The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Hidden layers of human small RNAs
Open accessAbstract
Background: Small RNA attracts increasing interest based on the discovery of RNA silencing and the rapid progress of our understanding of these phenomena. Although recent studies suggest the possible existence of yet undiscovered types of small RNAs in higher organisms, many studies to profile small RNA have focused on miRNA and/or siRNA rather than on the exploration of additional classes of RNAs. Results: Here, we explored human small RNAs by unbiased sequencing of RNAs with sizes of 19–40 nt. We provide substantial evidences for the existence of independent classes of small RNAs. Our data shows that well-characterized non-coding RNA, such as tRNA, snoRNA, and snRNA are cleaved at sites specific to the class of ncRNA. In particular, tRNA cleavage is regulated depending on tRNA type and tissue expression. We also found small RNAs mapped to genomic regions that are transcribed in both directions by bidirectional promoters, indicating that the small RNAs are a product of dsRNA formation and their subsequent cleavage. Their partial similarity with ribosomal RNAs (rRNAs) suggests unrevealed functions of ribosomal DNA or interstitial rRNA. Further examination revealed six novel miRNAs. Conclusion: Our results underscore the complexity of the small RNA world and the biogenesis of small RNAs.
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Cites
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<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
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Self-citationThe microRNAs of Caenorhabditis elegans
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Cited by
Landscape of transcription in human cells
Djebali, S., Davis, C. A., Merkel, A., Dobin, A., Lassmann, T., Mortazavi, A., Tanzer, A., Lagarde, J., Lin, W., Schlesinger, F., et al. (2012) · Nature · doi:10.1038/nature11233 · Cited by 5,187
Self-citationA novel class of small RNAs: tRNA-derived RNA fragments (tRFs)
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RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
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Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)
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Metadata
- Authors
- Kawaji, H., Nakamura, M., Takahashi, Y., Sandelin, A., Katayama, S., Fukuda, S., Daub, C. O., Kai, C., Kawai, J., Yasuda, J., Carninci, P., & Hayashizaki, Y.
- Venue
- BMC Genomics
- Published
- 2008-04-10
- Volume
- 9
- Issue
- 1
- Pages
- 157-157
- ISSN
- 1471-2164 (ISSN-L)
- OpenAlex
- W2093956979
- Cited by
- 298
- References
- 13
- FWCI
- 29.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kawaji, H., Nakamura, M., Takahashi, Y., Sandelin, A., Katayama, S., Fukuda, S., Daub, C. O., Kai, C., Kawai, J., Yasuda, J., Carninci, P., & Hayashizaki, Y. (2008). Hidden layers of human small RNAs. BMC Genomics. https://doi.org/10.1186/1471-2164-9-157
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