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Cited by 310

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Quantitative trait loci mapping in dairy cattle: review and meta-analysis

Open access
Khatkar, Mehar S, Thomson, Peter C, Tammen, Imke, Raadsma, Herman W·2004·Genetics Selection Evolution

Abstract

From an extensive review of public domain information on dairy cattle quantitative trait loci (QTL), we have prepared a draft online QTL map for dairy production traits. Most publications (45 out of 55 reviewed) reported QTL for the major milk production traits (milk, fat and protein yield, and fat and protein concentration (%)) and somatic cell score. Relatively few QTL studies have been reported for more complex traits such as mastitis, fertility and health. The collated QTL map shows some chromosomal regions with a high density of QTL, as well as a substantial number of QTL at single chromosomal locations. To extract the most information from these published records, a meta-analysis was conducted to obtain consensus on QTL location and allelic substitution effect of these QTL. This required modification and development of statistical methodologies. The meta-analysis indicated a number of consensus regions, the most striking being two distinct regions affecting milk yield on chromosome 6 at 49 cM and 87 cM explaining 4.2 and 3.6 percent of the genetic variance of milk yield, respectively. The first of these regions (near marker BM143) affects five separate milk production traits (protein yield, protein percent, fat yield, fat percent, as well as milk yield).

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Metadata

Authors
Khatkar, M. S., Thomson, P. C., Tammen, I., & Raadsma, H. W.
Venue
Genetics Selection Evolution
Published
2004-03-15
Volume
36
Issue
2
Pages
163-90
ISSN
  • 0999-193X (ISSN-L)
  • 1297-9686
OpenAlex
W2067569885
Cited by
310
References
42
FWCI
12.80
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Quantitative trait loci mapping in dairy cattle: review and meta-analysis. https://app.cochat.ai/papers/10.1186/1297-9686-36-2-163
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Khatkar, M. S., Thomson, P. C., Tammen, I., & Raadsma, H. W. (2004). Quantitative trait loci mapping in dairy cattle: review and meta-analysis. Genetics Selection Evolution. https://doi.org/10.1186/1297-9686-36-2-163

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