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Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors
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Key Points: Gpx4 is essential for preventing anemia in mice via inhibiting RIP3-dependent necroptosis in erythroid precursor cells. ROS accumulation and lipid peroxidation in erythroid precursor cells trigger receptor-independent activation of necroptosis.
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“GPx4 KO mice show impaired hematopoiesis without hemolysis (28), indicating that erythroid cells rather than adult RBCs are affected by deficient redox detoxification by GPx4.”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [28]
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“GPx4 KO mice show impaired hematopoiesis without hemolysis (28), indicating that erythroid cells rather than adult RBCs are affected by deficient redox detoxification by GPx4.”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [28]
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citationROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,288
Molecular mechanisms of necroptosis: an ordered cellular explosion
Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2970 · Cited by 2,382
Self-citationAutophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G., Mukherjee, C., Shi, Y., Gélinas, C., Fan, Y., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.06.001 · Cited by 2,069
Identification of RIP1 kinase as a specific cellular target of necrostatins
Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792
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Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
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Self-citationFerroptosis: machinery and regulation
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Recent Progress in Ferroptosis Inducers for Cancer Therapy
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Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
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Ferroptosis is a type of autophagy-dependent cell death
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Necroptosis: Mechanisms and Relevance to Disease
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GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues
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Modulating ROS to overcome multidrug resistance in cancer
Cui, Q., Wang, J., Assaraf, Y. G., Ren, L., Gupta, P., Wei, L., Ashby, C. R., Yang, D., & Chen, Z. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.11.001 · Cited by 677
Ferroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
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Xue, Q., Ding, Y., Chen, X., Li, X., Kang, R., Klionsky, D. J., Kroemer, G., Chen, X., Tang, D., & Liu, J. (2023) · Autophagy · doi:10.1080/15548627.2023.2165323 · Cited by 656
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Imai, H., Matsuoka, M., Kumagai, T., Sakamoto, T., & Koumura, T. (2016) · Current topics in microbiology and immunology · doi:10.1007/82_2016_508 · Cited by 635
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Kang, R., Zeng, L., Zhu, S., Xie, Y., Liu, J., Wen, Q., Cao, L., Xie, M., Ran, Q., Kroemer, G., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.009 · Cited by 627
Chaperone-mediated autophagy is involved in the execution of ferroptosis
Wu, Z., Geng, Y., Lu, X., Shi, Y., Wu, G., Zhang, M., Shan, B., Pan, H., & Yuan, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1819728116 · Cited by 582
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Conrad, M., Kagan, V. E., Bayir, H., Pagnussat, G. C., Head, B., Traber, M. G., & Stockwell, B. R. (2018) · Genes & Development · doi:10.1101/gad.314674.118 · Cited by 544
Oxidative Damage and Antioxidant Defense in Ferroptosis
Kuang, F., Liu, J., Tang, D., & Kang, R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.586578 · Cited by 549
Xu, C., Sun, S., Johnson, T. S., Qi, R. A., Zhang, S., Zhang, J., & Yang, K. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109235 · Cited by 530
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Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.034 · Cited by 511
Clockophagy is a novel selective autophagy process favoring ferroptosis
Yang, M., Chen, P., Liu, J., Zhu, S., Kroemer, G., Klionsky, D. J., Lotze, M. T., Zeh, H. J., Kang, R., & Tang, D. (2019) · Science Advances · doi:10.1126/sciadv.aaw2238 · Cited by 500
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Bebber, C. M., Müller, F., Clemente, L. P., Weber, J., & von Karstedt, S. (2020) · Cancers · doi:10.3390/cancers12010164 · Cited by 372
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis
Canli, Ö., Nicolas, A. M., Gupta, J. R. P., Finkelmeier, F., Goncharova, O., Pesic, M. H., Neumann, T., Horst, D. A., Löwer, M., Şahin, U., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.004 · Cited by 375
Self-citationEmerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications
Zheng, Y., Sun, J., Luo, Z., Li, Y., & Huang, Y. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07244-x · Cited by 378
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Idelchik, M. D. P. S., Begley, U., Begley, T. J., & Melendez, J. A. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.005 · Cited by 313
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Li, J., Liu, J., Zhou, Z., Wu, R., Chen, X., Yu, C., Stockwell, B. R., Kroemer, G., Kang, R., & Tang, D. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg3049 · Cited by 305
ESCRT-III–dependent membrane repair blocks ferroptosis
Dai, E., Meng, L., Kang, R., Wang, X., & Tang, D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.110 · Cited by 283
Wiernicki, B., Dubois, H., Tyurina, Y. Y., Hassannia, B., Bayır, H., Kagan, V. E., Vandenabeele, P., Wullaert, A., & Berghe, T. V. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03118-0 · Cited by 280
Self-citationConche, C., Finkelmeier, F., Pesic, M. H., Nicolas, A. M., Böttger, T. W., Kennel, K. B., Denk, D., Ceteci, F., Mohs, K., Engel, E., et al. (2023) · Gut · doi:10.1136/gutjnl-2022-327909 · Cited by 270
Self-citationEmerging roles for lipids in non-apoptotic cell death
Magtanong, L., Ko, P., & Dixon, S. J. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.25 · Cited by 267
Ferroptosis: when metabolism meets cell death
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Liu, Y., Wang, Y., Liu, J., Kang, R., & Tang, D. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0182-y · Cited by 227
Chen, X., Tsvetkov, A. S., Shen, H., Isidoro, C., Ktistakis, N. T., Linkermann, A., Koopman, W. J. H., Simon, H., Galluzzi, L., Luo, S., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2319901 · Cited by 240
Hu, Q., Zhang, Y., Lou, H., Ou, Z., Liu, J., Duan, W., Wang, H., Ge, Y., Min, J., Wang, F., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04008-9 · Cited by 219
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Zhang, Y., Unnikrishnan, A., Deepa, S. S., Liu, Y., Li, Y., Ikeno, Y., Sosnowska, D., Van Remmen, H., & Richardson, A. (2017) · Redox Biology · doi:10.1016/j.redox.2016.10.014 · Cited by 185
“For example, absence of glutathione peroxidase 4 has been shown to induce necroptosis in mouse erythroid precursor cells [39], and knocking out a necrosis mediating protein, RIP3 (receptor-interacting protein 3) reduces inflammation and mortality in a mouse model of atherosclerosis [40,41].”
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Brigelius‐Flohé, R., & Flohé, L. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.08.003 · Cited by 162
Jiang, T., Cheng, H., Su, J., Wang, X., Wang, Q., Chu, J., & Li, Q. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104715 · Cited by 160
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Vats, K., Kruglov, O., Mizes, A., Самович, С. Н., Amoscato, A. A., Tyurin, V. A., Tyurina, Y. Y., Kagan, V. E., & Bunimovich, Y. L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102143 · Cited by 161
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Xu, W., Deng, H., Hu, S., Zhang, Y., Li, Z., Liu, M., Chen, Y., Wei, J., Yang, H., & Lv, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s307081 · Cited by 155
miR-200a-5p regulates myocardial necroptosis induced by Se deficiency via targeting RNF11
Yang, T., Cao, C., Yang, J., Liu, T., Lei, X. G., Zhang, Z., & Xu, S. (2017) · Redox Biology · doi:10.1016/j.redox.2017.11.025 · Cited by 145
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The potential role of necroptosis in inflammaging and aging
Royce, G. H., Brown‐Borg, H. M., & Deepa, S. S. (2019) · GeroScience · doi:10.1007/s11357-019-00131-w · Cited by 137
The role of ferroptosis in lung cancer
Wu, S., Zhu, C., Tang, D., Dou, Q. P., Shen, J., & Chen, X. (2021) · Biomarker Research · doi:10.1186/s40364-021-00338-0 · Cited by 137
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Diao, J., Jia, Y., Dai, E., Liu, J., Kang, R., Tang, D., Han, L., Zhong, Y., & Meng, L. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01999-9 · Cited by 135
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Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis
Florean, C., Song, S., Dicato, M. A., & Diederich, M. F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.008 · Cited by 110
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Zheng, H., Jiang, L., Tsuduki, T., Conrad, M., & Toyokuni, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102175 · Cited by 109
Mohammed, S., Nicklas, E. H., Thadathil, N., Selvarani, R., Royce, G. H., Kinter, M. T., Richardson, A. G., & Deepa, S. S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.449 · Cited by 110
Lin, Y., Shen, Y.-C., Wu, C., Tsai, Y.-Y., Yang, Y., Lin, Y.-Y., Kuan, F., Lu, C.-N., Chang, G., Tsai, M., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01226 · Cited by 104
The role of lysosome in regulated necrosis
Alu, A., Han, X., Ma, X., Wu, M., Wei, Y., & Wei, X. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.003 · Cited by 109
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Mishima, E., & Conrad, M. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062320-114541 · Cited by 107
Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice
Liu, K., Liu, J., Zou, B., Li, C., Zeh, H. J., Kang, R., Kroemer, G., Huang, J. X., & Tang, D. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.09.008 · Cited by 107
Broad Spectrum Deubiquitinase Inhibition Induces Both Apoptosis and Ferroptosis in Cancer Cells
Li, Y., Chen, X., Yang, Q., Chen, J., Huang, Q., Yao, L., Ding, Y., Wu, J., Zhang, P., Tang, D., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00949 · Cited by 102
Page, G. P., Kanias, T., Guo, Y., Lanteri, M. C., Zhang, X., Mast, A. E., Cable, R. G., Spencer, B. R., Kiss, J. E., Fang, F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146077 · Cited by 103
Ferroptosis in life: To be or not to be
Xu, L., Liu, Y., Chen, X., Zhong, H., & Wang, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114241 · Cited by 100
Ferroptosis: Biological Rust of Lipid Membranes
Hassannia, B., Coillie, S. V., & Berghe, T. V. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8175 · Cited by 93
Wang, Q., & Zennadi, R. (2021) · Antioxidants · doi:10.3390/antiox10101608 · Cited by 105
Jinesh, G. G., & Brohl, A. S. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01132-6 · Cited by 96
Altamura, S., Naidu, V. M., Hoppe, P. S., Schroeder, T., Aichler, M., Walch, A. K., Okreglicka, K. M., Hültner, L., Schneider, M., Ladinig, C., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.212977 · Cited by 92
Self-citationRegulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy
Zheng, K., Dong, Y., Yang, R., Liang, Y., Wu, H., & He, Z. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105580 · Cited by 89
Necroptosis: A new way of dying?
Hanson, B. (2016) · Cancer Biology & Therapy · doi:10.1080/15384047.2016.1210732 · Cited by 93
Borchert, A., Kalms, J., Roth, S. R., Rademacher, M., Schmidt, A., Holzhütter, H., Kühn, H., & Scheerer, P. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.06.006 · Cited by 83
Fujiki, K., Inamura, H., Sugaya, T., & Matsuoka, M. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0307-8 · Cited by 83
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Metadata
- Authors
- Canli, Ö., Alankuş, Y. B., Grootjans, S., Vegi, N., Hültner, L., Hoppe, P. S., Schroeder, T., Vandenabeele, P., Bornkamm, G. W., & Greten, F. R.
- Affiliations
- Georg Speyer Haus (DE)
- TUM Klinikum (DE)
- Ghent University (BE)
- Institute of Experimental Cancer Research, Comprehensive Cancer Center and University Hospital Ulm, Ulm, Germany;
- Helmholtz Munich (DE)
- ETH Zurich (CH)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-01-07
- Volume
- 127
- Issue
- 1
- Pages
- 139-148
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4705604
- OpenAlex
- W2285203836
- Cited by
- 247
- References
- 53
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 29 · 2023: 35 · 2022: 35 · 2021: 37 · 2020: 21 · 2019: 21 · 2018: 8 · 2017: 10 · 2016: 18
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Keywords
- GPX4, necroptosis, erythroid precursors, RIPK3, caspase-8, glutathionylation, oxidative stress, reactive oxygen species, lipid peroxidation, lipid hydroperoxides, reticulocyte maturation, anemia, hematopoietic cells, redox homeostasis
- MeSH terms
- Phospholipid Hydroperoxide Glutathione Peroxidase, Animals, Cell Differentiation, Cells, Cultured, Flow Cytometry, Glutathione Peroxidase, Humans, Immunoenzyme Techniques, Necrosis, Blotting, Western, Apoptosis, Reactive Oxygen Species, Mice, Knockout, Oxidative Stress, Erythroid Cells, Cell Proliferation, Mice, Receptor-Interacting Protein Serine-Threonine Kinases
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