The developmental origins of sarcopenia
Open accessAbstract
Sarcopenia is defined as the loss of skeletal muscle mass and strength with age1. There is increasing recognition of the serious health consequences of sarcopenia both in terms of disability2, morbidity3 and mortality4, and in terms of significant healthcare costs5. Adult determinants of sarcopenia including age, gender, size, levels of physical activity and heritability have been well described1;6-8. In particular the place of physical activity and resistance exercise training as the most effective intervention to slow loss is widely accepted9;10.
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- Authors
- Sayer, A. A., Syddall, H., Martin, H., Patel, H., Baylis, D., & Cooper, C.
- Affiliations
- Southampton General Hospital (GB)
- Corresponding author
- Sayer, A.A.
- Venue
- The Journal of nutrition, health and aging
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 12
- Issue
- 7
- Pages
- 427-432
- ISSN
- 1279-7707 (ISSN-L)
- PMC
- PMC2652119
- OpenAlex
- W2000192253
- Cited by
- 450
- References
- 58
- Citations by year
- 2026: 16 · 2025: 37 · 2024: 46 · 2023: 49 · 2022: 48 · 2021: 54 · 2020: 40 · 2019: 14 · 2018: 21 · 2017: 18 · 2016: 19 · 2015: 17 · 2014: 8 · 2013: 15 · 2012: 21
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Institute for Health and Care Research (ACF-2008-26-006, ACF-2007-26-005)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenia, skeletal muscle mass, muscle strength, aging, developmental origins, physical activity, resistance training, heritability, disability, health care costs
- MeSH terms
- Aged, Aged, 80 and over, Aging, Female, Humans, Life Style, Male, Middle Aged, Muscle Contraction, Muscular Atrophy, Muscle, Skeletal
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