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Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells
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Background: Fatal human respiratory disease associated with influenza A subtype H5N1 has been documented in Hong Kong, and more recently in Vietnam, Thailand and Cambodia. We previously demonstrated that patients with H5N1 disease had unusually high serum levels of IP-10 (interferon-gamma-inducible protein-10). Furthermore, when compared with human influenza virus subtype H1N1, the H5N1 viruses in 1997 (A/Hong Kong/483/97) (H5N1/97) were more potent inducers of pro-inflammatory cytokines (e.g. tumor necrosis factor-a) and chemokines (e.g. IP-10) from primary human macrophages in vitro, which suggests that cytokines dysregulation may play a role in pathogenesis of H5N1 disease. Since respiratory epithelial cells are the primary target cell for replication of influenza viruses, it is pertinent to investigate the cytokine induction profile of H5N1 viruses in these cells. Methods: We used quantitative RT-PCR and ELISA to compare the profile of cytokine and chemokine gene expression induced by H5N1 viruses A/HK/483/97 (H5N1/97), A/Vietnam/1194/04 and A/Vietnam/3046/04 (both H5N1/04) with that of human H1N1 virus in human primary alveolar and bronchial epithelial cells in vitro. Results: We demonstrated that in comparison to human H1N1 viruses, H5N1/97 and H5N1/04 viruses were more potent inducers of IP-10, interferon beta, RANTES (regulated on activation, normal T cell expressed and secreted) and interleukin 6 (IL-6) in primary human alveolar and bronchial epithelial cells in vitro. Recent H5N1 viruses from Vietnam (H5N1/04) appeared to be even more potent at inducing IP-10 than H5N1/97 virus. Conclusion: The H5N1/97 and H5N1/04 subtype influenza A viruses are more potent inducers of proinflammatory cytokines and chemokines in primary human respiratory epithelial cells than subtype H1N1 virus. We suggest that this hyper-induction of cytokines may be relevant to the pathogenesis of human H5N1 disease.
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“It is highly expressed across infection models, including primary human respiratory epithelial cells (24, 125) and human monocyte-derived macrophages (26, 59, 62), compared with during seasonal H1N1 influenza virus and swine-origin H1N1 influenza virus (SOIV) infection (111).”
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“The concept of secondary effects of cytokine cascades, as opposed to the direct effect of the virus, in amplifying and broadening the proinflammatory response may be important in the escalation of cytokine storm (24,111,125).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [24]
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Citations
Cites
Evolution and ecology of influenza A viruses
Webster, R. G., Bean, W. J., Gorman, O. T., Chambers, T. M., & Kawaoka, Y. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.152-179.1992 · Cited by 4,739
Van Snick, J. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.001345 · Cited by 1,890
Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
Claas, E. C. J., Osterhaus, A. D. M. E., van Beek, R., de Jong, J. C., Rimmelzwaan, G. F., Senne, D. A., Krauss, S. L., Shortridge, K. F., & Webster, R. G. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11212-0 · Cited by 1,420
Subbarao, K., Klimov, A. I., Katz, J. M., Regnery, H. L., Lim, W., Hall, H. E., Perdue, M. L., Swayne, D. E., Bender, C. A., Huang, J., et al. (1998) · Science · doi:10.1126/science.279.5349.393 · Cited by 1,353
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
Li, K., Guan, Y., Wang, J., Smith, G. J. D., Xu, K., Duan, L., Rahardjo, A. P., Puthavathana, P., Buranathai, C., Nguyen, T., et al. (2004) · Nature · doi:10.1038/nature02746 · Cited by 1,341
Self-citationLung pathology of fatal severe acute respiratory syndrome
Nicholls, J. M., Poon, L. L., Lee, K. C., Ng, W. F., Lai, S. T., Leung, C. Y., Chu, C. M., Hui, P. K., Mak, K. L., Lim, W., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13413-7 · Cited by 1,076
Self-citationYuen, K., Chan, P., Peiris, M. J. S., Tsang, D., Que, T., Shortridge, K. F., Cheung, P., To, W., Ho, E., Sung, R. Y. T., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01182-9 · Cited by 1,054
Cheung, C., Poon, L., Lau, A., Luk, W., Lau, Y., Shortridge, K., Gordon, S., Guan, Y., & Peiris, J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11772-7 · Cited by 889
Self-citationAvian Influenza A (H5N1) in 10 Patients in Vietnam
Hien, T. T., Liem, N. T., Dung, N. T., Luong, S. T., Mai, P. P., Châu, N. V. V., Suu, P. T., Dong, V. C., Mai, L. T. Q., Thi, N. T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040419 · Cited by 854
Self-citationRe-emergence of fatal human influenza A subtype H5N1 disease
Peiris, J., Yu, W., Leung, C., Cheung, C., Ng, W., Nicholls, J., Ng, T., Chan, K., Lai, S., Lim, W., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15595-5 · Cited by 812
Self-citation
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Items 301–400 of 515
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Baz, M., Mhamdi, Z., Carbonneau, J., Lavigne, S., Couture, C., Abed, Y., & Boivin, G. (2019) · Scientific Reports · doi:10.1038/s41598-019-51877-4 · Cited by 21
dos Santos, A. C. M., dos Santos, B. R. C., dos Santos, B. B., de Moura, E. L., Ferreira, J. M., dos Santos, L. K. C., Oliveira, S. P., Dias, R. B. F., Silva, A. C. P. E., de Farias, K. F., et al. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104846 · Cited by 24
The Role of the Nrf2 Pathway in Airway Tissue Damage Due to Viral Respiratory Infections
Kombe, A. J. K., Abadi, L. F., Nanduri, R., Gerasimova, Y. V., Δάσκου, Μ., Gain, C., Sharma, E., Wong, M., & Kelesidis, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137042 · Cited by 20
The therapeutic effects of sodium cromoglycate against influenza A virus H5N1 in mice
Han, D., Wei, T., Zhang, S., Wang, M., Tian, H., Cheng, J., Xiao, J. Z., Hu, Y., & Chen, M. (2015) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12334 · Cited by 20
Jin, Y., Zhang, Y., Wan, C., Wang, H., Hou, L., Chang, J., Fan, K., & Xie, X. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/194976 · Cited by 20
Genetic basis of resistance to avian influenza in different commercial varieties of layer chickens
Drobik-Czwarno, W., Wolc, A., Fulton, J. E., Jankowski, T., Arango, J., O'Sullivan, N. P., & Dekkers, J. C. M. (2018) · Poultry Science · doi:10.3382/ps/pey233 · Cited by 20
Human Cytomegalovirus Infection in Lung Transplant Recipients Triggers a CXCL-10 Response
Weseslindtner, L., Nachbagauer, R., Kundi, M., Jaksch, P., Kerschner, H., Simon, B., Hatos-Agyi, L., Scheed, A., Aberle, J. H., Klepetko, W., et al. (2011) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2010.03404.x · Cited by 19
Lam, E., Ramke, M., Warnecke, G., Schrepfer, S., Kopfnagel, V., Dobner, T., & Heim, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131201 · Cited by 20
An overview of the highly pathogenic H5N1 influenza virus
Yin, J., Liu, S., & Zhu, Y. (2013) · Virologica Sinica · doi:10.1007/s12250-013-3294-9 · Cited by 19
SARS‐CoV‐2 innate effector associations and viral load in early nasopharyngeal infection
Liou, T. G., Adler, F. R., Cahill, B. C., Cox, D. R., Cox, J. E., Grant, G. J., Hanson, K. E., Hartsell, S. C., Hatton, N. D., Helms, M. N., et al. (2021) · Physiological Reports · doi:10.14814/phy2.14761 · Cited by 20
Song, B. M., Kang, Y. M., Kim, H. S., & Seo, S. H. (2011) · Viral Immunology · doi:10.1089/vim.2010.0125 · Cited by 19
Hemagglutinin from the H5N1 Virus Activates Janus Kinase 3 to Dysregulate Innate Immunity
Xu, W., Chen, M., Ge, N., & Xu, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031721 · Cited by 20
Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways
Zhong, M., Wang, H., Yan, H., Wu, S., Gu, Z., & Li, Y. (2018) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2018.1520221 · Cited by 19
Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus
Ichinohe, T., Nagata, N., Strong, P., Tamura, S., Takahashi, H., Ninomiya, A., Imai, M., Odagiri, T., Tashiro, M., Sawa, H., et al. (2007) · Journal of Medical Virology · doi:10.1002/jmv.20837 · Cited by 19
The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract
Nicholls, J. M. (2013) · Infection and Chemotherapy · doi:10.3947/ic.2013.45.1.11 · Cited by 19
Self-citationFujii, H., Tani, H., Egawa, K., Taniguchi, S., Yoshikawa, T., Fukushi, S., Yamada, S., Harada, S., Kurosu, T., Shimojima, M., et al. (2022) · Viruses · doi:10.3390/v14081668 · Cited by 18
Cheng, X., Xu, Q., Song, E., Yang, C., Kemble, G. W., & Jin, H. (2010) · Virology · doi:10.1016/j.virol.2010.06.048 · Cited by 17
Protective Memory Responses Are Modulated by Priming Events prior to Challenge
Rutigliano, J. A., Morris, M. Y., Yue, W. W., Keating, R., Webby, R. J., Thomas, P. G., & Doherty, P. C. (2009) · Journal of Virology · doi:10.1128/jvi.01535-09 · Cited by 18
Rohini, K., & Veerappapillai, S. (2017) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-017-2625-y · Cited by 18
Zhang, X., Cao, C., Liu, Y., Qi, H., Zhang, W., Hao, C., Chen, H., Zhang, Q., Zhang, W., Gao, M., et al. (2018) · Veterinary Research · doi:10.1186/s13567-018-0545-7 · Cited by 18
Zhang, J., Su, R., Jian, X., An, H., Jiang, R., & Mok, C. K. P. (2018) · Virologica Sinica · doi:10.1007/s12250-018-0072-8 · Cited by 18
Newly Established Monoclonal Antibodies for Immunological Detection of H5N1 Influenza Virus
Ohnishi, K., Takahashi, Y., Kono, N., Nakajima, N., Mizukoshi, F., Misawa, S., Yamamoto, T., Mitsuki, Y.-Y., Fu, S.-I., Hirayama, N., et al. (2012) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.65.19 · Cited by 18
Wei, P., Zhang, T., Dong, H., Chen, Q., Mu, X., & Hu, G. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.009 · Cited by 18
Zhu, H., Huang, H. Y., Shi, X., Zhou, W. M., Zhou, P., Yan, Q.-L., Zhu, H., & Ju, D. (2014) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-014-2020-2 · Cited by 17
Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China.
Duan, L., Zhu, H., Wang, J., Huang, K., Cheung, C.-L., Peiris, J. S. M., Chen, H., & Guan, Y. (2011) · PubMed · Cited by 17
Self-citationJazayeri, S. D., Ideris, A., Zakaria, Z., Yeap, S. K., & Omar, A. R. (2012) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2012.03.007 · Cited by 17
The threat of avian influenza a (H5N1): part II: Clues to pathogenicity and pathology
Cinatl, J. J., Michaelis, M., & Doerr, H. W. (2007) · Medical Microbiology and Immunology · doi:10.1007/s00430-007-0045-2 · Cited by 17
Anti-complementary effect of polysacchride B3-PS1 inHerba Scutellariae Barbatae(Scutellaria barbata)
Wu, Y., & Chen, D. (2009) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923970903095314 · Cited by 17
Peiris, M. J. S., Poon, L. C., Nicholls, J. M., & Guan, Y. (2009) · PubMed · Cited by 16
Self-citationRNA Viruses, Toll-Like Receptors, and Cytokines: The Perfect Storm?
Stegeman, S. K., Kourko, O., Amsden, H., Pellizzari-Delano, I. E., Mamatis, J. E., Roth, M., Colpitts, C. C., & Gee, K. (2025) · Journal of Innate Immunity · doi:10.1159/000543608 · Cited by 17
Demir, C., & Demir, M. (2013) · Internal Medicine Inside · doi:10.7243/2052-6954-1-2 · Cited by 16
Broadbent, A., Boonnak, K., & Subbarao, K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00059-8 · Cited by 18
Chon, H. (2012) · Studies in natural products chemistry · doi:10.1016/b978-0-444-59530-0.00011-3 · Cited by 16
Uno, Y., Usui, T., Soda, K., Fujimoto, Y., Takeuchi, T., Ito, H., Ito, T., & Yamaguchi, T. (2012) · Journal of Veterinary Medical Science · doi:10.1292/jvms.12-0433 · Cited by 15
RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice
Almutairi, F., Sarr, D., Tucker, S. L., Fantone, K. M., Lee, J., & Rada, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.772288 · Cited by 14
Kohwiwattanagun, J., Kawamura, I., Fujimura, T., & Mitsuyama, M. (2007) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2007.tb03897.x · Cited by 15
Park, W.-J., Park, B., Song, Y., Lee, D., Yuk, S., Lee, J., Park, S., Song, C., Lee, S., & Choi, I. (2015) · Archives of Virology · doi:10.1007/s00705-015-2395-1 · Cited by 15
Probenecid Inhibits Influenza A(H5N1) and A(H7N9) Viruses In Vitro and in Mice
Murray, J., Martin, D. E., Hosking, S., Orr‐Burks, N., Hogan, R. J., & Tripp, R. A. (2024) · Viruses · doi:10.3390/v16010152 · Cited by 14
Hook, J. L., & Bhattacharya, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1328453 · Cited by 18
An, S., Xu, L., Li, F.-D., Bao, L., Qin, C., & Gao, Z. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.09.001 · Cited by 14
Harpur, C. M., Page, M. A. L., & Tate, M. D. (2021) · Virulence · doi:10.1080/21505594.2021.1939608 · Cited by 16
Paquette, S. G., Banner, D., Chi, L. T. B., Leon, A. J., Xu, L., Ran, L., Huang, S. S. H., Farooqui, A., Kelvin, D. J., & Kelvin, A. A. (2013) · Virology · doi:10.1016/j.virol.2013.09.022 · Cited by 14
Samy, A., El-Enbaawy, M. I., El-Sanousi, A. A., El-Wanes, S. A. A., Ammar, A. M., Hikono, H., & Saito, T. (2015) · International Journal of Veterinary Science and Medicine · doi:10.1016/j.ijvsm.2015.01.001 · Cited by 14
Models of cytokine dynamics in the inflammatory response of viral zoonotic infectious diseases
Zhang, W., Jang, S. R. ‐., Jonsson, C. B., & Allen, L. J. S. (2018) · Mathematical Medicine and Biology A Journal of the IMA · doi:10.1093/imammb/dqy009 · Cited by 14
Vaccination: is it a real problem for anesthesia and surgery?
Currie, J. (2006) · Pediatric Anesthesia · doi:10.1111/j.1460-9592.2006.01898.x · Cited by 14
Development of DNA and mRNA-LNP vaccines against an H5N1 clade 2.3.4.4b influenza virus
Leonard, R. A., Spurrier, M. A., Skavicus, S., Luo, Z., Heaton, B. E., Spreng, R. L., Hong, J., Yuan, F., & Heaton, N. S. (2025) · Journal of Virology · doi:10.1128/jvi.00795-25 · Cited by 16
Influenza Virus in Community-Acquired Pneumonia: Current Understanding and Knowledge Gaps
Xu, J., Yu, J., Yang, L., Zhou, F., Li, H., & Cao, B. (2020) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0040-1710584 · Cited by 13
Sun, J., Ma, X., Zhang, M., Xie, M., Zhang, X., Han, X., Li, X., Zhou, E., Wang, J., She, D., et al. (2023) · BMC Infectious Diseases · doi:10.1186/s12879-023-08132-z · Cited by 13
Avian Influenza A (H5N1) Virus
Ortiz, J. R., & Uyeki, T. M. (2014) · ASM Press eBooks · doi:10.1128/9781555815585.ch1 · Cited by 13
Youssef, D. A., ABBASSI, A. M. E., Cutchins, D. C., Chhabra, S., & Peiris, A. N. (2011) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2011.00716.x · Cited by 13
Hui, K. P. Y., Kuok, D. I. T., Kang, S. S. R., Li, H. S., Ng, M. M. T., Bui, C. H. T., Peiris, M. J. S., Chan, R. W. Y., & Chan, M. C. W. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.04.005 · Cited by 13
Self-citationJain, S., Gitter, A., & Bar‐Joseph, Z. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003943 · Cited by 13
Friesenhagen, J., Viemann, D., Boergeling, Y., Schmolke, M., Spiekermann, C., Kirschnek, S., Ludwig, S., & Roth, J. (2013) · Journal of Innate Immunity · doi:10.1159/000346706 · Cited by 13
Fernando, F. S., Okino, C. H., Silva, K. R., Fernandes, C. C., Gonçalves, M. C. M., Montassier, M. D. F. S., Vasconcelos, R. D. O., & Montassier, H. J. (2015) · Pesquisa Veterinária Brasileira · doi:10.1590/s0100-736x2015000300002 · Cited by 13
Kobayashi, M., Kodama, M., Noshi, T., Yoshida, R., Kanazu, T., Nomura, N., Soda, K., Isoda, N., Okamatsu, M., Sakoda, Y., et al. (2016) · Antiviral Research · doi:10.1016/j.antiviral.2016.12.011 · Cited by 13
Kongsomros, S., Thanunchai, M., Manopwisedjaroen, S., Na-Ek, P., Wang, S., Taechalertpaisarn, T., & Thitithanyanont, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239488 · Cited by 13
H5N1, a wealth of knowledge to improve pandemic preparedness
Perez, D. R., & García‐Sastre, A. (2013) · Virus Research · doi:10.1016/j.virusres.2013.11.001 · Cited by 13
Sun, Y., Yu, H., Zhan, Z., Liu, W., Liu, P., Sun, J. Y., Zhang, P., Wang, X., Liu, X., & Xu, X. (2024) · iScience · doi:10.1016/j.isci.2024.111581 · Cited by 13
Early Activation of MAP Kinases by Influenza A Virus X-31 in Murine Macrophage Cell Lines
Cannon, G., Callahan, M. A., Gronemus, J. Q., & Lowy, R. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105385 · Cited by 12
Divergent Mast Cell Responses Modulate Antiviral Immunity During Influenza Virus Infection
Murphy-Schafer, A. R., & Paust, S. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.580679 · Cited by 12
Marinescu, I. P., Marinescu, D., Mogoantă, L., Efrem, I. C., & Stovicek, P. O. (2021) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.61.4.03 · Cited by 13
Hui, C. F. F., Chan, R. W. Y., Fung, K., Yu, W. C., Tsao, S., Chan, M. C. W., & Nicholls, J. M. (2011) · PubMed · Cited by 12
Self-citationJin, Y., Zhang, G., Hu, Y., Ding, M., Li, Y., Cao, S., Xue, J., Sun, L., & Wang, M. (2011) · The Journal of Gene Medicine · doi:10.1002/jgm.1558 · Cited by 12
Robinson, C. C. (2009) · Wiley eBooks · doi:10.1128/9781555815974.ch17 · Cited by 12
Karimabad, M. N., Hassanshahi, G., Kounis, N. G., Mplani, V., Roditis, P., Gogos, C., Lagadinou, M., Assimakopoulos, S. F., Dousdampanis, P., & Koniari, I. C. (2022) · Vaccines · doi:10.3390/vaccines10081299 · Cited by 10
The type I interferon response during viral infections: a “SWOT” analysis
Gaajetaan, G. R., Bruggeman, C. A., & Stassen, F. R. M. (2011) · Reviews in Medical Virology · doi:10.1002/rmv.713 · Cited by 12
Howard, W. A., Peiris, M. J. S., & Hayden, F. G. (2011) · Influenza and Other Respiratory Viruses · doi:10.1111/j.1750-2659.2011.00278.x · Cited by 11
Serrato, V., Azevedo, V. F., Sabatoski, V., Gonçalves, B. P., & Machado, D. M. (2010) · Clinical Rheumatology · doi:10.1007/s10067-010-1415-5 · Cited by 11
Potential Role of Vitamin D as an Antiviral Agent
Ghosh, J. (2021) · Medical Journal of Dr D Y Patil Vidyapeeth · doi:10.4103/mjdrdypu.mjdrdypu_236_20 · Cited by 11
Fage, C., Pizzorno, A., Rhéaume, C., Abed, Y., & Boivin, G. (2017) · Journal of Medical Virology · doi:10.1002/jmv.24911 · Cited by 11
University of Veterinary Medicine Hannover
Komm, K. (2010) · Cited by 11
Lu, Y. W. W., Landreth, S. L., Gaba, A., Hlasny, M., Liu, G., Huang, Y., & Zhou, Y. (2019) · Viruses · doi:10.3390/v11020193 · Cited by 10
Brügger, M., Machahua, C., Zumkehr, T., Cismaru, C. V., Jandrasits, D., Trüeb, B. S., Ezzat, S., Esteves, B. I. O., Dorn, P., Marti, T. M., et al. (2025) · Respiratory Research · doi:10.1186/s12931-025-03190-0 · Cited by 11
Márquez-Bandala, A. H., Gutiérrez‐Xicoténcatl, L., & Esquivel-Guadarrama, F. R. (2025) · Viruses · doi:10.3390/v17050694 · Cited by 10
Wang, Z., Chua, B. Y. L., Vega‐Ramos, J., Parra, S. M. Q., Fairmaid, E. J., Brown, L. E., Jackson, D. C., & Kedzierska, K. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.08.001 · Cited by 10
The Effects of Macrophage Polarity on Influenza Virus Replication and Innate Immune Responses
Dutry, I. (2015) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000297 · Cited by 10
Advanced pathophysiology mimicking lung models for accelerated drug discovery
Phan, T. H., Shi, H., Denes, C. E., Cole, A. J., Wang, Y., Cheng, Y. Y., Hesselson, D., Roelofs, S. H., Neely, G. G., Jang, J., et al. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00366-x · Cited by 10
System Biology Approach to Identify the Hub Genes and Pathways Associated with Human H5N1 Infection
Chaudhary, R. K., Ananthesh, L., Patil, P., Mateti, U. V., Sah, S. K., Mohanty, A., Rath, R. S., Padhi, B. K., Malik, S., Jassim, K. H., et al. (2023) · Vaccines · doi:10.3390/vaccines11071269 · Cited by 10
Zika virus: Antiviral immune response, inflammation, and cardiotonic steroids as antiviral agents
de Sales-Neto, J. M., Carvalho, D. C. M., Magalhães, D., Medeiros, A. B. A., Soares, M. M., & Rodrigues‐Mascarenhas, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111368 · Cited by 9
Yang, X., Du, N., Zhou, J., Li, Z., Wang, M., Guo, J., Wang, D., & Shu, Y. (2010) · Biomedical and Environmental Sciences · doi:10.1016/s0895-3988(10)60061-x · Cited by 10
Melnichuk, N., Kashuba, V. I., Рыбалко, С. Л., & Tkachuk, Z. Y. (2018) · Pharmaceuticals · doi:10.3390/ph11030073 · Cited by 10
Ye, S., Cowled, C. J., Yap, C.-H., & Stambas, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-33605-6 · Cited by 10
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Suksatu, A., Sangsawad, W., Thitithanyanont, A., Smittipat, N., Fukuda, M. M., & Ubol, S. (2009) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2009.00177.x · Cited by 9
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Plenge, F. O., Gómez, J., Ognio, L. S., Cabezas, C., Rosas, J. A., & Vargas, C. P. M. (2009) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 9
Wang, Y., Ru, Y., Zhuo, G., Sheng, M., Wang, S., Ma, J., Zhou, C., Sun, X., Zeng, Y., Zhang, Y., et al. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/8468303 · Cited by 8
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Arathy, D. S., Nair, S., Soman, S. S., Issac, A., & Sreekumar, E. (2010) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2010.09.005 · Cited by 8
Metadata
- Authors
- Chan, M., Cheung, C., Chui, W., Tsao, S., Nicholls, J., Chan, Y., Chan, R., Long, H., Poon, L., Guan, Y., & Peiris, J.
- Affiliations
- Queen Mary Hospital (CN)
- Grantham Hospital (CN)
- University of Hong Kong (HK)
- National Institute Of Hygiene And Epidemiology (VN)
- Corresponding author
- Peiris, JSM
- ORCID
- Guan, Y
- Venue
- Respiratory Research
- Published
- 2005-11-11
- Volume
- 6
- Issue
- 1
- Pages
- 135-135
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- PMC
- PMC1318487
- OpenAlex
- W2122988122
- Cited by
- 510
- References
- 37
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 16 · 2023: 10 · 2022: 10 · 2021: 23 · 2020: 24 · 2019: 14 · 2018: 20 · 2017: 19 · 2016: 16 · 2015: 21 · 2014: 26 · 2013: 36 · 2012: 26
- FWCI
- 20.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Respiratory Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Greater South Information System
- Funders
- University of Hong Kong
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- H5N1 avian influenza, influenza A virus, inflammatory cytokines, chemokines, CXCL10, interferon-beta, RANTES, interleukin-6, alveolar epithelial cells, bronchial epithelial cells, respiratory epithelium, cytokine imbalance, viral pathogenesis
- MeSH terms
- Bronchi, Cells, Cultured, Epithelial Cells, Humans, Immunologic Factors, Pulmonary Alveoli, Cytokines, Respiratory Mucosa, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H5N1 Subtype
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