Cited by 51Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

C‐type lectin‐like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease

Wang, Xin, Liu, Guo‐Jun, Gao, Qiang, Li, Na, Wang, Rui‐tao·2020·Acta Neurologica Scandinavica

Abstract

OBJECTIVE: Increased permeability and changes in gut microbiota contributed to the pathogenesis of Alzheimer's disease (AD). Zonulin is a key modulator that regulates intestinal barrier function. Peripheral platelet alterations have been involved in AD pathology. C-type lectin-like receptor 2 (CLEC-2) is a receptor on the platelet surface for activation. The purpose of this study was to determine zonulin and CLEC-2 levels in mild cognitive impairment (MCI) and AD, and investigate the relationship between zonulin and CLEC-2. METHODS: In this study, CLEC-2 and zonulin levels were measured using ELISA assay in 110 AD patients, 110 MCI patients, and 110 non-demented control subjects. RESULTS: Increased CLEC-2 and zonulin levels were observed in MCI and AD patients. Furthermore, AD patients had higher CLEC-2 and zonulin levels compared with MCI patients. In addition, CLEC-2 levels were positively correlated with zonulin levels, after adjusting confounding factors (r = .592, P < .001). Multivariate analysis revealed that increased CLEC-2 and zonulin levels were significantly associated with reduced Mini-Mental State Examination (MMSE) score. CONCLUSIONS: C-type lectin-like receptor 2 is correlated with zonulin after adjusting confounding covariates. Moreover, increased CLEC-2 and zonulin are the significant factors for reduced MMSE score in MCI and AD. Further studies are needed.

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Crossref · 10.1111/ane.13196

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Authors
Wang, X., Liu, G., Gao, Q., Li, N., & Wang, R.
Affiliations
  • Harbin Medical University (CN)
  • Department of Rehabilitation Medicine General Hospital of Heilongjiang General Administration of Agriculture and Reclamation Harbin Heilongjiang China
  • Department of Internal Medicine Harbin Medical University Cancer Hospital Harbin Medical University Harbin Heilongjiang China
Venue
Acta Neurologica Scandinavica
Publisher
Wiley
Published
2019-11-25
Volume
141
Issue
3
Pages
250-255
ISSN
  • 0001-6314 (ISSN-L)
  • 1600-0404
OpenAlex
W2982993456
Cited by
51
References
35
Citations by year
2026: 3 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 8 · 2020: 4
FWCI
4.18
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Neurologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
CLEC-2, zonulin, Alzheimer's disease, mild cognitive impairment, platelets, intestinal permeability, gut microbiota, intestinal barrier function, cognitive impairment, biomarkers
MeSH terms
Aged, Alzheimer Disease, Female, Haptoglobins, Humans, Male, Middle Aged, Protein Precursors, Biomarkers, Lectins, C-Type, Cognitive Dysfunction

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