The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Hepcidin in the diagnosis of iron disorders
Open accessAbstract
The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.
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In the citing paper
“Hepcidin expression is inhibited by iron deficiency, expansion of erythropoiesis, anemia/hypoxia, testosterone and possibly other factors.1,47”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [47]
In the citing paper
“However, besides being subject to circadian oscillations, hepcidin levels change rapidly in response to activating and inhibitory signals, making their measurement useful in only a limited number of conditions.47”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [47]
In the citing paper
“The expression of hepcidin in the liver is transcriptionally controlled by bone morphogenic proteins (BMP)- SMAD mediated signaling cascades which are regulated by different factors such as iron deficiency, iron overload, hypoxia, inflammation, infection, and hormones (Girelli et al., 2016; Silvestri et al., 2019).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Girelli et al., 2016
In the citing paper
“Regulation of hepcidin expression is mainly accomplished at the transcriptional level, and expression of the protein is induced by iron loading and inflammation, whereas it is reduced by hypoxia, active erythropoiesis, hormones and low plasma iron concentrations [148,149].”
From Iron in immune cell function and host defense (2021) · cites this paper as [149]
In the citing paper
“Regulation of hepcidin expression is mainly accomplished at the transcriptional level, and expression of the protein is induced by iron loading and inflammation, whereas it is reduced by hypoxia, active erythropoiesis, hormones and low plasma iron concentrations [148,149].”
From Iron in immune cell function and host defense (2021) · cites this paper as [149]
In the citing paper
“Regulation of hepcidin expression is mainly accomplished at the transcriptional level, and expression of the protein is induced by iron loading and inflammation, whereas it is reduced by hypoxia, active erythropoiesis, hormones and low plasma iron concentrations [148,149].”
From Iron in immune cell function and host defense (2021) · cites this paper as [149]
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Cites
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 1×
“For example, hepcidin production increases substantially within a few hours after iron administration or inflammatory stimulation.(15,28,29,33,34) Because many of the conditions listed in Figure 1 are common, several stimulimay be present simultaneously, with hepcidin output depending on the relative strength of each.”
BackgroundSelf-citationTwo to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Zimmermann, M. B., & Hurrell, R. F. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61235-5 · Cited by 1,405
Identification of erythroferrone as an erythroid regulator of iron metabolism
Kautz, L., Jung, G., Valore, E. V., Rivella, S., Nemeth, E., & Ganz, T. (2014) · Nature Genetics · doi:10.1038/ng.2996 · Cited by 1,127
Self-citationSazawal, S., Black, R. E., Ramsan, M., Chwaya, H. M., Stoltzfus, R. J., Dutta, A., Dhingra, U., Kabole, I., Deb, S., Othman, M. K., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67962-2 · Cited by 981
Hepcidin and iron regulation, 10 years later
Ganz, T. (2011) · Blood · doi:10.1182/blood-2011-01-258467 · Cited by 962
Iron homeostasis in host defence and inflammation
Ganz, T., & Nemeth, E. (2015) · Nature Reviews Immunology · doi:10.1038/nri3863 · Cited by 843
Self-citationImmunoassay for human serum hepcidin
Ganz, T., Olbina, G., Girelli, D., Nemeth, E., & Westerman, M. (2008) · Blood · doi:10.1182/blood-2008-02-139915 · Cited by 688
Self-citationHepcidin and the iron-infection axis
Drakesmith, H., & Prentice, A. M. (2012) · Science · doi:10.1126/science.1224577 · Cited by 686
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydınok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.130 · Cited by 675
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Weiss, G., Ganz, T., & Goodnough, L. T. (2019) · Blood · doi:10.1182/blood-2018-06-856500 · Cited by 1,219
Biomarkers of Nutrition for Development—Folate Review
Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., et al. (2015) · Journal of Nutrition · doi:10.3945/jn.114.206599 · Cited by 1,170
Pasricha, S.-R., Tye-Din, J., Muckenthaler, M. U., & Swinkels, D. W. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32594-0 · Cited by 1,069
Self-citationIron metabolism and iron disorders revisited in the hepcidin era
Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734
“Hepcidin expression is inhibited by iron deficiency, expansion of erythropoiesis, anemia/hypoxia, testosterone and possibly other factors.(1,47) The most powerful inhibitor is the liver transmembrane serine protease matriptase 2, encoded by TMPRSS6,(48) which cleaves the BMP co-receptor hemojuvelin,(49) thereby attenu…”
Camaschella, C. (2019) · Blood · doi:10.1182/blood-2018-05-815944 · Cited by 702
Metadata
- Authors
- Girelli, D., Nemeth, E., & Swinkels, D. W.
- Affiliations
- University of Verona (IT)
- University of California, Los Angeles (US)
- Radboud University Medical Center (NL)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-06-09
- Volume
- 127
- Issue
- 23
- Pages
- 2809-2813
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4956612
- OpenAlex
- W2343895948
- Cited by
- 417
- References
- 80
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 36 · 2023: 30 · 2022: 42 · 2021: 61 · 2020: 53 · 2019: 49 · 2018: 52 · 2017: 33 · 2016: 9
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107309)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- hepcidin, iron metabolism disorders, iron deficiency anemia, iron-refractory iron deficiency anemia, iron regulation, diagnostic biomarkers, assay harmonization, iron supplementation, infection, global health
- MeSH terms
- Animals, Blood Chemical Analysis, Hematologic Tests, Humans, Biomarkers, Iron Metabolism Disorders, Diagnostic Techniques and Procedures, Hepcidins
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