The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Interleukin-6 is a potent thrombopoietic factor in vivo in mice
Open accessAbstract
To determine the biologic activity of interleukin-6 (IL-6) on megakaryocytopoiesis and thrombocytopoiesis in vivo, the cytokine was administered intraperitoneally to mice every 12 hours at varying doses for five days or for varying time intervals, based on the kinetic analysis of IL-6 serum levels indicating the peak of 40 minutes following injection, with no detection at 150 minutes. A dose-response experiment showed that IL-6 increased platelet counts in a dose- dependent fashion at a plateau stimulation level of 5 micrograms. Administration of 5 micrograms of IL-6 reproducibly elevated platelet counts at five days by approximately 50% to 60% of increase. Moreover, a striking increase in megakaryocytic size in response to IL-6 was elicited by the treatment, but no change in megakaryocyte numbers; whereas IL-6 administration did not expand CFU-MK numbers. The in vivo studies in this manner had negligible effects on other hematologic parameters, with the minor exception of monocyte levels. These data show that IL-6 acts on maturational stages in megakaryocytopoiesis and promotes platelet production in vivo in mice, suggesting that IL-6 functions as thrombopoietin.
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Cites
Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139
Self-citationCorrection of the Anemia of End-Stage Renal Disease with Recombinant Human Erythropoietin
Eschbach, J. W., Egrie, J. C., Downing, M. R., Browne, J. K., & Adamson, J. W. (1987) · New England Journal of Medicine · doi:10.1056/nejm198701083160203 · Cited by 2,005
Ikebuchi, K., Wong, G. G., Clark, S. C., Ihle, J. N., Hirai, Y., & Ogawa, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9035 · Cited by 802
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimi, M., Maid, R., Feldmann, M., et al. (1988) · European Journal of Immunology · doi:10.1002/eji.1830181122 · Cited by 784
Self-citationSieff, C. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112988 · Cited by 596
Molecular Regulation of B Lymphocyte Response
Kishimoto, T., & Hirano, T. (1988) · Annual Review of Immunology · doi:10.1146/annurev.iy.06.040188.002413 · Cited by 567
Self-citationGuerne, P. A., Zuraw, B. L., Vaughan, J. H., Carson, D. A., & Lotz, M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113921 · Cited by 513
Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF
Donahue, R. E., Wang, E. A., Stone, D. K., Kamen, R., Wong, G. G., Sehgal, P. K., Nathan, D. G., & Clark, S. C. (1986) · Nature · doi:10.1038/321872a0 · Cited by 392
Matsuda, T., And, T. H., & Kishimoto, T. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180618 · Cited by 304
Self-citationHuman recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro.
Ishibashi, T., Koziol, J. A., & Burstein, S. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112796 · Cited by 185
Self-citation
Cited by
IL‐6 in inflammation, immunity, and disease
Tanaka, T., Narazaki, M., & Kishimoto, T. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016295 · Cited by 5,046
Self-citationIL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453
“…B-cell differentiation with immunoglobulin production (27), osteoclast activation (280, 281), the production of acute-phase proteins (39, 40), the increase of agalactosyl immunoglobulin (282) and megakaryocyte differentiation (281, 283, 284), suggested an intimate relationship between IL-6 and RA.”
BackgroundSelf-citationInterleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
Kaser, A., Brandacher, G., Steurer, W., Kaser, S., Offner, F. A., Zoller, H., Theurl, I., Widder, W., Molnar, C., Ludwiczek, O., et al. (2001) · Blood · doi:10.1182/blood.v98.9.2720 · Cited by 667
Iwaki, N., Fajgenbaum, D. C., Nabel, C. S., Gion, Y., Kondo, E., Kawano, M., Masunari, T., Yoshida, I., Moro, H., Nikkuni, K., et al. (2016) · American Journal of Hematology · doi:10.1002/ajh.24242 · Cited by 296
Dysregulated interleukin 6 expression produces a syndrome resembling Castleman’s disease in mice
Brandt, S. J., Bodine, D. M., Dunbar, C. E., & Nienhuis, A. W. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114749 · Cited by 248
Metadata
- Authors
- Ishibashi, T., Kimura, H., Shikama, Y., Uchida, T., Kariyone, S., Hirano, T., Kishimoto, T., Takatsuki, F., & Akiyama, Y.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1989-09-01
- Volume
- 74
- Issue
- 4
- Pages
- 1241-1244
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2298584763
- Cited by
- 432
- References
- 14
- FWCI
- 21.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ishibashi, T., Kimura, H., Shikama, Y., Uchida, T., Kariyone, S., Hirano, T., Kishimoto, T., Takatsuki, F., & Akiyama, Y. (1989). Interleukin-6 is a potent thrombopoietic factor in vivo in mice. Blood. https://doi.org/10.1182/blood.v74.4.1241.1241
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