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Cited by 274

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney

Open access
Tirkey, Naveen, Pilkhwal, Sangeeta, Kuhad, Anurag, Chopra, Kanwaljit·2005·BMC Pharmacology
DOI 10.1186/1471-2210-5-2
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Abstract

Background: CCl 4 is a well-established hepatotoxin inducing liver injury by producing free radicals. Exposure to CCl 4 also induces acute and chronic renal injuries. The present study was designed to establish the protective effect of hesperidin (HDN), a citrus bioflavonoid, on CCl 4-induced oxidative stress and resultant dysfunction of rat liver and kidney. Methods: Animals were pretreated with HDN (100 and 200 mg/kg orally) for one week and then challenged with CCl 4 (2 ml/kg/s.c.) in olive oil. Rats were sacrificed by carotid bleeding under ether anesthesia. Liver enzymes, urea and creatinine were estimated in serum. Oxidative stress in liver and kidney tissue was estimated using Thiobarbituric acid reactive substances (TBARS), glutathione (GSH) content, superoxide dismutase(SOD), and Catalase (CAT) Results: CCl 4 caused a marked rise in serum levels of ALT and AST (P < 0.05). TBARS levels were significantly increased whereas GSH, SOD and CAT levels decreased in the liver and kidney homogenates of CCl 4 treated rats. HDN (200 mg/kg) successfully attenuated these effects of CCl 4 Conclusion: In conclusion, our study demonstrated a protective effect of HDN in CCl 4 induced oxidative stress in rat liver and kidney. This protective effect of HDN can be correlated to its direct antioxidant effect.

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Metadata

Authors
Tirkey, N., Pilkhwal, S., Kuhad, A., & Chopra, K.
Venue
BMC Pharmacology
Publisher
Springer Science and Business Media LLC
Published
2005-01-31
Volume
5
Issue
1
Pages
2-2
ISSN
1471-2210 (ISSN-L)
DOI
10.1186/1471-2210-5-2
OpenAlex
W1791138468
Cited by
274
References
25
FWCI
6.66
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. https://app.cochat.ai/papers/10.1186/1471-2210-5-2
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Tirkey, N., Pilkhwal, S., Kuhad, A., & Chopra, K. (2005). Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacology. https://doi.org/10.1186/1471-2210-5-2

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