The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update
Open accessAbstract
Antimicrobial resistance is a major global concern. Tuberculosis (TB) strains resistant to rifampicin and other TB medicines challenge patient survival and public health. The World Health Organization (WHO) has published treatment guidelines for drug-resistant TB since 1997 and last updated them in 2016 based on reviews of aggregated and individual patient data from published and unpublished studies. An international expert panel formulated recommendations following the GRADE approach. The new WHO guidelines recommend a standardised 9–12 months shorter treatment regimen as first choice in patients with multidrug- or rifampicin-resistant TB (MDR/RR-TB) strains not resistant to fluoroquinolones or second-line injectable agents; resistance to these two classes of core second-line medicines is rapidly detectable with molecular diagnostics also approved by WHO in 2016. The composition of longer regimens for patients ineligible for the shorter regimen was modified. A first-ever meta-analysis of individual paediatric patient data allowed treatment recommendations for childhood MDR/RR-TB to be made. Delamanid is now also recommended in patients aged 6–17 years. Partial lung resection is a recommended option in MDR/RR-TB care. The 2016 revision highlighted the continued shortage of high-quality evidence and implementation research, and reiterated the need for clinical trials and best-practice studies to improve MDR/RR-TB patient treatment outcomes and strengthen policy.
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GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
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Self-citationGRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables
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Self-citationWHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
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Self-citationShort, Highly Effective, and Inexpensive Standardized Treatment of Multidrug-resistant Tuberculosis
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Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis
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Cited by
Mirzayev, F., Viney, K., Linh, N. N., Gonzalez-Angulo, L., Gegia, M., Jaramillo, E., Zignol, M., & Kasaeva, T. (2021) · European Respiratory Journal · doi:10.1183/13993003.03300-2020 · Cited by 301
Self-citationHead and neck tuberculosis: Literature review and meta-analysis
Qian, X., Albers, A. E., Nguyen, D. T. M., Dong, Y., Zhang, Y., Schreiber, F., Sinikovic, B., Bi, X., & Graviss, E. A. (2019) · Tuberculosis · doi:10.1016/j.tube.2019.04.014 · Cited by 60
Limenih, Y. A., & Workie, D. L. (2019) · BMC Public Health · doi:10.1186/s12889-019-6500-3 · Cited by 27
Metadata
- Authors
- Falzon, D., Schünemann, H. J., Harausz, E., González-Angulo, L., Lienhardt, C., Jaramillo, E., & Weyer, K.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2017-03
- Volume
- 49
- Issue
- 3
- Pages
- 1602308
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2603888074
- Cited by
- 420
- References
- 22
- FWCI
- 40.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Falzon, D., Schünemann, H. J., Harausz, E., González-Angulo, L., Lienhardt, C., Jaramillo, E., & Weyer, K. (2017). World Health Organization treatment guidelines for drug-resistant tuberculosis, 2016 update. European Respiratory Journal. https://doi.org/10.1183/13993003.02308-2016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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