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Erythroferrone inhibits the induction of hepcidin by BMP6
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Key Points: ERFE suppresses BMP/SMAD signaling in vitro and in vivo. ERFE inhibits hepcidin induction by BMP5, BMP6, and BMP7.
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“ERFE sequesters BMP receptor ligands, especially BMP6,72 inhibiting BMP-SMAD signaling and hepcidin.”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [72]
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Metadata
- Authors
- Arezes, J., Foy, N., McHugh, K., Sawant, A., Quinkert, D., Terraube, V., Brinth, A., Tam, M., LaVallie, E. R., Taylor, S., Armitage, A. E., Pasricha, S.-R., Cunningham, O., Lambert, M., Draper, S. J., Jasuja, R., & Drakesmith, H.
- Affiliations
- John Radcliffe Hospital (GB)
- Pfizer (Ireland) (IE)
- University of Oxford (GB)
- Pfizer (United States) (US)
- The University of Melbourne (AU)
- Corresponding author
- Foy, Niall
- McHugh, Kirsty
- Draper, Simon J.
- Jasuja, Reema
- Drakesmith, Hal
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-10-04
- Volume
- 132
- Issue
- 14
- Pages
- 1473-1477
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6238155
- OpenAlex
- W2887425495
- Cited by
- 277
- References
- 21
- Citations by year
- 2026: 24 · 2025: 21 · 2024: 23 · 2023: 42 · 2022: 35 · 2021: 45 · 2020: 49 · 2019: 34 · 2018: 4
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (106917/Z/15/Z)
- Medical Research Council (MC_UU_00008/10)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Keywords
- erythroferrone, hepcidin, BMP6, BMP5, BMP-7, BMP/Smad signaling, erythropoietin, iron homeostasis, erythropoiesis, beta-thalassemia, Smad phosphorylation, ligand trap
- MeSH terms
- Animals, Cell Line, Humans, Iron, Liver, Male, Muscle Proteins, Signal Transduction, Cytokines, Mice, Smad Proteins, Bone Morphogenetic Protein 6, Hep G2 Cells, Hepcidins
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