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Cited by 857

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach

Open access
Brand, P. L. P., Baraldi, E., Bisgaard, H., Boner, A. L., Castro-Rodriguez, J. A., Custovic, A., de Blic, J., de Jongste, J. C., Eber, E., Everard, M. L., Frey, U., Gappa, M., Garcia-Marcos, L., Grigg, J., Lenney, W., Le Souëf, P., McKenzie, S., Merkus, P. J. F. M., Midulla, F., Paton, J. Y., Piacentini, G., Pohunek, P., Rossi, G. A., Seddon, P., Silverman, M., Sly, P. D., Stick, S., Valiulis, A., van Aalderen, W. M. C., Wildhaber, J. H., Wennergren, G., Wilson, N., Zivkovic, Z., Bush, A.·2008·European Respiratory Journal
DOI 10.1183/09031936.00002108
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Abstract

There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis. Based on the limited evidence available, inhaled short-acting β 2-agonists by metered-dose inhaler/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) wheeze and can be started when symptoms of a viral cold develop. Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent wheeze, but should be discontinued if there is no clear clinical benefit. Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.

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Metadata

Authors
Brand, P. L. P., Baraldi, E., Bisgaard, H., Boner, A. L., Castro-Rodriguez, J. A., Custovic, A., de Blic, J., de Jongste, J. C., Eber, E., Everard, M. L., Frey, U., Gappa, M., Garcia-Marcos, L., Grigg, J., Lenney, W., Le Souëf, P., McKenzie, S., Merkus, P. J. F. M., Midulla, F., Paton, J. Y., Piacentini, G., Pohunek, P., Rossi, G. A., Seddon, P., Silverman, M., Sly, P. D., Stick, S., Valiulis, A., van Aalderen, W. M. C., Wildhaber, J. H., Wennergren, G., Wilson, N., Zivkovic, Z., & Bush, A.
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2008-09-30
Volume
32
Issue
4
Pages
1096-1110
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.00002108
OpenAlex
W2134466274
Cited by
857
References
16
FWCI
41.82
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. https://app.cochat.ai/papers/10.1183/09031936.00002108
The paper
Brand, P. L. P., Baraldi, E., Bisgaard, H., Boner, A. L., Castro-Rodriguez, J. A., Custovic, A., de Blic, J., de Jongste, J. C., Eber, E., Everard, M. L., Frey, U., Gappa, M., Garcia-Marcos, L., Grigg, J., Lenney, W., Le Souëf, P., McKenzie, S., Merkus, P. J. F. M., Midulla, F., . . . Bush, A. (2008). Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. European Respiratory Journal. https://doi.org/10.1183/09031936.00002108

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.