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Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
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Background: Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum levels of IP-10 (interferon-gamma-inducible protein-10). Furthermore, when compared with human influenza virus subtype H1N1, the H5N1 viruses in 1997 (A/Hong Kong/483/97) (H5N1/97) were more potent inducers of pro-inflammatory cytokines (e.g. tumor necrosis factor-a) and chemokines (e.g. IP-10) from primary human macrophages in vitro, which suggests that cytokines dysregulation may play a role in pathogenesis of H5N1 disease. Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells. Methods: We used quantitative RT-PCR and ELISA to compare the profile of cytokine and chemokine gene expression induced by H5N1 viruses A/HK/483/97 (H5N1/97), A/Vietnam/1194/04 and A/Vietnam/3046/04 (both H5N1/04) with that of human H1N1 virus in human primary alveolar and bronchial epithelial cells in vitro. Results: We demonstrated that in comparison to human H1N1 viruses, H5N1/97 and H5N1/04 viruses were more potent inducers of IP-10, interferon beta, RANTES (regulated on activation, normal T cell expressed and secreted) and interleukin 6 (IL-6) in primary human alveolar and bronchial epithelial cells in vitro. Recent H5N1 viruses from Vietnam (H5N1/04) appeared to be even more potent at inducing IP-10 than H5N1/97 virus. Conclusion: The H5N1/97 and H5N1/04 subtype influenza A viruses are more potent inducers of proinflammatory cytokines and chemokines in primary human respiratory epithelial cells than subtype H1N1 virus. We suggest that this hyper-induction of cytokines may be relevant to the pathogenesis of human H5N1 disease.
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“The concept of secondary effects of cytokine cascades, as opposed to the direct effect of the virus, in amplifying and broadening the proinflammatory response may be important in the escalation of cytokine storm (24,111,125).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [24]
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“It is highly expressed across infection models, including primary human respiratory epithelial cells (24, 125) and human monocyte-derived macrophages (26, 59, 62), compared with during seasonal H1N1 influenza virus and swine-origin H1N1 influenza virus (SOIV) infection (111).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [24]
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Cites
Evolution and ecology of influenza A viruses
Webster, R. G., Bean, W. J., Gorman, O. T., Chambers, T. M., & Kawaoka, Y. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.152-179.1992 · Cited by 4,739
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
Claas, E. C. J., Osterhaus, A. D. M. E., van Beek, R., de Jong, J. C., Rimmelzwaan, G. F., Senne, D. A., Krauss, S. L., Shortridge, K. F., & Webster, R. G. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11212-0 · Cited by 1,420
Subbarao, K., Klimov, A. I., Katz, J. M., Regnery, H. L., Lim, W., Hall, H. E., Perdue, M. L., Swayne, D. E., Bender, C. A., Huang, J., et al. (1998) · Science · doi:10.1126/science.279.5349.393 · Cited by 1,353
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
Li, K., Guan, Y., Wang, J., Smith, G. J. D., Xu, K., Duan, L., Rahardjo, A. P., Puthavathana, P., Buranathai, C., Nguyen, T., et al. (2004) · Nature · doi:10.1038/nature02746 · Cited by 1,341
Self-citationLung pathology of fatal severe acute respiratory syndrome
Nicholls, J. M., Poon, L. L., Lee, K. C., Ng, W. F., Lai, S. T., Leung, C. Y., Chu, C. M., Hui, P. K., Mak, K. L., Lim, W., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13413-7 · Cited by 1,076
Self-citationYuen, K., Chan, P., Peiris, M. J. S., Tsang, D., Que, T., Shortridge, K. F., Cheung, P., To, W., Ho, E., Sung, R. Y. T., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01182-9 · Cited by 1,054
Cheung, C., Poon, L., Lau, A., Luk, W., Lau, Y., Shortridge, K., Gordon, S., Guan, Y., & Peiris, J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11772-7 · Cited by 889
Self-citationAvian Influenza A (H5N1) in 10 Patients in Vietnam
Hien, T. T., Liem, N. T., Dung, N. T., Luong, S. T., Mai, P. P., Châu, N. V. V., Suu, P. T., Dong, V. C., Mai, L. T. Q., Thi, N. T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040419 · Cited by 854
Self-citationRe-emergence of fatal human influenza A subtype H5N1 disease
Peiris, J., Yu, W., Leung, C., Cheung, C., Ng, W., Nicholls, J., Ng, T., Chan, K., Lai, S., Lim, W., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15595-5 · Cited by 812
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Items 201–300 of 515
Belser, J. A., Zeng, H., Katz, J. M., & Tumpey, T. M. (2011) · Journal of Virology · doi:10.1128/jvi.05101-11 · Cited by 40
McDermott, J., Shankaran, H., Eisfeld, A. J., Belisle, S. E., Neumann, G., Li, C., McWeeney, S. K., Sabourin, C. L. K., Kawaoka, Y., Katze, M. G., et al. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-190 · Cited by 41
Kawaguchi, M., Kokubu, F., Huang, S.-K., Homma, T., Odaka, M., Watanabe, S., Suzuki, S., Ieki, K., Matsukura, S., Kurokawa, M., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.02.036 · Cited by 41
Highly pathogenic H5N1 avian influenza virus: Cause of the next pandemic?
Pappaioanou, M. (2009) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2008.01.003 · Cited by 44
Innate Immunity to H5N1 Influenza Viruses in Humans
Ramos, I., & Fernández-Sesma, A. (2012) · Viruses · doi:10.3390/v4123363 · Cited by 42
Vogel, A. J., Harris, S. P., Marsteller, N. L., Condon, S. A., & Brown, D. M. (2014) · Viral Immunology · doi:10.1089/vim.2013.0095 · Cited by 40
Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection
Gao, Y., Du, Y., Zhang, C., Cheng, C., Yang, H., Jin, Y., Duan, G., & Chen, S. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s265718 · Cited by 41
Wei, L., Jiao, P., Song, Y., Cao, L., Yuan, R., Gong, L., Cui, J., Zhang, S., Qi, W., Yang, S., et al. (2013) · Veterinary Microbiology · doi:10.1016/j.vetmic.2013.06.019 · Cited by 38
Innate immunity to influenza virus: implications for future therapy
White, M. R., Doss, M., Boland, P. M., Tecle, T., & Hartshorn, K. L. (2008) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.4.4.497 · Cited by 39
Wang, S., Le, T. Q., Chida, J., Cissé, Y., Yano, M., & Kido, H. (2010) · The Journal of Medical Investigation · doi:10.2152/jmi.57.26 · Cited by 38
Maemura, T., Fukuyama, S., & Kawaoka, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00144 · Cited by 38
McClain, M. T., Henao, R., Williams, J., Nicholson, B., Veldman, T., Hudson, L., Tsalik, E. L., Lambkin‐Williams, R., Gilbert, A., Mann, A., et al. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12736 · Cited by 37
Human H5N1 influenza: Current insight into pathogenesis
Thanh, T. T., van Doorn, H. R., & de Jong, M. D. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.05.019 · Cited by 38
Hui, K. P. Y., Chan, L., Kuok, D. I. T., Mok, C. K. P., Yang, Z., Li, R.-F., Luk, G. S. M., Lee, E. F., Lai, J. C. C., Yen, H., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.01710-2016 · Cited by 37
Self-citationLi, H., Bradley, K. C., Long, J. S., Frise, R., Ashcroft, J., Hartgroves, L. C., Shelton, H. A., Makris, S., Johansson, C., Cao, B., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006821 · Cited by 34
Kim, H. M., Kang, Y. M., Song, B. M., Kim, H. S., & Seo, S. H. (2012) · Viral Immunology · doi:10.1089/vim.2012.0007 · Cited by 37
Busch, M. G., Bateman, A., Landolt, G. A., Karasin, A. I., Brockman‐Schneider, R. A., Gern, J. E., Suresh, M., & Olsen, C. W. (2008) · Virus Research · doi:10.1016/j.virusres.2008.01.014 · Cited by 37
Mok, C. K. P., Kang, S. S. R., Chan, R. W. Y., Yue, P. Y. K., Mak, N. K., Poon, L. L. M., Wong, R. N., Peiris, M. J. S., & Chan, M. C. W. (2014) · Antiviral Research · doi:10.1016/j.antiviral.2014.03.019 · Cited by 36
Self-citationCohen-Lavi, L., Fiore-Gartland, A., Randolph, A. G., Panoskaltsis‐Mortari, A., Wong, S., Ralston, J., Wood, T., Seeds, R., Huang, Q. S., Webby, R. J., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01338 · Cited by 35
Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3
Hui, K. P. Y., Li, H. S., Cheung, M. C., Chan, R. W. Y., Yuen, K. M., Mok, C. K. P., Nicholls, J. M., Peiris, M. J. S., & Chan, M. C. W. (2016) · Scientific Reports · doi:10.1038/srep28593 · Cited by 35
Self-citationZhang, N., Bao, Y., Tong, A. H.-Y., Zuyderduyn, S., Bader, G. D., Peiris, M. J. S., Lok, S., & Lee, S. M.-Y. (2018) · BMC Medical Genomics · doi:10.1186/s12920-018-0335-0 · Cited by 36
Contribution of innate immune cells to pathogenesis of severe influenza virus infection
Cole, S., & Ho, L. (2017) · Clinical Science · doi:10.1042/cs20160484 · Cited by 38
Li, R., Qu, S., Qin, M., Huang, L., Huang, Y., Du, Y., Yu, Z., Fan, F., Sun, J., Li, Q., et al. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106030 · Cited by 34
Ng, Y. P., Lee, S. M. Y., Cheung, T., Nicholls, J. M., Peiris, M. J. S., & Ip, N. Y. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.013 · Cited by 36
Self-citationStudies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth
Kang, J., Liu, C., Wang, H., Li, B.-M., Li, C., Chen, R.-Y., & Liu, A. (2014) · Molecules · doi:10.3390/molecules19044479 · Cited by 34
Immune response during acute Chandipura viral infection in experimentally infected susceptible mice
Balakrishnan, A., & Mishra, A. C. (2008) · Virology Journal · doi:10.1186/1743-422x-5-121 · Cited by 34
Belser, J. A., Zeng, H., Katz, J. M., & Tumpey, T. M. (2010) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq018 · Cited by 35
Duan, M., Zhou, Z., Lin, R., Yang, J., Xia, X., & Wang, S. (2008) · Antiviral Therapy · doi:10.1177/135965350801300112 · Cited by 33
Zhu, F., Teng, Z., Zhou, X., Xu, R., Bing, X., Shi, L., Guo, N., Wang, M., Liu, C., & Xia, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.879575 · Cited by 33
Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells.
Damera, G., Zhao, H., Wang, M., Smith, M., Kirby, C., Jester, W., Lawson, J., & Panettieri, R. (2009) · American Journal of Physiology - Lung cellular and Molecular Physiology · doi:10.1152/ajplung.90585.2008 · Cited by 40
Nelli, R. K., Dunham, S. P., Kuchipudi, S. V., White, G. A., Baquero-Pérez, B., Chang, P., Ghaemmaghami, A. M., Brookes, S. M., Brown, I. H., & Chang, K. (2012) · Journal of Virology · doi:10.1128/jvi.00244-12 · Cited by 33
A nutritional supplement formula for influenza A (H5N1) infection in humans
Friel, H., & Lederman, H. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.02.040 · Cited by 33
Virus Infection and Systemic Inflammation: Lessons Learnt from COVID-19 and Beyond
Faist, A., Janowski, J., Kumar, S., Hinse, S., Çalışkan, D. M., Lange, J., Ludwig, S., & Brunotte, L. (2022) · Cells · doi:10.3390/cells11142198 · Cited by 31
Zhao, G., Du, L., Xiao, W., Sun, S., Lin, Y., Chen, M., Kou, Z., He, Y., Lustigman, S., Jiang, S., et al. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.08.049 · Cited by 32
Matthaei, M., Budt, M., & Wolff, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056659 · Cited by 33
The Dual Role of CCR5 in the Course of Influenza Infection: Exploring Treatment Opportunities
Ferrero, M. R., Tavares, L. P., & Garcia, C. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.826621 · Cited by 32
Wang, H., Li, R., Rao, Y. M., Liu, S., Hu, C., Zhang, Y., Meng, L., Wu, Q., Ouyang, Q., Liang, H., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091797 · Cited by 32
An, C., Wu, Y., Wu, J., Liu, H., Zhou, S., Ge, D., Dong, R., You, L., & Hao, Y. (2022) · Drug Development Research · doi:10.1002/ddr.21995 · Cited by 33
Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection
Rutigliano, J. A., Doherty, P. C., Franks, J., Morris, M. Y., Reynolds, C., & Thomas, P. G. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.04.003 · Cited by 32
Tanaka, T., KAMIYAMA, T., Daikoku, T., Takahashi, K., NOMURA, N., Kurokawa, M., & Shiraki, K. (2017) · Acta Virologica · doi:10.4149/av_2017_01_48 · Cited by 31
Kosai, K., Seki, M., Yanagihara, K., Nakamura, S., Kurihara, S., Izumikawa, K., Kakeya, H., Yamamoto, Y., Tashiro, T., & Kohno, S. (2008) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540701660486 · Cited by 31
Loving, C. L., Brockmeier, S. L., Ma, W., Richt, J. A., & Sacco, R. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8432 · Cited by 31
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Benam, K. H., Denney, L., & Ho, L. (2018) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0247tr · Cited by 33
Biologic therapy for psoriasis during the covid-19 outbreak is not a choice
Bardazzi, F., Loi, C., Sacchelli, L., & Altobrando, A. D. (2020) · Journal of Dermatological Treatment · doi:10.1080/09546634.2020.1749545 · Cited by 31
HOU, X. Q., Qin, J., ZHENG, X. X., WANG, L., YANG, S. T., Gao, Y., & H., X. Z. (2014) · Acta Virologica · doi:10.4149/av_2014_01_69 · Cited by 33
Chen, Y., Deng, W., Jia, C., Dai, X., Zhu, H., Kong, Q., Huang, L., Liu, Y., Ma, C., Li, J., et al. (2009) · Archives of Virology · doi:10.1007/s00705-008-0277-5 · Cited by 29
Miura, T. A., Wang, J., Holmes, K. V., & Mason, R. J. (2007) · Virology · doi:10.1016/j.virol.2007.07.030 · Cited by 30
Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia
Hou, X., Gao, Y., Yang, S., Wang, C., Ma, Z., & Xia, X. (2009) · Acta Virologica · doi:10.4149/av_2009_04_225 · Cited by 30
Human intestinal epithelial cells are susceptible to influenza virus subtype H9N2
Qu, B., Li, X., Gao, W., Sun, W., Jin, Y., Cardona, C. J., & Xing, Z. (2011) · Virus Research · doi:10.1016/j.virusres.2011.09.007 · Cited by 29
Zhang, X., Cao, C., Qu, Z., Zhang, W., Liu, Y., Qi, H., Hao, C., Zhang, W., Gao, M., Wang, J., et al. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.01.007 · Cited by 29
Host–Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model
Pharo, E. A., Williams, S. M., Boyd, V., Sundaramoorthy, V., Durr, P. A., & Baker, M. L. (2020) · Viruses · doi:10.3390/v12060679 · Cited by 30
Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination
Crofts, K. F., & Alexander‐Miller, M. A. (2020) · Vaccines · doi:10.3390/vaccines8040558 · Cited by 30
Altered pro-inflammatory cytokine mRNA levels in chickens infected with infectious bronchitis virus
Jang, H., Koo, B., Jeon, E.-O., Lee, H.-R., Lee, S., & Mo, I.-P. (2013) · Poultry Science · doi:10.3382/ps.2013-03116 · Cited by 29
Shelton, J. L., Wang, L., Cepinskas, G., Sandig, M., Scott, J. A., North, M. L., Inculet, R., & Mehta, S. (2007) · Microvascular Research · doi:10.1016/j.mvr.2007.02.008 · Cited by 29
Molecular Pathogenesis of H5N1 Influenza Virus Infections
Neumann, G., Shinya, K., & Kawaoka, Y. (2007) · Antiviral Therapy · doi:10.1177/135965350701200s08.1 · Cited by 29
Jakieła, B., Rebane, A., Soja, J., Bazan‐Socha, S., Laanesoo, A., Plutecka, H., Surmiak, M., Sanak, M., Sładek, K., & Bochenek, G. (2021) · Scientific Reports · doi:10.1038/s41598-021-92252-6 · Cited by 30
Adaption of Seasonal H1N1 Influenza Virus in Mice
Xu, L., Bao, L., Li, F., Lv, Q., Ma, Y., Zhou, J., Xu, Y., Deng, W., Zhan, L., Zhu, H., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028901 · Cited by 29
Brincks, E. L., Kucaba, T. A., Legge, K. L., & Griffith, T. S. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.07.012 · Cited by 28
Antiviral activity of the proteasome inhibitor VL-01 against influenza A viruses
Haasbach, E., Pauli, E.-K., Spranger, R., Mitzner, D., Schubert, U., Kircheis, R., & Planz, O. (2011) · Antiviral Research · doi:10.1016/j.antiviral.2011.07.006 · Cited by 27
Zhang, J., Wang, Q., Fang, H., Xu, W., Liu, A., & Du, G. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.01.020 · Cited by 27
Thanunchai, M., Kanrai, P., Wiboon-ut, S., Puthavathana, P., Hongeng, S., & Thitithanyanont, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081805 · Cited by 29
Induction of TNF-α in human macrophages by avian and human influenza viruses
Monteerarat, Y., Sakabe, S., Ngamurulert, S., Srichatraphimuk, S., Jiamtom, W., Chaichoun, K., Thitithanyanont, A., Permpikul, P., Songserm, T., Puthavathana, P., et al. (2010) · Archives of Virology · doi:10.1007/s00705-010-0716-y · Cited by 27
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Du, A., Daidoji, T., Koma, T., Ibrahim, M. S., Nakamura, S., de Silva, U. C., Ueda, M., Yang, C.-S., Yasunaga, T., Ikuta, K., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.022 · Cited by 27
Murphy, E. A., Davis, J. M., McClellan, J. L., Carmichael, M. D., van Rooijen, N., & Gangemi, J. D. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0143 · Cited by 26
A spatial model of the efficiency of T cell search in the influenza-infected lung
Levin, D., Forrest, S., Banerjee, S., Clay, C. C., Cannon, J. L., Moses, M. E., & Koster, F. T. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.02.022 · Cited by 27
Ng, Y. P., Yip, T. F., Peiris, M. J. S., Ip, N. Y., & Lee, S. M.-Y. (2018) · Journal of NeuroVirology · doi:10.1007/s13365-018-0659-8 · Cited by 27
de Jong, M. D. (2008) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181684d2d · Cited by 27
Pathogenicity and innate response to Avibacterium paragallinarum in chickens
Guo, M., Liu, D., Chen, X., Wu, Y., & Zhang, X. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101523 · Cited by 26
Ponticelli, M., Bellone, M. L., Parisi, V., Iannuzzi, A. M., Braca, A., Tommasi, N. D., Russo, D., Sileo, A., Quaranta, P., Freer, G., et al. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09855-2 · Cited by 26
Adapting global influenza management strategies to address emerging viruses
Noah, D. L., & Noah, J. W. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00105.2013 · Cited by 26
Chan, L., Nicholls, J. M., Peiris, M. J. S., Lau, Y., Chan, M. C. W., & Chan, R. W. Y. (2020) · Respiratory Research · doi:10.1186/s12931-020-01425-w · Cited by 26
Self-citationChan, R. W. Y., Leung, C. Y. H., Nicholls, J. M., Peiris, M. J. S., & Chan, M. C. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051057 · Cited by 26
Self-citationGounder, A. P., Yokoyama, C. C., Jarjour, N. N., Bricker, T. L., Edelson, B. T., & Boon, A. C. M. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007001 · Cited by 26
Sreenivasan, C. C., Thomas, M., Antony, L., Wormstadt, T., Hildreth, M. B., Wang, D., Hause, B. M., Francis, D. H., Li, F., & Kaushik, R. S. (2019) · Virology · doi:10.1016/j.virol.2018.12.016 · Cited by 26
Oxygen free radical involvement in acute lung injury induced by H5N1 virus in mice
He, G., Dong, C., Luan, Z., McAllan, B. M., Xu, T., Zhao, L., & Jian, Q. (2013) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12067 · Cited by 26
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Bel, M., Ocaña-Macchi, M., Liniger, M., McCullough, K. C., Matrosovich, M. N., & Summerfield, A. (2011) · Viruses · doi:10.3390/v3040312 · Cited by 25
Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells
Miura, T. A., & Holmes, K. V. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209078 · Cited by 25
Rendón-Ramírez, E. J., Ortiz-Stern, A., Martinez-Mejia, C., Salinas-Carmona, M. C., Rendón, A., Mata-Tijerina, V., & Rosas-Taraco, A. G. (2015) · Viral Immunology · doi:10.1089/vim.2014.0123 · Cited by 25
Sandbulte, M. R., Boon, A. C. M., Webby, R. J., & Riberdy, J. M. (2008) · Virology · doi:10.1016/j.virol.2008.08.018 · Cited by 25
Plotnikova, M. A., Klotchenko, S. A., & Vasin, A. V. (2016) · Journal of Immunological Methods · doi:10.1016/j.jim.2016.01.005 · Cited by 24
Mishra, A., Vijayakumar, P., & Raut, A. A. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1291640 · Cited by 24
Modelling within-host macrophage dynamics in influenza virus infection
Li, K., McCaw, J. M., & Cao, P. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110492 · Cited by 24
Lasrado, N., Gangaplara, A., Massilamany, C., Arumugam, R., Shelbourn, A., Rasquinha, M. T., Basavalingappa, R. H., Delhon, G. A., Xiang, S.-H., Pattnaik, A. K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90434-w · Cited by 25
Juno, J. A., Fowke, K. R., & Keynan, Y. (2011) · Clinical and Developmental Immunology · doi:10.1155/2012/797180 · Cited by 23
Meliopoulos, V., Cherry, S., Wohlgemuth, N., Honce, R., Barnard, K. N., Gauger, P. C., Davis, T. C., Shult, P. A., Parrish, C. R., & Schultz‐Cherry, S. (2020) · Journal of Virology · doi:10.1128/jvi.01091-20 · Cited by 22
Avian Influenza: The Next Pandemic?
McFee, R. B. (2007) · Disease-a-Month · doi:10.1016/j.disamonth.2007.05.006 · Cited by 24
Damlaj, M., Bartoo, G. T., Cartin‐Ceba, R., Gijima, D., Alkhateeb, H. B., Merten, J. A., Hashmi, S. K., Litzow, M. R., Gastineau, D. A., Hogan, W. J., et al. (2016) · Transplant Infectious Disease · doi:10.1111/tid.12513 · Cited by 23
Luo, H. L., Wang, D., CHE, H.-L., Zhao, Y., & Jin, H. (2011) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.350 · Cited by 21
Korteweg, C., & Gu, J. (2010) · Biochemistry and Cell Biology · doi:10.1139/o10-017 · Cited by 25
Yang, S. Q., Qu, J. X., Wang, C., Xiao, Y., Liu, Y. M., & Cao, B. (2013) · The Clinical Respiratory Journal · doi:10.1111/crj.12056 · Cited by 22
Profiles of Acute Cytokine and Antibody Responses in Patients Infected with Avian Influenza A H7N9
Huang, R., Zhang, L., Gu, Q., Zhou, Y., Hao, Y., Zhang, K., Liu, Y., Dong, D., Wang, S., Huang, Z., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101788 · Cited by 22
Linezolid Has Unique Immunomodulatory Effects in Post-Influenza Community Acquired MRSA Pneumonia
Bhan, U., Podsiad, A. B., Kovach, M. A., Ballinger, M. N., Keshamouni, V. G., & Standiford, T. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0114574 · Cited by 22
Comparison of cytokine profiles induced by nonlethal and lethal doses of influenza A virus in mice
Turianov�, L., Lachov�, V., Svetl�kova, D., Kostr�bov�, A., & Betáková, T. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8096 · Cited by 21
Differential replication of avian influenza H9N2 viruses in human alveolar epithelial A549 cells
Lee, D. C., Mok, C. K. P., Law, A. H., Peiris, M. J. S., & Lau, A. S. Y. (2010) · Virology Journal · doi:10.1186/1743-422x-7-71 · Cited by 22
Innate immune role of IL-6 in influenza a virus pathogenesis
Li, X., Huang, C., Rai, K. R., & Xu, Q. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1605446 · Cited by 26
Alteration of the nasal responses to influenza virus by tobacco smoke
Noah, T. L., Zhou, H., & Jaspers, I. (2011) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32834ecc80 · Cited by 21
Viral load of the highly pathogenic avian influenza H5N1 virus in infected human tissues
Sirinonthanawech, N., Uiprasertkul, M., Suptawiwat, O., & Auewarakul, P. (2011) · Journal of Medical Virology · doi:10.1002/jmv.22146 · Cited by 20
Thitithanyanont, A., Engering, A. J., Uiprasertkul, M., Ekchariyawat, P., Wiboon-ut, S., Kraivong, R., Limsalakpetch, A., Kum-Arb, U., Yongvanitchit, K., Sa‐Ard‐Iam, N., et al. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.017 · Cited by 21
Temporal dynamics of ovine airway epithelial cell differentiation at an air-liquid interface
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Cho, J., Yi, H., Jang, E. Y., Lee, M.-S., Lee, J.-Y., Kang, C., Lee, C. H., & Kim, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.037 · Cited by 21
Metadata
- Authors
- Chan, M., Cheung, C., Chui, W., Tsao, S., Nicholls, J., Chan, Y., Chan, R., Long, H., Poon, L., Guan, Y., & Peiris, J.
- Affiliations
- Queen Mary Hospital (CN)
- Grantham Hospital (CN)
- University of Hong Kong (HK)
- National Institute Of Hygiene And Epidemiology (VN)
- Corresponding author
- Peiris, JSM
- ORCID
- Guan, Y
- Venue
- Respiratory Research
- Published
- 2005-11-11
- Volume
- 6
- Issue
- 1
- Pages
- 135-135
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- PMC
- PMC1318487
- OpenAlex
- W2122988122
- Cited by
- 510
- References
- 37
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 16 · 2023: 10 · 2022: 10 · 2021: 23 · 2020: 24 · 2019: 14 · 2018: 20 · 2017: 19 · 2016: 16 · 2015: 21 · 2014: 26 · 2013: 36 · 2012: 26
- FWCI
- 20.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Respiratory Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Greater South Information System
- Funders
- University of Hong Kong
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- H5N1 avian influenza, influenza A virus, inflammatory cytokines, chemokines, CXCL10, interferon-beta, RANTES, interleukin-6, alveolar epithelial cells, bronchial epithelial cells, respiratory epithelium, cytokine imbalance, viral pathogenesis
- MeSH terms
- Bronchi, Cells, Cultured, Epithelial Cells, Humans, Immunologic Factors, Pulmonary Alveoli, Cytokines, Respiratory Mucosa, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype
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