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Hepcidin in the diagnosis of iron disorders
Open accessAbstract
The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our understanding of iron disorders, and its measurement should advance diagnosis/treatment of these conditions. Although several assays have been developed, a gold standard is still lacking, and efforts toward harmonization are ongoing. Nevertheless, promising applications can already be glimpsed, ranging from the use of hepcidin levels for diagnosing iron-refractory iron deficiency anemia to global health applications such as guiding safe iron supplementation in developing countries with high infection burden.
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In the citing paper
“Hepcidin expression is inhibited by iron deficiency, expansion of erythropoiesis, anemia/hypoxia, testosterone and possibly other factors.1,47”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [47]
In the citing paper
“However, besides being subject to circadian oscillations, hepcidin levels change rapidly in response to activating and inhibitory signals, making their measurement useful in only a limited number of conditions.47”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [47]
In the citing paper
“The expression of hepcidin in the liver is transcriptionally controlled by bone morphogenic proteins (BMP)- SMAD mediated signaling cascades which are regulated by different factors such as iron deficiency, iron overload, hypoxia, inflammation, infection, and hormones (Girelli et al., 2016; Silvestri et al., 2019).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Girelli et al., 2016
In the citing paper
“Regulation of hepcidin expression is mainly accomplished at the transcriptional level, and expression of the protein is induced by iron loading and inflammation, whereas it is reduced by hypoxia, active erythropoiesis, hormones and low plasma iron concentrations [148,149].”
From Iron in immune cell function and host defense (2021) · cites this paper as [149]
In the citing paper
“Regulation of hepcidin expression is mainly accomplished at the transcriptional level, and expression of the protein is induced by iron loading and inflammation, whereas it is reduced by hypoxia, active erythropoiesis, hormones and low plasma iron concentrations [148,149].”
From Iron in immune cell function and host defense (2021) · cites this paper as [149]
In the citing paper
“Regulation of hepcidin expression is mainly accomplished at the transcriptional level, and expression of the protein is induced by iron loading and inflammation, whereas it is reduced by hypoxia, active erythropoiesis, hormones and low plasma iron concentrations [148,149].”
From Iron in immune cell function and host defense (2021) · cites this paper as [149]
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Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 1×
“For example, hepcidin production increases substantially within a few hours after iron administration or inflammatory stimulation.(15,28,29,33,34) Because many of the conditions listed in Figure 1 are common, several stimulimay be present simultaneously, with hepcidin output depending on the relative strength of each.”
BackgroundSelf-citationTwo to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120
Zimmermann, M. B., & Hurrell, R. F. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61235-5 · Cited by 1,405
Identification of erythroferrone as an erythroid regulator of iron metabolism
Kautz, L., Jung, G., Valore, E. V., Rivella, S., Nemeth, E., & Ganz, T. (2014) · Nature Genetics · doi:10.1038/ng.2996 · Cited by 1,127 · cited 1×
“One such erythroid signal, erythroferrone, has been recently identified in a mouse model.(52) In line with this pathophysiological model, serum hepcidin fluctuates in transfusion-dependent b-thalassemia, with levels increasing soon after red blood cell transfusions (which suppress ineffective erythropoiesis) and decli…”
BackgroundSelf-citationSazawal, S., Black, R. E., Ramsan, M., Chwaya, H. M., Stoltzfus, R. J., Dutta, A., Dhingra, U., Kabole, I., Deb, S., Othman, M. K., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)67962-2 · Cited by 981
Hepcidin and iron regulation, 10 years later
Ganz, T. (2011) · Blood · doi:10.1182/blood-2011-01-258467 · Cited by 962
Iron homeostasis in host defence and inflammation
Ganz, T., & Nemeth, E. (2015) · Nature Reviews Immunology · doi:10.1038/nri3863 · Cited by 843
Self-citationImmunoassay for human serum hepcidin
Ganz, T., Olbina, G., Girelli, D., Nemeth, E., & Westerman, M. (2008) · Blood · doi:10.1182/blood-2008-02-139915 · Cited by 688
Self-citationHepcidin and the iron-infection axis
Drakesmith, H., & Prentice, A. M. (2012) · Science · doi:10.1126/science.1224577 · Cited by 686
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydınok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., et al. (2008) · Nature Genetics · doi:10.1038/ng.130 · Cited by 675
Drakesmith, H., Nemeth, E., & Ganz, T. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.006 · Cited by 638
Self-citationJaeggi, T., Kortman, G. A. M., Moretti, D., Chassard, C., Holding, P., Dostal, A., Boekhorst, J., Timmerman, H. M., Swinkels, D. W., Tjalsma, H., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307720 · Cited by 622
Self-citationIron Overload in Human Disease
Fleming, R. E., & Ponka, P. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1004967 · Cited by 607
Moretti, D., Goede, J. S., Zeder, C., Jiskra, M., Chatzinakou, V., Tjalsma, H., Melse-Boonstra, A., Brittenham, G., Swinkels, D. W., & Zimmermann, M. B. (2015) · Blood · doi:10.1182/blood-2015-05-642223 · Cited by 547
Self-citationTime-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
Kemna, E., Pickkers, P., Nemeth, E., van der Hoeven, H., & Swinkels, D. (2005) · Blood · doi:10.1182/blood-2005-03-1159 · Cited by 498
Self-citationHepcidin in iron overload disorders
Papanikolaou, G., Tzilianos, M., Christakis, J. I., Bogdanos, D., Tsimirika, K., MacFarlane, J., Goldberg, Y. P., Sakellaropoulos, N., Ganz, T., & Nemeth, E. (2005) · Blood · doi:10.1182/blood-2004-12-4844 · Cited by 445
Self-citationTheurl, I., Aigner, E., Theurl, M., Nairz, M., Seifert, M., Schroll, A., Sonnweber, T., Eberwein, L., Witcher, D. R., Murphy, A. T., et al. (2009) · Blood · doi:10.1182/blood-2008-12-195651 · Cited by 421
Hunter, H. N., Fulton, D. B., Ganz, T., & Vogel, H. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205305200 · Cited by 400
Liver iron concentrations and urinary hepcidin in -thalassemia
Origa, R., Galanello, R., Ganz, T., Giagu, N., Maccioni, L., Faa, G., & Nemeth, E. (2007) · Haematologica · doi:10.3324/haematol.10842 · Cited by 365
Self-citationSoofi, S., Cousens, S., Iqbal, S. P., Akhund, T., Khan, J., Ahmed, I., Zaidi, A. K., & Bhutta, Z. A. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60437-7 · Cited by 330
Serum hepcidin: reference ranges and biochemical correlates in the general population
Galesloot, T. E., Vermeulen, S. H., Geurts-Moespot, A. J., Klaver, S. M., Kroot, J. J., van Tienoven, D., Wetzels, J. F. M., Kiemeney, L. A. L. M., Sweep, F. C., den Heijer, M., et al. (2011) · Blood · doi:10.1182/blood-2011-02-337907 · Cited by 303
Self-citationDetection of serum hepcidin in renal failure and inflammation by using ProteinChip System
Tomosugi, N., Kawabata, H., Wakatabe, R., Higuchi, M., Yamaya, H., Umehara, H., & Ishikawa, I. (2006) · Blood · doi:10.1182/blood-2005-10-4043 · Cited by 293
Bachman, E., Feng, R., Travison, T., Li, M., Olbina, G., Ostland, V., Ulloor, J., Zhang, A., Basaria, S., Ganz, T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0864 · Cited by 247
Kemna, E., Tjalsma, H., Podust, V. N., & Swinkels, D. W. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.079186 · Cited by 222
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Yang, Q., Jian, J., Katz, S., Abramson, S. B., & Huang, X. (2012) · Endocrinology · doi:10.1210/en.2011-2045 · Cited by 208
Immunochemical and Mass-Spectrometry–Based Serum Hepcidin Assays for Iron Metabolism Disorders
Kroot, J. J., Laarakkers, C. M., Geurts-Moespot, A. J., Grebenchtchikov, N. I., Pickkers, P., van Ede, A. E., Peters, H. P. E., van Dongen-Lases, E. C., Wetzels, J. F. M., Sweep, F. C. G. J., et al. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.149187 · Cited by 196
Self-citationBregman, D. B., Morris, D., Koch, T. A., He, A., & Goodnough, L. T. (2013) · American Journal of Hematology · doi:10.1002/ajh.23354 · Cited by 187
Reduced serum hepcidin levels in patients with chronic hepatitis C
Girelli, D., Pasino, M., Goodnough, J. B., Nemeth, E., Guido, M., Castagna, A., Busti, F., Campostrini, N., Martinelli, N., Vantini, I., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.06.027 · Cited by 169
Self-citationHepcidin is the major predictor of erythrocyte iron incorporation in anemic African children
Prentice, A. M., Doherty, C. P., Abrams, S. A., Cox, S. E., Atkinson, S. H., Verhoef, H., Armitage, A. E., & Drakesmith, H. (2012) · Blood · doi:10.1182/blood-2011-11-391219 · Cited by 167
Pasricha, S., Frazer, D. M., Bowden, D. K., & Anderson, G. J. (2013) · Blood · doi:10.1182/blood-2012-12-471441 · Cited by 156
Zlotkin, S., Newton, S., Aimone, A. M., Azindow, I., Amenga-Etego, S., Tchum, K., Mahama, E., Thorpe, K. E., & Owusu-Agyei, S. (2013) · JAMA · doi:10.1001/jama.2013.277129 · Cited by 154
Piperno, A., Galimberti, S., Mariani, R., Pelucchi, S., Ravasi, G., Lombardi, C., Bilo, G., Revera, M., Giuliano, A., Faini, A., et al. (2011) · Blood · doi:10.1182/blood-2010-08-299859 · Cited by 151
van Santen, S., van Dongen-Lases, E. C., de Vegt, F., Laarakkers, C. M., van Riel, P. L. C. M., van Ede, A. E., & Swinkels, D. W. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30623 · Cited by 142
Self-citationThe pathophysiology and pharmacology of hepcidin
Ruchala, P. P., & Nemeth, E. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.01.004 · Cited by 141
Self-citationMolecular liaisons between erythropoiesis and iron metabolism
Kautz, L., & Nemeth, E. (2014) · Blood · doi:10.1182/blood-2014-05-516252 · Cited by 138
Self-citationIron deficiency in the elderly population, revisited in the hepcidin era
Busti, F., Campostrini, N., Martinelli, N., & Girelli, D. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00083 · Cited by 137
Self-citationClark, M. A., Goheen, M. M., Fulford, A., Prentice, A. M., Elnagheeb, M. A., Patel, J., Fisher, N., Taylor, S. M., Kasthuri, R. S., & Cerami, C. (2014) · Nature Communications · doi:10.1038/ncomms5446 · Cited by 134
Hepcidin, the hormone of iron metabolism, is bound specifically to α-2-macroglobulin in blood
Pešlová, G., Petrák, J., Kuželová, K., Hrdý, I., Halada, P., Kuchel, P. W., Soe-Lin, S., Ponka, P., Šuťák, R., Becker, E., et al. (2009) · Blood · doi:10.1182/blood-2009-01-201590 · Cited by 127
Hepcidin and iron-loading anemias.
Nemeth, E., & Ganz, T. (2006) · PubMed · Cited by 124
Self-citationKroot, J. J., Hendriks, J. C. M., Laarakkers, C. M., Klaver, S. M., Kemna, E., Tjalsma, H., & Swinkels, D. W. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.03.039 · Cited by 121
Self-citationRegulation of hepcidin: Insights from biochemical analyses on human serum samples
Kemna, E., Kartikasari, A. E. R., van Tits, L. J. H., Pickkers, P., Tjalsma, H., & Swinkels, D. W. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.10.002 · Cited by 117
Self-citationAnemia of chronic disorders: new diagnostic tools and new treatment strategies
Weiss, G. (2015) · Seminars in Hematology · doi:10.1053/j.seminhematol.2015.07.004 · Cited by 116
Peters, H. P. E., Laarakkers, C. M., Swinkels, D. W., & Wetzels, J. F. M. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp546 · Cited by 115
Self-citationNai, A., Pagani, A., Silvestri, L., Campostrini, N., Corbella, M., Girelli, D., Traglia, M., Toniolo, D., & Camaschella, C. (2011) · Blood · doi:10.1182/blood-2011-06-364034 · Cited by 113
Self-citationYoung, M. F., Glahn, R. P., Ariza‐Nieto, M., Inglis, J., Olbina, G., Westerman, M. E., & O'Brien, K. O. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26589 · Cited by 112
Expression of the iron hormone hepcidin distinguishes different types of anemia in African children
Pasricha, S.-R., Atkinson, S. H., Armitage, A. E., Khandwala, S., Veenemans, J., Cox, S. E., Eddowes, L. A., Hayes, T., Doherty, C. P., Demir, A. Y., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008249 · Cited by 108
Troutt, J. S., Rudling, M., Persson, L., Ståhle, L., Angelin, B., Butterfield, A. M., Schade, A. E., Cao, G., & Konrad, R. J. (2012) · Clinical Chemistry · doi:10.1373/clinchem.2012.186866 · Cited by 100
Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors
Pasricha, S., McQuilten, Z., Westerman, M., Keller, A. J., Nemeth, E., Ganz, T., & Wood, E. M. (2011) · Haematologica · doi:10.3324/haematol.2010.037960 · Cited by 99
Self-citationAdaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers
Goetze, O., Schmitt, J., Spliethoff, K., Theurl, I., Weiß, G., Swinkels, D. W., Tjalsma, H., Maggiorini, M., Krayenbühl, P. A., Rau, M., et al. (2013) · Hepatology · doi:10.1002/hep.26581 · Cited by 97
Self-citationTraglia, M., Girelli, D., Biino, G., Campostrini, N., Corbella, M., Sala, C., Masciullo, C., Viganò, F., Buetti, I., Pistis, G., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2011-100061 · Cited by 97
Self-citationvan Dijk, B. A. C., Laarakkers, C. M., Klaver, S. M., Jacobs, E. M. G., van Tits, L. J. H., Janssen, M. C. H., & Swinkels, D. W. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07273.x · Cited by 92
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Self-citationDonker, A. E., Raymakers, R. A. P., Vlasveld, L. T., van Barneveld, T., Terink, R., Dors, N., Brons, P., Knoers, N. V. A. M., & Swinkels, D. W. (2014) · Blood · doi:10.1182/blood-2014-01-548776 · Cited by 88
Self-citationLaarakkers, C. M., Wiegerinck, E. T. G., Klaver, S. M., Kolodziejczyk, M., Gille, H., Hohlbaum, A. M., Tjalsma, H., & Swinkels, D. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075518 · Cited by 84
Self-citationvan der Vorm, L. N., Hendriks, J. C. M., Laarakkers, C. M., Klaver, S. M., Armitage, A. E., Bamberg, A., Geurts-Moespot, A. J., Girelli, D., Herkert, M., Itkonen, O., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.256768 · Cited by 83
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Self-citationRoe, M. A., Collings, R., Dainty, J. R., Swinkels, D. W., & Fairweather‐Tait, S. J. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27297 · Cited by 77
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Sham, R. L., Phatak, P. D., Nemeth, E., & Ganz, T. (2009) · Blood · doi:10.1182/blood-2009-04-216226 · Cited by 74
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Kaneko, Y., Miyajima, H., Piperno, A., Tomosugi, N., Hayashi, H., Morotomi, N., Tsuchida, K., Ikeda, T., Ishikawa, A., Ota, Y., et al. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-010-0259-8 · Cited by 56
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Shu, T., Jing, C., Lv, Z., Xie, Y., Xu, J., & Wu, J. (2014) · European Journal Of Haematology · doi:10.1111/ejh.12402 · Cited by 44
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Bailey, L. B., Stover, P. J., McNulty, H., Fenech, M. F., Gregory, J. F., Mills, J. L., Pfeiffer, C. M., Fazili, Z., Zhang, M., Ueland, P. M., et al. (2015) · Journal of Nutrition · doi:10.3945/jn.114.206599 · Cited by 1,170
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Self-citationIron metabolism and iron disorders revisited in the hepcidin era
Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734
“Hepcidin expression is inhibited by iron deficiency, expansion of erythropoiesis, anemia/hypoxia, testosterone and possibly other factors.(1,47) The most powerful inhibitor is the liver transmembrane serine protease matriptase 2, encoded by TMPRSS6,(48) which cleaves the BMP co-receptor hemojuvelin,(49) thereby attenu…”
Camaschella, C. (2019) · Blood · doi:10.1182/blood-2018-05-815944 · Cited by 702
Metadata
- Authors
- Girelli, D., Nemeth, E., & Swinkels, D. W.
- Affiliations
- University of Verona (IT)
- University of California, Los Angeles (US)
- Radboud University Medical Center (NL)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2016-06-09
- Volume
- 127
- Issue
- 23
- Pages
- 2809-2813
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC4956612
- OpenAlex
- W2343895948
- Cited by
- 417
- References
- 80
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 36 · 2023: 30 · 2022: 42 · 2021: 61 · 2020: 53 · 2019: 49 · 2018: 52 · 2017: 33 · 2016: 9
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK107309)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- hepcidin, iron metabolism disorders, iron deficiency anemia, iron-refractory iron deficiency anemia, iron regulation, diagnostic biomarkers, assay harmonization, iron supplementation, infection, global health
- MeSH terms
- Animals, Blood Chemical Analysis, Hematologic Tests, Humans, Biomarkers, Iron Metabolism Disorders, Diagnostic Techniques and Procedures, Hepcidins
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