Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet
Open accessAbstract
BACKGROUND: Dietary polyunsaturated fatty acids (PUFA), in particular the long chain marine fatty acids docosahexaenoic (DHA) and eicosapentaenoic (EPA), are linked to many health benefits in humans and in animal models. Little is known of the molecular response to DHA and EPA of the small intestine, and the potential contribution of this organ to the beneficial effects of these fatty acids. Here, we assessed gene expression changes induced by DHA and EPA in the wildtype C57BL/6J murine small intestine using whole genome microarrays and functionally characterized the most prominent biological process. RESULTS: The main biological process affected based on gene expression analysis was lipid metabolism. Fatty acid uptake, peroxisomal and mitochondrial beta-oxidation, and omega-oxidation of fatty acids were all increased. Quantitative real time PCR, and -- in a second animal experiment -- intestinal fatty acid oxidation measurements confirmed significant gene expression differences and showed in a dose-dependent manner significant changes at biological functional level. Furthermore, no major changes in the expression of lipid metabolism genes were observed in the colon. CONCLUSION: We show that marine n-3 fatty acids regulate small intestinal gene expression and increase fatty acid oxidation. Since this organ contributes significantly to whole organism energy use, this effect on the small intestine may well contribute to the beneficial physiological effects of marine PUFAs under conditions that will normally lead to development of obesity, insulin resistance and diabetes.
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Whole genome microarray analysis on intestinal cells of C57BL/6J mice treated with EPA and DHA confirmed that the main biological process affected is lipid metabolism.
“Whole genome microarray analysis performed on intestinal cells of C57BL/6J mice treated with EPA and DHA confirmed that the main biological process affected by such treatment is lipid metabolism (increase in the expression of Acaa1, Acacb, CPT-1A) [287].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [287]
Cholesterol synthesis was reduced, while its reabsorption was increased in EPA/DHA-treated mice.
“Cholesterol synthesis was also reduced, while its reabsorption was increased [287].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [287]
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- Authors
- van Schothorst, E. M., Flachs, P., Franssen-van Hal, N. L., Kuda, O., Bunschoten, A., Molthoff, J., Vink, C., Hooiveld, G. J., Kopecky, J., & Keijer, J.
- Affiliations
- Czech Academy of Sciences (CZ)
- Wageningen University & Research (NL)
- Venue
- BMC Genomics
- Published
- 2009
- Volume
- 10
- Issue
- 1
- Pages
- 110
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC2662879
- OpenAlex
- W2163912174
- Cited by
- 64
- References
- 47
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Genomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Grantová Agentura České Republiky (1M6837805002)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- docosahexaenoic acid, eicosapentaenoic acid, omega-3 fatty acids, small intestine, high-fat diet, fatty acid oxidation, lipid metabolism, gene expression, fatty acid uptake, fatty acid beta-oxidation, omega-oxidation, intestinal energy metabolism, obesity, insulin resistance, diabetes mellitus
- MeSH terms
- Animals, Colon, Docosahexaenoic Acids, Gene Expression Regulation, Intestine, Small, Male, Mice, Inbred C57BL, Oxidation-Reduction, Phenotype, Promoter Regions, Genetic, RNA, Transcription Factors, Eicosapentaenoic Acid, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Lipid Metabolism, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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