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Erythroferrone inhibits the induction of hepcidin by BMP6
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Key Points: ERFE suppresses BMP/SMAD signaling in vitro and in vivo. ERFE inhibits hepcidin induction by BMP5, BMP6, and BMP7.
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“ERFE sequesters BMP receptor ligands, especially BMP6,72 inhibiting BMP-SMAD signaling and hepcidin.”
From Iron metabolism and iron disorders revisited in the hepcidin era (2020) · cites this paper as [72]
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Hoffmann, A., de Souza, L. V., & Weiß, G. (2022) · Nutrition and health · doi:10.1007/978-3-031-14521-6_17 · Cited by 29
Kurata, Y., Tanaka, T., & Nangaku, M. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000617 · Cited by 26
BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice
Xiao, X., Xu, Y., Moschetta, G. A., Yu, Y., Fisher, A. L., Alfaro-Magallanes, V. M., McMillen, S. A., Phillips, S., Wang, C., Christian, J. L., et al. (2023) · Blood · doi:10.1182/blood.2022019195 · Cited by 25
Andolfo, I., Rosato, B. E., Marra, R., Rosa, G. D., Manna, F., Gambale, A., Iolascon, A., & Russo, R. (2019) · American Journal of Hematology · doi:10.1002/ajh.25613 · Cited by 25
Mechanism and regulation of iron absorption throughout the life cycle
Qiu, L., Frazer, D. M., Hu, M., Song, R., Liu, X., Qin, X., Ma, J., Zhou, J., Tan, Z., Ren, F., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.002 · Cited by 33
Andersen, A. B., Bonne, T. C., Bejder, J., Jung, G., Ganz, T., Nemeth, E., Olsen, N. V., Huertas, J. R., & Nordsborg, N. B. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00070.2021 · Cited by 24
Maternal iron kinetics and maternal–fetal iron transfer in normal-weight and overweight pregnancy
Stoffel, N. U., Zimmermann, M. B., Cepeda-Lopez, A. C., Cervantes-Gracia, K., Llanas-Cornejo, D., Zeder, C., Tuntipopipat, S., Moungmaithong, S., Densupsoontorn, N., Lötscher, K. Q., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab406 · Cited by 24
Iron Mining for Erythropoiesis
Correnti, M., Gammella, E., Cairo, G., & Recalcati, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105341 · Cited by 30
Metadata
- Authors
- Arezes, J., Foy, N., McHugh, K., Sawant, A., Quinkert, D., Terraube, V., Brinth, A., Tam, M., LaVallie, E. R., Taylor, S., Armitage, A. E., Pasricha, S.-R., Cunningham, O., Lambert, M., Draper, S. J., Jasuja, R., & Drakesmith, H.
- Affiliations
- John Radcliffe Hospital (GB)
- Pfizer (Ireland) (IE)
- University of Oxford (GB)
- Pfizer (United States) (US)
- The University of Melbourne (AU)
- Corresponding author
- Foy, Niall
- McHugh, Kirsty
- Draper, Simon J.
- Jasuja, Reema
- Drakesmith, Hal
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-10-04
- Volume
- 132
- Issue
- 14
- Pages
- 1473-1477
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC6238155
- OpenAlex
- W2887425495
- Cited by
- 277
- References
- 21
- Citations by year
- 2026: 24 · 2025: 21 · 2024: 23 · 2023: 42 · 2022: 35 · 2021: 45 · 2020: 49 · 2019: 34 · 2018: 4
- FWCI
- 23.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (106917/Z/15/Z)
- Medical Research Council (MC_UU_00008/10)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Keywords
- erythroferrone, hepcidin, BMP6, BMP5, BMP-7, BMP/Smad signaling, erythropoietin, iron homeostasis, erythropoiesis, beta-thalassemia, Smad phosphorylation, ligand trap
- MeSH terms
- Animals, Cell Line, Humans, Iron, Liver, Male, Muscle Proteins, Signal Transduction, Cytokines, Mice, Smad Proteins, Bone Morphogenetic Protein 6, Hep G2 Cells, Hepcidins
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