Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 276

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis

Peters, Malte, Müller, Albrecht M., Rose-John, Stefan·1998·Blood

Abstract

T HE INTERLEUKIN-6 (IL-6) family of cytokines acts via receptor complexes that contain at least one subunit of the signal transducing protein gp130.[1][1] The family comprises IL-6, IL-11, ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), leukemia inhibitory factor (LIF), and oncostatin M

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1182/blood.v92.10.3495

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 82

  1. Taga, 1997, gp130 and the interleukin-6 family of cytokines., Annu Rev Immunol, 15, 797, 10.1146/annurev.immunol.15.1.797 · DOI · Paper page
  2. Mosley, 1996, Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation., J Biol Chem, 271, 32635, 10.1074/jbc.271.51.32635 · DOI · Paper page
  3. Pennica, 1995, Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex., J Biol Chem, 270, 10915, 10.1074/jbc.270.18.10915 · DOI · Paper page
  4. Pennica, 1996, Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons., Neuron, 17, 63, 10.1016/S0896-6273(00)80281-0 · DOI
  5. Morrison, 1995, The biology of hematopoietic stem cells., Annu Rev Cell Dev Biol, 11, 35, 10.1146/annurev.cb.11.110195.000343 · DOI · Paper page
  6. Ogawa, 1993, Differentiation and proliferation of heamtopoietic stem cells., Blood, 81, 2844, 10.1182/blood.V81.11.2844.2844 · DOI · Paper page
  7. Ikebuchi, 1987, Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hematopoietic progenitors., Proc Natl Acad Sci USA, 84, 9035, 10.1073/pnas.84.24.9035 · DOI · Paper page
  8. Heaney, 1996, Soluble cytokine receptors., Blood, 87, 847, 10.1182/blood.V87.3.847.bloodjournal873847 · DOI · Paper page
  9. Rose-John, 1994, Soluble receptors for cytokines and growth factors: Generation and biological function., Biochem J, 300, 281, 10.1042/bj3000281 · DOI · Paper page
  10. Hooper, 1997, Membrane protein secretases., Biochem J, 321, 265, 10.1042/bj3210265 · DOI · Paper page
  11. Kishimoto, 1995, Interleukin-6 family of cytokines and gp130., Blood, 86, 1243, 10.1182/blood.V86.4.1243.bloodjournal8641243 · DOI · Paper page
  12. Müllberg, 1992, Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor., Biochem Biophys Res Commun, 189, 794, 10.1016/0006-291X(92)92272-Y · DOI
  13. Müllberg, 1993, Differential shedding of the two subunits of the interleukin-6 receptor., FEBS Lett, 332, 174, 10.1016/0014-5793(93)80507-Q · DOI
  14. Müllberg, 1993, The soluble interleukin-6 receptor is generated by shedding., Eur J Immunol, 23, 473, 10.1002/eji.1830230226 · DOI · Paper page
  15. Müllberg, 1994, The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site., J Immunol, 152, 4958, 10.4049/jimmunol.152.10.4958 · DOI · Paper page
  16. Müllberg, 1995, A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor., J Immunol, 155, 5198, 10.4049/jimmunol.155.11.5198 · DOI
  17. McGeehan, 1994, Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor., Nature, 370, 558, 10.1038/370558a0 · DOI · Paper page
  18. Mohler, 1994, Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing., Nature, 370, 218, 10.1038/370218a0 · DOI · Paper page
  19. Moss, 1997, Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha., Nature, 385, 733, 10.1038/385733a0 · DOI · Paper page
  20. Wolfsberg, 1996, ADAMs in fertilization and development., Dev Biol, 180, 389, 10.1006/dbio.1996.0313 · DOI · Paper page
  21. Lust, 1995, Sequence, expression and function of an mRNA encoding a soluble form of the human interleukin-6 receptor (sIL-6R)., Curr Top Microbiol Immunol, 194, 199
  22. Lust, 1992, Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor., Cytokine, 4, 96, 10.1016/1043-4666(92)90043-Q · DOI · Paper page
  23. Honda, 1992, Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection., J Immunol, 148, 2175, 10.4049/jimmunol.148.7.2175 · DOI · Paper page
  24. Frieling, 1995, Circulating interleukin-6 receptor in patients with sepsis syndrome., J Infect Dis, 171, 469, 10.1093/infdis/171.2.469 · DOI
  25. Lavabre Bertrand, 1995, Detection of membrane and soluble interleukin-6 receptor in lymphoid malignancies., Br J Haematol, 91, 871, 10.1111/j.1365-2141.1995.tb05403.x · DOI
  26. Walev, 1996, Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide., Proc Natl Acad Sci USA, 93, 7882, 10.1073/pnas.93.15.7882 · DOI
  27. Vollmer, 1996, Novel pathogenic mechanism of microbial metalloproteinases: Liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor., Infect Immun, 64, 3646, 10.1128/IAI.64.9.3646-3651.1996 · DOI
  28. Taga, 1990, Immune and hematopoietic cell regulation: Cytokines and their receptors., Curr Opin Cell Biol, 2, 174, 10.1016/0955-0674(90)90003-W · DOI
  29. Mackiewicz, 1992, Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins., J Immunol, 149, 2021, 10.4049/jimmunol.149.6.2021 · DOI · Paper page
  30. Davis, 1993, Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses., Science, 259, 1736, 10.1126/science.7681218 · DOI · Paper page
  31. Baumann, 1996, Complex of the soluble IL-11 receptor and IL-11 acts as IL-6-type cytokine in hepatic and nonhepatic cells., J Immunol, 157, 284, 10.4049/jimmunol.157.1.284 · DOI
  32. Narazaki, 1993, Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130., Blood, 82, 1120, 10.1182/blood.V82.4.1120.1120 · DOI · Paper page
  33. Layton, 1992, A major binding protein for leukemia inhibitory factor in normal mouse serum: Identification as a soluble form of the cellular receptor., Proc Natl Acad Sci USA, 89, 8616, 10.1073/pnas.89.18.8616 · DOI
  34. Taga, 1989, Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130., Cell, 58, 573, 10.1016/0092-8674(89)90438-8 · DOI · Paper page
  35. Mackiewicz, 1995, Soluble interleukin 6 receptor is biologically active in vivo., Cytokine, 7, 142, 10.1006/cyto.1995.1019 · DOI
  36. Peters, 1996, The function of the soluble interleukin 6 (IL-6) receptor in vivo: Sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6., J Exp Med, 183, 1399, 10.1084/jem.183.4.1399 · DOI · Paper page
  37. van Snick, 1990, Interleukin-6: An overview., Annu Rev Immunol, 8, 253, 10.1146/annurev.iy.08.040190.001345 · DOI · Paper page
  38. Gaillard, 1997, Major role of the soluble interleukin-6/interleukin-6 receptor complex for the proliferation of interleukin-6-dependent human myeloma cell lines., Eur J Immunol, 27, 3332, 10.1002/eji.1830271232 · DOI
  39. Peters, 1997, Extramedullary expansion of hematopoietic progenitor cells in IL-6/sIL-6R double transgenic mice., J Exp Med, 185, 755, 10.1084/jem.185.4.755 · DOI
  40. Peters, 1997, Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice., J Immunol, 159, 1474, 10.4049/jimmunol.159.3.1474 · DOI
  41. Schirmacher, 1998, Hepatocellular hyperplasia, plasmacytoma formation, and extracellular hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice., Am J Pathol, 153, 639, 10.1016/S0002-9440(10)65605-2 · DOI
  42. Okada, 1992, In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells., Blood, 80, 3044, 10.1182/blood.V80.12.3044.3044 · DOI · Paper page
  43. Osawa, 1996, In vivo self-renewal of c-Kit+ Sca-1+ Lin(low/−) hemopoietic stem cells., J Immunol, 156, 3207, 10.4049/jimmunol.156.9.3207 · DOI
  44. Dzierzak, 1995, Mouse embryonic hematopoiesis., Trends Genet, 11, 359, 10.1016/S0168-9525(00)89107-6 · DOI
  45. Bonifer, 1998, Developmental changes in the differentiation capacity of haematopoietic stem cells., Immunol Today, 19, 236, 10.1016/S0167-5699(98)01259-6 · DOI
  46. Lansdorp, 1993, Ontogeny-related changes in proliferative potential of human hematopoietic cells., J Exp Med, 178, 787, 10.1084/jem.178.3.787 · DOI · Paper page
  47. Vormoor, 1994, Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice., Blood, 83, 2489, 10.1182/blood.V83.9.2489.bloodjournal8392489 · DOI
  48. Petzer, 1996, Differential cytokine effects on primitive (CD34+CD38−) human hematopoietic cells: Novel responses to Flt3-ligand and thrombopoietin., J Exp Med, 183, 2551, 10.1084/jem.183.6.2551 · DOI · Paper page
  49. Mukouyama, 1998, In vitro expansion of murine multipotential hematopoietic progenitors from the embryonic aorta-gonad-mesonephros region., Immunity, 8, 105, 10.1016/S1074-7613(00)80463-X · DOI
  50. Tajima, 1996, Analysis of interleukin-6 receptor and gp130 expressions and proliferative capability of human CD34+ cells., J Exp Med, 184, 1357, 10.1084/jem.184.4.1357 · DOI
  51. McKinstry, 1997, Cytokine receptor expression on hematopoietic stem and progenitor cells., Blood, 89, 65, 10.1182/blood.V89.1.65 · DOI
  52. Sui, 1995, gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells., Proc Natl Acad Sci USA, 92, 2859, 10.1073/pnas.92.7.2859 · DOI
  53. Kimura, 1997, Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors., Blood, 90, 4767
  54. Fischer, 1997, A designer cytokine with high activity on human hematopoietic progenitor cells., Nat Biotech, 15, 142, 10.1038/nbt0297-142 · DOI · Paper page
  55. Yamasaki, 1988, Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor., Science, 241, 825, 10.1126/science.3136546 · DOI · Paper page
  56. Rose-John, 1990, Studies on the structure and regulation of the human hepatic interleukin-6 receptor., Eur J Biochem, 190, 79, 10.1111/j.1432-1033.1990.tb15548.x · DOI
  57. Wells, 1996, Binding in the growth hormone receptor complex., Proc Natl Acad Sci USA, 93, 1, 10.1073/pnas.93.1.1 · DOI · Paper page
  58. Toniatti, 1996, Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity., EMBO J, 15, 2726, 10.1002/j.1460-2075.1996.tb00633.x · DOI
  59. Grötzinger, 1997, The family of the IL-6-type cytokines: Specificity and promiscuity of the receptor complexes., Proteins: Structure, Function, and Genetics, 27, 96, 10.1002/(SICI)1097-0134(199701)27:1<96::AID-PROT10>3.0.CO;2-D · DOI
  60. Chebath, 1997, Interleukin-6 receptor-interleukin-6 fusion proteins with enhanced interleukin-6 type pleiotropic activities., Eur Cytokine Netw, 8, 359
  61. Conneally, 1997, Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in NOD/SCID mice., Proc Natl Acad Sci USA, 94, 9836, 10.1073/pnas.94.18.9836 · DOI · Paper page
  62. Spangrude, 1988, Purification and characterization of mouse hematopoietic stem cells., Science, 241, 58, 10.1126/science.2898810 · DOI
  63. Jordan, 1990, Cellular and developmental properties of fetal hematopoietic stem cells., Cell, 61, 953, 10.1016/0092-8674(90)90061-I · DOI · Paper page
  64. Yoshida, 1996, Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders., Proc Natl Acad Sci USA, 93, 407, 10.1073/pnas.93.1.407 · DOI · Paper page
  65. Ware, 1995, Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death., Development, 121, 1283, 10.1242/dev.121.5.1283 · DOI · Paper page
  66. Ishihara, 1997, Oncostatin- M and leukemia inhibitory factor do not use the same functional receptor in mice., Blood, 90, 165, 10.1182/blood.V90.1.165 · DOI
  67. Malik, 1995, Developmental abnormalities in mice transgenic for oncostatin M., Mol Cell Biol, 15, 2349, 10.1128/MCB.15.5.2349 · DOI
  68. Clegg, 1996, Regulation of an extrathymic T-cell development pathway by oncostatin M., Nature, 384, 261, 10.1038/384261a0 · DOI
  69. Hawley, 1996, Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11., Proc Natl Acad Sci USA, 93, 10297, 10.1073/pnas.93.19.10297 · DOI
  70. Nandurkar, 1997, Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis., Blood, 90, 2148, 10.1182/blood.V90.6.2148 · DOI
  71. Bernad, 1994, Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system., Immunity, 1, 725, 10.1016/S1074-7613(94)80014-6 · DOI
  72. Hibi, 1990, Molecular cloning and expression of an IL-6 signal transducer, gp130., Cell, 63, 1149, 10.1016/0092-8674(90)90411-7 · DOI · Paper page
  73. Romano, 1997, Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment., Immunity, 6, 315, 10.1016/S1074-7613(00)80334-9 · DOI · Paper page
  74. März, 1997, Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation., Eur J Neurosci, 9, 2765, 10.1111/j.1460-9568.1997.tb01705.x · DOI
  75. März, 1998, Sympathetic neurons can produce and respond to interleukin-6., Proc Natl Acad Sci USA, 95, 3251, 10.1073/pnas.95.6.3251 · DOI · Paper page
  76. Udagawa, 1995, Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors., J Exp Med, 182, 1461, 10.1084/jem.182.5.1461 · DOI · Paper page
  77. Yasuda, 1998, Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL., Proc Natl Acad Sci USA, 95, 3597, 10.1073/pnas.95.7.3597 · DOI · Paper page
  78. Curtis, 1997, Recombinant soluble interleukin-11 (IL-11) receptor alpha-chain can act as an IL-11 antagonist., Blood, 90, 4403, 10.1182/blood.V90.11.4403 · DOI
  79. Wang, 1998, gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6., Blood, 91, 3308, 10.1182/blood.V91.9.3308 · DOI
  80. Stewart, 1994, Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryo., Mol Reprod Dev, 39, 233, 10.1002/mrd.1080390217 · DOI
  81. Piquet-Pellorce, 1994, Are LIF and related cytokines functionally equivalent?, Exp Cell Res, 213, 340, 10.1006/excr.1994.1208 · DOI
  82. Yoshida, 1994, Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways., Mech Dev, 45, 163, 10.1016/0925-4773(94)90030-2 · DOI

Cited by

Metadata

Authors
Peters, M., Müller, A. M., & Rose-John, S.
Venue
Blood
Published
1998-11-15
Volume
92
Issue
10
Pages
3495-3504
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W196618629
Cited by
276
References
3
FWCI
6.19
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.