Erythroferrone inhibits the induction of hepcidin by BMP6
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Key Points: ERFE suppresses BMP/SMAD signaling in vitro and in vivo. ERFE inhibits hepcidin induction by BMP5, BMP6, and BMP7.
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ERFE sequesters BMP receptor ligands, especially BMP6, inhibiting BMP-SMAD signaling and hepcidin.
“ERFE sequesters BMP receptor ligands, especially BMP6,72 inhibiting BMP-SMAD signaling and hepcidin.”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [72]
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Sardo, U., Perrier, P., Cormier, K., Sotin, M., Personnaz, J., Medjbeur, T., Desquesnes, A., Cannizzo, L., Ruíz-Martínez, M., Thevenin, J., et al. (2024) · Blood · doi:10.1182/blood.2023022724 · Cited by 34 · see citing works
C-FGF23 peptide alleviates hypoferremia during acute inflammation
Agoro, R., Park, M. Y., Hénaff, C. L., Jankauskas, S. S., Gaias, A., Chen, G., Mohammadi, M., & Sitara, D. (2020) · Haematologica · doi:10.3324/haematol.2019.237040 · Cited by 33 · see citing works
de Souza, L. V., Hoffmann, A., Fischer, C., Petzer, V., Aßhoff, M., Theurl, I., Tymoszuk, P., Seifert, M., Brigo, N., Hilbe, R., et al. (2022) · Haematologica · doi:10.3324/haematol.2022.281149 · Cited by 33 · see citing works
Wang, C., Canali, S., Bayer, A. L., Dev, S., Agarwal, A., & Babitt, J. L. (2018) · American Journal of Hematology · doi:10.1002/ajh.25366 · Cited by 32 · see citing works
Anemia de las enfermedades crónicas: fisiopatología, diagnóstico y tratamiento
Allende, R. D. L. C., de Entresotos, L. D., & Díez, S. C. (2020) · Medicina Clínica · doi:10.1016/j.medcli.2020.07.035 · Cited by 34 · see citing works
Targeting iron-metabolism:a potential therapeutic strategy for pulmonary fibrosis
Sun, Y., Ren, Y., Song, L., Wang, Y.-Y., Li, T., Wu, Y., Li, L., & Yang, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116270 · Cited by 31 · see citing works
Impact of bacterial infections on erythropoiesis
de Souza, L. V., Hoffmann, A., & Weiß, G. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2021.1841636 · Cited by 30 · see citing works
The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry
Castro-Mollo, M. W., Gera, S., Ruíz-Martínez, M., Feola, M., Gumerova, A. A., Planoutene, M., Clementelli, C., Sangkhae, V., Casu, C., Kim, S., et al. (2021) · eLife · doi:10.7554/elife.68217 · Cited by 30 · see citing works
Liu, D., Liu, J., Li, Y., Liu, H., Hassan, H. M., He, W., Li, M., Zhou, Y., Fu, X., Zhan, J., et al. (2021) · The Prostate · doi:10.1002/pros.24241 · Cited by 30 · see citing works
Deciphering the role of hepcidin in iron metabolism and anemia management
Kesharwani, P., Dash, D., & Koiri, R. K. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127591 · Cited by 33 · see citing works
Iron and Chronic Kidney Disease: Still a Challenge
Wojtaszek, E., Głogowski, T., & Małyszko, J. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.565135 · Cited by 29 · see citing works
The mutual crosstalk between iron and erythropoiesis
Camaschella, C., Pagani, A., Silvestri, L., & Nai, A. (2022) · International Journal of Hematology · doi:10.1007/s12185-022-03384-y · Cited by 33 · see citing works
Ferreira, J. P., Anker, S. D., Butler, J., Filippatos, G., Januzzi, J. L., Schueler, E., Panova‐Noeva, M., Wetzel, K., Prochaska, J. H., Pocock, S., et al. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.03.503 · Cited by 30 · see citing works
20 years of Hepcidin: How far we have come
Colucci, S., Marques, O., & Altamura, S. (2021) · Seminars in Hematology · doi:10.1053/j.seminhematol.2021.05.001 · Cited by 28 · see citing works
Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms
Ruan, B., & Paulson, R. F. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1063294 · Cited by 29 · see citing works
The Role of Iron in Benign and Malignant Hematopoiesis
Sinha, S., Pereira-Reis, J., Guerra, A., Rivella, S., & Duarte, D. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8155 · Cited by 29 · see citing works
Hypobaric hypoxia regulates iron metabolism in rats
Li, Y., Zhou, Y., Zhang, D., Wu, W., Kang, X., Wu, Q., Wang, P., Liu, X., Gao, G., Zhou, Y., et al. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28683 · Cited by 25 · see citing works
Iron Deficiency and Anemia Associated with Infectious and Inflammatory Diseases
Hoffmann, A., de Souza, L. V., & Weiß, G. (2022) · Nutrition and health · doi:10.1007/978-3-031-14521-6_17 · Cited by 27 · see citing works
Kurata, Y., Tanaka, T., & Nangaku, M. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000617 · Cited by 26 · see citing works
BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice
Xiao, X., Xu, Y., Moschetta, G. A., Yu, Y., Fisher, A. L., Alfaro-Magallanes, V. M., McMillen, S. A., Phillips, S., Wang, C., Christian, J. L., et al. (2023) · Blood · doi:10.1182/blood.2022019195 · Cited by 25 · see citing works
Andolfo, I., Rosato, B. E., Marra, R., Rosa, G. D., Manna, F., Gambale, A., Iolascon, A., & Russo, R. (2019) · American Journal of Hematology · doi:10.1002/ajh.25613 · Cited by 25 · see citing works
Mechanism and regulation of iron absorption throughout the life cycle
Qiu, L., Frazer, D. M., Hu, M., Song, R., Liu, X., Qin, X., Ma, J., Zhou, J., Tan, Z., Ren, F., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.002 · Cited by 29 · see citing works
Andersen, A. B., Bonne, T. C., Bejder, J., Jung, G., Ganz, T., Nemeth, E., Olsen, N. V., Huertas, J. R., & Nordsborg, N. B. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00070.2021 · Cited by 24 · see citing works
Maternal iron kinetics and maternal–fetal iron transfer in normal-weight and overweight pregnancy
Stoffel, N. U., Zimmermann, M. B., Cepeda-Lopez, A. C., Cervantes-Gracia, K., Llanas-Cornejo, D., Zeder, C., Tuntipopipat, S., Moungmaithong, S., Densupsoontorn, N., Lötscher, K. Q., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab406 · Cited by 24 · see citing works
Iron Mining for Erythropoiesis
Correnti, M., Gammella, E., Cairo, G., & Recalcati, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105341 · Cited by 27 · see citing works
- Authors
- Arezes, J., Foy, N., McHugh, K., Sawant, A., Quinkert, D., Terraube, V., Brinth, A., Tam, M., LaVallie, E. R., Taylor, S., Armitage, A. E., Pasricha, S.-R., Cunningham, O., Lambert, M., Draper, S. J., Jasuja, R., & Drakesmith, H.
- Affiliations
- John Radcliffe Hospital (GB)
- Pfizer (Ireland) (IE)
- University of Oxford (GB)
- Pfizer (United States) (US)
- The University of Melbourne (AU)
- Corresponding author
- Foy, Niall
- McHugh, Kirsty
- Draper, Simon J.
- Jasuja, Reema
- Drakesmith, Hal
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-10-04
- Volume
- 132
- Issue
- 14
- Pages
- 1473-1477
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6238155
- OpenAlex
- W2887425495
- Cited by
- 277
- References
- 21
- Citations by year
- 2026: 24 · 2025: 21 · 2024: 23 · 2023: 42 · 2022: 35 · 2021: 45 · 2020: 49 · 2019: 34 · 2018: 4
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (106917/Z/15/Z)
- Medical Research Council (MC_UU_00008/10)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Keywords
- erythroferrone, hepcidin, BMP6, BMP5, BMP-7, BMP/Smad signaling, erythropoietin, iron homeostasis, erythropoiesis, beta-thalassemia, Smad phosphorylation, ligand trap
- MeSH terms
- Animals, Cell Line, Humans, Iron, Liver, Male, Muscle Proteins, Signal Transduction, Cytokines, Mice, Smad Proteins, Bone Morphogenetic Protein 6, Hep G2 Cells, Hepcidins
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