The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation
Abstract
Thymic-dependent differentiation of bone marrow (BM)-derived progenitors and thymic-independent antigen-driven peripheral expansion of mature T cells represent the 2 primary pathways for T-cell regeneration. These pathways are interregulated such that peripheral T-cell expansion is increased in thymectomized versus thymus-bearing hosts after bone marrow transplantation (BMT). This study shows that this interregulation is due to competition between progeny of these 2 pathways because depletion of thymic progeny leads to increased peripheral expansion in thymus-bearing hosts. To test the hypothesis that competition for growth factors modulates the magnitude of antigen-driven peripheral expansion during immune reconstitution in vivo, a variety of T-cell active cytokines were administered after BMT. Of the cytokines (interleukins) tested (IL-3, IL-12, IL-6, IL-2, and IL-7), IL-2 modestly increased peripheral expansion in the face of increasing numbers of thymic emigrants, whereas IL-7 potently accomplished this. This report also demonstrates that the beneficial effect of IL-7 on immune reconstitution is related to both increases in thymopoiesis as well as a direct increase in the magnitude of antigen-driven peripheral expansion. Therefore, the administration of exogenous IL-7, and to a lesser extent IL-2, abrogates the down-regulation in antigen-driven peripheral expansion that occurs in thymus-bearing hosts after BMT. These results suggest that one mechanism by which T-cell–depleted hosts may support antigen-driven T-cell expansion in vivo is via an increased availability of T-cell–active cytokines to support clonal expansion.
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Cites
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Cited by
Estrogen deficiency and bone loss: an inflammatory tale
Weitzmann, M. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28550 · Cited by 990
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834
Thymic involution and immune reconstitution.
Lynch, H. E., Goldberg, G. L., Chidgey, A., Van den Brink, M. R. M., Boyd, R., & Sempowski, G. D. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.003 · Cited by 522
T cell immune reconstitution following lymphodepletion
Williams, K. M., Hakim, F. T., & Gress, R. E. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.004 · Cited by 340
Self-citationKomanduri, K. V., St. John, L. S., de Lima, M., McMannis, J., Rosinski, S., McNiece, I., Bryan, S. G., Kaur, I., Martin, S., Wieder, E. D., et al. (2007) · Blood · doi:10.1182/blood-2007-05-092130 · Cited by 313
Metadata
- Authors
- Mackall, C. L., Fry, T. J., Bare, C., Morgan, P., Galbraith, A., & Gress, R. E.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2001-03-01
- Volume
- 97
- Issue
- 5
- Pages
- 1491-1497
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2123434358
- Cited by
- 300
- References
- 34
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mackall, C. L., Fry, T. J., Bare, C., Morgan, P., Galbraith, A., & Gress, R. E. (2001). IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood. https://doi.org/10.1182/blood.v97.5.1491
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