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Cited by 179Exercise and Physiological ResponsesCardiovascular and exercise physiologyMuscle metabolism and nutrition

Effect of exercise, training, and glycogen availability on IL-6 receptor expression in human skeletal muscle

Keller, Charlotte, Steensberg, Adam, Hansen, Anne K., Fischer, Christian P., Plomgaard, Peter, Pedersen, Bente Klarlund·2005·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00590.2005
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Abstract

The cytokine interleukin-6 (IL-6) exerts it actions via the IL-6 receptor (IL-6R) in conjunction with the ubiquitously expressed gp130 receptor. IL-6 is tightly regulated in response to exercise, being affected by factors such as exercise intensity and duration, as well as energy availability. Although the IL-6 response to exercise has been extensively studied, little is known about the regulation of the IL-6R response. In the present study, we aimed to investigate the effect of exercise, training, and glycogen availability, factors known to affect IL-6, on the regulation of gene expression of the IL-6R in human skeletal muscle. Human subjects performed either 10 wk of training with an acute exercise bout before and after the training period, or a low-glycogen vs. normal-glycogen acute exercise trial. The IL-6R mRNA response was evaluated in both trials. In response to acute exercise, an increase in IL-6R mRNA levels was observed. Neither training nor intramuscular glycogen levels had an effect on the IL-6R mRNA response to exercise. However, after 10 wk of training, the skeletal muscle expressed a higher mRNA level of IL-6R compared with before training. The present study demonstrated that the IL-6R gene expression levels in skeletal muscle are increased in response to acute exercise, a response that is very well conserved, being affected by neither training status nor intramuscular glycogen levels, as opposed to IL-6. However, after the training period, IL-6R mRNA production was increased in skeletal muscle, suggesting a sensitization of skeletal muscle to IL-6 at rest.

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Crossref · 10.1152/japplphysiol.00590.2005

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  • Muscular expression of the IL-6 receptor is elevated in trained human muscle, suggesting that muscular sensitivity to IL-6 is increased by training adaptation.

    “In contrast, the muscular expression of the IL-6 receptor (IL-6R) is elevated in trained human muscle (57), suggesting that muscular sensitivity to IL-6 is increased by training adaptation.”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [57]

  • In humans, chronic exercise training lowers plasma IL-6, but this effect may be partly offset by increased skeletal muscle mRNA expression of IL-6 receptor.

    “in humans, chronic exercise training reduces plasma concentrations of IL-6; however, this effect could be partially mitigated by increased skeletal muscle mRNA expression of IL-6 receptor32.”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [32]

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Authors
Keller, C., Steensberg, A., Hansen, A. K., Fischer, C. P., Plomgaard, P., & Pedersen, B. K.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2005-12
Volume
99
Issue
6
Pages
2075-2079
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00590.2005
OpenAlex
W2147235183
Cited by
179
References
32
Citations by year
2026: 6 · 2025: 14 · 2024: 4 · 2023: 8 · 2022: 13 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 16 · 2012: 8
FWCI
5.30
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • National Research Centre
  • Danmarks Grundforskningsfond
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
IL-6 receptor, skeletal muscle, physical activity, training, acute exercise, interleukin-6, gp130, energy availability
MeSH terms
Adaptation, Physiological, Adult, Physical Exertion, Gene Expression Regulation, Glycogen, Humans, Male, Physical Fitness, Exercise, Muscle, Skeletal, Receptors, Interleukin-6

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