · Cells · doi:10.3390/cells12162089 · Cited by 4
Reǐter, L., Niehoff, N., Weiland, D., Helbig, D., Eming, S. A., Krieg, T., Etich, J., Brachvogel, B., Wiesner, R., & Knuever, J. (2024) · Matrix Biology · doi:10.1016/j.matbio.2024.07.002 · Cited by 4
Engineered Strategies to Interfere with Macrophage Fate in Myocardial Infarction
Zhai, Z., Yang, C., Yin, W., Liu, Y., Li, S., Ye, Z., Xie, M., & Song, X. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c02061 · Cited by 4
Jiawang, W., Liu, T., Zhang, X., Qu, C. F., Wu, J., Xu, S., Yang, J., & Xing, X. (2025) · Biofabrication · doi:10.1088/1758-5090/adde15 · Cited by 4
“Macrophages at the site secrete pro-angiogenic factors (VEGF, TGF-β ) and proteases matrix metalloproteinases (MMPs), directly driving angiogenesis [26–28].”
Arrevillaga-Boni, G., Hernández-Ruiz, M., Castillo, E. C., & Ortiz-Navarrete, V. (2014) · Cell Communication & Adhesion · doi:10.3109/15419061.2014.923993 · Cited by 3
“During early phase of the healing response to skin injury, macrophages are recruited to wound site (Willenborg et al., 2012).”
BackgroundThe Heterogeneity of White Adipose Tissue
Luong, Q. V., & Lee, K. Y. (2018) · InTech eBooks · doi:10.5772/intechopen.76898 · Cited by 5
“Macrophages have an established role in regulating angiogenesis during tissue repair [114].”
BackgroundNanomaterials for Wound Healing
Uzunallı, G. (2019) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-31202-2_3 · Cited by 4
Willcockson, H. H., Ozkan, H., Valdés‐Fernández, J., Arbeeva, L. S., Mucahit, E., Musawwir, L., Hooper, L. B., Granero‐Moltó, F., Prósper, F., & Longobardi, L. (2023) · Biomolecules · doi:10.3390/biom13060891 · Cited by 4
Luo, Y., Zhou, X., Xie, J., Chen, Z., Wu, Y., Lan, Z., & Chen, L. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102147 · Cited by 4
The mapping of mRNA alterations elucidates the etiology of radiation-induced pulmonary fibrosis
Yuan, M., Zhao, M., Sun, X., & Hui, Z. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.999127 · Cited by 3
“On the other hand, they produce a variety of growth factors such as VEGF-α, IGF-1, TGF-β, and Wnt proteins, which can regulate proliferation of epithelial and endothelial cells, activation of myofibroblasts, and differentiation of stem and tissue progenitor cells (Rappolee et al., 1988; Willenborg et al., 2012).”
BackgroundChin, C. W., Nicholson, G. T., & Bichell, D. P. (2023) · JTCVS Open · doi:10.1016/j.xjon.2023.09.012 · Cited by 3
“4,5 4-6 Inflammatory stimuli, such as chest tube placement at pleural apices, may predispose patients to APC development.”
BackgroundNew technologies for tissue replacement
authors, T. S. S. P. I. T. 1. W. U. T. I. T. R. L. A. L. S. W. P. I. P. A. E. F. E. T. I. I. T. D. T. S. C. T. P. O. 2. T. A. R. F. T. I. T. W. A. T. E. T. S. R. A. T. S. R.-V. L. B. O. T. A. D. O. ‘. T. D. F. T. D. A. L. I. I. B. T., relevant, I., & (2)., T. D. T. A. C. B. E. I. T. T. A. L. M. F. O. T. P. C. I. T. S. T. L. W. E. W. R. T. T. G. M. (2023) · Journal of Wound Management Official journal of the European Wound Management Association · doi:10.35279/jowm2023.24.01.sup01 · Cited by 3
Dysregulated inflammation in diabetic wounds
denDekker, A. D., & Gallagher, K. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816413-6.00005-8 · Cited by 5
Cao, J., Zhong, L., Feng, Y., Qian, K., Xiao, Y., Wang, G., Tu, W., Yue, L., Zhang, Q., Jiao, Y., et al. (2020) · Radiation Research · doi:10.1667/rade-20-00050.1 · Cited by 3
Heiskala, M. K., Joensuu, K. M., & Heikkilä, P. (2021) · Onco · doi:10.3390/onco2010001 · Cited by 3
Developmental Models for Wound Healing
Matsubayashi, Y., & Millard, T. H. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0021306 · Cited by 3
Deep skin fibroblast-mediated macrophage recruitment supports acute wound healingPreprint
Amuso, V. M., Haas, M. R., Cooper, P. O., Chatterjee, R., Hafiz, S., Salameh, S., Gohel, C., Mazumder, M. F., Josephson, V., Khorsandi, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.09.607357 · Cited by 3
Yuan, R., Yang, C., Mishra, B., Oliver, D., Bell, R. D., & Ivashkiv, L. B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.28.667180 · Cited by 3
The Potential of Macrophages for Skin Anti-aging
Zhou, H., Wang, Y., Li, Y., & Zheng, Y. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl38891 · Cited by 2
Gupta, R., Cooper, P. O., Chai, W., Mulagura, P., Lee, S. M., Theocharidis, G., Sidawy, A. N., Shook, B. A., & Nguyen, B.-N. H. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70103 · Cited by 2
Wu, M.-S., Shiue, S., Zheng, Q.-Y., Chen, Y.-S., & Lin, H.-Y. (2026) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00786-x · Cited by 2
Biomimetic nanomaterial-based strategies for spinal cord injury repair
Chen, R.-L., Jiang, L., Teng, H.-B., Yang, J.-L., He, W.-B., Zhang, Y., Ren, Q.-Q., Chen, H.-X., Fan, R., & Xu, J.-G. (2026) · Nano Today · doi:10.1016/j.nantod.2025.102969 · Cited by 3
The regulatory logic linking inflammation and fibrosis
Alexanian, M., & Srivastava, D. (2026) · Cell · doi:10.1016/j.cell.2026.08.001 · Cited by 2
Skwara, A. J., Schilder, R. J., Zibelli, A. M., & Rosenblum, N. G. (2013) · Gynecologic Oncology Case Reports · doi:10.1016/j.gynor.2013.06.005 · Cited by 2
“The vaginal cuff may have thereby been more susceptible to dehiscence following treatment with bevacizumab due to the increased presence of VEGF-A during the inflammatory and proliferative stages.”
InfluentialAn artificial silk elastin-like protein modifies the polarization of human macrophages line THP-1
Unzai, T., Washisaka, T., & Tabata, Y. (2023) · Journal of Biomaterials Applications · doi:10.1177/08853282231192186 · Cited by 3
“Macrophages function as one of the important inflammatory cell types during all stages of wound healing.(54) At the first phase of inflammation, macrophages play a key role in controlling the subsequent processes.”
BackgroundHasegawa, A., Obara, K., Takaoka, N., Shirai, K., Hamada, Y., Arakawa, N., Aki, R., Hoffman, R. M., & Amoh, Y. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304676 · Cited by 2
“The main sources of VEGF-A are keratinocytes and macrophages [27, 28], therefore, it is thought that VEGF was produced from macrophages and keratinocytes differentiated from the HAP-cell-sheets and promoted angiogenesis.”
BackgroundVelanki, H., Tyreman, N., Seres, P., Solis, L. R., Lu, S., Thompson, R. B., & Mushahwar, V. K. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70102 · Cited by 3
“The role of macrophages in the tissue healing process is well described in many studies [60–63].”
Tissue Remodeling and Repair During Type 2 Inflammation
Chan, A. J., Jang, J. C., & Nair, M. G. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2911-5_7 · Cited by 3
Isolation of macrophages from mouse skin wounds for single-cell RNA sequencing
Willenborg, S., Roscito, J. G., Gerbaulet, A., Roers, A., Dahl, A., Eming, S. A., & Reinhardt, S. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101337 · Cited by 3
“However, additional markers such as MHC II, Trem2, CD301b, Ly6C, CCR2, and CD64 (which has been used to identify dermal macrophages), can be added for sorting and/or as an index marker (Joshi et al., 2020; Kolter et al., 2019; Tamoutounour et al., 2013; Willenborg et al., 2012).”
BackgroundLemonnier, D., Mezghani, I., Theocharidis, G., Sumpio, B. J., Sia, S. K., Veves, A., & Chitnis, P. V. (2023) · IRBM · doi:10.1016/j.irbm.2023.100818 · Cited by 2
Peripheral Blood Mononuclear Cells
Carella, S., & Onesti, M. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-45453-0_26 · Cited by 2
Enhanced Vascularization of Modular Engineered Tissues Using Activated Macrophages
West, M. E. D. (2016) · TSpace (University of Toronto) · Cited by 2
da Costa, M. C. (2019) · doi:10.14393/ufu.di.2019.1246 · Cited by 2
Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healingPreprint
Zhang, Y., Wang, P., Neng, L., Sharma, K., Kachelmeier, A., & Shi, X. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.03.635565 · Cited by 2
Ageing and its role in modulating healthy and tumour-associated macrophages
Duong, L., Jackaman, C., & Nelson, D. J. (2024) · Ageing and Cancer Research & Treatment · doi:10.37155/2972-4759-2024-02-01-1 · Cited by 1
Redox state of aging skin: A double-edged sword in wound healing
Chen, Q., Sophabmixay, A., Albertson, T., Ghasb, G., Terzian, A., Yan, L., Young, L. H., & Barsotti, R. (2024) · Advances in biogerontology · doi:10.1016/bs.abger.2024.05.008 · Cited by 1
Zhu, L., Feng, J., Cai, J., Liu, J., & Wang, D. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106739 · Cited by 1
GAS reduced inflammatory responses in activated microglia by regulating the Ccr2/Akt/Gsk-3β pathway
Shi, H., Shi, J., Wang, Z., Zuo, H., Guo, T., Zheng, H., Xiao, R., Zhang, X., Yang, S., & Li, J. (2025) · Molecular Brain · doi:10.1186/s13041-025-01206-w · Cited by 1
“Based on previous studies [24], before other treatments, the cells were pre-treated with RS102895 (Tocris, UK) at a concentration of 100 ng/ml for 1 h, followed by treatment with GAS at a concentration of 0.34 mM for 1 h. Subsequently, the corresponding groups were subjected to OGD treatment.”
InfluentialCaporarello, N., Mehta, D., Tsukasaki, Y., Sarkar, A., Crawford, B. C., & Bauer, N. N. (2025) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00311.2025 · Cited by 3
Gao, X.-F., Lin, Z., Wang, J., Wu, S.-J., Li, H., Li, F.-S., Han, S.-Q., Xie, L.-F., Shao, H., & Liu, S. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.121811 · Cited by 1
Seo, K. S., Nicols, L. M., Palmer, C. D., Hellmann, K. T., Robinson, D. A., Olivier, A. K., Thornton, J. A., Ferdous, K., Brookshire, W. C., & Park, J. Y. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1805111 · Cited by 1
The potential of calcitriol gel in accelerating the healing of traumatic oral ulcers
Radithia, D., Ernawati, D. S., Ayuningtyas, N. F., Mahdani, F. Y., Parmadiati, A. E., Pratiwi, A. S., Sarasati, A., Bakti, R. K., Fatarnaha, N. T., Fitri, A. R., et al. (2026) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2026.05.012 · Cited by 1
Crane, M. J., & Albina, J. E. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_12 · Cited by 1
Engineering Vascular Niche for Bone Tissue Regeneration
Ng, J., Spiller, K. L., Bernhard, J., & Vunjak‐Novakovic, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802734-9.00032-9 · Cited by 1
Role of Macrophages and Immunotherapy in Wound Healing
Oake, A., Gupta, S., & Pathak, Y. V. (2022) · Springer eBooks · doi:10.1007/978-3-030-84164-5_22 · Cited by 1
Role of macrophages in systemic inflammation: wound healing
Ahmed, M. S., Rahman, M., Matin, M. A., Hossen, M. J., & Sikder, M. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822368-0.00015-3 · Cited by 1
Dermal macrophages in health and disease
Salina, A. C. G., Klopfenstein, N., Pinon, J., & Serezani, C. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821385-8.00008-1 · Cited by 2
Bitar, M. S. (2017) · Recent clinical techniques, results, and research in wounds · doi:10.1007/15695_2017_44 · Cited by 1
Macrophage Plasticity in Skin Fibrosis
Rodrigues, M., & Bonham, C. A. (2018) · Molecular and translational medicine · doi:10.1007/978-3-319-98143-7_3 · Cited by 2
Role of Stromal Cells in Angiogenesis of Skin Wounds: Review
Михайловна, Ч. Т., Сергеевна, Н. М., Kachkurkina, A. A., Ененков, Н. В., & Chukhanov, M. S. (2023) · Nauka molodykh (Eruditio Juvenium) · doi:10.23888/hmj2023112271-280
Jacome-Galarza, C. E. (2013) · OpenCommons - UConn (University of Connecticut) · Cited by 1
Ballotta, V. (2014) · TU/e Research Portal · doi:10.6100/ir780925 · Cited by 1
Vieillissement chimique de membranes d'osmose inverse
Ettori, A. (2011) · Thèses en ligne de l'Université Toulouse III (Université Toulouse III) · Cited by 1
Cherry, C., Andorko, J. I., Krishnan, K., Mejías, J. C., Nguyen, H. H., Stivers, K. B., Gray-Gaillard, E. F., Ruta, A., Hamada, N., Hamada, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.22.485297 · Cited by 1
“Pericytes are well recognized as progenitor cells that can contribute to angiogenesis but myeloid cells also promote vascular development through production of VEGF as demonstrated in the FBR (Dondossola et al., 2016; Stockmann, Kirmse, Helfrich, Weidemann, & Takeda, 2011; Willenborg et al., 2012).”
BackgroundInjarabian, L., Willenborg, S., Welcker, D., Pasparakis, M., Kashkar, H., & Eming, S. (2023) · bioRxiv · doi:10.1101/2023.03.29.534669 · Cited by 1
Development of novel wound dressing based on elastin-like recombinamers for skin regeneration
Juanes‐Gusano, D. (2024) · doi:10.35376/10324/71600 · Cited by 1
Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healingPreprint
Zhang, Y., Wang, P., Neng, L., Sharma, K., Kachelmeier, A., & Shi, X. (2025) · eLife · doi:10.7554/elife.106393.1 · Cited by 1
Characterisation of leukocytes in reproductive tissues before and after pregnancy
Oldham, R. S. (2013) · Enlighten: Theses (The University of Glasgow)
Endothelial and Accessory Cell Interactions in Neuroblastoma Tumor Microenvironment
Gershan, J. A., Chan, A. M.-L., Chrzanowska‐Wodnicka, M., Johnson, B. D., Robert, Q., & Ramchandr, R. (2013) · InTech eBooks · doi:10.5772/55486 · Cited by 1
“Using a physiologic model of skin wound repair, CCR2hi/VEGF-expressing macrophages were shown to initiate vascular sprouts during the early stages of tissue repair [195].”
BackgroundMethodMicroglia: A Double-Sided Sword in Stroke
Shi, H., Xu, M., Shi, Y., Gao, Y., Chen, J., & Hu, X. (2016) · Springer series in translational stroke research · doi:10.1007/978-3-319-32337-4_7
Wells, A. J. (2015) · Journal of International Crisis and Risk Communication Research
Manipulating the Angiogenesis by Inflammation
Kim, M. J., Jin, S., Whang, Y. M., & Chang, I. H. (2017) · Journal of Urologic Oncology · doi:10.22465/kjuo.2017.15.1.1
“국소허혈 모델에서 MCP-1은 이 세포들을 집합시켜 초기 혈관 생성과 동맥 신 생을 촉진시킨다.(36,37) M1 대식 세포는 보통 상처 치유 방지 반응에 관여되어 있고, M2 대식 세포는 혈관 신생과 혈관 의 성장에 관여하고 있다.”
Microglial Function in Intracerebral Hemorrhage Injury and Recovery
Cho, A.-H., Michael, N., Cribbs, D. H., & Fisher, M. (2017) · Springer series in translational stroke research · doi:10.1007/978-3-319-66679-2_23
Development of a Mathematical Model to Understand, Design & Improve Oncolytic Virus Therapies
Batenchuk, C. (2014) · uO Research (University of Ottawa) · doi:10.20381/ruor-3780
“TILs with defined function in blocking immune responses during wound repair include neutrophiles (81), regulatory T-cells (82), M2 macrophages (83, 84) and Myeloid Derived Suppressor Cells (85).”
BackgroundModulating Aged Macrophages and Osteoprogenitors with a Calcium Phosphate Drug Delivery System
Alhamdi, J. R. (2018) · OpenCommons at University of Connecticut (University of Connecticut)
Os leucotrienos no diabetes tipo 1
Ramalho, T. R. D. O. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2019.tde-18042019-141413
YAP-mediated mechanotransduction promotes fibrotic activity
Racanelli, M. (2019) · Scholarship@Western (Western University)
Cellular and Molecular Mechanisms of Hypertrophic Scarring
Nguyen, A. T., Ding, J., & Tredget, E. E. (2019) · Springer eBooks · doi:10.1007/978-981-32-9791-3_3
Bone marrow monopoiesis and wound healing in diabetes
Barman, P. K., & Koh, T. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816413-6.00025-3
Zbesko, J. C. (2020) · UA Campus Repository (The University of Arizona)
The versatile nature of MIF (macrophage migration inhibitory factor) in chronic lung diseases
Florez‐Sampedro, L. (2020) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.135375699
The role of Angiopoietin-like protein 4 in macrophage activation
Wee, J. W. K. (2020) · doi:10.32657/10356/151419
Zhou, C., Lei, F., Mittermaier, M., Ksander, B., Dana, R., Dohlman, C. H., Vavvas, D. G., Chodosh, J., & Paschalis, E. I. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.25.453707
Agent Based Modeling of Skeletal Muscle Adaptation
Martin, K. (2015) · doi:10.18130/v31570
Zhai, T., Mitamura, T., Wang, L., Kubota, S. I., Murakami, M., Tanaka, S., & Watari, H. (2022) · Research Square · doi:10.21203/rs.3.rs-1661419/v1
Spatial compartmentalization of signalling imparts source-specific functions on secreted factorsPreprint
Groppa, E., Martini, P. G. V., Derakhshan, N., Théret, M., Ritso, M., Tung, L. H., Wang, Y. X., Soliman, H., Hamer, M., Stankiewicz, L. N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.20.504649
Skin Lesion Vitality Assessment for Forensic Science: Current Research and New perspectives
(2022) · Frontiers research topics · doi:10.3389/978-2-83250-060-6
Cherry, C., Andorko, J. I., Krishnan, K., Mejías, J. C., Nguyen, H. H., Stivers, K. B., Gray-Gaillard, E. F., Ruta, A., Han, J., Hamada, N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1847932/v1
Unveiling Macrophage-Biofilm Interactions: Implications for Cellular Metabolism and Wound Healing
Versey, Z. (2023) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2023-15377
Transcriptional analysis of efferocytosis in mouse skin woundsPreprint
Krause, W., King, D. E., & Horsley, V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.12.607219 · Cited by 1
“Monocyte-derived macrophages are a prevalent phagocytic cell within early skin wounds (Aitcheson et al., 2021; Shook et al., 2018; Willenborg et al., 2012) and thus we analyzed mGFP expression in skin wounds of tamoxifen-treated LysMCreER/mTmG mice at D1 and D3 after injury.”
BackgroundAi, S., Arutyunov, A., Liu, J., Hill, J. D., Jiang, X., & Klein, R. S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.17.613307
Heydari, M., Seyyedkazemi, S. M., Joghataei, M. T., Ghomi, F. M., Kenari, H. M., Sadigh, N., Rustamzadeh, A., Bakhtiari, M., & Alizadeh-Otaghvar, H. (2024) · Medical Journal of the Islamic Republic of Iran · doi:10.47176/mjiri.39.16
“Studies on human wounds and animal models have shown that VEGF is produced by keratinocytes in the early stages of wound healing, but more recent evidence shows that keratinocytes also produce VEGF in the later stages of healing (103).”
Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healingPreprint
Zhang, Y., Wang, P., Neng, L., Sharma, K., Kachelmeier, A., & Shi, X. (2025) · eLife · doi:10.7554/elife.106393
cellSight: Characterizing dynamics of cells using single-cell RNA-sequencingPreprint
Chatterjee, R., Gohel, C., Taheriyoun, A. R., Shook, B. A., & Rahnavard, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.16.654572
“Our analysis suggests that increased Ccl2 expression could facilitate monocyte/macrophage recruitment 39 , while pro-154 inflammatory cytokines ( IL-1 , IL-6 , IL-8 ) may initiate immune response and pathogen clearance 40,41 .”
Adé, K., Zhao, K., & Bowdish, D. M. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00171-x
Crane, M. J., McKinney, R. L., Jordon, A. R. D., Eberson, C. P., & Jamieson, A. M. (2025) · Wound Repair and Regeneration · doi:10.1111/wrr.70076
Computational tracking of cell origins using CellSexID from single-cell transcriptomes
Tai, H., Li, Q., Wang, J., Tan, J., Zhao, B., Lang, R., Petrof, B. J., & Ding, J. (2025) · Cell Reports Methods · doi:10.1016/j.crmeth.2025.101181
Toyonaga, H., Cheng, L., & Tanaka, H. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00982
Silveira, B. M. D., Ribeiro, T. O., Freire, S. M., Costa, B., Maffili, V. V., Gonçalves, M. D. S., Sogayar, M. C., Nascimento, R. J. M., & Fortuna, V. (2025) · Cellular Immunology · doi:10.1016/j.cellimm.2025.105047
Follow the science: How fat cells taught us about scarring and ECM homeostasis
Horsley, V. (2025) · Matrix Biology · doi:10.1016/j.matbio.2025.12.003
Metadata
- Authors
- Willenborg, S., Lucas, T., van Loo, G., Knipper, J. A., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A., Ferrara, N., Pasparakis, M., & Eming, S. A.
- Affiliations
- University of Cologne (DE)
- Department for Molecular Biomedical Research, Vlaams Instituut voor Biotechnologie, Ghent, Belgium;
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON;
- Genentech (US)
- Corresponding author
- Willenborg, Sebastian
- Lucas, Tina
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-07-19
- Volume
- 120
- Issue
- 3
- Pages
- 613-625
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2065145765
- Cited by
- 534
- References
- 40
- Citations by year
- 2026: 29 · 2025: 43 · 2024: 38 · 2023: 55 · 2022: 46 · 2021: 40 · 2020: 40 · 2019: 34 · 2018: 38 · 2017: 43 · 2016: 32 · 2015: 29 · 2014: 37 · 2013: 24 · 2012: 5
- FWCI
- 32.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- European Commission (2007–2013, 214402)
- Deutsche Forschungsgemeinschaft
- Universiteit Gent
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- CCR2, macrophage plasticity, VEGF-A, angiogenesis, skin wound healing, tissue repair, monocyte recruitment, vascular sprouting, tissue vascularization
- MeSH terms
- Animals, Cells, Cultured, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Regeneration, Skin, Wound Healing, Signal Transduction, Macrophages, Peritoneal, Neovascularization, Physiologic, Gene Expression Profiling, Myeloid Cells, Vascular Endothelial Growth Factor A, Green Fluorescent Proteins, Mice, Receptors, CCR2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
