The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Targeted disruption of the murine tissue factor gene results in embryonic lethality
Open accessAbstract
Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11.5 of gestation. On E9.5, TF(-/-) embryos appear indistinguishable from their TF(+/+) and TF(+/-) littermates. By E10.5, TF(-/-) embryos are severely growth retarded, appear nearly bloodless, and are in most cases dead. Initial observations suggest that TF(-/-) embryos are dying of circulatory failure. Approximately 15% of the TF(-/-) embryos survive beyond E10.5, but none complete gestation. Heterozygotes appear normal and free of bleeding complications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
The Atlas of Mouse Development
Kaufman, M. H. (1992) · Medical Entomology and Zoology · Cited by 1,750
Implantation and the placenta: key pieces of the development puzzle
Cross, J., Werb, Z., & Fisher, S. (1994) · Science · doi:10.1126/science.7985020 · Cited by 1,352
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H., & Hynes, R. O. (1993) · Development · doi:10.1242/dev.119.4.1079 · Cited by 1,305
An early haematopoietic defect in mice lacking the transcription factor GATA-2
Tsai, F.-Y., Keller, G., Kuo, F. C., Weiss, M., Chen, J., Rosenblatt, M., Alt, F. W., & Orkin, S. H. (1994) · Nature · doi:10.1038/371221a0 · Cited by 1,237
Drake, T. A., Morrissey, J. H., & Edgington, T. S. (1989) · Europe PMC (PubMed Central) · Cited by 1,192
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,179
PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS
Herschman, H. R. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.001433 · Cited by 1,079
Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Fiers, W., Cotran, R. S., & Gimbrone, M. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4533 · Cited by 1,067
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
Cited by
Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development
Mackman, N. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000130465.23430.74 · Cited by 658
Tissue Factor in Cardiovascular Diseases: Molecular Mechanisms and Clinical Implications
Steffel, J., Lüscher, T. F., & Tanner, F. C. (2006) · Circulation · doi:10.1161/circulationaha.105.567297 · Cited by 456
Expression of Tissue Factor in Prostate Cancer Correlates With Malignant Phenotype
Kaushal, V., Mukunyadzi, P., Siegel, E. R., Dennis, R. A., Johnson, D. E., & Kohli, M. (2008) · Applied Immunohistochemistry & Molecular Morphology · doi:10.1097/01.pai.0000213157.94804.fc · Cited by 32
Metadata
- Authors
- Toomey, Jr., Kratzer, K., Lasky, N., Stanton, J., & Broze, G. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1996-09-01
- Volume
- 88
- Issue
- 5
- Pages
- 1583-1587
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W9494736
- Cited by
- 279
- References
- 25
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Targeted disruption of the murine tissue factor gene results in embryonic lethality. https://app.cochat.ai/papers/10.1182/blood.v88.5.1583.1583
- The paper
- Toomey, Jr., Kratzer, K., Lasky, N., Stanton, J., & Broze, G. J. (1996). Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood. https://doi.org/10.1182/blood.v88.5.1583.1583
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
