Closing the gap between T-cell life span estimates from stable isotope-labeling studies in mice and humans

Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans

den Braber, I., Mugwagwa, T., Vrisekoop, N., Westera, L., Mögling, R., Bregje de Boer, A., Willems, N., Schrijver, E. H. R., Spierenburg, G., Gaiser, K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.006 · Cited by 572 · see citing works

Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy

Mohri, H., Perelson, A. S., Tung, K. S., Ribeiro, R. M., Ramratnam, B., Markowitz, M. H., Kost, R. G., Hurley, Weinberger, L. S., Cesar, D., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1277 · Cited by 358 · see citing works

Measurement in vivo of proliferation rates of slow turnover cells by 2 H 2 O labeling of the deoxyribose moiety of DNA

Neese, R. A., Misell, L. M., Turner, S., Chu, A., Kim, J., Cesar, D., Hoh, R., Antelo, F., Strawford, A., McCune, J. M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232551499 · Cited by 279 · see citing works

Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection

Hellerstein, M. K., Hoh, R., Hanley, M. B., Cesar, D., Lee, D. C., Neese, R. A., & McCune, J. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317533 · Cited by 243 · see citing works

Quantifying T lymphocyte turnover

de Boer, R. J., & Perelson, A. S. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2012.12.025 · Cited by 241 · see citing works

Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool

Vrisekoop, N., den Braber, I., de Boer, A. B., Ruiter, A. F. C., Ackermans, M. T., van der Crabben, S. N., Schrijver, E. H. R., Spierenburg, G. T., Sauerwein, H. P., Hazenberg, M. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709713105 · Cited by 230 · see citing works

In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: Why are CD4 + but not CD8 + T cells depleted?

Ribeiro, R. M., Mohri, H., Ho, D. D., & Perelson, A. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242358099 · Cited by 199 · see citing works

Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans

Macallan, D. C., Wallace, D. L., Zhang, Y., de Lara, C., Worth, A. T., Ghattas, H., Griffin, G. E., Beverley, P. C. L., & Tough, D. F. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040341 · Cited by 193 · see citing works

Measurement of cell proliferation by heavy water labeling

Busch, R., Neese, R. A., Awada, M., Hayes, G. M., & Hellerstein, M. K. (2007) · Nature Protocols · doi:10.1038/nprot.2007.420 · Cited by 184 · see citing works

Measurement and modeling of human T cell kinetics

Macallan, D. C., Asquith, B., Irvine, A. J., Wallace, D. L., Worth, A. T., Ghattas, H., Zhang, Y., Griffin, G. E., Tough, D. F., & Beverley, P. C. L. (2003) · European Journal of Immunology · doi:10.1002/eji.200323763 · Cited by 129 · see citing works

Lymphocyte kinetics: the interpretation of labelling data

Asquith, B., Debacq, C., Macallan, D. C., Willems, L., & Bangham, C. R. M. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02337-2 · Cited by 118 · see citing works

Direct measurement of T cell subset kinetics in vivo in elderly men and women

Wallace, D. L., Zhang, Y., Ghattas, H., Worth, A., Irvine, A., Bennett, A. R., Griffin, G. E., Beverley, P. C. L., Tough, D. F., & Macallan, D. C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.3.1787 · Cited by 115 · see citing works

Kinetics of In Vivo Proliferation and Death of Memory and Naive CD8 T Cells: Parameter Estimation Based on 5-Bromo-2′-Deoxyuridine Incorporation in Spleen, Lymph Nodes, and Bone Marrow

Parretta, E., Cassese, G., Santoni, A., Guardiola, J., Vecchio, A., & Rosa, F. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7230 · Cited by 78 · see citing works

Quantification of T‐cell dynamics: from telomeres to DNA labeling

Borghans, J. A. M., & de Boer, R. J. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00497.x · Cited by 76 · see citing works

Memory Phenotype CD4 T Cells Undergoing Rapid, Nonburst-Like, Cytokine-Driven Proliferation Can Be Distinguished from Antigen-Experienced Memory Cells

Younes, S., Punkosdy, G. A., Caucheteux, S. M., Chen, T., Grossman, Z., & Paul, W. E. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001171 · Cited by 70 · see citing works

In vivo Dynamics of Stable Chronic Lymphocytic Leukemia Inversely Correlate with Somatic Hypermutation Levels and Suggest No Major Leukemic Turnover in Bone Marrow

van Gent, R., Kater, A. P., Otto, S. A., Jaspers, A., Borghans, J. A. M., Vrisekoop, N., Ackermans, M. T., Ruiter, A. F. C., Wittebol, S. H., Eldering, E., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2325 · Cited by 69 · see citing works

Homeostatic Turnover of Virus-Specific Memory CD8 T Cells Occurs Stochastically and Is Independent of CD4 T Cell Help

Choo, D. K., Murali‐Krishna, K., Anita, R., & Ahmed, R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001421 · Cited by 63 · see citing works

Explicit Kinetic Heterogeneity: Mathematical Models for Interpretation of Deuterium Labeling of Heterogeneous Cell Populations

Ganusov, V. V., Borghans, J. A. M., & de Boer, R. J. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000666 · Cited by 41 · see citing works

Lymphocyte kinetics in health and disease

Asquith, B., Borghans, J. A. M., Ganusov, V. V., & Macallan, D. C. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.01.003 · Cited by 36 · see citing works

Determination of total body water by a simple and rapid mass spectrometric method

KREEL, B. K. V., der Vegt, F. V., Meers, M., Wagenmakers, T., Westerterp, K. R., & Coward, A. (1996) · Journal of Mass Spectrometry · doi:10.1002/(sici)1096-9888(199601)31:1 · Cited by 35 · see citing works

Modelling deuterium labelling of lymphocytes with temporal and/or kinetic heterogeneity

de Boer, R. J., Perelson, A. S., & Ribeiro, R. M. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0149 · Cited by 24 · see citing works

Quantitating Lymphocyte Homeostasis In Vivo in Humans Using Stable Isotope Tracers

Westera, L., Zhang, Y., Tesselaar, K., Borghans, J. A. M., & Macallan, D. C. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-290-2_10 · Cited by 19 · see citing works

The who's who of <scp>T</scp> ‐cell differentiation: Human memory <scp>T</scp> ‐cell subsets

Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817 · see citing works

Origin and differentiation of human memory CD8 T cells after vaccination

Akondy, R. S., Fitch, M., Edupuganti, S., Yang, S., Kissick, H. T., Li, K. W., Youngblood, B. A., Abdelsamed, H. A., McGuire, D. J., Cohen, K. W., et al. (2017) · Nature · doi:10.1038/nature24633 · Cited by 517 · see citing works

Mechanisms underlying T cell ageing

Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506 · see citing works

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

Ívetic, A., Green, H. L. H., & Hart, S. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01068 · Cited by 471 · see citing works

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works

Post-treatment control of HIV infection

Conway, J. M., & Perelson, A. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419162112 · Cited by 227 · see citing works

How many TCR clonotypes does a body maintain?

Lythe, G., Callard, R. E., Hoare, R. L., & Molina-París, C. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.10.016 · Cited by 175 · see citing works

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options

Periman, L. M., Perez, V. L., Saban, D. R., Lin, M. C., & Neri, P. (2020) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2019.0060 · Cited by 174 · see citing works

Advances in NK cell production

Fang, F., Xie, S., Chen, M., Li, Y., Yue, J., Ma, J., Shu, X., He, Y., Xiao, W., & Tian, Z. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00808-3 · Cited by 123 · see citing works

Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

Zhang, M. J., Pisco, A. O., Darmanis, S., & Zou, J. (2021) · eLife · doi:10.7554/elife.62293 · Cited by 114 · see citing works

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

Säwen, P., Eldeeb, M., Erlandsson, E., Kristiansen, T. A., Laterza, C., Kokaia, Z., Karlsson, G., Yuan, J., Soneji, S., Mandal, P. K., et al. (2018) · eLife · doi:10.7554/elife.41258 · Cited by 120 · see citing works

Fluctuating fitness shapes the clone-size distribution of immune repertoires

Desponds, J., Mora, T., & Walczak, A. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512977112 · Cited by 96 · see citing works

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

Sadowski, I., & Hashemi, F. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03156-8 · Cited by 106 · see citing works

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover

Westera, L., van Hoeven, V., Drylewicz, J., Spierenburg, G., van Velzen, J. F., de Boer, R. J., Tesselaar, K., & Borghans, J. A. M. (2015) · Aging Cell · doi:10.1111/acel.12311 · Cited by 96 · see citing works

Carbon Monoxide: from Poison to Clinical Trials

Siracusa, R., Schaufler, A., Calabrese, V., Fuller, P. M., & Otterbein, L. E. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.02.003 · Cited by 97 · see citing works

Mechanisms of HBV immune evasion

Kuipery, A., Gehring, A. J., & Isogawa, M. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104816 · Cited by 86 · see citing works

Human T Cell Memory: A Dynamic View

Macallan, D. C., Borghans, J. A. M., & Asquith, B. (2017) · Vaccines · doi:10.3390/vaccines5010005 · Cited by 78 · see citing works

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

Gossel, G. H., Hogan, T. V., Cownden, D., Seddon, B. P., & Yates, A. J. (2017) · eLife · doi:10.7554/elife.23013 · Cited by 78 · see citing works

Immune Aging and Immunotherapy in Cancer

Kaiser, M., Semeraro, M. D., Herrmann, M., Absenger, G., Gerger, A., & Renner, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137016 · Cited by 78 · see citing works

Clay Nanoparticles Elicit Long‐Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation

Chen, W., Zuo, H., Li, B., Duan, C., Rolfe, B. E., Zhang, B., Mahony, T. J., & Xu, Z. P. (2018) · Small · doi:10.1002/smll.201704465 · Cited by 77 · see citing works

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

del Amo, P. C., Lahoz-Beneytez, J., Boelen, L., Ahmed, R., Miners, K. L., Zhang, Y., Roger, L., Jones, R. E., Marraco, S. A. F., Speiser, D. E., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005523 · Cited by 74 · see citing works

Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles

Chen, W., Zhang, B., Mahony, T. J., Gu, W., Rolfe, B. E., & Xu, Z. P. (2016) · Small · doi:10.1002/smll.201503359 · Cited by 74 · see citing works

Residual Viremia in Treated HIV+ Individuals

Conway, J. M., & Perelson, A. S. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004677 · Cited by 67 · see citing works

Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

Jiang, X., Chen, X., Carpenter, T. J., Wang, J., Zhou, R., Davis, H. M., Heald, D. L., & Wang, W. (2018) · mAbs · doi:10.1080/19420862.2018.1480299 · Cited by 60 · see citing works

Chronic Kidney Disease and Premature Ageing of the Adaptive Immune Response

Betjes, M. G. H., & Litjens, N. H. R. (2014) · Current Urology Reports · doi:10.1007/s11934-014-0471-9 · Cited by 58 · see citing works

Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice

Hogan, T. V., Gossel, G. H., Yates, A. J., & Seddon, B. P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517246112 · Cited by 56 · see citing works

Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium‐labeling experiments

Borghans, J. A. M., Tesselaar, K., & de Boer, R. J. (2018) · Immunological Reviews · doi:10.1111/imr.12693 · Cited by 53 · see citing works

Clonal dynamics after allogeneic haematopoietic cell transplantation

Spencer Chapman, M., Wilk, C. M., Boettcher, S., Mitchell, E., Dawson, K., Williams, N., Müller, J., Kovtonyuk, L., Jung, H., Caiado, F., et al. (2024) · Nature · doi:10.1038/s41586-024-08128-y · Cited by 60 · see citing works

Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial

Denk, D., Singh, A., Kasler, H. G., D’Amico, D., Rey, J., Alcober-Boquet, L., Gorol, J. M., Steup, C., Tiwari, R., Kwok, R., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00996-x · Cited by 53 · see citing works

Lifitegrast for the treatment of dry eye disease in adults

Donnenfeld, E. D., Perry, H. D., Nattis, A. S., & Rosenberg, E. D. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1372748 · Cited by 49 · see citing works

Mathematics in modern immunology

Castro, M., Lythe, G., Molina-Parı́s, C., & Ribeiro, R. M. (2016) · Interface Focus · doi:10.1098/rsfs.2015.0093 · Cited by 46 · see citing works

Short Lifespans of Memory T-cells in Bone Marrow, Blood, and Lymph Nodes Suggest That T-cell Memory Is Maintained by Continuous Self-Renewal of Recirculating Cells

Baliu‐Piqué, M., Verheij, M. W., Drylewicz, J., Ravesloot, L., de Boer, R. J., Koets, A. P., Tesselaar, K., & Borghans, J. A. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02054 · Cited by 45 · see citing works

Innate Immunity Plays a Key Role in Controlling Viral Load in COVID-19: Mechanistic Insights from a Whole-Body Infection Dynamics Model

Dogra, P., Ruiz-Ramírez, J., Sinha, K., Butner, J. D., Peláez, M. J., Rawat, M., Yellepeddi, V., Pasqualini, R., Arap, W., Sostman, H. D., et al. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00183 · Cited by 45 · see citing works

Integrating between-host transmission and within-host immunity to analyze the impact of varicella vaccination on zoster

Ogunjimi, B., Willem, L., Beutels, P., & Hens, N. (2015) · eLife · doi:10.7554/elife.07116 · Cited by 42 · see citing works

Current estimates of T cell kinetics in humans

Macallan, D. C., Busch, R., & Asquith, B. (2019) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2019.10.002 · Cited by 41 · see citing works

Quantification of T-cell dynamics during latent cytomegalovirus infection in humans

van den Berg, S. P. H., Derksen, L. Y., Drylewicz, J., Nanlohy, N. M., Beckers, L., Lanfermeijer, J., Gessel, S., Vos, M. W., Otto, S. A., de Boer, R. J., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010152 · Cited by 40 · see citing works

Lifitegrast Ophthalmic Solution 5% Is a Safe and Efficient Eyedrop for Dry Eye Disease: A Systematic Review and Meta-Analysis

Li, J., Tsai, Y., Lai, C., Li, Y., Wu, Y.-H., & Chiang, C.-C. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175014 · Cited by 40 · see citing works

Rates of CTL Killing in Persistent Viral Infection In Vivo

Elemans, M., Florins, A., Willems, L., & Asquith, B. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003534 · Cited by 37 · see citing works

Heterogeneity of memory T cells in aging

Jain, A. K., Sturmlechner, I., Weyand, C. M., & Goronzy, J. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1250916 · Cited by 33 · see citing works

T cell fate decisions during memory cell generation with aging

Sturmlechner, I., Jain, A. K., Mu, Y., Weyand, C. M., & Goronzy, J. J. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101800 · Cited by 31 · see citing works

Quantification of naive and memory T-cell turnover during HIV-1 infection

Vrisekoop, N., Drylewicz, J., van Gent, R., Mugwagwa, T., van Lelyveld, S. F. L., Veel, E. M., Otto, S. A., Ackermans, M. T., Vermeulen, J. N., Huidekoper, H. H., et al. (2015) · AIDS · doi:10.1097/qad.0000000000000822 · Cited by 31 · see citing works

Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples

Liechti, T., Iftikhar, Y., Mangino, M., Beddall, M. H., Goss, C. W., O’Halloran, J. A., Mudd, P. A., & Roederer, M. (2022) · Nature Communications · doi:10.1038/s41467-022-34638-2 · Cited by 29 · see citing works

Fc Effector Function of Immune Checkpoint Blocking Antibodies in Oncology

Martineau, R., Susini, S., & Marabelle, A. (2024) · Immunological Reviews · doi:10.1111/imr.13427 · Cited by 27 · see citing works

Modeling the immune response to HIV infection

Conway, J. M., & Ribeiro, R. M. (2018) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2018.10.006 · Cited by 29 · see citing works

Bone marrow is the preferred site of memory CD4+ T cell proliferation during recovery from sepsis

Skirecki, T., Swacha, P., Hoser, G., Gołąb, J., Nowis, D., & Kozłowska, E. (2020) · JCI Insight · doi:10.1172/jci.insight.134475 · Cited by 27 · see citing works

Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments

Ahmed, R., Westera, L., Drylewicz, J., Elemans, M., Zhang, Y., Kelly, E. W., Reljić, R., Tesselaar, K., de Boer, R. J., Macallan, D. C., et al. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004355 · Cited by 26 · see citing works

Development of a minimal physiologically-based pharmacokinetic/pharmacodynamic model to characterize target cell depletion and cytokine release for T cell-redirecting bispecific agents in humans

Jiang, X., Chen, X., Jaiprasart, P., Carpenter, T. J., Zhou, R. Z., & Wang, W. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105260 · Cited by 25 · see citing works

Modeling T Cell Fate

de Boer, R. J., & Yates, A. J. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101721-040924 · Cited by 24 · see citing works

Memories that last: Dynamics of memory T cells throughout the body

Derksen, L. Y., Tesselaar, K., & Borghans, J. A. M. (2023) · Immunological Reviews · doi:10.1111/imr.13211 · Cited by 23 · see citing works

Mathematical model for the growth of Mycobacterium tuberculosis in the granuloma

Burbano-Rosero, E. M., Esteva, L., & Ibargüen-Mondragón, E. (2017) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2018018 · Cited by 24 · see citing works

Environmentally relevant exposures of male mice to carbendazim and thiram cause persistent genotoxicity in male mice

Rai, B., & Mercurio, S. D. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-07088-5 · Cited by 23 · see citing works

Absence of autoreactive CD4+ T-cells targeting HLA-DQA1*01:02/DQB1*06:02 restricted hypocretin/orexin epitopes in narcolepsy type 1 when detected by EliSpot

Kornum, B. R., Burgdorf, K. S., Holm, A., Ullum, H., Jennum, P., & Knudsen, S. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.05.001 · Cited by 22 · see citing works

Early HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b)

Andrade, A. S., Guedj, J., Rosenkranz, S. L., Lu, D., Mellors, J. W., Kuritzkes, D. R., Perelson, A. S., & Ribeiro, R. M. (2015) · AIDS · doi:10.1097/qad.0000000000000843 · Cited by 21 · see citing works

Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension

Batchu, S. N., Hughson, A., Wadosky, K. M., Morrell, C. N., Fowell, D. J., & Korshunov, V. A. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307848 · Cited by 21 · see citing works

Brief exposure to hyperglycemia activates dendritic cells in vitro and in vivo

Thomas, A. M., Dong, Y., Beskid, N. M., Garcı́a, A. J., Adams, A. B., & Babensee, J. E. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29380 · Cited by 20 · see citing works

Mechanistic prediction of first-in-human dose for bispecific CD3/EpCAM T-cell engager antibody M701, using an integrated PK/PD modeling method

Song, L., Xue, J., Zhang, J., Li, S., Liu, D., & Zhou, T. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105584 · Cited by 19 · see citing works

Liquid Chromatography–Mass Spectrometry Analysis of Frataxin Proteoforms in Whole Blood as Biomarkers of the Genetic Disease Friedreich’s Ataxia

Rojsajjakul, T., Wu, L., Grady, C. B., Hwang, W., Mesaros, C., Lynch, D. R., & Blair, I. A. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c00091 · Cited by 19 · see citing works

Development of a multiscale mechanistic modeling framework integrating differential cellular kinetics of CAR T‐ cell subsets and immunophenotypes in cancer patients

Salem, A. M., Mugundu, G. M., & Singh, A. P. (2023) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.13009 · Cited by 19 · see citing works

Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design

Ke, R., Conway, J. M., Margolis, D. M., & Perelson, A. S. (2018) · JCI Insight · doi:10.1172/jci.insight.123052 · Cited by 21 · see citing works

Predicting chromosome damage in astronauts participating in international space station missions

Feiveson, A., George, K., Shavers, M., Moreno-Villanueva, M., Zhang, Y., Babiak-Vazquez, A., Crucian, B., Semones, E., & Wu, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-84242-5 · Cited by 19 · see citing works

The maths of memory

Borghans, J. A. M., & Ribeiro, R. M. (2017) · eLife · doi:10.7554/elife.26754 · Cited by 16 · see citing works

Dynamics of Recent Thymic Emigrants in Young Adult Mice

van Hoeven, V., Drylewicz, J., Westera, L., den Braber, I., Mugwagwa, T., Tesselaar, K., Borghans, J. A. M., & de Boer, R. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00933 · Cited by 16 · see citing works

Fate-mapping mice: new tools and technology for immune discovery

Lee, S. E., Rudd, B. D., & Smith, N. L. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.01.004 · Cited by 15 · see citing works

Mécanismes de la lymphopénie radio-induite et implications thérapeutiques

Césaire, M., Mauff, B. L., Rambeau, A., Toutirais, O., & Thariat, J. (2020) · Bulletin du Cancer · doi:10.1016/j.bulcan.2020.04.009 · Cited by 16 · see citing works

Quantifying T Cell Cross-Reactivity: Influenza and Coronaviruses

Gaevert, J. A., Duque, D. L., Lythe, G., Molina-Parı́s, C., & Thomas, P. G. (2021) · Viruses · doi:10.3390/v13091786 · Cited by 15 · see citing works

Emergence and competition of virus variants in respiratory viral infections

Bessonov, N., Neverova, D., Попов, В. А., & Volpert, V. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945228 · Cited by 15 · see citing works

CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients

Khiew, S. H. W., Yang, J., Young, J. S., Chen, J., Wang, Q., Yin, D., Vu, V., Miller, M. L., Sciammas, R., Alegre, M., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92033 · Cited by 15 · see citing works

Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory

Radbruch, A., McGrath, M. A., Siracusa, F., Hoffmann, U., Sercan-Alp, Ö., Hutloff, A., Tokoyoda, K., Chang, H.-D., & Dong, J. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038083 · Cited by 16 · see citing works

Cell-Mediated Immunity

Kamperschroer, C., Collinge, M., Heyen, J. R. R., Ji, C., O’Donnell, L. M., & Zhu, X. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64229-0 · Cited by 15 · see citing works

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

Zarnitsyna, V. I., Akondy, R. S., Ahmed, H., McGuire, D. J., Zarnitsyn, V. G., Moore, M., Johnson, P. L. F., Ahmed, R., Li, K. W., Hellerstein, M. K., et al. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009468 · Cited by 15 · see citing works

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Alonso-Garrido, M., Manyes, L., Pralea, I.-E., & Iuga, C. A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111432 · Cited by 14 · see citing works

Physiologically Based Simulations of Deuterated Glucose for Quantifying Cell Turnover in Humans

Lahoz-Beneytez, J., Schaller, S., Macallan, D. C., Eißing, T., Niederalt, C., & Asquith, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00474 · Cited by 13 · see citing works

Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

Baliu‐Piqué, M., van Hoeven, V., Drylewicz, J., van der Wagen, L. E., Janssen, A., Otto, S. A., van Zelm, M. C., de Boer, R. J., Kuball, J. H. E., Borghans, J. A. M., et al. (2021) · eLife · doi:10.7554/elife.59775 · Cited by 12 · see citing works

Effect of lymphoid volume irradiation on radiation-induced lymphopenia in head and neck cancers

Césaire, M., Rambeau, A., Cherifi, F., Géry, B., Johnson, A., Nacher, M., & Thariat, J. (2023) · Cancer/Radiothérapie · doi:10.1016/j.canrad.2022.08.008 · Cited by 12 · see citing works

TGF-β Signaling Supports HIV Latency in a Memory CD4+ T Cell Based In Vitro Model

Bergstresser, S., & Kulpa, D. A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1871-4_6 · Cited by 12 · see citing works

Fate of a Naive T Cell: A Stochastic Journey

de la Higuera, L., López‐García, M., Castro, M., Abourashchi, N., Lythe, G., & Molina-Parı́s, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00194 · Cited by 11 · see citing works

Counting generations in birth and death processes with competing Erlang and exponential waiting times

Belluccini, G., López‐García, M., Lythe, G., & Molina-Parı́s, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-14202-0 · Cited by 11 · see citing works

The Hayflick Limit May Determine the Effective Clonal Diversity of Naive T Cells

Ndifon, W. O., & Dushoff, J. G. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502343 · Cited by 11 · see citing works

Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression

Schappi, J. M., & Rasenick, M. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1012778 · Cited by 11 · see citing works

High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor−/CD52− T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell–Depleted Allogeneic Stem Cell Transplantation

Loeff, F. C., Falkenburg, J. H. F., Hageman, L., Huisman, W., Veld, S. A. J., van Egmond, H. M. E., van de Meent, M., Borne, P. A. V. D., Veelken, H., Halkes, C. J. M., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701018 · Cited by 11 · see citing works

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host

Bullock, M. E., Hogan, T. V., Williams, C., Morris, S. E., Nowicka, M., Sharjeel, M., van Dorp, C. H., Yates, A. J., & Seddon, B. P. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002380 · Cited by 10 · see citing works

Improving Reliability of Immunological Assays by Defining Minimal Criteria for Cell Fitness

Ivison, S. M., Boucher, G., Zheng, G., García, R., Kohen, R., Bitton, A., Rioux, J. D., & Levings, M. K. (2024) · ImmunoHorizons · doi:10.4049/immunohorizons.2300095 · Cited by 11 · see citing works

Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats

Baliu‐Piqué, M., Kurniawan, H., Ravesloot, L., Verheij, M. W., Drylewicz, J., Lievaart‐Peterson, K., Borghans, J. A. M., Koets, A. P., & Tesselaar, K. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.12.004 · Cited by 9 · see citing works

In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow

Baliu‐Piqué, M., Otto, S. A., Borghans, J. A. M., & Tesselaar, K. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.04.004 · Cited by 8 · see citing works

Turnover of Murine Cytomegalovirus–Expanded CD8+ T Cells Is Similar to That of Memory Phenotype T Cells and Independent of the Magnitude of the Response

Baliu‐Piqué, M., Drylewicz, J., Zheng, X., Borkner, L., Swain, A. C., Otto, S. A., de Boer, R. J., Tesselaar, K., Čičin‐Šain, L., & Borghans, J. A. M. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100883 · Cited by 8 · see citing works

Space-velocity thermostatted kinetic theory model of tumor growth

Masurel, L., Laboratoire de Physique Théorique de la Matière Condensée, S. U., Bianca, C., Lemarchand, A., & École Supérieure d'Ingénieurs en Génie Électrique, P. E. M. I. (2021) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2021279 · Cited by 7 · see citing works

T and NK Cells in IL2RG-Deficient Patient 50 Years After Hematopoietic Stem Cell Transplantation

Melsen, J. E., Dam, M. M. V. O.-T., van den Akker, E. B., Welters, M. J. P., Heezen, K. C., Pico‐Knijnenburg, I., Kolijn, P. M., Bredius, R. G. M., van Doorn, R., Langerak, A. W., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01279-5 · Cited by 7 · see citing works

The Rules of Human T Cell Fate in vivo

del Amo, P. C., Debebe, J., Razavi-Mohseni, M., Nakaoka, S., Worth, A. T., Wallace, D. L., Beverley, P. C. L., Macallan, D. C., & Asquith, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00573 · Cited by 7 · see citing works

Nanoparticle-Based Delivery of Anaplasma marginale Membrane Proteins; VirB9-1 and VirB10 Produced in the Pichia pastoris Expression System

Zhang, B., Cavallaro, A., Mody, K. T., Zhang, J., Deringer, J. R., Brown, W. C., Mahony, T. J., Yu, C., & Mitter, N. (2016) · Nanomaterials · doi:10.3390/nano6110201 · Cited by 7 · see citing works

Ibrutinib exposure correlates with improved efficacy of CAR T cells in patients with mantle cell lymphoma

Darnell, E. P., Gallagher, K., Kanska, J. E., Scarfò, I., Balderrama-Gutierrez, G., Berger, T. R., Budka, J. A., Bozym, D. J., Tungsuchat-Huang, T., Shen, R., et al. (2026) · Blood Advances · doi:10.1182/bloodadvances.2025018137 · Cited by 6 · see citing works

In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei

Reddi, D., Durant, L. R., Bernardo, D., Noble, A., English, N. R., Hendy, P., Clark, G. C., Prior, J. L., Williamson, E. D., & Knight, S. C. (2021) · Vaccines · doi:10.3390/vaccines9080929 · Cited by 6 · see citing works

Antigen-specific T H 17 cells offset the age-related decline in durable T cell immunity

Sturmlechner, I., Jain, A. K., Jiang, J., Okuyama, H., Mu, Y., Own, M., Weyand, C. M., & Goronzy, J. J. (2026) · Science Advances · doi:10.1126/sciadv.aea7131 · Cited by 5 · see citing works

Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

Chandler, J. S., Bullock, M. E., Swain, A. C., Williams, C., van Dorp, C. H., Seddon, B. P., & Yates, A. J. (2025) · eLife · doi:10.7554/elife.104278.3 · Cited by 5 · see citing works

Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus)

Jasinska, A. J., Pandrea, I., He, T., Benjamin, C., Newton, M., Lee, J. C., Freimer, N. B., Coppola, G., & Jentsch, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-59934-z · Cited by 5 · see citing works

Defects in Long-Term APC Repopulation Ability of Adult Human Bone Marrow Hematopoietic Stem Cells (HSCs) Compared with Fetal Liver HSCs

Nauman, G., Danzl, N. M., Lee, J., Borsotti, C., Madley, R., Fu, J., Hölzl, M. A., Dahmani, A., Dorronsoro, A., Chavez, É., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100966 · Cited by 5 · see citing works

From Cell–Cell Interaction to Stochastic and Deterministic Descriptions of a Cancer–Immune System Competition Model

Morgado, G., Lemarchand, A., & Bianca, C. (2023) · Mathematics · doi:10.3390/math11092188 · Cited by 4 · see citing works

Long-term impact of antiretroviral strategies for a functional HIV cure: A virtual clinical trial

Hernandez-Vargas, E. A., Martínez‐Picado, J., & Hernández-Mejía, G. (2018) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2018.11.663 · Cited by 4 · see citing works

Thymus

Majumdar, S., Pathak, S., & Nandi, D. (2018) · Resonance · doi:10.1007/s12045-018-0605-3 · Cited by 4 · see citing works

Mouse Aging Cell Atlas Analysis Reveals Global and Cell Type Specific Aging Signatures Revision 1Preprint

Zhang, M. J., Pisco, A. O., Darmanis, S., & Zou, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.23.887604 · Cited by 4 · see citing works

Geometric immunosuppression in CAR T-cell treatment: Insights from mathematical modeling

Bordel-Vozmediano, S., Sabir, S., Benito-Barca, L., Weigelin, B., & Pérez‐García, V. M. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110427 · Cited by 3 · see citing works

Current best estimates for the average lifespans of mouse and human leukocytes: reviewing two decades of deuterium‐labeling experiments

Borghans, J. A. M., Tesselaar, K., & de Boer, R. J. (2018) · Immunological Reviews · doi:10.1111/imr.12693 · Cited by 53 · see citing works

Leukocyte dynamics in mice and men

den Braber, A. J. (2006) · Utrecht University Repository (Utrecht University)

Current estimates of T cell kinetics in humans

Macallan, D. C., Busch, R., & Asquith, B. (2019) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2019.10.002 · Cited by 41 · see citing works

Human T cell lifespan (P1284)

Réu, P., Mold, J. E., Michaëlsson, J., Salehpour, M., & Frisén, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.190.supp.119.1

Revealing the dynamics of immune cells in humans: mechanistic modelling of deuterium labelling data

Lahoz-Beneytez, J. (2016) · Spiral (Imperial College London) · doi:10.25560/68511