Cited by 450Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

The developmental origins of sarcopenia

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Sayer, A.A., Syddall, H., Martin, H., Patel, H., Baylis, D., Cooper, C.·2008·The Journal of nutrition, health and aging

Abstract

Sarcopenia is defined as the loss of skeletal muscle mass and strength with age1. There is increasing recognition of the serious health consequences of sarcopenia both in terms of disability2, morbidity3 and mortality4, and in terms of significant healthcare costs5. Adult determinants of sarcopenia including age, gender, size, levels of physical activity and heritability have been well described1;6-8. In particular the place of physical activity and resistance exercise training as the most effective intervention to slow loss is widely accepted9;10.

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Authors
Sayer, A. A., Syddall, H., Martin, H., Patel, H., Baylis, D., & Cooper, C.
Affiliations
Southampton General Hospital (GB)
Corresponding author
Sayer, A.A.
Venue
The Journal of nutrition, health and aging
Publisher
Elsevier BV
Published
2008-09
Volume
12
Issue
7
Pages
427-432
ISSN
1279-7707 (ISSN-L)
OpenAlex
W2000192253
Cited by
450
References
58
Citations by year
2026: 16 · 2025: 37 · 2024: 46 · 2023: 49 · 2022: 48 · 2021: 54 · 2020: 40 · 2019: 14 · 2018: 21 · 2017: 18 · 2016: 19 · 2015: 17 · 2014: 8 · 2013: 15 · 2012: 21
FWCI
5.87
Type
journal article
Language
en
Open access
Locations
  • The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Funders
National Institute for Health and Care Research (ACF-2008-26-006, ACF-2007-26-005)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
sarcopenia, skeletal muscle mass, muscle strength, aging, developmental origins, physical activity, resistance training, heritability, disability, health care costs
MeSH terms
Aged, Aged, 80 and over, Aging, Female, Humans, Life Style, Male, Middle Aged, Muscle Contraction, Muscular Atrophy, Muscle, Skeletal

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