The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
Open accessAbstract
Key Points: Gpx4 is essential for preventing anemia in mice via inhibiting RIP3-dependent necroptosis in erythroid precursor cells. ROS accumulation and lipid peroxidation in erythroid precursor cells trigger receptor-independent activation of necroptosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“GPx4 KO mice show impaired hematopoiesis without hemolysis (28), indicating that erythroid cells rather than adult RBCs are affected by deficient redox detoxification by GPx4.”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [28]
In the citing paper
“GPx4 KO mice show impaired hematopoiesis without hemolysis (28), indicating that erythroid cells rather than adult RBCs are affected by deficient redox detoxification by GPx4.”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citationROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382
Self-citationAutophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gélinas, C., Fan, Y., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.001 · Cited by 2,069
Identification of RIP1 kinase as a specific cellular target of necrostatins
Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.005 · Cited by 1,470
Self-citationCatalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature · doi:10.1038/nature09852 · Cited by 1,278 · cited 1×
“Cell death observed in the absence of caspase 8 is inhibited upon the additional deletion of Rip3, suggesting that caspase 8 inhibits RIP3-mediated necroptosis.(24,25,29) For personal use only.”
BackgroundRIP3 mediates the embryonic lethality of caspase-8-deficient mice
Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S. (2011) · Nature · doi:10.1038/nature09857 · Cited by 1,057
Schulze‐Osthoff, K., Bakker, A. C., Vanhaesebroeck, B., Beyaert, R., Jacob, W. A., & Fiers, W. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42768-8 · Cited by 941
More than one way to die: apoptosis, necrosis and reactive oxygen damage
Fiers, W. C., Beyaert, R., Declercq, W., & Vandenabeele, P. (1999) · Oncogene · doi:10.1038/sj.onc.1203249 · Cited by 871
Self-citationEssential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., & Van Etten, R. A. (2003) · Nature · doi:10.1038/nature01819 · Cited by 801
Yant, L. J., Ran, Q., Rao, L., Van Remmen, H., Shibatani, T., Belter, J. G., Motta, L., Richardson, A., & Prolla, T. A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01360-6 · Cited by 797
Necroptosis as an alternative form of programmed cell death
Christofferson, D. E., & Yuan, J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.003 · Cited by 794
Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts
Socolovsky, M., Nam, H.-S., Fleming, M. D., Haase, V. H., Brugnara, C., & Lodish, H. F. (2001) · Blood · doi:10.1182/blood.v98.12.3261 · Cited by 674
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672 · cited 4×
“In fact, recent data suggested an important role of Gpx4 for the survival of T cells and renal tubular cells by preventing ferroptosis.(14) In this study, we provide evidence that in erythroid cells, Gpx4 instead suppresses Rip3-dependent necroptosis.”
BackgroundInfluentialSelf-citationNecroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features
Berghe, T. V., Vanlangenakker, N., Parthoens, E., Deckers, W., Devos, M., Festjens, N., Guerin, C. J., Brunk, U. T., Declercq, W., & Vandenabeele, P. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.184 · Cited by 639
Self-citationRIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis
Rickard, J. A., O’Donnell, J. A., Evans, J. M., Lalaoui, N., Poh, A. R., Rogers, T., Vince, J. E., Lawlor, K. E., Ninnis, R. L., Anderton, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.019 · Cited by 598
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
Welz, P.-S., Wullaert, A., Vlantis, K., Kondylis, V., Fernández-Majada, V., Ermolaeva, M., Kirsch, P., Sterner-Kock, A., van Loo, G., & Pasparakis, M. (2011) · Nature · doi:10.1038/nature10273 · Cited by 594
Newton, K., Sun, X., & Dixit, V. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.4.1464-1469.2004 · Cited by 554
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
Dannappel, M., Vlantis, K., Kumari, S., Polykratis, A., Kim, C., Wachsmuth, L., Eftychi, C., Lin, J., Corona, T., Hermance, N., et al. (2014) · Nature · doi:10.1038/nature13608 · Cited by 534 · cited 1×
“16 our findings may nevertheless also be relevant for classical TNFα dependent necrosome activation as ROS that are formed downstream of RIP1/RIP3 may interfere with caspase 8 activity and therefore fuel into a feed-forward loop.(44) Furthermore, we cannot rule out that caspase 8 is also inhibited by direct oxidation…”
BackgroundThe diverse role of RIP kinases in necroptosis and inflammation
Silke, J., Rickard, J. A., & Gerlic, M. (2015) · Nature Immunology · doi:10.1038/ni.3206 · Cited by 531
Kim, Y., Morgan, M. J., Choksi, S., & Liu, Z.-G. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.021 · Cited by 523
Caspase 8 inhibits programmed necrosis by processing CYLD
O’Donnell, M. A., Perez-Jimenez, E., Oberst, A., Ng, A., Massoumi, R., Xavier, R., Green, D. R., & Ting, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2362 · Cited by 494
M AMMALIAN S ELENIUM -C ONTAINING P ROTEINS
BEHNE, D., & Kyriakopoulos, A. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.453 · Cited by 465
Poly(ADP-ribose) signals to mitochondrial AIF: A key event in parthanatos
Wang, Y., Dawson, V. L., & Dawson, T. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.020 · Cited by 430
Functional complementation between FADD and RIP1 in embryos and lymphocytes
Zhang, H., Zhou, X., McQuade, T. J., Li, J., Chan, F. K.-M., & Zhang, J. (2011) · Nature · doi:10.1038/nature09878 · Cited by 428
Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice
Lee, T.-H. (2003) · Blood · doi:10.1182/blood-2002-08-2548 · Cited by 420
Programmed necrosis: backup to and competitor with apoptosis in the immune system
Han, J., Zhong, C., & Zhang, D. (2011) · Nature Immunology · doi:10.1038/ni.2159 · Cited by 375
Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene
Imai, H., Hirao, F., Sakamoto, T., Sekine, K., Mizukura, Y., Saito, M., Kitamoto, T., Hayasaka, M., Hanaoka, K., & Nakagawa, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00734-4 · Cited by 357
Survival Function of the FADD-CASPASE-8-cFLIPL Complex
Dillon, C. P., Oberst, A., Weinlich, R., Janke, L. J., Kang, T.-B., Ben-Moshe, T., Mak, T. W., Wallach, D., & Green, D. R. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.03.010 · Cited by 331 · cited 1×
“Cell death observed in the absence of caspase 8 is inhibited upon the additional deletion of Rip3, suggesting that caspase 8 inhibits RIP3-mediated necroptosis.(24,25,29) For personal use only.”
BackgroundRIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
Takahashi, N., Vereecke, L., Bertrand, M. J. M., Duprez, L., Berger, S. B., Divert, T., Gonçalves, A., Sze, M., Gilbert, B., Kourula, S., et al. (2014) · Nature · doi:10.1038/nature13706 · Cited by 318
Self-citationSuperoxide dismutase 1 regulates caspase-1 and endotoxic shock
Meissner, F., Molawi, K., & Zychlinsky, A. (2008) · Nature Immunology · doi:10.1038/ni.1633 · Cited by 308
Bonnet, M. C., Preukschat, D., Welz, P.-S., van Loo, G., Ermolaeva, M. A., Bloch, W., Haase, I., & Pasparakis, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.014 · Cited by 295
Hameyer, D., Loonstra, A., Eshkind, L. G., Schmitt, S., Antunes, C., Groen, A., Bindels, E. M., Jonkers, J., Krimpenfort, P., Meuwissen, R. L. J., et al. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00019.2007 · Cited by 200
Glutathiolation Regulates Tumor Necrosis Factor-α–Induced Caspase-3 Cleavage and Apoptosis
Pan, S., & Berk, B. C. (2006) · Circulation Research · doi:10.1161/01.res.0000256089.30318.20 · Cited by 169
Wortmann, M., Schneider, M., Pircher, J., Hellfritsch, J., Aichler, M., Naidu, V. M., Kölle, P., Kuhlencordt, P., Walch, A. K., Pohl, U., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.279984 · Cited by 163
Self-citationRedox regulation of TNF signaling
Goossens, V., Vos, K. J. D., Vercammen, D., Steemans, M., Vancompernolle, K., Fiers, W., Vandenabeele, P., & Grooten, J. (1999) · BioFactors · doi:10.1002/biof.5520100210 · Cited by 136
Self-citationGlutathione Peroxidase 4 Is Required for Maturation of Photoreceptor Cells
Ueta, T., Inoue, T., Furukawa, T., Tamaki, Y., Nakagawa, Y., Imai, H., & Yanagi, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.335174 · Cited by 129
Caspases are reversibly inactivated by hydrogen peroxide
Borutaitė, V., & Brown, G. C. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02593-5 · Cited by 126
Johnson, R. M., Ho, Y.-S., Yu, D., Kuypers, F. A., Ravindranath, Y., & Goyette, G. W. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.021 · Cited by 106
Interaction with substrate sensitises caspase‐3 to inactivation by hydrogen peroxide
Hampton, M. B., Stamenkovic, I., & Winterbourn, C. C. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02629-7 · Cited by 70
The Regulation of Erythropoiesis by Selenium in Mice
Kaushal, N., Hegde, S., Lumadue, J. A., Paulson, R. F., & Prabhu, K. S. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3323 · Cited by 63
Shuga, J., Zhang, J., Samson, L. D., Lodish, H. F., & Griffith, L. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701829104 · Cited by 53
Xie, C., Zhang, N., Zhou, H., Li, J., Li, Q., Zarubin, T., Lin, S., & Han, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6673-6681.2005 · Cited by 52
Chelation of lysosomal iron protects against ionizing radiation
Berndt, C., Kurz, T., Selenius, M., Fernandes, A. P., Edgren, M., & Brunk, U. T. (2010) · Biochemical Journal · doi:10.1042/bj20100996 · Cited by 44
DNA vaccination against multiple myeloma.
Stevenson, F. K., Cj, L., Traynor, A. E., Yu, H., & Corr, M. (1999) · PubMed · Cited by 37
Beutler, E. K., & Luzzatto, L. (1999) · PubMed · Cited by 7
Cited by
Sorted by citations
Ferroptosis: molecular mechanisms and health implications
Tang, D., Chen, X., Kang, R., & Kroemer, G. (2020) · Cell Research · doi:10.1038/s41422-020-00441-1 · Cited by 4,495
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
Broadening horizons: the role of ferroptosis in cancer
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00462-0 · Cited by 3,012
The molecular machinery of regulated cell death
Tang, D., Kang, R., Berghe, T. V., Vandenabeele, P., & Kroemer, G. (2019) · Cell Research · doi:10.1038/s41422-019-0164-5 · Cited by 2,675
Self-citation
Metadata
- Authors
- Canli, Ö., Alankuş, Y. B., Grootjans, S., Vegi, N., Hültner, L., Hoppe, P. S., Schroeder, T., Vandenabeele, P., Bornkamm, G. W., & Greten, F. R.
- Affiliations
- Georg Speyer Haus (DE)
- TUM Klinikum (DE)
- Ghent University (BE)
- Institute of Experimental Cancer Research, Comprehensive Cancer Center and University Hospital Ulm, Ulm, Germany;
- Helmholtz Munich (DE)
- ETH Zurich (CH)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-01-07
- Volume
- 127
- Issue
- 1
- Pages
- 139-148
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4705604
- OpenAlex
- W2285203836
- Cited by
- 247
- References
- 53
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 29 · 2023: 35 · 2022: 35 · 2021: 37 · 2020: 21 · 2019: 21 · 2018: 8 · 2017: 10 · 2016: 18
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- GPX4, necroptosis, erythroid precursors, RIPK3, caspase-8, glutathionylation, oxidative stress, reactive oxygen species, lipid peroxidation, lipid hydroperoxides, reticulocyte maturation, anemia, hematopoietic cells, redox homeostasis
- MeSH terms
- Phospholipid Hydroperoxide Glutathione Peroxidase, Animals, Cell Differentiation, Cells, Cultured, Flow Cytometry, Glutathione Peroxidase, Humans, Immunoenzyme Techniques, Necrosis, Blotting, Western, Apoptosis, Reactive Oxygen Species, Mice, Knockout, Oxidative Stress, Erythroid Cells, Cell Proliferation, Mice, Receptor-Interacting Protein Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
