Cited by 277Iron Metabolism and DisordersErythropoietin and Anemia TreatmentHemoglobinopathies and Related Disorders

Erythroferrone inhibits the induction of hepcidin by BMP6

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Arezes, João, Foy, Niall, McHugh, Kirsty, Sawant, Anagha, Quinkert, Doris, Terraube, Virginie, Brinth, Alette, Tam, May +9 more·2018·Blood

Abstract

Key Points: ERFE suppresses BMP/SMAD signaling in vitro and in vivo. ERFE inhibits hepcidin induction by BMP5, BMP6, and BMP7.

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Crossref · 10.1182/blood-2018-06-857995

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Authors
Arezes, J., Foy, N., McHugh, K., Sawant, A., Quinkert, D., Terraube, V., Brinth, A., Tam, M., LaVallie, E. R., Taylor, S., Armitage, A. E., Pasricha, S.-R., Cunningham, O., Lambert, M., Draper, S. J., Jasuja, R., & Drakesmith, H.
Affiliations
  • John Radcliffe Hospital (GB)
  • Pfizer (Ireland) (IE)
  • University of Oxford (GB)
  • Pfizer (United States) (US)
  • The University of Melbourne (AU)
Corresponding author
  • Foy, Niall
  • McHugh, Kirsty
  • Draper, Simon J.
  • Jasuja, Reema
  • Drakesmith, Hal
Venue
Blood
Published
2018-10-04
Volume
132
Issue
14
Pages
1473-1477
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2887425495
Cited by
277
References
21
Citations by year
2026: 24 · 2025: 21 · 2024: 23 · 2023: 42 · 2022: 35 · 2021: 45 · 2020: 49 · 2019: 34 · 2018: 4
FWCI
23.67
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust (106917/Z/15/Z)
  • Medical Research Council (MC_UU_00008/10)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords
erythroferrone, hepcidin, BMP6, BMP5, BMP-7, BMP/Smad signaling, erythropoietin, iron homeostasis, erythropoiesis, beta-thalassemia, Smad phosphorylation, ligand trap
MeSH terms
Animals, Cell Line, Humans, Iron, Liver, Male, Muscle Proteins, Signal Transduction, Cytokines, Mice, Smad Proteins, Bone Morphogenetic Protein 6, Hep G2 Cells, Hepcidins

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