The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age
Open accessAbstract
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene–environment interactions using longitudinal data from an established cohort study. Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups. Generalised estimating equations were used to quantify associations and the potential modifying effect of glutathioneS-transferase gene variants. Living <200 m from a major road was associated with increased prevalence of current asthma and wheeze, and lower lung function. The association between living <200 m from a major road and current asthma and wheeze was more marked for carriers of theGSTT1null andGSTP1 val/valorile/valgenotypes. Over the 5-year period, higher NO2exposures were associated with increased current asthma prevalence. Higher NO2exposure was associated with lower forced vital capacity for carriers of theGSTT1null genotype. TRAP exposures were associated with increased risk of asthma, wheeze and lower lung function in middle-aged adults. The interaction with theGSTT1genotype suggests that deficient antioxidant mechanisms may play a role in these adverse health effects.
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“Residential markers of traffic-related air pollution, including nitrogen dioxide (NO2) exposure and distance to major roads, have been associated with increased risk for new-onset asthma, persistence of asthma and current asthma in a middle-aged, asthma-enriched, population-based cohort (125).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [125]
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Oxidative Stress and Antioxidant Defense
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1 of the 40 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Curjuric, 2009, HMOX1 and GST variants modify attenuation of FEF25–75% decline due to PM10 reduction, Eur Respir J, 35, 505
- HEI Panel on the Health Effects of Traffic-Related Air Pollution . Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects. Special Report. Boston, Health Effects Institute, 2010.
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Items 101–111 of 111
Zaccarelli-Marino, M. A., Balderi, T. Z., Crepaldi, F. M., Alessi, R., & Martins, M. A. (2022) · Fortune Journal of Health Sciences · doi:10.26502/fjhs.046
Effects of the COVID-19 Quarantine Measures on PM2.5, PM10 and NO2 Concentration Levels in Serbia
Bežanović, V., Novaković, M., Milovanović, D., Čepić, Z. M., & Adamović, D. (2022) · Polish Journal of Environmental Studies · doi:10.15244/pjoes/147591
Vilcins, D., Lee, W. R., Pham, C., Tanner, S., Knibbs, L. D., Burgner, D. P., Blake, T. L., Mansell, T., Ponsonby, A., Sly, P. D., et al. (2023) · medRxiv · doi:10.1101/2023.10.13.23296994
Self-citationResearch on air pollution by PM10 and NO2 pollutants in Slovakia from 2016 to 2022 years
Cimbala, J. (2024) · Geografická revue/Geografická revue · doi:10.24040/gr.2024.20.1.4-28
Mukherjee, S., Haldar, S., Paul, S., & Ghosh, S. (2025) · Atmospheric Pollution Research · doi:10.1016/j.apr.2025.102517
Bouma, F., Nyberg, F., Olin, A.-C., & Carlsen, H. K. (2024) · Figshare · doi:10.6084/m9.figshare.26600758
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Leung, C., Ryu, M. H., Bølling, A. K., Maestre‐Batlle, D., Rider, C. F., Hüls, A., Urtatiz, O., MacIsaac, J. L., Lau, K. S.-K., Lin, D. T. S., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21151262
Gagnon, L. G., Yang, L. H., Mickley, L. J., & Oak, Y. J. (2026) · Atmospheric Environment · doi:10.1016/j.atmosenv.2026.122176
Meng, Y., Lim, J. S., Chen, C., Rider, C. F., Ryu, M. H., & Carlsten, C. (2026) · European Respiratory Review · doi:10.1183/16000617.0326-2025
Metadata
- Authors
- Bowatte, G., Erbas, B., Lodge, C. J., Knibbs, L. D., Gurrin, L. C., Marks, G. B., Thomas, P. S., Johns, D. P., Giles, G. G., Hui, J., Dennekamp, M., Perret, J. L., Abramson, M. J., Walters, E. H., Matheson, M. C., & Dharmage, S. C.
- Affiliations
- The University of Melbourne (AU)
- La Trobe University (AU)
- The University of Queensland (AU)
- The University of Sydney (AU)
- UNSW Sydney (AU)
- University of Tasmania (AU)
- The University of Western Australia (AU)
- University of Limerick (IE)
- Monash University (AU)
- ORCID
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2017-10
- Volume
- 50
- Issue
- 4
- Pages
- 1602357
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2765204948
- Cited by
- 111
- References
- 40
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 17 · 2021: 13 · 2020: 20 · 2019: 15 · 2018: 9
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UTAS Research Repository (submittedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- traffic-related air pollution, asthma, wheezing, lung function, nitrogen dioxide, gene-environment interaction, glutathione S-transferase, GSTT1, GSTP1, antioxidant defense, middle-aged adults, Tasmanian Longitudinal Health Study
- MeSH terms
- Air Pollution, Asthma, Australia, Cross-Sectional Studies, Environmental Exposure, Female, Glutathione Transferase, Heterozygote, Humans, Longitudinal Studies, Lung, Male, Middle Aged, Nitrogen Dioxide, Respiratory Sounds, Severity of Illness Index, Vital Capacity, Multivariate Analysis, Logistic Models, Risk Assessment, Gene-Environment Interaction
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