The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Detection of expiratory flow limitation in COPD using the forced oscillation technique
Open accessAbstract
Expiratory flow limitation (EFL) during tidal breathing is a major determinant of dynamic hyperinflation and exercise limitation in chronic obstructive pulmonary disease (COPD). Current methods of detecting this are either invasive or unsuited to following changes breath-by-breath. It was hypothesised that tidal flow limitation would substantially reduce the total respiratory system reactance (X rs) during expiration, and that this reduction could be used to reliably detect if EFL was present. To test this, 5‐Hz forced oscillations were applied at the mouth in seven healthy subjects and 15 COPD patients (mean±sd forced expiratory volume in one second was 36.8±11.5 % predicted) during quiet breathing. COPD breaths were analysed (n=206) and classified as flow-limited if flow decreased as alveolar pressure increased, indeterminate if flow decreased at constant alveolar pressure, or nonflow-limited. Of these, 85 breaths were flow-limited, 80 were not and 41 were indeterminate. Among other indices, mean inspiratory minus mean expiratory X rs(Δ Xrs) and minimum expiratory X rs(X exp,min) identified flow-limited breaths with 100% specificity and sensitivity using a threshold between 2.53–3.12 cmH 2 O·s·L−1(Δ Xrs) and −7.38– −6.76 cmH 2 O·s·L−1(X exp,min) representing 6.0% and 3.9% of the total range of values respectively. No flow-limited breaths were seen in the normal subjects by either method. Within-breath respiratory system reactance provides an accurate, reliable and noninvasive technique to detect expiratory flow limitation in patients with chronic obstructive pulmonary disease.
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Self-citationLung volumes and forced ventilatory flows
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Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease
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A simple method for assessing the validity of the esophageal balloon technique.
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Wave-speed limitation on expiratory flow-a unifying concept
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Physiology of obesity and effects on lung function
Salome, C. M., King, G. G., & Berend, N. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00694.2009 · Cited by 831
Long-term air pollution exposure and living close to busy roads are associated with COPD in women
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Techniques of assessing small airways dysfunction
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Flow limitation and dynamic hyperinflation: key concepts in modern respiratory physiology
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Self-citationClinical significance and applications of oscillometry
Kaminsky, D. A., Simpson, S. J., Berger, K. I., Calverley, P., de Melo, P. L., Dandurand, R., Dellacà, R. L., Farah, C. S., Farré, R., Hall, G. L., et al. (2022) · European Respiratory Review · doi:10.1183/16000617.0208-2021 · Cited by 257
Self-citation
Metadata
- Authors
- Dellacà, R. L., Santus, P., Aliverti, A., Stevenson, N., Centanni, S., Macklem, P. T., Pedotti, A., & Calverley, P. M. A.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2004-02
- Volume
- 23
- Issue
- 2
- Pages
- 232-240
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2160808191
- Cited by
- 351
- References
- 20
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dellacà, R. L., Santus, P., Aliverti, A., Stevenson, N., Centanni, S., Macklem, P. T., Pedotti, A., & Calverley, P. M. A. (2004). Detection of expiratory flow limitation in COPD using the forced oscillation technique. European Respiratory Journal. https://doi.org/10.1183/09031936.04.00046804
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