TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production
Open accessAbstract
BACKGROUND: Bone marrow derived mesenchymal stem cells (bmMSCs) are multipotent cells that can differentiate into diverse cell types, including cardiomyocytes. BmMSC-based transplantation is capable of repairing acute and chronic myocardial infarction. Prior to the transplantation, MSCs are usually induced in vitro by biological reagents and chemicals for directional differentiation. Transforming growth factor beta (TGF-β) is one of the most commonly used biological reagents for induction of cardiomyocyte differentiation of bmMSCs. Previous studies have shown that TGF-β induces senescence in several cell types. However, whether TGF-β affects senescence of bmMSCs has not been elucidated. The goal of this study was to investigate the effect of TGF-β1 on senescence of bmMSCs and the underlying mechanisms. RESULTS: We found that TGF-β1 increased activity of senescence-associated-galactosidase (SA-Gal) and production of mitochondrial reactive oxygen species (mtROS) in bmMSCs in a dose-dependent manner. TGF-β1 also significantly decreased expression of superoxide dismutase 2 (SOD2) and Id1, and increased expression of 4-Hydroxynonenal (4-HNE) subunits and p16 in bmMSCs in a dose-dependent manner. Pre-treatment with mtROS inhibitor acetyl-L-carnitine (ALCAR, 0.1 mM) significantly inhibited TGF-β1-induced mtROS production and SA-Gal activity. CONCLUSION: TGF-β1 can induce senescence of bmMSCs, which at least partially depends on mtROS production.
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mtROS inhibitor reduces senescence in bone marrow mesenchymal stem cells.
“mtROS has been shown as a key inducer for premature aging, and mtROS inhibitor reduces senescence in bone marrow mesenchymal stem cells (52, 53).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [52]
mtROS has been shown as a key inducer for premature aging.
“mtROS has been shown as a key inducer for premature aging, and mtROS inhibitor reduces senescence in bone marrow mesenchymal stem cells (52, 53).”
From Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease (2015) · cites this paper as [52]
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- Authors
- Wu, J., Niu, J., Li, X., Wang, X., Guo, Z., & Zhang, F.
- Affiliations
- Henan Medical University (CN)
- Corresponding author
- Zhang, Fenxi
- Venue
- BMC Developmental Biology
- Published
- 2014-05-18
- Volume
- 14
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1471-213X (ISSN-L)
- PMC
- PMC4031602
- OpenAlex
- W2080878133
- Cited by
- 120
- References
- 38
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 15 · 2017: 14 · 2016: 11 · 2015: 14 · 2012: 1
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- BMC Developmental Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81370428)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- TGF-β1, bone marrow mesenchymal stem cells, cellular senescence, mitochondrial reactive oxygen species, manganese superoxide dismutase, Id1, 4-hydroxynonenal, p16, acetyl-L-carnitine, cardiomyocyte differentiation, myocardial infarction
- MeSH terms
- Superoxide Dismutase 2, Acetylcarnitine, Aldehydes, Animals, Bone Marrow Cells, Cells, Cultured, Dose-Response Relationship, Drug, Galactosidases, Mice, Inbred C57BL, Microscopy, Fluorescence, Mitochondria, Osteogenesis, Superoxide Dismutase, Vitamin B Complex, Blotting, Western, Cellular Senescence, Reactive Oxygen Species, Cyclin-Dependent Kinase Inhibitor p16, Adipogenesis, Mice, Inhibitor of Differentiation Protein 1, Transforming Growth Factor beta1, Mesenchymal Stem Cells
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