The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Erythroferrone inhibits the induction of hepcidin by BMP6
Open accessAbstract
Key Points: ERFE suppresses BMP/SMAD signaling in vitro and in vivo. ERFE inhibits hepcidin induction by BMP5, BMP6, and BMP7.
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“ERFE sequesters BMP receptor ligands, especially BMP6,72 inhibiting BMP-SMAD signaling and hepcidin.”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [72]
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Cites
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
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Identification of erythroferrone as an erythroid regulator of iron metabolism
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Hepcidin and iron regulation, 10 years later
Ganz, T. (2011) · Blood · doi:10.1182/blood-2011-01-258467 · Cited by 962
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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
Andriopoulos Jr, B., Corradini, E., Xia, Y., Faasse, S. A., Chen, S., Grgurevic, L., Knutson, M. D., Pietrangelo, A., Vukicevic, S., Lin, H. Y., et al. (2009) · Nature Genetics · doi:10.1038/ng.335 · Cited by 769
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., & Roth, M.-P. (2009) · Nature Genetics · doi:10.1038/ng.320 · Cited by 587
Suppression of hepcidin during anemia requires erythropoietic activity
Pak, M., Lopez, M. A., Gabayan, V., Ganz, T., & Rivera, S. (2006) · Blood · doi:10.1182/blood-2006-06-028787 · Cited by 472
Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
Cuny, G. D., Yu, P. B., Laha, J. K., Xing, X., Liu, J.-F., Lai, C. S. C., Deng, D. Y., Sachidanandan, C., Bloch, K. D., & Peterson, R. T. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.06.052 · Cited by 351
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Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
Vokurka, M., Krijt, J., Šulc, K., & Nečas, E. (2006) · Physiological Research · doi:10.33549/physiolres.930841 · Cited by 263
Structural insights into BMP receptors: Specificity, activation and inhibition
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Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6
Canali, S., Wang, C., Zumbrennen‐Bullough, K. B., Bayer, A., & Babitt, J. L. (2017) · American Journal of Hematology · doi:10.1002/ajh.24888 · Cited by 133
Immunoassay for human serum erythroferrone
Ganz, T., Jung, G., Naeim, A., Ginzburg, Y., Pakbaz, Z., Walter, P. B., Kautz, L., & Nemeth, E. (2017) · Blood · doi:10.1182/blood-2017-04-777987 · Cited by 125
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Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice
Wang, C., Core, A. B., Canali, S., Zumbrennen‐Bullough, K. B., Özer, S., Umans, L., Zwijsen, A., & Babitt, J. L. (2017) · Blood · doi:10.1182/blood-2016-12-759423 · Cited by 92
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
Pasricha, S., Lim, P. J., Duarte, T. L., Casu, C., Oosterhuis, D., Mleczko‐Sanecka, K., Suciu, M., da Silva, A. R., Al-Hourani, K., Arezes, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00500-z · Cited by 65
Self-citationErythroferrone and matriptase‐2 independently regulate hepcidin expression
Aschemeyer, S., Gabayan, V. R., Ganz, T., Nemeth, E., & Kautz, L. (2017) · American Journal of Hematology · doi:10.1002/ajh.24672 · Cited by 30
Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia
Armitage, A. E., Lim, P. J., Frost, J. N., Pasricha, S.-R., Soilleux, E. J., Evans, E., Morovat, A., Santos, A., Diaz, R., Biggs, D., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000447713 · Cited by 20
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Mechanisms controlling cellular and systemic iron homeostasis
Galy, B., Conrad, M., & Muckenthaler, M. U. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00648-1 · Cited by 843
Iron metabolism and iron disorders revisited in the hepcidin era
Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734
“(C) Erythropoiesis enhanced by erythropoietin consumes a large amount of iron: low serum iron (and diferric transferrin) suppresses the BMP2-ALK3 pathway,(152) while BMP6 and other BMP are sequestered by erythroferrone (ERFE) released by erythroid cells.(72,154) The result is hepcidin inhibition.”
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Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis
Yu, Y., Jiang, L., Wang, H., Shen, Z., Cheng, Q., Zhang, P., Wang, J., Wu, Q., Fang, X., Duan, L., et al. (2020) · Blood · doi:10.1182/blood.2019002907 · Cited by 610
Metadata
- Authors
- Arezes, J., Foy, N., McHugh, K., Sawant, A., Quinkert, D., Terraube, V., Brinth, A., Tam, M., LaVallie, E. R., Taylor, S., Armitage, A. E., Pasricha, S.-R., Cunningham, O., Lambert, M., Draper, S. J., Jasuja, R., & Drakesmith, H.
- Affiliations
- John Radcliffe Hospital (GB)
- Pfizer (Ireland) (IE)
- University of Oxford (GB)
- Pfizer (United States) (US)
- The University of Melbourne (AU)
- Corresponding author
- Foy, Niall
- McHugh, Kirsty
- Draper, Simon J.
- Jasuja, Reema
- Drakesmith, Hal
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-10-04
- Volume
- 132
- Issue
- 14
- Pages
- 1473-1477
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6238155
- OpenAlex
- W2887425495
- Cited by
- 277
- References
- 21
- Citations by year
- 2026: 24 · 2025: 21 · 2024: 23 · 2023: 42 · 2022: 35 · 2021: 45 · 2020: 49 · 2019: 34 · 2018: 4
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (106917/Z/15/Z)
- Medical Research Council (MC_UU_00008/10)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Keywords
- erythroferrone, hepcidin, BMP6, BMP5, BMP-7, BMP/Smad signaling, erythropoietin, iron homeostasis, erythropoiesis, beta-thalassemia, Smad phosphorylation, ligand trap
- MeSH terms
- Animals, Cell Line, Humans, Iron, Liver, Male, Muscle Proteins, Signal Transduction, Cytokines, Mice, Smad Proteins, Bone Morphogenetic Protein 6, Hep G2 Cells, Hepcidins
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