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CPAP and measures of cardiovascular risk in males with OSAS
Open accessAbstract
Obstructive sleep apnoea syndrome (OSAS) has been associated with hypertension, stroke and myocardial ischaemia in epidemiological and observational studies. Continuous positive airway pressure (CPAP) is the treatment of choice for OSAS, but the impact of this intervention on established risk factors for cardiovascular disease remains incompletely understood. A total of 102 males with moderate-to-severe OSAS were randomised to therapeutic (n = 51) or subtherapeutic (n = 51) CPAP treatment for 4 weeks to investigate the effects of active treatment on 24-h urinary catecholamine excretion, baroreflex sensitivity (BRS), arterial stiffness (augmentation index) and 24-h ambulatory blood pressure (ABP). After 4 weeks of therapeutic CPAP, significant reductions were seen in urine normetanephrine excretion (from mean±sd 179.7±80.1 to 132.7±46.5 µmol·mol−1 creatinine) and augmentation index (from 14.5±11.3 to 9.1±13.8%) compared with the subtherapeutic control group. Furthermore, therapeutic CPAP significantly improved BRS (from 7.1±3.3 to 8.8±4.2 ms·mmHg−1) and reduced mean arterial ABP by 2.6±5.4 mmHg. In conclusion, treatment of obstructive sleep apnoea with continuous positive airway pressure may lower cardiovascular risk by reducing sympathetic nerve activity, ambulatory blood pressure and arterial stiffness and by increasing sensitivity of the arterial baroreflex.
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Metadata
- Authors
- Kohler, M., Pepperell, J. C. T., Casadei, B., Craig, S., Crosthwaite, N., Stradling, J. R., & Davies, R. J. O.
- Affiliations
- Churchill Hospital (GB)
- Musgrove Park Hospital (GB)
- John Radcliffe Hospital (GB)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2008-07-24
- Volume
- 32
- Issue
- 6
- Pages
- 1488-1496
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2134126089
- Cited by
- 197
- References
- 56
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 10 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 13 · 2016: 13 · 2015: 16 · 2014: 10 · 2013: 14 · 2012: 22
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- European Respiratory Society
- Universität Zürich
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- obstructive sleep apnea, continuous positive airway pressure, cardiovascular risk, sympathetic activity, baroreflex sensitivity, arterial stiffness, augmentation index, ambulatory blood pressure, hypertension
- MeSH terms
- Adult, Aged, Blood Pressure, Cardiovascular Diseases, Catecholamines, Humans, Male, Middle Aged, Normetanephrine, Risk Factors, Sleep, Treatment Outcome, Baroreflex, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
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