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Cited by 16T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory

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Radbruch, Andreas, McGrath, Mairi Anne, Siracusa, Francesco, Hoffmann, Ute, Sercan-Alp, Özen, Hutloff, Andreas, Tokoyoda, Koji, Chang, Hyun-Dong +1 more·2021·Cold Spring Harbor Perspectives in Biology
DOI 10.1101/cshperspect.a038083PMC PMC8247562
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Abstract

The molecular basis of the persistence of experienced T lymphocytes, also known as "memory T lymphocytes," is still enigmatic. We are beginning to understand their considerable heterogeneity and topographic compartmentalization into memory T cells circulating through the body and those residing in a particular tissue. In some tissues, like murine spleen, subpopulations of memory T cells proliferating in the absence of antigen (homeostatic proliferation) have been described. Other populations are maintained resting in terms of transcription, mobility, and proliferation in dedicated survival niches organized by stromal cells. The survival of these memory T cells is conditional on being in such a niche, where they can persist for a lifetime. Circulating memory T lymphocytes of distinct immune responses slowly decline in numbers over time. The rules governing their entry into and exit from blood, as well as their lifestyle outside of the blood and their relation to resident memory T cells are poorly understood. Homeostasis of circulating, proliferating, and resting memory T cells is obviously controlled by different rheostats: tissue-exit and tissue-entry signals for circulating and proliferation-inducing signals for proliferating memory T cells. For tissue-resident, resting memory T cells, it is the availability of their survival niche. Apparently, this mechanism (i.e., the link between memory T cell and stromal cell) is so robust that it provides efficient T-cell memory over a lifetime in tissues such as the bone marrow.

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Cited by

Sorted by citations

Authors
Radbruch, A., McGrath, M. A., Siracusa, F., Hoffmann, U., Sercan-Alp, Ö., Hutloff, A., Tokoyoda, K., Chang, H.-D., & Dong, J.
Affiliations
Leibniz Association (DE)
ORCID
Venue
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Published
2021-04-26
Volume
13
Issue
7
Pages
a038083
ISSN
1943-0264 (ISSN-L)
DOI
10.1101/cshperspect.a038083
PMC
PMC8247562
OpenAlex
W3159782113
Cited by
16
References
12
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 2
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (389687267)
  • Dr. Rolf M. Schwiete Stiftung
  • Leibniz-Gemeinschaft
  • Japan Society for the Promotion of Science (20K22764, 21K07081)
  • FP7 Ideas: European Research Council (268987)
  • FP7 People: Marie-Curie Actions (FP7-PEOPLE-2011-ITN, 289150)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
memory T cells, T cell homeostasis, homeostatic proliferation, tissue-resident memory T cells, stromal cells, T cell migration, bone marrow, spleen
MeSH terms
Memory T Cells, Animals, Cell Survival, Homeostasis, Humans, Immunologic Memory

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