The role of mitochondrial dysfunction in age-related diseases

Lane, Rebecca K.; Hilsabeck, Tyler; Rea, Shane L.

doi:10.1016/j.bbabio.2015.05.021

Cited by 205Mitochondrial Function and PathologyAutophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

The role of mitochondrial dysfunction in age-related diseases

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Lane, Rebecca K., Hilsabeck, Tyler, Rea, Shane L.·2015·Biochimica et Biophysica Acta (BBA) - Bioenergetics

DOI 10.1016/j.bbabio.2015.05.021PMC PMC10481969

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Abstract

The aging process is accompanied by the onset of disease and a general decline in wellness. Insights into the aging process have revealed a number of cellular hallmarks of aging, among these epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion. Mitochondrial dysfunction increasingly appears to be a common factor connecting several of these hallmarks, driving the aging process and afflicting tissues throughout the body. Recent research has uncovered a much more complex involvement of mitochondria in the cell than has previously been appreciated and revealed novel ways in which mitochondrial defects feed into disease pathology. In this review we evaluate ways in which problems in mitochondria contribute to disease beyond the well-known mechanisms of oxidative stress and bioenergetic deficits, and we predict the direction that mitochondrial disease research will take in years to come.

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Mitochondrial dysfunction has been associated with age-related diseases such as neurological disorders, cardiovascular disease, liver and kidney diseases, diabetes and cancer.
“it has been associated with a number of age-related diseases such as neurological disorders, cardiovascularCVD, liver and kidney diseases, diabetes and cancer (Lane et al., 2015; Payne and Chinnery, 2015; Ryan et al., 2015; Wallace, 2012).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Lane et al., 2015
Mitochondrial dysfunction is a major contributor to aging and aging-driven degenerative diseases such as diabetes, heart diseases, cancer, Alzheimer's disease and Parkinson's disease.
“It is now recognized that mitochondrial dysfunction is a major contributor to aging and aging-driven degenerative disease, such as diabetes, heart diseases, cancer, Alzheimer’s disease and Parkinson’s disease [35,36,37,38,39,40].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [35]

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Mitochondrial and Metabolic Remodeling During Reprogramming and Differentiation of the Reprogrammed Cells
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Mitochondrial oxidative stress and mammalian healthspan
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Reprint of: The Great Beauty of the osteoclast
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Mitochondria Localize to the Cleavage Furrow in Mammalian Cytokinesis
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Contact-Induced Mitochondrial Polarization Supports HIV-1 Virological Synapse Formation
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Mitochondrial dysfunction in cell senescence and aging
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Mitochondrial DNA Integrity: Role in Health and Disease
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Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment
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Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis
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Modelling the molecular mechanisms of aging
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Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age‐related disorders
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Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry
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Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism
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Where Metabolism Meets Senescence: Focus on Endothelial Cells
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Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis
Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Burgess, J. K., Mutsaers, S. E., Prêle, C. M., Schuliga, M. J., Grainge, C., & Knight, D. A. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00037.2018 · Cited by 167 · see citing works
Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice
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Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson’s disease
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Mitochondrial-derived peptides in energy metabolism
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Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction
Manna, S., McCarthy, C., & McCarthy, F. P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3095383 · Cited by 141 · see citing works
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson’s disease
Shen, Y., Wu, Q., Shi, J., & Zhou, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110928 · Cited by 132 · see citing works
Estrogens regulate life and death in mitochondria
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Regulation of longevity by FGF21: interaction between energy metabolism and stress responses
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.004 · Cited by 121 · see citing works
Polyphenols as Caloric Restriction Mimetics Regulating Mitochondrial Biogenesis and Mitophagy
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Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
Kandul, N. P., Zhang, T., Hay, B. A., & Guo, M. (2016) · Nature Communications · doi:10.1038/ncomms13100 · Cited by 103 · see citing works
A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions
Iakovou, E., & Kourti, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.827900 · Cited by 113 · see citing works
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview
Martemucci, G., Portincasa, P., Ciaula, A. D., Mariano, M., Centonze, V., & D‘Alessandro, A. G. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111707 · Cited by 110 · see citing works
Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity
López-Lluch, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.005 · Cited by 103 · see citing works
“…during ageing (Riera et al., 2016) and, for this reason, it has been associated with a number of age-related diseases such as neurological disorders, cardiovascularCVD, liver and kidney diseases, diabetes and cancer (Lane et al., 2015; Payne and Chinnery, 2015; Ryan et al., 2015; Wallace, 2012).”
Background
Mitochondrial Damage‐Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease‐Associated Plaque Vulnerability
Bi, X., Du, C., Wang, X., Wang, X., Han, W., Wang, Y., Qiao, Y., Zhu, Y., Ran, L., Liu, Y., et al. (2021) · Advanced Science · doi:10.1002/advs.202002738 · Cited by 102 · see citing works
Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases
Kakavandi, S., Zare, I., Vaezjalali, M., Dadashi, M., Azarian, M., Akbari, A., Farani, M. R., Zalpoor, H., & Hajikhani, B. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01104-5 · Cited by 104 · see citing works
Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria
Miwa, S., Czapiewski, R., Wan, T., Bell, A., Hill, K. N., von Zglinicki, T., & Saretzki, G. C. (2016) · Aging · doi:10.18632/aging.101089 · Cited by 98 · see citing works
Mitochondrial Transplantation as a Novel Therapeutic Strategy for Mitochondrial Diseases
Park, A., Oh, M., Lee, S. H., Oh, K., Lee, E., Lee, S.-W., Bae, K., Han, B., & Kim, W. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094793 · Cited by 97 · see citing works
PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state
Caporarello, N., Meridew, J. A., Jones, D. L., Tan, Q., Haak, A. J., Choi, K. M., Manlove, L. J., Prakash, Y. S., Tschumperlin, D. J., & Ligresti, G. (2019) · Thorax · doi:10.1136/thoraxjnl-2019-213064 · Cited by 97 · see citing works
The mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94 · see citing works
Mitochondrial quality control and its role in osteoporosis
Yan, C., Shi, Y., Yuan, L., Lv, D., Sun, B. T., Wang, J., Liu, X., & An, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1077058 · Cited by 85 · see citing works
Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone
Shum, L. C., White, N., Nadtochiy, S. M., Bentley, K. L. D. M., Brookes, P. S., Jonason, J. H., & Eliseev, R. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155709 · Cited by 85 · see citing works
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
Fedintsev, A., & Moskalev, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101097 · Cited by 81 · see citing works
Mitochondrial lipids in neurodegeneration
Aufschnaiter, A., Kohler, V., Diessl, J., Peselj, C., Carmona‐Gutiérrez, D., Keller, W., & Büttner, S. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2463-1 · Cited by 85 · see citing works
The importance of estradiol for body weight regulation in women
Pilar Vigil, P., Meléndez, J., Petkovic, G., & Río, J. P. D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.951186 · Cited by 82 · see citing works
Metabolomic profiles associated with bone mineral density in US Caucasian women
Zhao, Q., Shen, H., Su, K., Zhang, J.-G., Tian, Q., Zhao, L., Qiu, C., Zhang, Q., Garrett, T. J., Liu, J., et al. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0296-5 · Cited by 76 · see citing works
Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases
Cameron, R. B., Beeson, C. C., & Schnellmann, R. G. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00669 · Cited by 74 · see citing works
Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health
Moustakli, E., Stavros, S., Katopodis, P., Skentou, C., Potiris, A., Panagopoulos, P., Domali, E., Arkoulis, I., Karampitsakos, T., Sarafi, E., et al. (2025) · Cells · doi:10.3390/cells14010036 · Cited by 64 · see citing works
DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans
Munkácsy, E., Khan, M. H., Lane, R. K., Borror, M. B., Park, J. H., Bokov, A. F., Fisher, A. L., Link, C. D., & Rea, S. L. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006133 · Cited by 61 · see citing works
Self-citation
Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment
Toledo, C., Andrade, D. C., Díaz, H. S., Inestrosa, N. C., & Rio, R. D. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01655-0 · Cited by 58 · see citing works
Leonurine Protects Bone Mesenchymal Stem Cells from Oxidative Stress by Activating Mitophagy through PI3K/Akt/mTOR Pathway
Zhao, B., Peng, Q., Wang, D. M., Zhou, R., Wang, R., Zhu, Y. Z., & Qi, S. (2022) · Cells · doi:10.3390/cells11111724 · Cited by 59 · see citing works
Mitochondrial metabolism: a common link between neuroinflammation and neurodegeneration
Garabadu, D., Agrawal, N., Sharma, A., & Sharma, S. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000505 · Cited by 57 · see citing works
BNIP3-Dependent Mitophagy via PGC1α Promotes Cartilage Degradation
Kim, D., Song, J., & Jin, E.-J. (2021) · Cells · doi:10.3390/cells10071839 · Cited by 55 · see citing works
Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases
Irwin, M. H., Moos, W. H., Faller, D. V., Steliou, K., & Pinkert, C. A. (2016) · Drug Development Research · doi:10.1002/ddr.21294 · Cited by 56 · see citing works
Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?
López‐Lluch, G., Hernández‐Camacho, J. D., Fernández‐Ayala, D. J. M., & Navas, P. (2018) · Biogerontology · doi:10.1007/s10522-018-9768-2 · Cited by 57 · see citing works
Premature aging disorders: A clinical and genetic compendium
Schnabel, F., Kornak, U., & Wollnik, B. (2020) · Clinical Genetics · doi:10.1111/cge.13837 · Cited by 57 · see citing works
Mitochondrial dysfunction and therapeutic perspectives in osteoporosis
Liu, J., Gao, Z., & Liu, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1325317 · Cited by 57 · see citing works
Mitophagy Regulates Neurodegenerative Diseases
Cen, X., Zhang, M., Zhou, M., Ye, L., & Xia, H. (2021) · Cells · doi:10.3390/cells10081876 · Cited by 58 · see citing works
Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline
Berchtold, N. C., Prieto, G. A., Phelan, M. J., Gillen, D. L., Baldi, P., Bennett, D. A., Buchman, A. S., & Cotman, C. W. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.02.012 · Cited by 53 · see citing works
Auditory Dysfunction in Parkinson's Disease
Jafari, Z., Kolb, B. E., & Mohajerani, M. H. (2020) · Movement Disorders · doi:10.1002/mds.28000 · Cited by 54 · see citing works
MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men
Pham, T., MacRae, C. L., Broome, S. C., D’Souza, R. F., Narang, R. K., Wang, H. W., Mori, T. A., Hickey, A. J., Mitchell, C. J., & Merry, T. L. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04396-4 · Cited by 53 · see citing works
Proteomics of human mitochondria
Palmfeldt, J., & Bross, P. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.07.006 · Cited by 53 · see citing works
Mitochondria as the Essence of Yang Qi in the Human Body
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Authors: Lane, R. K., Hilsabeck, T., & Rea, S. L.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Rea, Shane L.
ORCID: Lane, Rebecca K.
Hilsabeck, Tyler
Rea, Shane L.
Venue: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher: Elsevier BV
Published: 2015-11
Volume: 1847
Issue: 11
Pages: 1387-1400
ISSN: 0005-2728 (ISSN-L)
DOI: 10.1016/j.bbabio.2015.05.021
PMC: PMC10481969
OpenAlex: W625172625
Cited by: 205
References: 200
Citations by year: 2026: 7 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 22 · 2021: 25 · 2020: 27 · 2019: 20 · 2018: 12 · 2017: 21 · 2016: 22 · 2015: 3
FWCI: 1.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute for Aging
R21AG047561 (SLR)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: mitochondrial dysfunction, aging, age-related diseases, cellular senescence, stem cell exhaustion, proteostasis, epigenetic modifications, oxidative stress, mitochondrial disease
MeSH terms: Aging, Animals, Cell Differentiation, Humans, Mitochondria, Osteoporosis, Stem Cells, Neurodegenerative Diseases, Atherosclerosis

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