The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival
Open accessAbstract
The identification of tumour biomarkers that detect the presence of disease using noninvasive diagnostic procedures is a key part of cancer research. We determined in plasma the vesicle-related microRNA (miRNA) expression profile of nonsmall cell lung cancer (NSCLC) and evaluate whether plasma miRNAs can be both discriminating (between patients and healthy controls) and prognostic markers. 365 human miRNAs were analysed by Taqman® low-density arrays (Applied Biosystems, Foster City, CA, USA) in the plasma from 28 NSCLC patients and 20 controls. Five selected miRNAs (let-7f, miR-20b, miR-30e-3p, miR-223 and miR-301) were validated independently by real-time PCR in plasma from 78 NSCLC and 48 controls and correlated with pathologic parameters and survival. Levels of let-7f, miR-20b and miR-30e-3p were decreased in plasma vesicles of NSCLC patients. Moreover, levels of let-7f and miR-30e-3p distinguished between two groups of patients for stage of disease and therefore possibility of surgery. Plasma levels of miR-30e-3p and let-7f were associated with short disease-free survival and overall survival, respectively. NSCLC patients and healthy controls differ in vesicle-related miRNAs in plasma. Levels of let-7f and miR-30e-3p in NSCLC patients are associated with poor outcome. Thus, plasma vesicle-related miRNAs obtained by noninvasive methods could serve as circulating tumour biomarkers of discriminating and prognostic value.
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Role of microRNAs in vascular diseases, inflammation, and angiogenesis
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García, J. M., García, V., Peña, C., Domínguez, G., Silva, J., Diaz, R., Espinosa, P., Citores, M. J., Collado, M., & Bonilla, F. (2008) · RNA · doi:10.1261/rna.755908 · Cited by 86
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Cited by
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
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Clinical relevance of circulating cell-free microRNAs in cancer
Schwarzenbach, H., Nishida, N., Calin, G. A., & Pantel, K. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.5 · Cited by 969
Methodological challenges in utilizing mi RNA s as circulating biomarkers
Moldovan, L., Batte, K. E., Trgovcich, J., Wisler, J., Marsh, C. B., & Piper, M. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12236 · Cited by 436
Current Knowledge on Exosome Biogenesis, Cargo-Sorting Mechanism and Therapeutic Implications
Xie, S., Zhang, Q., & Jiang, L. (2022) · Membranes · doi:10.3390/membranes12050498 · Cited by 262
Ninomiya, M., Kondo, Y., Funayama, R., Nagashima, T., Kogure, T., Kakazu, E., Kimura, O., Ueno, Y., Nakayama, K., & Shimosegawa, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066086 · Cited by 83
Circulating MicroRNAs as Minimally Invasive Biomarkers for Cancer Theragnosis and Prognosis
Cho, W. C. S. (2011) · Frontiers in Genetics · doi:10.3389/fgene.2011.00007 · Cited by 61
Recent advances in microfluidic methods in cancer liquid biopsy
Iliescu, F. S., Poenar, D. P., Yu, F., Ni, M., Chan, K. H., Cima, I., Taylor, H. K., Cima, I., & Iliescu, C. (2019) · Biomicrofluidics · doi:10.1063/1.5087690 · Cited by 51
Liu, Y., Xia, Y., Smollar, J., Mao, W., & Wan, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188539 · Cited by 23
Metadata
- Authors
- Silva, J., García, V., Zaballos, Á., Provencio, M., Lombardía, L., Almonacid, L., García, J. M., Domínguez, G., Peña, C., Diaz, R., Herrera, M., Varela, A., & Bonilla, F.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2010-07-01
- Volume
- 37
- Issue
- 3
- Pages
- 617-623
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2158330587
- Cited by
- 280
- References
- 4
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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