Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2
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Key Points: VWF synthesis in liver endothelial cells is regulated by gut microbiota through TLR2 signaling. Reduced plasma VWF levels in GF and Tlr2−/− mice cause reduced thrombus formation at the ligation-injured carotid artery.
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The absence of microbiota was associated with reduced hepatic von Willebrand factor synthesis and reduced thrombus growth after carotid artery injury in C57BL/6 germfree mice as compared to conventionally raised littermates.
“A recent study reported that the absence of microbiota was associated with reduced hepatic von Willebrand factor (VWF) synthesis and reduced thrombus growth after carotid artery injury in C57BL/6 germfree mice as compared to conventionally raised littler mates127.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [127]
Absence of microbiota alters cardiovascular homeostasis, including blood pressure regulation, myocardial repair following post-infarction cardiac repair, and thrombosis growth.
“This is indirectly supported by the fact that absence of microbiota alters cardiovascular homeostasis, such as blood pressure regulation150, myocardial repair following post-infarction cardiac repair66, or thrombosis growth127 – functions that all involve ADRs.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [127]
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- Authors
- Jäckel, S., Kiouptsi, K., Lillich, M., Hendrikx, T., Khandagale, A., Kollar, B., Hörmann, N., Reiss, C., Subramaniam, S., Wilms, E., Ebner, K., Brühl, M.-L. V., Rausch, P., Baines, J. F., Haberichter, S., Lämmle, B., Binder, C. J., Jurk, K., Ruggeri, Z. M., Massberg, S., Walter, U., Ruf, W., & Reinhardt, C.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Austrian Academy of Sciences (AT)
- Ludwig-Maximilians-Universität München (DE)
- Max Planck Institute for Evolutionary Biology (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Medical College of Wisconsin (US)
- Department of Molecular Medicine and
- Scripps Research Institute (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-07-27
- Volume
- 130
- Issue
- 4
- Pages
- 542-553
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2621353746
- Cited by
- 156
- References
- 65
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 18 · 2023: 19 · 2022: 17 · 2021: 19 · 2020: 18 · 2019: 23 · 2018: 13 · 2017: 2
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Alexander von Humboldt-Stiftung
- Deutsche Forschungsgemeinschaft (RE 3450/3‐1, 01EO1003, BMBF 01EO1503)
- Bundesministerium für Bildung und Forschung (BMBF 01EO1503, BMBF 01EO1003, 01EO1503, BMBF 01EO1003 and BMBF 01EO1503, 01EO1003)
- Austrian Science Fund (SFB‐F54)
- Else Kröner-Fresenius-Stiftung (2014-A151)
- Boehringer Ingelheim Stiftung
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- gut microbiota, von Willebrand factor, TLR2, hepatic endothelium, arterial thrombus formation, platelet integrin, platelet adhesion, liver, TLR2 signaling
- MeSH terms
- Gastrointestinal Microbiome, Animals, Blood Platelets, Germ-Free Life, Liver, Platelet Aggregation, Thrombosis, von Willebrand Factor, Signal Transduction, Mice, Knockout, Toll-Like Receptor 2, Mice
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