The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
Open accessAbstract
Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis of myeloid or lymphoid neoplasia and increased all-cause mortality. Although myelodysplastic syndromes (MDS) are defined by cytopenias, dysplastic morphology of blood and marrow cells, and clonal hematopoiesis, most individuals who acquire clonal hematopoiesis during aging will never develop MDS. Therefore, acquisition of somatic mutations that drive clonal expansion in the absence of cytopenias and dysplastic hematopoiesis can be considered clonal hematopoiesis of indeterminate potential (CHIP), analogous to monoclonal gammopathy of undetermined significance and monoclonal B-cell lymphocytosis, which are precursor states for hematologic neoplasms but are usually benign and do not progress. Because mutations are frequently observed in healthy older persons, detection of an MDS-associated somatic mutation in a cytopenic patient without other evidence of MDS may cause diagnostic uncertainty. Here we discuss the nature and prevalence of CHIP, distinction of this state from MDS, and current areas of uncertainty regarding diagnostic criteria for myeloid malignancies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“While the standard diagnostic threshold is often set at 2%, high-sensitivity sequencing can detect small clones at levels as low as 0.5%”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“reaching approximately 39% in individuals older than 60 years when utilizing high-sensitivity sequencing (Variant Allele Fraction (VAF) greater than 0.5%) [2,3]”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Most large-population-based studies define CHIP using a VAF threshold of ≥2%, reflecting the lower limit of reliable detection in standard whole-exome sequencing pipelines [2,32].”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [2]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition affecting over 10–20% of individuals older than 70 years”
In the citing paper
“in healthy elderly individuals, DNA mutations in specific loci are associated with the establishment of clonal hematopoiesis”
From Aging of hematopoietic stem cells (2018) · cites this paper as [52]
In the citing paper
“A gain of novel bivalent domains is observed in ageing cells 65,66 (Figure 2),”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [66]
In the citing paper
“In ageing cells, a gain of novel bivalent domains is observed, mostly due to gains of repressive H3K27me3 marks on regions that were marked by the active histone modification H3K4me3 in young cells 65,66 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [66]
In the citing paper
“Bivalent domains show the lowest DNA methylation in normal cells 66 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma
Rajkumar, S. V., Dimopoulos, M. A., Palumbo, A., Blade, J., Merlini, G., Mateos, M.-V., Kumar, S., Hillengass, J., Kastritis, E., Richardson, P., et al. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70442-5 · Cited by 4,978
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841
Self-citationVardiman, J. W., Thiele, J., Arber, D. A., Brunning, R. D., Borowitz, M. J., Porwit‐MacDonald, A., Harris, N. L., Beau, M. M. L., Hellström‐Lindberg, E., Tefferi, A., et al. (2009) · Blood · doi:10.1182/blood-2009-03-209262 · Cited by 4,532
International scoring system for evaluating prognosis in myelodysplastic syndromes
Greenberg, P., Cox, C., LeBeau, M. M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., et al. (1997) · Blood · doi:10.1182/blood.v89.6.2079 · Cited by 4,427
Proposals for the classification of the myelodysplastic syndromes
Bennett, J. M., Catovsky, D., Daniel, M., Flandrin, G., Galton, D. A. G., Gralnick, H. R., & Sultan, C. (1982) · British Journal of Haematology · doi:10.1111/j.1365-2141.1982.tb08475.x · Cited by 3,619
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531
Recurring mutations found by sequencing an acute myeloid leukemia genome
Mardis, E. R., Ding, L., Dooling, D. J., Larson, D. E., McLellan, M. D., Chen, K., Koboldt, D. C., Fulton, R. S., Delehaunty, K. D., McGrath, S. D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903840 · Cited by 2,219
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874
Clinical and biological implications of driver mutations in myelodysplastic syndromes
Papaemmanuil, E., Gerstung, M., Malcovati, L., Tauro, S., Gundem, G., Van Loo, P., Yoon, C. J., Ellis, P., Wedge, D. C., Pellagatti, A., et al. (2013) · Blood · doi:10.1182/blood-2013-08-518886 · Cited by 1,832
Clinical Effect of Point Mutations in Myelodysplastic Syndromes
Bejar, R., Stevenson, K., Abdel-Wahab, O., Galili, N., Nilsson, B., Garcia-Manero, G., Kantarjian, H., Raza, A., Levine, R. L., Neuberg, D., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1013343 · Cited by 1,627
Self-citationGreenberg, P. L., Attar, E. C., Bennett, J. M., Bloomfield, C. D., Borate, U., Castro, C. M. D., Deeg, H. J., Frankfurt, O., Gaensler, K. M. L., Garcia-Manero, G., et al. (2013) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2013.0104 · Cited by 1,625
The origin and evolution of mutations in acute myeloid leukemia
Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
Haferlach, T., Nagata, Y., Grossmann, V, Okuno, Y., Bacher, U., Nagae, G., Schnittger, S., Sanada, M., Kon, A., Alpermann, T., et al. (2014) · Leukemia · doi:10.1038/leu.2013.336 · Cited by 1,532
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443
Prevalence of monoclonal gammopathy of undetermined significance
Kyle, R. A., Therneau, T. M., Rajkumar, S. V., Larson, D. R., Plevak, M. F., Offord, J. R., Dispenzieri, A., Katzmann, J. A., & Melton, L. J. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054494 · Cited by 1,423
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
Papaemmanuil, E., Cazzola, M., Boultwood, J., Malcovati, L., Vyas, P., Bowen, D., Pellagatti, A., Wainscoat, J. S., Hellstrom-Lindberg, E., Gambacorti-Passerini, C., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1103283 · Cited by 1,222
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
Wong, T. N., Ramsingh, G., Young, A. L., Miller, C. A., Touma, W., Welch, J. S., Lamprecht, T. L., Shen, D., Hundal, J., Fulton, R. S., et al. (2015) · Nature · doi:10.1038/nature13968 · Cited by 892
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
Jan, M., Snyder, T. M., Corces-Zimmerman, M. R., Vyas, P., Weissman, I. L., Quake, S. R., & Majeti, R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004315 · Cited by 721
Malcovati, L., Hellström‐Lindberg, E., Bowen, D., Adès, L., Čermák, J., del Cañizo, C., Porta, M. G. D., Fenaux, P., Gattermann, N., Germing, U., et al. (2013) · Blood · doi:10.1182/blood-2013-03-492884 · Cited by 682
Polycythemia Vera: Stem-Cell and Probable Clonal Origin of the Disease
Adamson, J. W., Fialkow, P. J., Murphy, S., Prchal, J. F., & Steinmann, L. (1976) · New England Journal of Medicine · doi:10.1056/nejm197610212951702 · Cited by 637
Detectable clonal mosaicism from birth to old age and its relationship to cancer
Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2271 · Cited by 594
Detectable clonal mosaicism and its relationship to aging and cancer
Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2270 · Cited by 589
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients
Bejar, R. L., Lord, A. M., Stevenson, K. E., Bar‐Natan, M., Pérez-Ladaga, A., Zaneveld, J. E., Wang, H., Caughey, B. A., Stojanov, P., Getz, G. A., et al. (2014) · Blood · doi:10.1182/blood-2014-06-582809 · Cited by 575
Self-citationOncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML
Maxson, J. E., Gotlib, J., Pollyea, D., Fleischman, A. G., Agarwal, A., Eide, C., Bottomly, D., Wilmot, B., McWeeney, S., Tognon, C., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214514 · Cited by 568
Ma, X., Does, M. B., Raza, A., & Mayne, S. T. (2007) · Cancer · doi:10.1002/cncr.22570 · Cited by 537
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.005 · Cited by 534
Valent, P., Horny, H., Bennett, J. M., Fonatsch, C., Germing, U., Greenberg, P. L., Haferlach, T., Haase, D. T., Kölb, H.-J., Krieger, O., et al. (2007) · Leukemia Research · doi:10.1016/j.leukres.2006.11.009 · Cited by 514
Biernaux, C., Loos, M., Sels, A., Huez, G., & Stryckmans, P. (1995) · Blood · doi:10.1182/blood.v86.8.3118.3118 · Cited by 485
Overdiagnosis and Overtreatment in Cancer
Esserman, L. J., Thompson, I. M., & Reid, B. J. (2013) · JAMA · doi:10.1001/jama.2013.108415 · Cited by 467
Bejar, R. L., Stevenson, K. E., Caughey, B. A., Abdel-Wahab, O. I., Steensma, D. P., Galili, N., Raza, A., Kantarjian, H. M., Levine, R. L., Neuberg, D. S., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.40.7379 · Cited by 450
Self-citationLandscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes
Nagata, Y., Grossmann, V., Okuno, Y., Bacher, U., Nagae, G., Schnittger, S., Shiozawa, Y., Kon, A., Alpermann, T., Yoshida, K., et al. (2013) · Blood · doi:10.1182/blood.v122.21.521.521 · Cited by 430
Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals
Limpens, J., Stad, R. K., Vos, C., et al. (1995) · Blood · doi:10.1182/blood.v85.9.2528.bloodjournal8592528 · Cited by 420
Bejar, R. L., Stevenson, K. E., Caughey, B. A., Lindsley, R. C., Mar, B. G., Stojanov, P., Getz, G. A., Steensma, D. P., Ritz, J., Soiffer, R. J., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.52.3381 · Cited by 403
Self-citationTraina, F., Visconte, V., Elson, P. J., Tabarroki, A., Jankowska, A., Hasrouni, E., Sugimoto, Y., Szpurka, H., Makishima, H., O'Keefe, C., et al. (2013) · Leukemia · doi:10.1038/leu.2013.269 · Cited by 296
Self-citationDistinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia
Maciejewski, J. P., Risitano, A. M., Sloand, E. M., Núñez, O., & Young, N. S. (2002) · Blood · doi:10.1182/blood.v99.9.3129 · Cited by 249
Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management
Shanafelt, T. D., Ghia, P., Lanasa, M. C., Landgren, O., & Rawstron, A. C. (2010) · Leukemia · doi:10.1038/leu.2009.287 · Cited by 227
Wang, S. A., Hasserjian, R. P., Fox, P. S., Rogers, H. J., Geyer, J. T., Chabot‐Richards, D., Weinzierl, E. P., Hatem, J., Jaso, J. M., Kanagal‐Shamanna, R., et al. (2014) · Blood · doi:10.1182/blood-2014-02-553800 · Cited by 205
Self-citationLaï, J., Preudhomme, C., Zandecki, M., FLACTIF, M., Vanrumbeke, M., Lepelley, P., Wattel, E., & Fenaux, P. (1995) · PubMed · Cited by 197
Recent developments in myelodysplastic syndromes
Bejar, R. L., & Steensma, D. P. (2014) · Blood · doi:10.1182/blood-2014-04-522136 · Cited by 179
Self-citationChampion, K. M., Gilbert, J. G. R., Asimakopoulos, F. A., Hinshelwood, S., & Green, A. R. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.1933010.x · Cited by 171
The dynamics of X‐inactivation skewing as women age
Hatakeyama, C., Anderson, C., Beever, C. L., Peñaherrera, M., Brown, C. J., & Robinson, W. (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00310.x · Cited by 150
Porta, M. G. D., Travaglino, E., Boveri, E., Ponzoni, M., Malcovati, L., Papaemmanuil, E., Rigolin, G. M., Pascutto, C., Croci, G. A., Gianelli, U., et al. (2014) · Leukemia · doi:10.1038/leu.2014.161 · Cited by 149
Wassie, E. A., Itzykson, R., Lasho, T. L., Kosmider, O., Finke, C. M., Hanson, C. A., Ketterling, R. P., Solary, É., Tefferi, A., & Patnaik, M. M. (2014) · American Journal of Hematology · doi:10.1002/ajh.23846 · Cited by 139
The bone marrow aspirate of healthy subjects
Bain, B. J. (1996) · British Journal of Haematology · doi:10.1046/j.1365-2141.1996.d01-1786.x · Cited by 129
Myelodysplastic Syndromes Clinical Practice Guidelines in Oncology
_, _. (2006) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2006.0007 · Cited by 128
Valent, P., Bain, B. J., Bennett, J. M., Wimazal, F., Sperr, W. R., Mufti, G. J., & Horny, H. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.08.016 · Cited by 111
Cotter, P. D., May, A. M., Fitzsimons, E. J., et al. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118258 · Cited by 107
Clinical and genetic predictors of prognosis in myelodysplastic syndromes
Bejar, R. L. (2014) · Haematologica · doi:10.3324/haematol.2013.085217 · Cited by 107
Self-citationStarczynowski, D. T., Vercauteren, S., Telenius, A., Sung, S., Tohyama, K., Brooks-Wilson, A. R., Spinelli, J. J., Eaves, C. J., Eaves, A. C., Horsman, D. E., et al. (2008) · Blood · doi:10.1182/blood-2007-11-122028 · Cited by 101
Steensma, D. P. (2012) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-012-0140-3 · Cited by 99
Self-citationValent, P., Sotlar, K., Sperr, W. R., Reiter, A., Arock, M., & Horny, H. (2014) · Leukemia Research · doi:10.1016/j.leukres.2014.09.010 · Cited by 96
Steensma, D. P., Higgs, D. R., Fisher, C. A., et al. (2003) · Blood · doi:10.1182/blood-2003-09-3360 · Cited by 93
Self-citationAssessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors
Parmentier, S., Schetelig, J., Lorenz, K., Krämer, M., Ireland, R. M., Schuler, U. S., Ordemann, R., Rall, G., Schaich, M. A., Bornhäuser, M., et al. (2011) · Haematologica · doi:10.3324/haematol.2011.056879 · Cited by 91
SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications
Damm, F., Thol, F. R., Kosmider, O., Kade, S., Löffeld, P., Dreyfus, F., Stamatoullas, A., Schmidt, A., Beyne‐Rauzy, O., de Botton, S., et al. (2011) · Leukemia · doi:10.1038/leu.2011.321 · Cited by 83
Valent, P., & Horny, H. ‐. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02151.x · Cited by 77
Clonal Origin of Chronic Myelocytic Leukemia
Barr, R. D., & Fialkow, P. J. (1973) · New England Journal of Medicine · doi:10.1056/nejm197308092890608 · Cited by 76
Jeromin, S., Haferlach, T., Weißmann, S., Meggendorfer, M., Eder, C., Nadarajah, N., Alpermann, T., Kohlmann, A., Kern, W., Haferlach, C., et al. (2014) · Haematologica · doi:10.3324/haematol.2014.119032 · Cited by 75
Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding
Shim, Y. K., Rachel, J. M., Ghia, P., et al. (2013) · Blood · doi:10.1182/blood-2013-08-523704 · Cited by 73
Low frequency clonal mutations recoverable by deep sequencing in patients with aplastic anemia
Lane, A. A., Odejide, O. O., Kopp, N., Kim, S. S., Yoda, A., Erlich, R., Wagle, N., Abel, G. A., Rodig, S. J., Antin, J. H., et al. (2013) · Leukemia · doi:10.1038/leu.2013.30 · Cited by 71
Steensma, D. P., Dewald, G. W., Hodnefield, J. M., Tefferi, A., & Hanson, C. A. (2003) · Leukemia Research · doi:10.1016/s0145-2126(02)00161-3 · Cited by 66
Self-citationMyelodysplastic syndrome: a search for minimal diagnostic criteria
Ramos, F., Fernández-Ferrero, S., Suárez, D., Barbón, M., Rodrı́guez, J. A., Gil, S., Megido, M., Ciudad, J., López, N., del Cañizo, C., et al. (1999) · Leukemia Research · doi:10.1016/s0145-2126(98)00166-0 · Cited by 66
Increased skewing of X chromosome inactivation with age in both blood and buccal cells
Knudsen, G. P., Pedersen, J. V., Klingenberg, O., Lygren, I., & Ørstavik, K. H. (2007) · Cytogenetic and Genome Research · doi:10.1159/000097414 · Cited by 66
Buckstein, R. J., Jang, K., Friedlich, J. D., Zhang, L., Reis, M. D., Chesney, A. E., & Wells, R. A. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.02.010 · Cited by 57
Braun, T., de Botton, S., Taksin, A., Park, S., Beyne‐Rauzy, O., Coiteux, V., Sapena, R., Lazareth, A., Leroux, G., Guenda, K., et al. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.02.008 · Cited by 48
Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes
Kulasekararaj, A. G., Mohamedali, A. M., & Mufti, G. J. (2013) · British Journal of Haematology · doi:10.1111/bjh.12435 · Cited by 47
Molecular Pathogenesis of MDS.
Look, A. (2005) · Hematology. American Society of Hematology. Education Program · doi:10.1182/asheducation-2005.1.156 · Cited by 47
45,X CELL LINES IN ADULT MEN: LOSS OF Y CHROMOSOME, A NORMAL AGING PHENOMENON ?
Pierre, R. V., & Hoagland, H. C. (1971) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)00644-5 · Cited by 47
Wardrop, D., & Steensma, D. P. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07526.x · Cited by 44
Self-citationPrevalence and distribution of ringed sideroblasts in primary myelodysplastic syndromes.
Juneja, S., Imbert, M., Sigaux, F., et al. (1983) · Journal of Clinical Pathology · doi:10.1136/jcp.36.5.566 · Cited by 43
Refractory anemia with ring sideroblasts
Malcovati, L., & Cazzola, M. (2013) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2013.09.005 · Cited by 40
Steensma, D. P., Komrokji, R. S., Stone, R. M., List, A. F., Garcia‐Manero, G., Huber, J. M., Dennison, B., & Sekeres, M. A. (2014) · Cancer · doi:10.1002/cncr.28631 · Cited by 37
Self-citationEvaluation of clonality in myeloid stem-cell disorders.
Gale, R. E. (1999) · PubMed · Cited by 36
Hanson, C. A., Steensma, D. P., Hodnefield, J. M., et al. (2008) · American Journal of Clinical Pathology · doi:10.1309/2vqldhvjb9yw83kb · Cited by 26
Self-citationAre myelodysplastic syndromes “cancer”?
Steensma, D. P. (2006) · Leukemia Research · doi:10.1016/j.leukres.2005.12.001 · Cited by 25
Self-citationShlush, L. I., & Minden, M. D. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000111 · Cited by 25
Hasserjian, R. P., Campigotto, F., Klepeis, V. E., Fu, B., Wang, S. A., Bueso-Ramos, C., Cascio, M. J., Rogers, H. J., Hsi, E. D., Soderquist, C. R., et al. (2014) · American Journal of Hematology · doi:10.1002/ajh.23808 · Cited by 24
Self-citationPrecursors in Cancer Epidemiology: Aligning Definition and Function
Wacholder, S. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0084 · Cited by 24
Valent, P., Jäger, E., Mitterbauer‐Hohendanner, G., Müllauer, L., Schwarzinger, I., Sperr, W. R., Thalhammer, R., & Wimazal, F. (2011) · Europe PMC (PubMed Central) · Cited by 23
Soupir, C. P., Vergilio, J., Kelly, E. M., et al. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07508.x · Cited by 23
Lichtman, M. A. (2013) · The Oncologist · doi:10.1634/theoncologist.2013-0099 · Cited by 16
Hanson, C. A., Hoyer, J. D., Zakko, L., et al. (2009) · Leukemia Research · doi:10.1016/s0145-2126(09)70169-9 · Cited by 7
Characteristics of myelodysplastic syndrome, unclassifiable by WHO classification 2008
Hwang, Y., Huh, J., Mun, Y., et al. (2010) · Annals of Hematology · doi:10.1007/s00277-010-1018-x · Cited by 7
Hall, J., Hafidh, J. A., Balmert, E., et al. (2014) · Blood · doi:10.1182/blood.v124.21.3272.3272 · Cited by 7
Kwok, B. S., Reddy, P., Lin, K., et al. (2014) · Blood · doi:10.1182/blood.v124.21.166.166 · Cited by 4
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., et al. (2014) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/rprj-jx97 · Cited by 1
Cited by
Sorted by citations
Arber, D. A., Orazi, A., Hasserjian, R., Thiele, J., Borowitz, M. J., Le Beau, M. M., Bloomfield, C. D., Cazzola, M., & Vardiman, J. W. (2016) · Blood · doi:10.1182/blood-2016-03-643544 · Cited by 10,119
Self-citationKhoury, J. D., Solary, E., Abla, O., Akkari, Y., Alaggio, R., Apperley, J. F., Bejar, R., Berti, E., Busque, L., Chan, J. K. C., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01613-1 · Cited by 4,274
Self-citationThe changing landscape of atherosclerosis
Libby, P. (2021) · Nature · doi:10.1038/s41586-021-03392-8 · Cited by 2,873
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683
Self-citationKastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906
Metadata
- Authors
- Steensma, D. P., Bejar, R., Jaiswal, S., Lindsley, R. C., Sekeres, M. A., Hasserjian, R. P., & Ebert, B. L.
- Affiliations
- Brigham and Women's Hospital (US)
- University of California San Diego (US)
- Cleveland Clinic (US)
- Massachusetts General Hospital (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-07-02
- Volume
- 126
- Issue
- 1
- Pages
- 9-16
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4624443
- OpenAlex
- W1985823023
- Cited by
- 1,971
- References
- 87
- Citations by year
- 2026: 133 · 2025: 156 · 2024: 176 · 2023: 229 · 2022: 222 · 2021: 221 · 2020: 202 · 2019: 182 · 2018: 181 · 2017: 149 · 2016: 99 · 2015: 16
- FWCI
- 115.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Edward P. Evans Foundation
- National Heart, Lung, and Blood Institute (T32HL066987)
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK091360)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Hematology › Hematological disorders and diagnostics
- Keywords
- clonal hematopoiesis of indeterminate potential, myelodysplastic syndrome, somatic mutations, clonal expansion, aging, hematopoietic stem cells, myeloid neoplasms, diagnostic criteria, monoclonal gammopathy of undetermined significance, monoclonal B-cell lymphocytosis, cytopenia, dysplastic hematopoiesis
- MeSH terms
- Diagnosis, Differential, Hematopoiesis, Humans, Monoclonal Gammopathy of Undetermined Significance, Mutation, Myelodysplastic Syndromes, Precancerous Conditions, Hematologic Neoplasms, Clonal Evolution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
