Angiotensin II revisited: new roles in inflammation, immunology and aging
Open accessAbstract
That the renin-angiotensin system (RAS) is involved in regulation of blood pressure, vasoconstriction, sodium intake and potassium excretion is well established. Studies in the last few years have however documented new roles for this molecule as a pro-inflammatory molecule and more recently as a possible pro-fibrotic agent that contributes to progressive deterioration of organ function in disease. Binding of Ang II to its receptors (in particular AT(1)) mediates intracellular free radical generation that contributes to tissue damage by promoting mitochondrial dysfunction. Blocking Ang II signalling protects against neurodegenerative processes and promotes longevity in rodents. Altogether these findings open the unanticipated perspective for exploring Ang II signalling in therapeutic interventions in inflammatory diseases and aging-related tissue injury. This review extends from the discovery of Ang II and its implications in renal and cardiovascular physiology to cover the roles of the system in inflammation, tissue injury, autoimmunity, oxidative stress and aging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
For males, no significant GO terms were identified at 25% FDR; the strongest enrichment with nominal P<0.001 involved immune responses to accumulation of amyloid-β in the brain, such as regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, and other biological processes recently implicated in AD such as response to angiotensin [
“For males, we did not identify any significant GO terms at 25% FDR; the strongest enrichment with nominal P-value less than 0.001 involved immune responses to the accumulation of amyloid-β (Aβ) in the brain, such as regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, and other biological processes recently implicated in AD such”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [58]
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredLocal RAAS pathways support pro-inflammatory, proliferative, and profibrotic activities via angiotensin type 1 receptors that couple to Gq and Gαi.
“While systemic effects of angiotensin II are related to hemodynamic and metabolic functions (see above), local RAAS pathways support pro-inflammatory, proliferative, and profibrotic activities via angiotensin type (AT)1 receptors that couple to G proteins of the type Gq and Gαi (recently summarized in [137]).”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [137]
In different organs such as kidney, heart, and vasculature, angiotensin II induces an inflammatory response by fostering expression of pro-inflammatory chemokines responsible for tissue accumulation of immunocompetent cells.
“In different organs such as kidney, heart, and vasculature, angiotensin II induces an inflammatory response by fostering the expression of pro-inflammatory chemokines, responsible for tissue accumulation of immunocompetent cells [137].”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [137]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P., & Soubrier, F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114844 · Cited by 3,767 · see citing works
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735 · see citing works
STUDIES ON EXPERIMENTAL HYPERTENSION
Goldblatt, H., Lynch, J., Hanzal, R. F., & Summerville, W. W. (1934) · The Journal of Experimental Medicine · doi:10.1084/jem.59.3.347 · Cited by 2,145 · see citing works
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
Marc De Gasparo, B., Catt, K. J., Inagami, T., Wright, J. W., & Unger, T. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01458-3 · Cited by 2,131 · see citing works
Evolving functions of endothelial cells in inflammation
Pober, J. S., & Sessa, W. C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2171 · Cited by 2,022 · see citing works
Ondetti, M. A., Rubin, B., & Cushman, D. W. (1977) · Science · doi:10.1126/science.191908 · Cited by 1,866 · see citing works
Angiotensin II receptors and angiotensin II receptor antagonists.
Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P. A., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,854 · see citing works
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736 · see citing works
Angiotensin-converting enzyme 2 is an essential regulator of heart function
Crackower, M. A., Sarao, R., Oudit, G. Y., Yagil, C., Kozieradzki, I., Scanga, S. E., Oliveira-dos-Santos, A. J., da Costa, J., Zhang, L., Pei, Y., et al. (2002) · Nature · doi:10.1038/nature00786 · Cited by 1,733 · see citing works
Transcriptional control of the inflammatory response
Medzhitov, R., & Horng, T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2634 · Cited by 1,035 · see citing works
Molecular and Cellular Mechanisms of Angiotensin II-Mediated Cardiovascular and Renal Diseases
Kim, S., & Iwao, H. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01434-0 · Cited by 985 · see citing works
Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection
Dragun, D., Müller, D. N., Bräsen, J. H., Fritsche, L., Nieminen-Kelhä, M., Dechend, R., Kintscher, U., Rudolph, B. D., Hoebeke, J., Eckert, D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa035717 · Cited by 868 · see citing works
Interleukin 17 Promotes Angiotensin II–Induced Hypertension and Vascular Dysfunction
Madhur, M. S., Lob, H. E., McCann, L. A., Iwakura, Y., Blinder, Y., Guzik, T. J., & Harrison, D. G. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.145094 · Cited by 829 · see citing works
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor
Wallukat, G., Homuth, V., Fischer, T., Lindschau, C., Horstkamp, B., Jüpner, A., Baur, E., Nissen, E., Vetter, K. J., Neichel, D., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4106 · Cited by 825 · see citing works
Tigerstedt, R., & Bergman, P. Q. (1898) · Skandinavisches Archiv Für Physiologie · doi:10.1111/j.1748-1716.1898.tb00272.x · Cited by 797 · see citing works
Singh, K. D., & Karnik, S. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00020-9 · Cited by 705 · see citing works
Inflammation and angiotensin II
Suzuki, Y., Ruiz‐Ortega, M., Lorenzo, Ó., Rupérez, M., Esteban, V., & Egido, J. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00271-6 · Cited by 696 · see citing works
Renin-angiotensin system and cardiovascular risk
Schmieder, R. E., Hilgers, K. F., Schlaich, M. P., & Schmidt, B. M. W. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60242-6 · Cited by 659 · see citing works
Regulation of blood pressure by the type 1A angiotensin II receptor gene.
Ito, M., Oliverio, M. I., Mannon, P., Best, C. F., Maeda, N., Smithies, O., & Coffman, T. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3521 · Cited by 610 · see citing works
Hunyady, L., & Catt, K. J. (2006) · Molecular Endocrinology · doi:10.1210/me.2004-0536 · Cited by 541 · see citing works
Pueyo, M. E., Gonzalez, W., Nicoletti, A., Savoie, F., Arnal, J., & Michel, J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.3.645 · Cited by 516 · see citing works
Li, N.-C., Lee, A., Whitmer, R. A., Kivipelto, M., Lawler, E., Kazis, L. E., & Wolozin, B. (2010) · BMJ · doi:10.1136/bmj.b5465 · Cited by 486 · see citing works
Disruption of the Ang II type 1 receptor promotes longevity in mice
Benigni, A., Corna, D., Zoja, C., Sonzogni, A., Latini, R., Salio, M., Conti, S., Rottoli, D., Longaretti, L., Cassis, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36703 · Cited by 486 · see citing works
Self-citationAngiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice
Zhou, C. C., Zhang, Y., Irani, R. A., Zhang, H., Mi, T., Popek, E. J., Hicks, J. M., Ramin, S. M., Kellems, R. E., & Xia, Y. (2008) · Nature Medicine · doi:10.1038/nm.1856 · Cited by 470 · see citing works
Renin-Angiotensin-Aldosterone System and Progression of Renal Disease
Rüster, C., & Wolf, G. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006040356 · Cited by 462 · see citing works
Page, I. H., & Helmer, O. M. (1940) · The Journal of Experimental Medicine · doi:10.1084/jem.71.1.29 · Cited by 435 · see citing works
Role of the renin–angiotensin system in vascular inflammation
Marchesi, C., Paradis, P., & Schiffrin, E. L. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.05.003 · Cited by 432 · see citing works
Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart.
Urata, H., Boehm, K. D., Philip, A., Kinoshita, A., Gabrovsek, J., Bumpus, F. M., & Husain, A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116325 · Cited by 398 · see citing works
The renin-angiotensin-aldosterone system and the kidney: effects on kidney disease
Brewster, U. C., & Perazella, M. A. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.034 · Cited by 390 · see citing works
The substance causing renal hypertension
Braun-Menendez, E., Fasciolo, J. C., Leloir, L. F., & Muñoz, J. M. (1940) · The Journal of Physiology · doi:10.1113/jphysiol.1940.sp003850 · Cited by 365 · see citing works
Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage
Kvakan, H., Kleinewietfeld, M., Qadri, F., Park, J.-K., Fischer, R., Schwarz, I., Rahn, H.-P., Plehm, R., Wellner, M., Elitok, S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.832782 · Cited by 339 · see citing works
Wang, J., Ho, L., Chen, L., Zhao, Z., Zhao, W., Qian, X., Humala, N., Seror, I., Bartholomew, S. R., Rosendorff, C., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31547 · Cited by 331 · see citing works
Karlsson, C., Lindell, K., Ottosson, M., Sjöström, L., Carlsson, B., & Carlsson, L. M. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.11.5276 · Cited by 325 · see citing works
Platten, M., Youssef, S., Hur, E. M., Ho, P. P.-K., Han, M. H., Lanz, T. V., Phillips, L., Goldstein, M. J., Bhat, R., Raine, C. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903958106 · Cited by 321 · see citing works
Immunosuppressive Treatment Protects Against Angiotensin II-Induced Renal Damage
Müller, D. N., Shagdarsuren, E., Park, J.-K., Dechend, R., Mervaala, E. M. A., Hampich, F., Fiebeler, A., Ju, X., Finckenberg, P., Theuer, J., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64445-8 · Cited by 278 · see citing works
Angiotensin-Converting Enzyme II in the Heart and the Kidney
Danilczyk, U. G., & Penninger, J. M. (2006) · Circulation Research · doi:10.1161/01.res.0000205761.22353.5f · Cited by 271 · see citing works
Regulation of T-cell function by endogenously produced angiotensin II
Hoch, N. E., Guzik, T. J., Chen, W., Deans, T., Maalouf, S., Gratze, P., Weyand, C. M., & Harrison, D. G. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90521.2008 · Cited by 263 · see citing works
Blood pressure and dietary salt in human populations
Gleibermann, L. (1973) · Ecology of Food and Nutrition · doi:10.1080/03670244.1973.9990329 · Cited by 261 · see citing works
The AT2 receptor—A matter of love and hate
Steckelings, U. M., Kaschina, E., & Unger, T. (2005) · Peptides · doi:10.1016/j.peptides.2005.03.010 · Cited by 257 · see citing works
Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression
Ohrui, T., Tomita, N., Satoh‐Nakagawa, T., Matsui, T., Maruyama, M., Niwa, K., Arai, H., & Sasaki, H. (2004) · Neurology · doi:10.1212/01.wnl.0000140705.23869.e9 · Cited by 246 · see citing works
Smith, H. W. (1953) · ETHZ Thomas Mann Archiv · doi:10.24448/ethz-1890 · Cited by 242 · see citing works
Cardiovascular risk factors and Alzheimer’s disease
Luchsinger, J. A., & Mayeux, R. P. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0056-z · Cited by 238 · see citing works
Esteban, V., Lorenzo, Ó., Accent]rez, M. A. A. R. A., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000130564.75008.f5 · Cited by 234 · see citing works
Wolf, G., Wenzel, U. O., Burns, K. D., Harris, R. C., Stahl, R. A. K., & Thaiss, F. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00365.x · Cited by 226 · see citing works
Chymase Is Upregulated in Diabetic Nephropathy
Huang, X. R., Chen, W. Y., Truong, L. D., & Lan, H. Y. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000071512.93927.4e · Cited by 226 · see citing works
Differential expression of angiotensin receptor 1A and 1B in mouse
Burson, J. M., Aguilera, G., Gross, K. W., & Sigmund, C. D. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e260 · Cited by 225 · see citing works
Savaskan, E., Höck, C., Olivieri, G., Bruttel, S., Rosenberg, C., Hulette, C., & Müller-Spahn, F. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00259-1 · Cited by 217 · see citing works
Human T and Natural Killer Cells Possess a Functional Renin-Angiotensin System
Jurewicz, M. M., McDermott, D. H., Sechler, J. M. G., Tinckam, K. J., Takakura, A., Carpenter, C. B., Milford, E. L., & Abdi, R. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070707 · Cited by 211 · see citing works
Angiotensin Production by the Heart
van Kats, J. P., Danser, A. H. J., van Meegen, J. R., SASSEN, L. M. A., Verdouw, P. D., & Schalekamp, M. A. D. H. (1998) · Circulation · doi:10.1161/01.cir.98.1.73 · Cited by 206 · see citing works
Divergent functions of angiotensin II receptor isoforms in the brain
Davisson, R. L., Oliverio, M. I., Coffman, T. M., & Sigmund, C. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10022 · Cited by 202 · see citing works
Role of Remission Clinics in the Longitudinal Treatment of CKD
Ruggenenti, P. L., Perticucci, E., Cravedi, P., Gambara, V., Costantini, M., Sharma, S. K., Perna, A., & Remuzzi, G. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007090970 · Cited by 200 · see citing works
Self-citationKarlsson, C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.11.3925 · Cited by 197 · see citing works
Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system
Stegbauer, J., Lee, D.-H., Seubert, S., Ellrichmann, G., Manzel, A., Kvakan, H., Müller, D. N., Gaupp, S., Rump, L. C., Gold, R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903602106 · Cited by 193 · see citing works
Enalapril and losartan attenuate mitochondrial dysfunction in aged rats
de Cavanagh, E. M. V., Piotrkowski, B., Basso, N., Stella, I., Inserra, F., Ferder, L., & Fraga, C. G. (2003) · The FASEB Journal · doi:10.1096/fj.02-0063fje · Cited by 185 · see citing works
Enhancement of Angiotensinogen Expression in Angiotensin II–Dependent Hypertension
Kobori, H., Harrison‐Bernard, L. M., & Navar, L. G. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1329 · Cited by 184 · see citing works
Direct evidence of leukocyte adhesion in arterioles by angiotensin II
Álvarez, Á., Cerdá‐Nicolás, M., Nabah, Y. N. A., Mata, M., Issekutz, A. C., Panés, J., Lobb, R. R., & Sanz, M. (2004) · Blood · doi:10.1182/blood-2003-08-2974 · Cited by 180 · see citing works
Upregulation of vascular endothelial growth factor by angiotensin II in rat heart endothelial cells
Chua, C. C., Hamdy, R. C., & Chua, B. H. L. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)00129-8 · Cited by 178 · see citing works
Signaling by the Angiotensin-Converting Enzyme
Fleming, I. (2006) · Circulation Research · doi:10.1161/01.res.0000217340.40936.53 · Cited by 171 · see citing works
Kobori, H., Prieto‐Carrasquero, M. C., Ozawa, Y., et al. (2004) · Hypertension · doi:10.1161/01.hyp.0000122875.91100.28 · Cited by 168 · see citing works
Miners, J. S., Ashby, E., Helmond, Z. V., Chalmers, K. A., Palmer, L. E., Love, S., & Kehoe, P. G. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00885.x · Cited by 166 · see citing works
Angiotensins in Alzheimer's disease – friend or foe?
Kehoe, P. G., Miners, J. S., & Love, S. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.07.006 · Cited by 166 · see citing works
Protective effect of long-term angiotensin II inhibition
Basso, N., Cini, R., Pietrelli, A., Ferder, L., Terragno, N. A., & Inserra, F. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00393.2007 · Cited by 165 · see citing works
Donadelli, R., Abbate, M., Zanchi, C., Corna, D., Tomasoni, S., Benigni, A., Remuzzi, G., & Zoja, C. (2000) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2000.19838 · Cited by 161 · see citing works
Self-citationPiqueras, L., Kubes, P., Álvarez, Á., O’Connor, E., Issekutz, A. C., Esplugues, J. V., & Sanz, M. (2000) · Circulation · doi:10.1161/01.cir.102.17.2118 · Cited by 161 · see citing works
Bush, E. L., Maeda, N., Kuziel, W. A., et al. (2000) · Hypertension · doi:10.1161/01.hyp.36.3.360 · Cited by 160 · see citing works
Arregui, A., Perry, E. K., Rossor, M. N., & Tomlinson, B. E. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb07930.x · Cited by 156 · see citing works
Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension
Crowley, S. D., Frey, C. W., Gould, S., et al. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00527.2007 · Cited by 155 · see citing works
Angiotensin III: a central regulator of vasopressin release and blood pressure
Goazigo, A. R.-L., Fournié-Zaluski, M. C., & Llorens‐Cortés, C. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00381-2 · Cited by 149 · see citing works
Remuzzi, G., Zoja, C., Gagliardini, E., et al. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1071542 · Cited by 142 · see citing works
Self-citationNakajima, T., Wooding, S., Sakagami, T., Emi, M., Tokunaga, K., Tamiya, G., Ishigami, T., Umemura, S., Munkhbat, B., Jin, F., et al. (2004) · American Journal of Human Genetics · doi:10.1086/420793 · Cited by 140 · see citing works
Ji, Y., Liu, J.-T., Wang, Z., & Liu, N. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000218173 · Cited by 139 · see citing works
The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor
Porrello, E. R. (2009) · Frontiers in bioscience · doi:10.2741/3289 · Cited by 131 · see citing works
Shah, K. R., Qureshi, S. U., Johnson, M. L., Parikh, N. M., Schulz, P. E., & Kunik, M. E. (2009) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2009.11.001 · Cited by 130 · see citing works
Benigni, A., Morigi, M., & Remuzzi, G. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60237-1 · Cited by 130 · see citing works
Self-citationAngiotensin II- and IV-induced changes in cerebral blood flow
Kramár, E. A., Harding, J. W., & Wright, J. W. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(96)02116-7 · Cited by 128 · see citing works
What?s new in the renin-angiotensin system?
Ferrario, C. M., & Chappell, M. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4243-4 · Cited by 127 · see citing works
From Mitochondria to Disease: Role of the Renin-Angiotensin System
de Cavanagh, E. M. V., Inserra, F., Ferder, M., & Ferder, L. (2007) · American Journal of Nephrology · doi:10.1159/000107757 · Cited by 124 · see citing works
Control of dendritic cell differentiation by angiotensin II
Nahmod, K. A., Vermeulen, M. E., Radien, S., Salamone, G. V., Gamberale, R., Fernández‐Calotti, P., Alvarez, A. L., Nahmod, V. E., Giordano, M., & Geffner, J. R. (2003) · The FASEB Journal · doi:10.1096/fj.02-0755fje · Cited by 124 · see citing works
Suggested Revision of Nomenclature--Angiotensin
Braun-Menendez, E., & Page, I. H. (1958) · Science · doi:10.1126/science.127.3292.242-a · Cited by 121 · see citing works
Ruiz‐Ortega, M., Lorenzo, Ó., & Egido, J. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00089.x · Cited by 116 · see citing works
Tissue Angiotensin II Generating System by Angiotensin-Converting Enzyme and Chymase
Miyazaki, M., & Takai, S. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cpj06008x · Cited by 110 · see citing works
Angiotensin II–Dependent Superoxide
Welch, W. J. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.090472 · Cited by 109 · see citing works
Ruggenenti, P. L., Bettinaglio, P., Pinares, F., et al. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04140907 · Cited by 108 · see citing works
Role of oxidative stress and AT<sub>1</sub> receptors in cerebral vascular dysfunction with aging
Modrick, M. L., Didion, S. P., Sigmund, C. D., & Faraci, F. M. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00300.2009 · Cited by 108 · see citing works
López-Real, A. M., Rey, P., Soto‐Otero, R., Méndez‐Álvarez, E., & Labandeira-García, J. L. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20598 · Cited by 107 · see citing works
The intracrine hypothesis: An update
Ré, R. N., & Cook, J. L. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.09.012 · Cited by 100 · see citing works
The role of the central renin-angiotensin system in Parkinson’s disease
Mertens, B., Vanderheyden, P., Michotte, Y. M., & Sarre, S. (2009) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320309347789 · Cited by 99 · see citing works
Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection
Perico, N., Benigni, A., & Remuzzi, G. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2685 · Cited by 95 · see citing works
Self-citationCrowley, S. D., Vasievich, M. P., Ruiz, P., Gould, S., Parsons, K. K., Pazmino, A. K., Facemire, C. S., Chen, B. J., Kim, H., Tran, T. T., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci34862 · Cited by 95 · see citing works
Signaling mechanisms of angiotensin II in regulating vascular senescence
Min, L., Mogi, M., Iwai, M., & Horiuchi, M. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.12.002 · Cited by 93 · see citing works
Dai, Q., Xu, M., Yao, M., & Sun, B. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707454 · Cited by 90 · see citing works
Muñoz, A., Rey, P., Guerra, M. J., Méndez‐Álvarez, E., Soto‐Otero, R., & Labandeira-García, J. L. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.03.004 · Cited by 88 · see citing works
Aguilera, G. (1992) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(92)90101-b · Cited by 87 · see citing works
Renal expression of angiotensin type 2 (AT2) receptors during kidney damage
Ruiz‐Ortega, M., Esteban, V., Suzuki, Y., et al. (2003) · Kidney International · doi:10.1046/j.1523-1755.64.s86.5.x · Cited by 85 · see citing works
Yang, J., Jiang, H., Yang, J., et al. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0098-1 · Cited by 82 · see citing works
Irani, R. A., Zhang, Y., Blackwell, S. C., Zhou, C. C., Ramin, S. M., Kellems, R. E., & Xia, Y. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090872 · Cited by 79 · see citing works
Effects of Antihypertensive Drug Treatment on the Risk of Dementia and Cognitive Impairment
Poon, I. O. (2008) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.28.3.366 · Cited by 78 · see citing works
Cesari, M., Rossi, G. P., & Pessina, A. C. (2002) · Journal of Hypertension · doi:10.1097/00004872-200205000-00002 · Cited by 75 · see citing works
Wilson, S. K. (1990) · Circulation Research · doi:10.1161/01.res.66.3.722 · Cited by 73 · see citing works
Benndorf, R. A., Krebs, C. F., Hirsch-Hoffmann, B., Schwedhelm, E., Cieslar, G., Schmidt-Haupt, R., Steinmetz, O. M., Meyer‐Schwesinger, C., Thaiss, F., Haddad, M., et al. (2009) · Kidney International · doi:10.1038/ki.2009.2 · Cited by 72 · see citing works
Renin Is Expressed in Rat Macrophage/Monocyte Cells
Iwai, N., Inagami, T., Ohmichi, N., & Kinoshita, M. (1996) · Hypertension · doi:10.1161/01.hyp.27.3.399 · Cited by 71 · see citing works
Candesartan attenuates Angiotensin II-induced mesangial cell apoptosis via TLR4/MyD88 pathway
Lv, J., Jia, R., Yang, D., Zhu, J., & Ding, G. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.035 · Cited by 71 · see citing works
Activation and suppression of renin–angiotensin system in human dendritic cells
Lapteva, N., Ide, K., Nieda, M., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00855-0 · Cited by 68 · see citing works
Wu, R., Laplante, M., & de Champlain, J. (2005) · Hypertension · doi:10.1161/01.hyp.0000164572.92049.29 · Cited by 68 · see citing works
A role for the angiotensin IV/AT4 system in mediating natriuresis in the rat
Hamilton, T. A., Handa, R. K., Harding, J. W., et al. (2001) · Peptides · doi:10.1016/s0196-9781(01)00405-3 · Cited by 67 · see citing works
Advances in our understanding of aging: role of the renin–angiotensin system
Ferder, L. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00139-x · Cited by 61 · see citing works
Wright, J. W., & Harding, J. W. (2008) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320308099084 · Cited by 59 · see citing works
Ito, N., Ohishi, M., Yamamoto, K. I., et al. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2007.02.004 · Cited by 55 · see citing works
KITAYAMA, H., Maeshima, Y., Takazawa, Y., et al. (2006) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.09.022 · Cited by 50 · see citing works
Ghiani, B. U., & Masini, M. A. (1995) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(95)00030-b · Cited by 49 · see citing works
Bacani, C. J., & Frishman, W. H. (2006) · Cardiology in Review · doi:10.1097/01.crd.0000195220.62533.c5 · Cited by 48 · see citing works
Salt and hypertension: a phylogenetic perspective
Lev-Ran, A., & Porta, M. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.539 · Cited by 46 · see citing works
Thekkumkara, T., Cookson, R., & Linas, S. L. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.274.5.f897 · Cited by 43 · see citing works
The immunocytochemical localization of angiotensinogen in the rat ovary
Thomas, W. G., & Sernia, C. (1990) · Cell and Tissue Research · doi:10.1007/bf00318679 · Cited by 37 · see citing works
Suppression of Experimental Autoimmune Uveitis by Angiotensin II Type 1 Receptor Blocker Telmisartan
Okunuki, Y., Usui, Y., Nagai, N., Kezuka, T., Ishida, S., Takeuchi, M., & Gotô, H. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2649 · Cited by 35 · see citing works
The angiotensin II type 2 receptor: What is its clinical significance?
Schulman, I. H., & Raij, L. R. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0036-8 · Cited by 34 · see citing works
Lapteva, N., Nieda, M., Ando, Y., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5215 · Cited by 34 · see citing works
de Cavanagh, E. M. V., Flores, I., Ferder, M., Inserra, F., & Ferder, L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.08.007 · Cited by 30 · see citing works
Renal Medicine 3 Kidney regeneration
Negri, M., Morigi, M., Remuzzi, G., & Benigni, A. (2010) · Cited by 28 · see citing works
Self-citationAngiotensin II receptor subtype distribution in the rabbit brain
Moulik, S., Speth, R. C., Turner, B., et al. (2002) · Experimental Brain Research · doi:10.1007/s00221-001-0940-5 · Cited by 25 · see citing works
Angiotensin II Receptor Physiology Using Gene Targeting
Oliverio, M. I., & Coffman, T. M. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.4.171 · Cited by 24 · see citing works
Effects of angiotensin-II receptor blockers on experimental autoimmune myocarditis
Liu, X., Zhu, X., Wang, A., Fan, H. Z., & Yuan, H. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.09.540 · Cited by 19 · see citing works
Thermal Decomposition of 8-Quinolinol Chelates of Silver (I)
Wendlandt, W. W., & Tassel, J. H. V. (1958) · Science · doi:10.1126/science.127.3292.242 · Cited by 18 · see citing works
Mello, W. D. (2003) · Regulatory Peptides · doi:10.1016/s0167-0115(03)00121-6 · Cited by 16 · see citing works
The Metabolic Response to Trauma
Rhoads, J. E., Roberts, B., & Helwig, J. (1956) · Annual Review of Medicine · doi:10.1146/annurev.me.07.020156.001041 · Cited by 15 · see citing works
Valsartan inhibited the accumulation of dendritic cells in rat fibrotic renal tissue.
Wu, K., Zhou, T., Sun, G., et al. (2006) · PubMed · Cited by 15 · see citing works
Natural Selection: Sign, Sign, Everywhere a Sign
Wooding, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.041 · Cited by 9 · see citing works
Yun, A. J., Doux, J. D., & Lee, P. Y. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.10.019 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cross talk between mitochondria and NADPH oxidases
Dikalov, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.033 · Cited by 783 · see citing works
Renal Aging: Causes and Consequences
O’Sullivan, E. D., Hughes, J., & Ferenbach, D. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121308 · Cited by 484 · see citing works
Calcific aortic valve disease: mechanisms, prevention and treatment
Moncla, L.-H. M., Briend, M., Bossé, Y., & Mathieu, P. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00845-7 · Cited by 319 · see citing works
Kidney and eye diseases: Common risk factors, etiological mechanisms, and pathways
Wong, C. W., Wong, T. Y., Cheng, C.-Y., & Sabanayagam, C. (2014) · Kidney International · doi:10.1038/ki.2013.491 · Cited by 276 · see citing works
Molecular mechanisms of renal aging
Schmitt, R., & Melk, A. (2017) · Kidney International · doi:10.1016/j.kint.2017.02.036 · Cited by 235 · see citing works
Protecting against vascular disease in brain
Faraci, F. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01310.2010 · Cited by 196 · see citing works
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
Bekassy, Z., Lopatko Fagerström, I., Bader, M., & Karpman, D. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-021-00634-8 · Cited by 167 · see citing works
NADPH Oxidases and Mitochondria in Vascular Senescence
Salazar, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051327 · Cited by 133 · see citing works
Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“While systemic effects of angiotensin II are related to hemodynamic and metabolic functions (see above), local RAAS pathways support pro-inflammatory, proliferative, and profibrotic activities via angiotensin type (AT)1 receptors that couple to G proteins of the type Gq and Gαi (recently summarized in [137]).”
BackgroundEffects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney
Jang, I.-A., Kim, E. N., Lim, J. H., Kim, M. Y., Ban, T. H., Yoon, H. E., Park, C. W., Chang, Y. S., & Choi, B. S. (2018) · Nutrients · doi:10.3390/nu10111741 · Cited by 110 · see citing works
Liu, H., Naxerova, K., Pinter, M., Incio, J., Lee, H., Shigeta, K., Ho, W. W., Crain, J. A., Jacobson, A., Michelakos, T., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0256 · Cited by 96 · see citing works
Bild, W., Hritcu, L., Stefanescu, C., & Ciobica, A. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.009 · Cited by 83 · see citing works
Shah, H., Khan, M. S. H., Dhurandhar, N. V., & Hegde, V. (2021) · Acta Diabetologica · doi:10.1007/s00592-020-01636-z · Cited by 80 · see citing works
Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients
van Lier, D., Kox, M., Santos, K., van der Hoeven, H., Pillay, J., & Pickkers, P. (2021) · ERJ Open Research · doi:10.1183/23120541.00848-2020 · Cited by 73 · see citing works
Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01177-8 · Cited by 58 · see citing works
“001 involved immune responses to the accumulation of amyloid-β (Aβ) in the brain, such as regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, and other biological processes recently implicated in AD such as response to angiotensin [57, 58] and cell…”
BackgroundBeck, T. N., Nicolas, E., Kopp, M. C., & Golemis, E. A. (2014) · Oncoscience · doi:10.18632/oncoscience.64 · Cited by 50 · see citing works
Effect of renin–angiotensin system on senescence
Mogi, M. (2020) · Geriatrics & Gerontology International · doi:10.1111/ggi.13927 · Cited by 48 · see citing works
Linking chronic kidney disease and Parkinson’s disease: a literature review
Meléndez-Flores, J. D., & Estrada-Bellmann, I. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-020-00623-1 · Cited by 44 · see citing works
Insights in Chloroquine Action: Perspectives and Implications in Malaria and <scp>COVID</scp>‐19
Pillat, M. M., Krüger, A., Guimarães, L. M. F., Lameu, C., de Souza, E. E., Wrenger, C., & Ulrich, H. (2020) · Cytometry Part A · doi:10.1002/cyto.a.24190 · Cited by 17 · see citing works
- Authors
- Benigni, A., Cassis, P., & Remuzzi, G.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- Corresponding author
- Remuzzi, Giuseppe
- Venue
- EMBO Molecular Medicine
- Published
- 2010-07-01
- Volume
- 2
- Issue
- 7
- Pages
- 247-257
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC3377325
- OpenAlex
- W2148802014
- Cited by
- 757
- References
- 133
- Citations by year
- 2026: 35 · 2025: 44 · 2024: 68 · 2023: 68 · 2022: 72 · 2021: 116 · 2020: 90 · 2019: 33 · 2018: 48 · 2017: 26 · 2016: 25 · 2015: 36 · 2014: 27 · 2013: 19 · 2012: 24
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Keywords
- angiotensin II, renin-angiotensin system, inflammation, immunology, aging, angiotensin II type 1 receptor, oxidative stress, mitochondrial dysfunction, free radicals, fibrosis, autoimmunity, neurodegeneration, longevity, tissue damage, blood pressure regulation
- MeSH terms
- Aging, Angiotensin II, Humans, Inflammation, Receptors, Angiotensin, Renin-Angiotensin System, Signal Transduction, Autoimmunity, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
