Different definitions in childhood asthma: how dependable is the dependent variable?
Open accessAbstract
There is abundant literature on how to select and statistically deal with predictors in prediction models. Less attention has been paid to the choice of the outcome. We assessed the impact of different asthma definitions on prevalence estimates and on the prediction model's performances. We searched PubMed and extracted data of definitions used to diagnose childhood asthma (between 6 and 18 yrs) in cohort studies. Next, using data from an ongoing cohort study (n = 186), we constructed and compared four prediction models which all predict asthma at age 6 yrs, using a fixed set of predictors and four different definitions in turn. We defined an area of clinical indecision (posterior probability between 25% and 60%) and calculated the number of children who remained inside this area. 122 papers yielded 60 different definitions. Prevalence estimates varied between 15.1% and 51.1% depending on the asthma definition used. The percentage of children whose posterior asthma probability was in the area of clinical indecision varied from 14.9% to 65.3%. Variation in definitions and its effect on the performance of prediction models may be another source of otherwise inexplicable variation in daily clinical decision making. More uniformity of operational asthma definitions seems needed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Agreement between four seemingly very similar and commonly used definitions of childhood asthma was overall relatively low (61%).
“As an example, the above study has shown that the agreement between four seemingly very similar and commonly used definitions was overall relatively low (61%)”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [17]
Well-over a third of children in a study could move from being considered asthma cases to controls depending on the definition used.
“and well-over a third of children in a study could move from being considered “asthma cases” to “controls” depending on the definition used (17).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [17]
As many as 60 different definitions of childhood asthma have been used across 122 published studies.
“Despite attempts to reach a consensus definition for epidemiological studies, as many as 60 different definitions of “childhood asthma” have been used across 122 published studies (17).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [17]
The multiplicity in the way the primary outcome is defined can have a substantial impact on the estimated prevalence and risk factors.
“Although some of these definitions may appear almost identical, the multiplicity in the way the primary outcome is defined can have a substantial impact on the estimated prevalence and risk factors.”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sterne, J. A. C., White, I. R., Carlin, J. B., Spratt, M., Royston, P., Kenward, M. G., Wood, A. M., & Carpenter, J. R. (2009) · BMJ · doi:10.1136/bmj.b2393 · Cited by 7,299 · see citing works
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493 · see citing works
Asthma and Wheezing in the First Six Years of Life
Martinez, F. D., Wright, A. L., Taussig, L. M., Holberg, C. J., Halonen, M., & Morgan, W. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320301 · Cited by 3,823 · see citing works
Beasley, R. W. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07302-9 · Cited by 3,773 · see citing works
Multiple imputation of discrete and continuous data by fully conditional specification
van Buuren, S. (2007) · Statistical Methods in Medical Research · doi:10.1177/0962280206074463 · Cited by 2,827 · see citing works
Guidelines for the diagnosis and management of asthma.
Solomon, P. A. (1992) · PubMed · Cited by 2,007 · see citing works
Bronchial reactivity to inhaled histamine: a method and clinical survey
Cockcroft, D. W., Killian, D. N., MELLON, J. J. A., & Hargreave, F. E. (1977) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1977.tb01448.x · Cited by 1,838 · see citing works
Prognosis and prognostic research: validating a prognostic model
Altman, D. G., Vergouwe, Y., Royston, P., & Moons, K. G. M. (2009) · BMJ · doi:10.1136/bmj.b605 · Cited by 1,436 · see citing works
Prognosis and prognostic research: what, why, and how?
Moons, K. G. M., Royston, P., Vergouwe, Y., Grobbee, D. E., & Altman, D. G. (2009) · BMJ · doi:10.1136/bmj.b375 · Cited by 1,337 · see citing works
Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
Jackson, D. J., Gangnon, R. E., Evans, M. D., Roberg, K. A., Anderson, E. L., Pappas, T., Printz, M. C., Lee, W.-M., Shult, P. A., Reisdorf, E. S., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-309oc · Cited by 1,310 · see citing works
Prognosis and prognostic research: Developing a prognostic model
Royston, P., Moons, K. G. M., Altman, D. G., & Vergouwe, Y. (2009) · BMJ · doi:10.1136/bmj.b604 · Cited by 1,172 · see citing works
A Clinical Index to Define Risk of Asthma in Young Children with Recurrent Wheezing
Castro-Rodríguez, J. A., Holberg, C. J., Wright, A. L., & Martinez, F. D. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.9912111 · Cited by 1,137 · see citing works
National Asthma Education and Prevention Program
VanGraafeiland, B. (2002) · The Nurse Practitioner · doi:10.1097/00006205-200206001-00003 · Cited by 1,093 · see citing works
Prognosis and prognostic research: application and impact of prognostic models in clinical practice
Moons, K. G. M., Altman, D. G., Vergouwe, Y., & Royston, P. (2009) · BMJ · doi:10.1136/bmj.b606 · Cited by 934 · see citing works
Receiver operating characteristic (ROC) methodology: the state of the art.
Hanley, J. A. (1989) · PubMed · Cited by 685 · see citing works
Henderson, A. J., Granell, R., Heron, J., Sherriff, A., Simpson, A., Woodcock, A. A., Strachan, D. P., Shaheen, S. O., & Sterne, J. A. C. (2008) · Thorax · doi:10.1136/thx.2007.093187 · Cited by 519 · see citing works
Day Care Attendance in Early Life, Maternal History of Asthma, and Asthma at the Age of 6 Years
Celedon, J. C., Wright, R. J., Litonjua, A. A., Sredl, D. L., RYAN, L. M., Weiss, S. T., & Gold, D. R. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200209-1063oc · Cited by 159 · see citing works
Eysink, P. E. D., ter Riet, G., Aalberse, R. C., van Aalderen, W. M. C., Roos, C. M., van der Zee, J. S., & Bindels, P. (2005) · Europe PMC (PubMed Central) · Cited by 77 · see citing works
Self-citationHederos, C., Hasselgren, M., Hedlin, G., & Bornehag, C. (2006) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2006.00474.x · Cited by 59 · see citing works
Bronchoprovocation Methods: Direct Challenges
Cockcroft, D. W. (2003) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:24:1:19 · Cited by 59 · see citing works
Predictors of Asthma in Young Children: Does Reporting Source Affect Our Conclusions?
Miller, J. E. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.3.245 · Cited by 48 · see citing works
Trends in Asthma Prevalence, Admission Rates, and Asthma Deaths
Martínez, F. D. (2008) · Respiratory Care · doi:10.4187/respcare.08530561 · Cited by 38 · see citing works
Ninomiya, T., Donnan, G. A., Anderson, N., Bladin, C., Chambers, B. R., Gordon, G., Sharpe, N., Chalmers, J. P., Woodward, M., & Neal, B. C. (2009) · Stroke · doi:10.1161/strokeaha.108.539601 · Cited by 30 · see citing works
IgE testing in capillary blood
Stapel, S. O., Eysink, P. E. D., de Vrieze, J., & Aalberse, R. C. (2004) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2004.00142.x · Cited by 30 · see citing works
Wördemann, M., Polman, K., Díaz, R. J., Heredia, L. T. M., Madurga, A. M. C., Sagué, K. A., Gryseels, B., & Gorbea, M. B. (2006) · Allergy · doi:10.1111/j.1398-9995.2006.01129.x · Cited by 19 · see citing works
Elementary concepts of medicine: III. Illness: somatic anomaly with . . .
Miettinen, O. S., & Flegel, K. M. (2003) · Journal of Evaluation in Clinical Practice · doi:10.1046/j.1365-2753.2003.00416.x · Cited by 15 · see citing works
van Wonderen, K. E., van der Mark, L. B., Mohrs, J., Geskus, R. B., van der Wal, W. M., van Aalderen, W. M. C., Bindels, P., & ter Riet, G. (2009) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-9-13 · Cited by 14 · see citing works
Self-citationGreenlee, R. T., Chyou, P., Kieke, A., Naik, Y. G., & Kirkhorn, S. R. (2008) · Journal of Agromedicine · doi:10.1080/10599240802454593 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200 · see citing works
After asthma: redefining airways diseases
Pavord, I. D., Beasley, R., Agusti, A., Anderson, G. P., Bel, E., Brusselle, G., Cullinan, P., Custovic, A., Ducharme, F. M., Fahy, J. V., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(17)30879-6 · Cited by 1,073 · see citing works
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 554 · see citing works
Juhn, Y. J., & Liu, H. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.12.897 · Cited by 287 · see citing works
Gascon, M., Casas, M., Morales, E., Valvi, D., Ballesteros-Gómez, A., Luque, N., Rubio, S., Monfort, N., Ventura, R., Martínez, D., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.09.030 · Cited by 261 · see citing works
Guilbert, T. W., Bacharier, L. B., & Fitzpatrick, A. M. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.06.022 · Cited by 216 · see citing works
Increased airway smooth muscle in preschool wheezers who have asthma at school age
O’Reilly, R., Ullmann, N., Irving, S. J., Bossley, C. J., Sonnappa, S., Zhu, J., Oates, T., BANYA, W. A. S., Jeffery, P. K., Bush, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.08.044 · Cited by 158 · see citing works
A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project
Mölter, A., Simpson, A., Berdel, D., Brunekreef, B., Čustović, A., Cyrys, J., de Jongste, J. C., de Vocht, F., Fuertes, E., Gehring, U., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00083614 · Cited by 142 · see citing works
Predicting who will have asthma at school age among preschool children
Savenije, O. E. M., Kerkhof, M., Koppelman, G. H., & Postma, D. S. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.007 · Cited by 127 · see citing works
Tsuo, K., Zhou, W., Wang, Y., Kanai, M., Namba, S., Gupta, R., Majara, L., Nkambule, L. L., Morisaki, T., Okada, Y., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100212 · Cited by 120 · see citing works
Distinguishing Asthma Phenotypes Using Machine Learning Approaches
Howard, R., Rattray, M., Prosperi, M., & Čustović, A. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0542-0 · Cited by 120 · see citing works
Risk Prediction Models for Postoperative Delirium: A Systematic Review and Meta‐Analysis
van Meenen, L. C. C., van Meenen, D. M. P., de Rooij, S. E., & ter Riet, G. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13138 · Cited by 122 · see citing works
Hu, Y., Xu, Z., Jiang, F., Li, S., Liu, S., Wu, M., Yan, C., Tan, J., Yu, G., Hu, Y., et al. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135975 · Cited by 101 · see citing works
Defining pediatric asthma: phenotypes to endotypes and beyond
Conrad, L. A., Cabana, M. D., & Rastogi, D. (2020) · Pediatric Research · doi:10.1038/s41390-020-01231-6 · Cited by 104 · see citing works
Operational definitions of asthma in recent epidemiological studies are inconsistent
Sá‐Sousa, A., Jacinto, T., Azevedo, L. F., Morais‐Almeida, M., Cordeiro, C. R., Bugalho‐Almeida, A., Bousquet, J. J., & Fonseca, J. (2014) · Clinical and Translational Allergy · doi:10.1186/2045-7022-4-24 · Cited by 97 · see citing works
Genomic Predictors of Asthma Phenotypes and Treatment Response
Hernandez‐Pacheco, N., Pino-Yanes, M. D. M., & Flores, C. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00006 · Cited by 96 · see citing works
Childhood asthma prediction models: a systematic review
Smit, H. A., Pinart, M., Antó, J. M., Keil, T. O. P., Bousquet, J., Carlsen, K. H., Moons, K. G. M., Hooft, L., & Carlsen, K. C. L. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00428-2 · Cited by 91 · see citing works
Pols, D. H. J., Wartna, J. B., Moed, H. D., van Alphen, E. I., Bohnen, A. M., & Bindels, P. (2016) · Scandinavian Journal of Primary Health Care · doi:10.3109/02813432.2016.1160629 · Cited by 90 · see citing works
Self-citationLoymans, R. J. B., Honkoop, P., Termeer, E. H., Snoeck-Stroband, J. B., Assendelft, W. J., Schermer, T. R., Chung, K. F., Sousa, A. R., Sterk, P. J., Reddel, H. K., et al. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-208138 · Cited by 88 · see citing works
Childhood Asthma: Diagnosis and Treatment
van Aalderen, W. M. C. (2012) · Scientifica · doi:10.6064/2012/674204 · Cited by 79 · see citing works
A systematic review of predictive models for asthma development in children
Luo, G., Nkoy, F. L., Stone, B. L., Schmick, D., & Johnson, M. D. (2015) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-015-0224-9 · Cited by 77 · see citing works
Diagnosis and Management of Asthma – The Swiss Guidelines
Rothe, T., Spagnolo, P., Bridevaux, P., Clarenbach, C. F., Eich-Wanger, C., Meyer, F., Miedinger, D., Mœller, A., Nicod, L. P., Nicolet-Chatelain, G., et al. (2018) · Respiration · doi:10.1159/000486797 · Cited by 71 · see citing works
Asthma diagnosis in infants and preschool children: a systematic review of clinical guidelines
Moral, L., Vizmanos, G., Torres-Borrego, J., Praena-Crespo, M., Tortajada‐Girbés, M., Pellegrini, F. J., & la Cruz, O. A.-D. (2018) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2018.05.002 · Cited by 66 · see citing works
Groen, E. H., Lingsma, H. F., Caudri, D., Levie, D., Wijga, A. H., Koppelman, G. H., Duijts, L., Jaddoe, V. W. V., Smit, H. A., Kerkhof, M., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.07.007 · Cited by 65 · see citing works
Development of childhood asthma prediction models using machine learning approaches
Kothalawala, D. M., Murray, C. S., Simpson, A., Čustović, A., Tapper, W., Arshad, S. H., Holloway, J. W., Rezwan, F. I., & STELAR/UNICORN investigators (2021) · Clinical and Translational Allergy · doi:10.1002/clt2.12076 · Cited by 59 · see citing works
Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review
Brown, S. B., Reeves, K. W., & Bertone‐Johnson, E. R. (2013) · Nutrition Reviews · doi:10.1111/nure.12080 · Cited by 57 · see citing works
Asthma phenotypes and endotypes in childhood
FAINARDI, V., Esposito, S., CHETTA, A., & Giovanna, P. I. S. I. (2022) · Minerva Medica · doi:10.23736/s0026-4806.21.07332-8 · Cited by 57 · see citing works
Epidemiology of Allergy: Natural Course and Risk Factors of Allergic Diseases
Genuneit, J., & Standl, M. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_507 · Cited by 52 · see citing works
A systematic review of the association between obesity and asthma in children
Liu, P., Kieckhefer, G. M., & Gau, B. (2013) · Journal of Advanced Nursing · doi:10.1111/jan.12129 · Cited by 52 · see citing works
Furu, K., Karlstad, Ø., Skurtveit, S. O., Håberg, S. E., Nafstad, P. H. J., London, S. J., & Nystad, W. (2011) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.10.014 · Cited by 52 · see citing works
Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice
Karakuş, C. Ö., Haider, S., Fontanella, S., Frainay, C., & Čustović, A. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00258 · Cited by 51 · see citing works
Matterne, U., Schmitt, J. M., Diepgen, T. L., & Apfelbacher, C. (2011) · Quality of Life Research · doi:10.1007/s11136-011-9868-9 · Cited by 46 · see citing works
Inflammatory markers in childhood asthma
Dodig, S., Richter, D., & Zrinski-Topić, R. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.094 · Cited by 46 · see citing works
Belgrave, D. C. M., Čustović, A., & Simpson, A. (2013) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2013.836450 · Cited by 45 · see citing works
Horikawa, Y. T., Udaka, T. Y., Crow, J. K., Takayama, J. I., & Stein, M. T. (2014) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000029 · Cited by 45 · see citing works
van der Mark, L. B., van Wonderen, K. E., Mohrs, J., van Aalderen, W. M. C., ter Riet, G., & Bindels, P. (2014) · Primary Care Respiratory Journal · doi:10.4104/pcrj.2014.00003 · Cited by 45 · see citing works
Self-citationChildhood asthma phenotypes and endotypes: a glance into the mosaic
Foppiano, F., & Schaub, B. (2023) · Molecular and Cellular Pediatrics · doi:10.1186/s40348-023-00159-1 · Cited by 45 · see citing works
Expert artificial intelligence-based natural language processing characterises childhood asthma
Seol, H. Y., Rolfes, M., Chung, W., Sohn, S., Ryu, E., Park, M. A., Kita, H., Ono, J., Croghan, I. T., Armasu, S. M., et al. (2020) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2019-000524 · Cited by 37 · see citing works
Preterm Birth with Childhood Asthma: The Role of Degree of Prematurity and Asthma Definitions
He, H., Butz, A. M., Keet, C. A., Minkovitz, C. S., Hong, X., Caruso, D., Pearson, C., Cohen, R. T., Wills-Karp, M. A., ZUCKERMAN, B. S., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201503-0522le · Cited by 37 · see citing works
The highs and lows of wheezing: A review of the most popular adventitious lung sound
Pasterkamp, H. (2017) · Pediatric Pulmonology · doi:10.1002/ppul.23930 · Cited by 35 · see citing works
García‐Marcos, L., Edwards, J., Kennington, E. J., Aurora, P., Baraldi, E., Carraro, S., Gappa, M., Louis, R. E., Moreno, A., Peroni, D. G., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.13080 · Cited by 33 · see citing works
Fitzpatrick, A. M., Baena‐Cagnani, C. E., & Bacharier, L. B. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32835090ac · Cited by 31 · see citing works
Nakamura, T., Haider, S., Colicino, S., Murray, C. S., Holloway, J. W., Simpson, A., Cullinan, P., Čustović, A., & the STELAR investigators (2019) · British Journal of Dermatology · doi:10.1111/bjd.17853 · Cited by 29 · see citing works
Lloyd, J. C., Nseyo, U., Madden-Fuentes, R. J., Ross, S. S., Wiener, J. S., & Routh, J. C. (2013) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2013.02.006 · Cited by 25 · see citing works
Reduced neonatal lung function and wheezing illnesses during the first 5 years of life
van der Gugten, A. C., Uiterwaal, C. S. P. M., van Putte‐Katier, N., Koopman, M., Verheij, T. J., & van der Ent, C. K. (2012) · European Respiratory Journal · doi:10.1183/09031936.00214711 · Cited by 24 · see citing works
Bryant-Stephens, T. C., West, C., Dirl, C., Banks, T., Briggs, V., & Rosenthal, M. P. (2012) · Journal of Asthma · doi:10.3109/02770903.2012.690476 · Cited by 23 · see citing works
Visness, C. M., Gebretsadik, T. S., Jackson, D. J., Myers, J. M. B., Havstad, S. L., Lemanske, R. F., Hartert, T. V., Hershey, G. K. K., Zoratti, E. M., Martin, L. J., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.05.025 · Cited by 22 · see citing works
Fifty years of pediatric asthma in developed countries: How reliable are the basic data sources?
Chawla, J., Seear, M. D., Zhang, T., Smith, A., & Carleton, B. (2011) · Pediatric Pulmonology · doi:10.1002/ppul.21537 · Cited by 22 · see citing works
Epidemiological measures of childhood asthma: Cross-sectional and longitudinal consistency
Canova, C., Harris, J. M., Mills, P., White, C., Moffat, S., Shread, L., & Cullinan, P. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.05.008 · Cited by 21 · see citing works
Kraai, S., Verhagen, L. M., Valladares, E., Goecke, J., Rasquin, L., Colmenares, P., del Nogal, B., Hermans, P. W. M., & de Waard, J. H. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-76 · Cited by 21 · see citing works
What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression
Hernandez-Pacheco, N., Flores, C., Oh, S. S., Burchard, E., & Pino-Yanes, M. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-016-0635-4 · Cited by 23 · see citing works
Systematic Review on the Definition of Allergic Diseases in Children: The MeDALL Study
Pinart, M., Albang, R., Maier, D., Duran‐Tauleria, E., Mena, G., Gimeno‐Santos, E., Solà, I., García‐Aymerich, J., Guerra, S., Stein, R. T., et al. (2015) · International Archives of Allergy and Immunology · doi:10.1159/000442414 · Cited by 20 · see citing works
Development of a Symptom-Based Tool for Screening of Children at High Risk of Preschool Asthma
Reyna, M. E., Dai, R., Tran, M. M., Breton, V. L., Medeleanu, M., Lou, W. Y. W., Foong, R. E., Emmerson, M. N., Dharma, C., Miliku, K., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.34714 · Cited by 19 · see citing works
The state of asthma epidemiology: an overview of systematic reviews and their quality
for the Task Force “Overview of Systematic Reviews in Allergy Epidemiology (OSRAE)” of the EAACI Interest Group on Epidemiology, Genuneit, J., Seibold, A. M., Apfelbacher, C., Konstantinou, G. Ν., Koplin, J. J., Grutta, S. L., Logan, K., Flohr, C., & Perkin, M. R. (2017) · Clinical and Translational Allergy · doi:10.1186/s13601-017-0146-y · Cited by 18 · see citing works
Adult Asthma Scores—Development and Validation of Multivariable Scores to Identify Asthma in Surveys
Sá‐Sousa, A., Pereira, A. M., Almeida, R., Araújo, L. M., Couto, M., Jacinto, T., Freitas, A., Bousquet, J., & Fonseca, J. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.06.024 · Cited by 17 · see citing works
Pols, D. H. J., Nielen, M. M. J., Korevaar, J. C., Bindels, P., & Bohnen, A. M. (2017) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-017-0025-y · Cited by 16 · see citing works
Self-citationKwon, J. H., Wi, C., Seol, H. Y., Park, M., King, K. S., Ryu, E., Sohn, S., Liu, H., & Juhn, Y. J. (2021) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2021.13.5.697 · Cited by 15 · see citing works
Ferreira‐Magalhães, M., Sá‐Sousa, A., Morais‐Almeida, M., Pité, H., Azevedo, L. F., Azevedo, M. I., Bugalho‐Almeida, A., & Fonseca, J. (2015) · Journal of Asthma · doi:10.3109/02770903.2015.1095926 · Cited by 13 · see citing works
Genetics of Asthma and Allergic Diseases
Haider, S., Simpson, A., & Čustović, A. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_484 · Cited by 14 · see citing works
Epidemiology of Allergic Diseases
Čustović, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37579-5.00003-9 · Cited by 12 · see citing works
Economic Burden of Pediatric Asthma: Annual Cost of Disease in Iran.
Sharifi, L., Dashti, R., Pourpak, Z., Fazlollahi, M. R., Movahedi, M., Chavoshzadeh, Z., Soheili, H., Bokaie, S., Kazemnejad, A., & Moin, M. (2018) · PubMed Central · Cited by 12 · see citing works
A systematic review of asthma case definitions in 67 birth cohort studies
Dubovyi, A. I., Chelimo, C., Schierding, W. S., Bisyuk, Y., Camargo, C. A., & Grant, C. C. (2020) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2019.12.005 · Cited by 12 · see citing works
Defining asthma in children: how well do parents, doctors and spirometry agree?
Korsten, K., Naaktgeboren, C. A., Bont, L., van der Ent, C. K., & de Hoog, M. L. A. (2020) · ERJ Open Research · doi:10.1183/23120541.00348-2019 · Cited by 11 · see citing works
Cox, J., Ryan, P., Burkle, J. W., Jandarov, R., Mendell, M. J., Hershey, G. K. K., LeMasters, G. K., & Reponen, T. A. (2020) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000101 · Cited by 11 · see citing works
Mendes, F. C., Paciência, I., Rufo, J. C., Silva, D., Cunha, P., Farraia, M., Delgado, L., Moreira, P. A. M., & Moreira, A. M. (2019) · ERJ Open Research · doi:10.1183/23120541.00076-2019 · Cited by 10 · see citing works
Watkinson, R. L., Looi, K., Laing, I. A., Cianferoni, A., & Kicic, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.773600 · Cited by 10 · see citing works
Seol, H. Y., Wi, C., Ryu, E., King, K. S., Divekar, R. D., & Juhn, Y. J. (2020) · Journal of Asthma · doi:10.1080/02770903.2020.1759624 · Cited by 9 · see citing works
Desalu, O. O., Sanya, E. O., Adeoti, A. O., Aderibigbe, S. A., & Kolo, P. M. (1970) · Ethiopian Journal of Health Sciences · doi:10.4314/ejhs.v28i6.7 · Cited by 8 · see citing works
Breaking Down Silos in Asthma Research: The Case for an Integrated Approach
Haider, S., & Čustović, A. (2019) · EMJ Innovation · doi:10.33590/emjinnov/10314913 · Cited by 8 · see citing works
Asthma: From one disease to endotypes
Nadif, R., & Savouré, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85419-1.00004-9 · Cited by 7 · see citing works
Sex and age characteristics of thunderstorm asthma emergency department visits
Smith, M. L., MacLehose, R. F., Wendt, C. H., & Berman, J. D. (2024) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2024.100099 · Cited by 6 · see citing works
Year‐in‐review 2010: Asthma, COPD, cystic fibrosis and airway biology
Reddel, H. K., Lim, T. K., Mishima, M., Wainwright, C. E., & Knight, D. A. (2011) · Respirology · doi:10.1111/j.1440-1843.2011.01949.x · Cited by 5 · see citing works
European Respiratory Society Research Seminar on Preventing Pediatric Asthma
Grigg, J., Barratt, B., Bønnelykke, K., Čustović, A., Ege, M. J., Pasquali, C., Palomares, Ó., Shaheen, S. O., Sokołowska, M., Vercelli, D., et al. (2024) · Pediatric Pulmonology · doi:10.1002/ppul.27401 · Cited by 5 · see citing works
Gern, J. E., & Martínez, F. D. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.01.043 · Cited by 4 · see citing works
Validation of the Spanish language version of the control of allergic rhinitis and asthma test
Diana, Q., Alí-Munive, A., Arevalo, Y., Peter, O., & Juan, T. (2022) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-022-00313-8 · Cited by 3 · see citing works
Heterogeneity in the Diagnostic Criteria Physicians Use in Pediatric Asthma
Koumbourlis, A. C., & Pérez, G. F. (2018) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201807-457rl · Cited by 3 · see citing works
Asher, M. I., Twiss, J., & Ellwood, E. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1984-0.00044-9 · Cited by 3 · see citing works
Pieters, L. E., Vijverberg, S. J. H., Raaijmakers, J. A. M., van der Ent, C. K., & der Zee, A. H. M. (2014) · Huisarts en Wetenschap · doi:10.1007/s12445-014-0234-3 · Cited by 2 · see citing works
Dodd, K. E., & Mazurek, J. M. (2016) · Journal of Asthma · doi:10.3109/02770903.2016.1155221 · Cited by 2 · see citing works
The Epidemiology of Severe Childhood Asthma
Čustović, A., & Martínez, F. D. (2019) · Springer eBooks · doi:10.1007/978-3-030-27431-3_1 · Cited by 2 · see citing works
Impact of varying childhood asthma definitions on incidence and clinical outcomes
Ghabousian, A., Bezerra, G. N., Zhu, Z., Espinola, J. A., Sullivan, A. F., & Camargo, C. A. (2025) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2025.08.006 · Cited by 1 · see citing works
Wi, C., Pongdee, T., Seol, H. Y., Sohn, S., Sagheb, E., Kshatriya, B. S. A., Overgaard, S. M., Sharma, D. K., Moon, S., Krusemark, E. A., et al. (2025) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2025.100618 · Cited by 1 · see citing works
Application and Interpretation of Paediatric Lung Function Tests in Health and Disease
Kirkby, J. C. (2012) · UCL Discovery (University College London) · Cited by 1 · see citing works
Asthma in children : origins and outcomes
Kooijker, K. Z. (2014) · Utrecht University Repository (Utrecht University)
Epidemiology of asthma drug use in children, adolescents and young adults in Norway
Karlstad, Ø. (2011) · NORA - Norwegian Open Research Archives
Atopic Children in General Practice
Pols, D. H. J. (2017) · RePub (Erasmus University Rotterdam)
Parsons, M. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3vh5cs0j
Asthma in electronic health records: validity and phenotyping
Nissen, F. (2019) · LSHTM Research Online (London School of Hygiene and Tropical Medicine) · doi:10.17037/pubs.04653375
Future Directions in Severe Childhood Asthma
Forno, E., & Celedon, J. C. (2019) · Springer eBooks · doi:10.1007/978-3-030-27431-3_16
Patterns of Sensitization to Inhalant Allergens among Asthmatic Children in Karbala Province
Abood, H. A. A. N., Al-Musawi, Z. M., & Ghazal, M. R. I. (2013) · Karbala Journal of Medicine
Spirometric assessment in asthma in children
Stana, B. A., & Shahid, A. (2021) · Pediatru ro · doi:10.26416/pedi.62.2.2021.4890
Epidemiology of Allergic Diseases
Čustović, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-80912-2.00003-2
Astma bij kinderen voorspellen met de CAPS
van Loghum, B. S. (2015) · Praktische Huisartsgeneeskunde · doi:10.1007/s41045-015-0041-7
Validation of screening tool for diagnosis of childhood asthma by exclusion method
Kondekar, S. V., Dange, N. S., & Rathi, S. (2022) · Indian Journal of Child Health · doi:10.32677/ijch.v9i6.3263
Emmanuel, C. J., Oran, A., Jensen, E. T., Fichorova, R. N., Gower, W. A., Perrin, E. M., Sanderson, K., South, A. M., Gogcu, S., Shenberger, J. S., et al. (2024) · Pediatric Research · doi:10.1038/s41390-024-03325-x
Padró, C., Basagaña, M., Martínez-Colls, M. D. M., García-Olivé, I., Guisasola, C. P., Teniente‐Serra, A., Martínez-Cáceres, E. M., Navarro, J., & Martínez‐Rivera, C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237202
Wongyikul, P., Phinyo, P., Seephueng, P., Tanasombatkul, K., Kawamatawong, T., Wongsa, C., & Thongngarm, T. (2025) · BMC Medical Research Methodology · doi:10.1186/s12874-025-02680-5
- Authors
- Van Wonderen, K. E., Van Der Mark, L. B., Mohrs, J., Bindels, P. J. E., Van Aalderen, W. M. C., & Ter Riet, G.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Amsterdam Public Health (NL)
- ORCID
- Bindels, P.J.E.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2009-12-23
- Volume
- 36
- Issue
- 1
- Pages
- 48-56
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2144150352
- Cited by
- 100
- References
- 30
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 2 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 11 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 10 · 2013: 7 · 2012: 10
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- childhood asthma, asthma definition, outcome definitions, asthma prevalence, prediction model, posterior probability, asthma diagnosis, clinical decision-making
- MeSH terms
- Adolescent, Asthma, Child, Humans, Cohort Studies, Prevalence, Logistic Models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
