Hertfordshire sarcopenia study: design and methods
Open accessAbstract
BACKGROUND: Sarcopenia is defined as the loss of muscle mass and strength with age. Although a number of adult influences are recognised, there remains considerable unexplained variation in muscle mass and strength between older individuals. This has focused attention on influences operating earlier in life. Our objective for this study was to identify life course influences on muscle mass and strength in an established birth cohort and develop methodology for collection of muscle tissue suitable to investigate underlying cellular and molecular mechanisms. METHODS: One hundred and five men from the Hertfordshire Cohort Study (HCS), born between 1931 and 1939 who have historical records of birth weight and weight at one year took part in the Hertfordshire Sarcopenia Study (HSS). Each participant consented for detailed characterisation of muscle mass, muscle function and aerobic capacity. In addition, a muscle biopsy of the vastus lateralis using a Weil-Blakesley conchotome was performed. Data on muscle mass, function and aerobic capacity was collected on all 105 participants. Muscle biopsy was successfully carried out in 102 participants with high rates of acceptability. No adverse incidents occurred during the study. DISCUSSION: The novel approach of combining epidemiological and basic science characterisation of muscle in a well established birth cohort will allow the investigation of cellular and molecular mechanisms underlying life course influences on sarcopenia.
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Treating primary myotubes from donors with sarcopenia and aged-matched healthy controls with trigonelline raised cellular NAD+ with comparable efficiency between groups.
“Treating primary myotubes from different donors with sarcopenia and aged-matched healthy controls35 raised cellular NAD+ (Fig. 1g) with comparable efficiency between groups (Extended Data Fig. 1j).”
From Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia (2024) · cites this paper as [35]
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Turner, D. C., Kasper, A. M., Seaborne, R. A. E., Brown, A. D., Close, G. L., Murphy, M., Stewart, C. E., Martin, N. R. W., & Sharples, A. P. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8897-6_5 · Cited by 11 · see citing works
Self-citationCelik, D., Campisi, M., Cannella, L., & Pavanello, S. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13455 · Cited by 10 · see citing works
Ageing of human myofibres in the Vastus Lateralis muscle: A narrative review
Granic, A., Simoes, D. C. M., Bowen, T. S., Almaghtuf, N., Richardson, G. D., & Sayer, A. A. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103022 · Cited by 8 · see citing works
Self-citationA perspective on muscle phenotyping in musculoskeletal research
Foessl, I., Ackert‐Bicknell, C. L., Kague, É., Laskou, F., Jakob, F. J., Karasik, D., Obermayer-Pietsch, B. M., Alonso, N., Bjørnerem, Å., Brandi, M. L., et al. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.01.004 · Cited by 8 · see citing works
“Muscle biopsy analysis can provide details of morphological characteristics, gene transcription and expression, and metabolism, allowing identi fi cation of the mechanisms of skeletal muscle loss/sarcopenia [108 – 111].”
Mei, C. T. Y., Ying, S. S. S., Yanshan, D. L., Koh, S. V., Karthikeyan, G., Xia, O. J., Low, X. L., Quek, H. Y., Shuyi, A. O., Low, L. L., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0291702 · Cited by 8 · see citing works
Burton, M. A., Antoun, E., Garratt, E. S., Westbury, L. D., Dennison, E. M., Harvey, N. C., Cooper, C. C., Patel, H. P., Godfrey, K. M., & Lillycrop, K. A. (2024) · The FASEB Journal · doi:10.1096/fj.202301089rr · Cited by 7 · see citing works
Self-citationExercício resistido em idosos frágeis: uma revisão da literatura
Câmara, L. C., Bastos, C. C., & Volpe, E. T. (2012) · Fisioterapia em Movimento · doi:10.1590/s0103-51502012000200021 · Cited by 10 · see citing works
Laskou, F., Linfield, A., Aggarwal, P., Dennison, E. M., & Patel, H. P. (2022) · Osteology · doi:10.3390/osteology2010005 · Cited by 5 · see citing works
“We have previously studied muscle–bone interrelationships in the HCS [30,31], but SaLSA provides an opportunity to perform detailed investigation of bone trabecular and cortical microarchitecture using HRpQCT [32–36], muscle ultrasound [24], and muscle biopsy—a technique which we have previously shown to be acceptable…”
MethodSelf-citationRygiel, K. A., Dodds, R. M., Patel, H. P., Syddall, H. E., Westbury, L. D., Granic, A., Cooper, C. C., Cliff, J., Rocha, M. C., Turnbull, D. M., et al. (2017) · JCSM Clinical Reports · doi:10.17987/jcsm-cr.v2i2.35 · Cited by 3 · see citing works
“Biopsies of the VL muscle were obtained from 99 participants using a Weil Blakesley conchotome using a standard aseptic technique [19,22].”
MethodSelf-citationA Lifecourse Approach to Sarcopenia
Dodds, R. M., & Sayer, A. A. (2021) · doi:10.1002/9781119597896.ch8 · Cited by 3 · see citing works
Self-citationAntoun, E., Migliavacca, E., Garratt, E. S., Barton, S. J., Titcombe, P., Westbury, L. D., Baczynska, A., Dodds, R., Roberts, H. C., Sayer, A. A., et al. (2021) · JCSM Rapid Communications · doi:10.1002/rco2.44 · Cited by 2 · see citing works
Self-citationA Lifecourse Approach to Sarcopenia
Sayer, A. A. (2012) · doi:10.1002/9781118338032.ch9
Self-citationFilonov, I. L., Владимировна, А. А., Данилович, С. В., & Чуйко, Д. С. (2018) · Medical Herald of the South of Russia · doi:10.21886/2219-8075-2018-9-2-6-14
A life course approach for understanding later life sustainability
Dodds, R. M., Syddall, H. E., & Sayer, A. A. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198701590.003.0014_update_001
Self-citationSalud y envejecimiento situación actual, retos y propuestas
Acosta, I., Suárez", I. N. D. N. Y. N. ". V., Cordero, R. Á., de Medicina, U. N. A. D. M. (., Góngora, A. A., Suárez", I. N. D. N. Y. N. ". V., Morales, N. A., Suárez", I. N. D. N. Y. N. ". V., Rueda, C. A., de Durango, U. J., et al. (2013) · Universidad Nacional Autónoma de México, Secretaría de Desarrollo Institucional, Seminario sobre Medicina y Salud eBooks · doi:10.22201/sdi.9786070248597p.2013
Tan, C. Y. M., Seah, S. S. Y., Yanshan, D. L., Koh, S. V., Ganeshan, K., Xia, O. J., Low, X. L., Quek, H. Y., Shuyi, A. O., Low, L. L., et al. (2023) · medRxiv · doi:10.1101/2023.09.06.23295117
Cooper, R., Hurst, C., Syddall, H. E., Atkinson, H., Bunn, J. G., Carpinelli, D., Granic, A., Hillman, S. J., Lewis, E. G., McDonald, C., et al. (2026) · medRxiv · doi:10.64898/2026.02.18.26346577
Self-citationCooper, R., Hurst, C., Syddall, H. E., Atkinson, H., Bunn, J. G., Carpinelli, D., Granic, A., Hillman, S. J., Lewis, E. G., McDonald, C., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02341-5
Self-citation
- Authors
- Patel, H. P., Syddall, H. E., Martin, H. J., Stewart, C. E., Cooper, C., & Sayer, A. A.
- Affiliations
- Southampton General Hospital (GB)
- Manchester Metropolitan University (GB)
- Corresponding author
- Patel, Harnish P
- Venue
- BMC Geriatrics
- Published
- 2010-06-29
- Volume
- 10
- Issue
- 1
- Pages
- 43-43
- ISSN
- 1471-2318 (ISSN-L)
- PMC
- PMC2909243
- OpenAlex
- W2083826547
- Cited by
- 48
- References
- 52
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 4 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Geriatrics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Liverpool John Moores University (acceptedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Wellcome Trust
- National Institute for Health and Care Research (ACF-2008-26-006, NF-SI-0508-10082)
- British Geriatrics Society
- Research Councils UK
- University of Southampton
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenia, muscle mass, muscle strength, birth cohort, Hertfordshire Cohort Study, muscle biopsy, vastus lateralis, cardiorespiratory fitness, muscle function, birth weight, older men, cellular and molecular mechanisms
- MeSH terms
- Aged, Aging, Biopsy, England, Humans, Male, Retrospective Studies, Cohort Studies, Muscle, Skeletal, Hand Strength, Sarcopenia
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