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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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Pyroptosis: host cell death and inflammation

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

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Identification of RIP1 kinase as a specific cellular target of necrostatins

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Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

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Protein modification and degradation in ferroptosis

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Epidemiology, virulence factors and management of the pneumococcus

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A new discovery of polystyrene microplastics toxicity: The injury difference on bladder epithelium of mice is correlated with the size of exposed particles

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Ferroptosis in tumor immunity and therapy

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Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration

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Heat Shock Proteins and Ferroptosis

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Mercuric chloride induces sequential activation of ferroptosis and necroptosis in chicken embryo kidney cells by triggering ferritinophagy

Chu, J., Li, L., Gao, P., Chen, X.-W., Wang, Z., & Fan, R. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.002 · Cited by 55

Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia

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Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer

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Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

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Current understanding of eryptosis: mechanisms, physiological functions, role in disease, pharmacological applications, and nomenclature recommendations

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Ferroptosis: Mechanism and connections with cutaneous diseases

Liu, L., Lian, N., Shi, L., Hao, Z., & Chen, K. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1079548 · Cited by 52

A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis

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MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation

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Emerging roles for non-selenium containing ER-resident glutathione peroxidases in cell signaling and disease

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Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency

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Selenium-Dependent Glutathione Peroxidases During Tumor Development

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Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants

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Disulfidptosis: a new form of regulated cell death for cancer treatment

Yu, M., Chen, X., & Deng, G. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00132-4 · Cited by 42

Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke

Du, B., Deng, Z., Chen, K., Yang, Z., Wei, J., Zhou, L., Meng, J., Cheng, Y., Tian, X., Tuo, Q., et al. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101262 · Cited by 46

Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells

Zeng, C., Nie, D., Wang, X., Zhong, S., Zeng, X., Liu, X., Qiu, K., Peng, X., Zhang, W., Chen, S., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02162-0 · Cited by 42

Ferroptosis, autophagy, tumor and immunity

Xie, Y., Zhou, Y., Wang, J., Lijuan, D., Ren, Y., & Liu, F. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19799 · Cited by 40

Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis

Zhao, C., Yu, Y., Yin, G., Xu, C., Wang, J., Wang, L., Zhao, G., Ni, S., Zhang, H., Zhou, B., et al. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01439-6 · Cited by 40

SMG9 drives ferroptosis by directly inhibiting GPX4 degradation

Han, L., Bai, L., Fang, X., Liu, J., Kang, R., Zhou, D., Tang, D., & Dai, E. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.06.038 · Cited by 40

Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death

Chen, X., Zhang, B., Liu, T., Feng, M., Zhang, Y., Zhang, C., Yao, W., & Wan, L. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00539 · Cited by 38

The pathogenesis of organ fibrosis: Focus on necroptosis

Hao, M., Han, X., Yao, Z., Zhang, H., Zhao, M., Peng, M., Wang, K., Shan, Q., Sang, X., Wu, X., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15952 · Cited by 40

Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation

Kagan, V. E., Tyurina, Y. Y., Vlasova, I. I., Kapralov, A. A., Amoscato, A. A., Anthonymuthu, T. S., Tyurin, V. A., Shrivastava, I. H., Cinemre, F. B. S., Lamade, A. M., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.628079 · Cited by 39

A novel nanozyme based on selenopeptide-modified gold nanoparticles with a tunable glutathione peroxidase activity

Zhang, D., Shen, N., Zhang, J., Zhu, J., Guo, Y., & Xu, L. (2020) · RSC Advances · doi:10.1039/c9ra10262k · Cited by 37

A new role of glutathione peroxidase 4 during human erythroblast enucleation

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Reactive oxygen species levels control NF-κB activation by low dose deferasirox in erythroid progenitors of low risk myelodysplastic syndromes

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Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage

Stolwijk, J. M., Stefely, J. A., Veling, M. T., Erve, T. J. V. ‘., Wagner, B. A., Raife, T. J., & Buettner, G. R. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102073 · Cited by 36

Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition

Sakai, O., Yasuzawa, T., Yoshie, S., Ueta, T., Imai, H., Sawabe, A., & Ueshima, S. (2016) · Pathophysiology · doi:10.1016/j.pathophys.2016.11.002 · Cited by 35

Identification of three mechanistic pathways for iron-deficient heart failure

Packer, M., Anker, S. D., Butler, J., Cleland, J. G. F., Kalra, P. R., Mentz, R. J., & Ponikowski, P. P. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae284 · Cited by 37

Reactive Oxygen Species and Antioxidants in Carcinogenesis and Tumor Therapy

Vostrikova, S. M., Grinev, A. B., & Gogvadze, V. G. (2020) · Biochemistry (Moscow) · doi:10.1134/s0006297920100132 · Cited by 36

Necroptosis and Prostate Cancer: Molecular Mechanisms and Therapeutic Potential

Beretta, G. L., & Zaffaroni, N. (2022) · Cells · doi:10.3390/cells11071221 · Cited by 36

Construction of Oxidative Stress-Related Genes Risk Model Predicts the Prognosis of Uterine Corpus Endometrial Cancer Patients

Liu, Q., Yu, M., & Zhang, T. (2022) · Cancers · doi:10.3390/cancers14225572 · Cited by 31

Ferroptosis in cardiovascular diseases: role and mechanism

Zhang, Q., Luo, Y., Peng, L., Rong, X., Liu, Y., Li, J., & Luo, J. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01169-2 · Cited by 33

Ferroptosis: Mechanism and potential applications in cervical cancer

Chang, X., & Miao, J. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1164398 · Cited by 30

Characteristics and time points to inhibit ferroptosis in human osteoarthritis

Xu, Y., Yang, Z., Dai, T., Xue, X., Xia, D., Feng, Z., Huang, J., Chen, X., Sun, S., Zhou, J., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-49089-y · Cited by 30

Electrophiles against (Skin) Diseases: More Than Nrf2

Hennig, P., Fenini, G., Filippo, M. D., & Beer, H. (2020) · Biomolecules · doi:10.3390/biom10020271 · Cited by 31

Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study

Wu, Y., Sun, Y., Wu, Y., Zhang, K., & Chen, Y. (2023) · Acta Diabetologica · doi:10.1007/s00592-022-02028-1 · Cited by 30

Male Subfertility Induced by Heterozygous Expression of Catalytically Inactive Glutathione Peroxidase 4 Is Rescued in Vivo by Systemic Inactivation of the Alox15 Gene

Brütsch, S. H., Rademacher, M., Roth, S. R., Müller, K., Eder, S., Viertel, D., Franz, C., Kühn, H., & Borchert, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.738930 · Cited by 30

Cyclophosphamide-induced GPX4 degradation triggers parthanatos by activating AIFM1

Liu, L., Liu, B., Guan, G., Kang, R., Dai, Y., & Tang, D. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.098 · Cited by 29

Pathological mechanisms and crosstalk among different forms of cell death in systemic lupus erythematosus

Xu, Y., Li, P., Li, K., Li, N., Liu, H., Zhang, X., Liu, W., & Liu, Y. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102890 · Cited by 30

From marginal to essential: the golden thread between nutrient sensing, medium composition and Plasmodium vivax maturation in in vitro culture

Thomson-Luque, R., Adams, J. H., Kocken, C. H. M., & Pasini, E. M. (2019) · Malaria Journal · doi:10.1186/s12936-019-2949-x · Cited by 27

Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 mice

Yan, B., Xie, D., Wu, Y., Wang, S., Zhang, X., Zhao, T., Liu, L., Ma, P., Li, G., Yang, Y., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01025-1 · Cited by 27

The Emerging Role of Ferroptosis in Sepsis, Opportunity or Challenge?

Huang, Q., Ding, Y., Fang, C., Wang, H., & Kong, L. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s419993 · Cited by 28

The Art of War: Ferroptosis and Pancreatic Cancer

Liu, J., Kang, R., & Tang, D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.773909 · Cited by 27

Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis

Ono, K., Fujiwara, T., Saito, K., Nishizawa, H., Takahashi, N., Suzuki, C., Ochi, T., Kato, H., Ishii, Y., Onodera, K., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12940-9 · Cited by 26

The Protective Role of Glutathione on Zinc-Induced Neuron Death after Brain Injuries

Park, M. K., Choi, B. Y., Kho, A. R., Lee, S. H., Hong, D. K., Kang, B. S., Lee, S. H., & Suh, S. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032950 · Cited by 25

Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

Zhao, S.-S., Guo, Y., & Yin, X. (2024) · Frontiers in Bioscience · doi:10.31083/j.fbl2901030 · Cited by 24

From fat to fire: The lipid–inflammasome connection

Anand, P. (2024) · Immunological Reviews · doi:10.1111/imr.13403 · Cited by 27

Targeting regulated cell death pathways in acute myeloid leukemia

Garciaz, S., Miller, T. W., Collette, Y., & Vey, N. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2022.108 · Cited by 25

The Therapeutic Potential of Pyroptosis in Melanoma

Zaffaroni, N., & Beretta, G. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021285 · Cited by 23

Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice

Xi, C., Pang, J., Xue, W., Cui, Y., Jiang, N., Zhi, W., Shi, H., Horuzsko, A., Pace, B. S., & Zhu, X. (2025) · Communications Biology · doi:10.1038/s42003-024-07424-7 · Cited by 26

Emerging Potential Mechanism and Therapeutic Target of Ferroptosis in PDAC: A Promising Future

Li, C., Yin, X., Liu, Z., & Wang, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315031 · Cited by 24

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Zhu, L., Luo, S., Zhu, Y., Tang, S., Li, C., Jin, X., Wu, F.-L., Jiang, H., Wu, L., & Xu, Y. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s385977 · Cited by 21

New perspectives on ferroptosis and its role in hepatocellular carcinoma

Cong, T., Luo, Y., Fu, Y. H. H., Liu, Y., Li, Y., & Li, X. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002327 · Cited by 21

Retinal pigment epithelium-specific ablation of GPx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration

Azuma, K., Suzuki, T., Kobayashi, K., Nagahara, M., Imai, H., Suga, A., Iwata, T., Shiraya, T., Aihara, M., & Ueta, T. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07150-2 · Cited by 22

Cell death signaling in human erythron: erythrocytes lose the complexity of cell death machinery upon maturation

Tkachenko, A. S., & Havránek, O. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02081-5 · Cited by 24

Ginseng Saponin Rb1 Attenuates Cigarette Smoke Exposure-Induced Inflammation, Apoptosis and Oxidative Stress via Activating Nrf2 and Inhibiting NF-κB Signaling Pathways

Li, Z., Li, L., Lv, X., Hu, Y., & Cui, K. (2023) · International Journal of COPD · doi:10.2147/copd.s418421 · Cited by 20

LiCl Treatment Induces Programmed Cell Death of Schwannoma Cells through AKT- and MTOR-Mediated Necroptosis

Wang, Y., Zhang, Q., Wang, B., Li, P., & Liu, P. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2256-2 · Cited by 20

Scabertopin Derived from Elephantopus scaber L. Mediates Necroptosis by Inducing Reactive Oxygen Species Production in Bladder Cancer In Vitro

Gao, Y., Nie, Z., Cao, H., Huang, D., Chen, M., Xiang, Y., Yu, X., & Zhang, S. (2022) · Cancers · doi:10.3390/cancers14235976 · Cited by 22

Programmed Cell Death in Rheumatoid Arthritis

Tong, L., Qiu, J., Xu, Y., Lian, S., Xu, Y., & Wu, X. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s499345 · Cited by 21

Ferroptosis: potential targets and emerging roles in pancreatic diseases

Huang, Z., Ma, Y., Sun, Z., Cheng, L., & Wang, G. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03625-x · Cited by 19

METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4

Liu, D., Ren, L., & Liu, J. (2024) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.15297 · Cited by 18

A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency

van Vuren, A. J., van Beers, E. J., & van Wijk, R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.609103 · Cited by 17

Chitosan oligosaccharides alleviate macrophage pyroptosis and protect sepsis mice via activating the Nrf2/GPX4 pathway

Lu, Z., Liu, L.-X., Fu, Z., Wang, S.-N., Sun, C.-N., Yu, W., & Lu, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133899 · Cited by 17

Function and regulation of GPX4 in the development and progression of fibrotic disease

Li, Z., Zhu, Z., Liu, Y., Liu, Y., & Zhao, H. W. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30780 · Cited by 16

Novel role and mechanism of glutathione peroxidase-4 in nutritional pancreatic atrophy of chicks induced by dietary selenium deficiency

Huang, J., Jiang, Y., Ren, F., & Lei, X. G. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102482 · Cited by 16

Mitochondria: Emerging Consequential in Sickle Cell Disease

Akhter, M. S., Hamali, H. A., Rashid, H., Dobie, G., Madkhali, A. M., Mobarki, A. A., Oldenburg, J., & Biswas, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12030765 · Cited by 17

Basics and News on Glutathione Peroxidases

Flohé, L., & Brigelius‐Flohé, R. (2016) · Springer eBooks · doi:10.1007/978-3-319-41283-2_17 · Cited by 16

Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis

Fan, Y., Ma, K., Lin, Y., Ren, J., Peng, H., Yuan, L., Nasser, M. I., Jiang, X., & Wang, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1520570 · Cited by 16

Galectin-3 Possesses Anti-Necroptotic and Anti-Apoptotic Effects in Cisplatin-Induced Acute Tubular Necrosis

Al‐Salam, S., Jagadeesh, G. S., Sudhadevi, M., Ahmed, H. T., & Yasin, J. (2021) · Cellular Physiology and Biochemistry · doi:10.33594/000000381 · Cited by 15

Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages

Aoyama, Y., Yamazaki, H., Nishimua, K., Nomura, M., Shigehiro, T., Suzuki, T., Zang, W., Tatara, Y., Ito, H., Hayashi, Y., et al. (2025) · Blood · doi:10.1182/blood.2024025402 · Cited by 14

Characterization of Glutathione Peroxidase 4 in Rat Oocytes, Preimplantation Embryos, and Selected Maternal Tissues during Early Development and Implantation

Kreheľová, A., Kovaříková, V., Domoráková, I., Solár, P., Pastornická, A., Pavliuk-Karachevtseva, A., Rybárová, S., Hodorová, I., & Mihálik, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105174 · Cited by 14

Epimedium koreanum Nakai–Induced Liver Injury—A Mechanistic Study Using Untargeted Metabolomics

Li, P., Zhang, L., Guo, Z., Kang, Q., Chen, C., Liu, X., Ma, Q., Zhang, J., Hu, Y., & Wang, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.934057 · Cited by 14

Ammonia triggers ferroptosis in macrophages of yellow catfish Pelteobagrus fulvidraco

Gan, L., Li, Y., Zhang, M., He, K., Zhang, H., Lin, Y., Qin, C., Shao, J., Jiang, H., & Wen, M. (2021) · Aquaculture Research · doi:10.1111/are.15600 · Cited by 12

Keeping the host alive – lessons from obligate intracellular bacterial pathogens

Loterio, R. K., Zamboni, D. S., & Newton, H. J. (2021) · Pathogens and Disease · doi:10.1093/femspd/ftab052 · Cited by 13

Effects of Ferrocene and Ferrocenium on MCF-7 Breast Cancer Cells and Interconnection with Regulated Cell Death Pathways

Favaron, C., Gabano, E., Zanellato, I., Gaiaschi, L., Casali, C., Bottone, M. G., & Ravera, M. (2023) · Molecules · doi:10.3390/molecules28186469 · Cited by 12

Red Blood Cells as Therapeutic Target to Treat Sickle Cell Disease

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Necroptosis Resumes Apoptosis in Hippocampus but Not in Frontal Cortex

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