Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: results from an open-label trial.
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BACKGROUND: Hospitalized patients are at increased risk for candidemia and invasive candidiasis (C/IC). Improved therapeutic regimens with enhanced clinical and pharmacoeconomic outcomes utilizing existing antifungal agents are still needed. METHODS: An open-label, non-comparative study evaluated an intravenous (i.v.) to oral step-down strategy. Patients with C/IC were treated with i.v. anidulafungin and after 5 days of i.v. therapy had the option to step-down to oral azole therapy (fluconazole or voriconazole) if they met prespecified criteria. The primary endpoint was the global response rate (clinical + microbiological) at end of treatment (EOT) in the modified intent-to-treat (MITT) population (at least one dose of anidulafungin plus positive Candida within 96 hours of study entry). Secondary endpoints included efficacy at other time points and in predefined patient subpopulations. Patients who stepped down early (≤ 7 days' anidulafungin) were identified as the "early switch" subpopulation. RESULTS: In total, 282 patients were enrolled, of whom 250 were included in the MITT population. The MITT global response rate at EOT was 83.7% (95% confidence interval, 78.7-88.8). Global response rates at all time points were generally similar in the early switch subpopulation compared with the MITT population. Global response rates were also similar across multiple Candida species, including C. albicans, C. glabrata, and C. parapsilosis. The most common treatment-related adverse events were nausea and vomiting (four patients each). CONCLUSIONS: A short course of i.v. anidulafungin, followed by early step-down to oral azole therapy, is an effective and well-tolerated approach for the treatment of C/IC. TRIAL REGISTRATION: ClinicalTrials.gov: NCT00496197.
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De-escalation to fluconazole was shown to be safe and feasible for multiple Candida species, including C. glabrata.
“This strategy was shown to be safe and feasible for multiple Candida species, including C. glabrata [94].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [94]
Various PCR formats focusing specifically on the detection of mutations in C. glabrata have been developed.
“Various PCR formats focussing specifically on the detection of mutations in C. glabrata have been developed (50;51).”
From Echinocandin resistance: an emerging clinical problem? (2014) · cites this paper as [51]
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Cites
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174 · cited 2× · see citing works
“; licensee BioMed Centra Commons Attribution License (http://creativec reproduction in any medium, provided the or The incidence of candidemia appears to be considerably higher in the United States (US) compared with Canada and Europe, with the exception of Denmark [1,2].”
BackgroundInternational Study of the Prevalence and Outcomes of Infection in Intensive Care Units
Vincent, J. (2009) · JAMA · doi:10.1001/jama.2009.1754 · Cited by 3,639 · see citing works
Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191 · see citing works
Self-citationComparison of Caspofungin and Amphotericin B for Invasive Candidiasis
Mora-Duarte, J., Betts, R., Rotstein, C., Colombo, A. L., Thompson-Moya, L., Smietana, J., Lupinacci, R., Sable, C., Kartsonis, N., & Perfect, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021585 · Cited by 1,380 · see citing works
Cornely, O. A., Bassetti, M., Calandra, T., Garbino, J., Kullberg, B. J., Lortholary, O., Meersseman, W., Akova, M., Arendrup, M. C., Arikan-Akdagli, S., et al. (2012) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12039 · Cited by 1,217 · see citing works
Attributable Mortality of Nosocomial Candidemia, Revisited
Gudlaugsson, O., Gillespie, S., Lee, K., Berg, J. V., Hu, J., Messer, S., Herwaldt, L., Pfaller, M., & Diekema, D. (2003) · Clinical Infectious Diseases · doi:10.1086/378745 · Cited by 1,140 · see citing works
Denning, D. W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14472-8 · Cited by 1,131 · see citing works
Anidulafungin versus Fluconazole for Invasive Candidiasis
Reboli, A. C., Rotstein, C., Pappas, P. G., Chapman, S. W., Kett, D. H., Kumar, D., Betts, R., Wible, M., Goldstein, B. P., Schranz, J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066906 · Cited by 894 · see citing works
Self-citationParczewska, O. K., Posaconazol, przeciwgrzybicze, L., Anidulafungina, Micafungina, & wrażliwość, O. (2009) · Cited by 656 · see citing works
Morgan, J., Meltzer, M. I., Plikaytis, B. D., Sofair, A. N., Huie-White, S., Wilcox, S., Harrison, L. H., Seaberg, E. C., Hajjeh, R. A., & Teutsch, S. M. (2005) · Infection Control & Hospital Epidemiology · doi:10.1086/502581 · Cited by 437 · see citing works
Pfaller, M. A., Diekema, D. J., Ostrosky-Zeichner, L., Rex, J. H., Alexander, B. D., Andes, D., Brown, S. D., Chaturvedi, V., Ghannoum, M. A., Knapp, C. C., et al. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00566-08 · Cited by 250 · see citing works
Krause, D. S., Simjee, A. E., van Rensburg, C. E. J., Viljoen, J., Walsh, T. J., Goldstein, B. P., Wible, M., & Henkel, T. (2004) · Clinical Infectious Diseases · doi:10.1086/423378 · Cited by 241 · see citing works
Krause, D. S., Reinhardt, J. F., Vázquez, J. A., Reboli, A. C., Goldstein, B. P., Wible, M., & Henkel, T. J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.2021-2024.2004 · Cited by 177 · see citing works
Self-citationSevinç, F., Prins, J. M., Koopmans, R. P., Langendijk, P. N. J., Bossuyt, P. M., Dankert, J., & Speelman, P. (1999) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/43.4.601 · Cited by 172 · see citing works
Outcomes of early switching from intravenous to oral antibiotics on medical wards
Mertz, D., Koller, M., Haller, P., Lampert, M. L., Plagge, H., Hug, B. L., Koch, G., Battegay, M., Flückiger, U. M., & Bassetti, S. (2009) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkp131 · Cited by 165 · see citing works
Antimicrobial Stewardship Programs: How to Start and Steer a Successful Program
Drew, R. H. (2009) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2009.15.s2.18 · Cited by 119 · see citing works
Kett, D. H., Shorr, A. F., Reboli, A. C., Reisman, A. L., Biswas, P., & Schlamm, H. T. (2011) · Critical Care · doi:10.1186/cc10514 · Cited by 101 · see citing works
Self-citationMcLaughlin, C., Bodasing, N., Boyter, A. C., Fenelon, C., Fox, J., & Seaton, R. A. (2005) · QJM · doi:10.1093/qjmed/hci114 · Cited by 90 · see citing works
Chalmers, J. D., Al-Khairalla, M. Z. H., Short, P., Fardon, T. C., & Winter, J. H. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq038 · Cited by 54 · see citing works
Vázquez, J. A., Schranz, J., Clark, K., Goldstein, B. P., Reboli, A. C., & Fichtenbaum, C. J. (2008) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31817af47a · Cited by 45 · see citing works
Self-citationDesai, M., Franklin, B. D., Holmes, A. H., Sarah Trust, Richards, M., Jacklin, A., & Bamford, K. B. (2006) · BMC Infectious Diseases · doi:10.1186/1471-2334-6-94 · Cited by 35 · see citing works
Containing Costs and Containing Bugs: Are They Mutually Exclusive?
Nicolau, D. P. (2009) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2009.15.s2.12 · Cited by 11 · see citing works
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Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Self-citationPappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L., & Kullberg, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.26 · Cited by 1,636 · see citing works
Self-citationKullberg, B. J., & Arendrup, M. C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1315399 · Cited by 1,315 · see citing works
Tissot, F., Agrawal, S., Pagano, L., Petrikkos, G., Groll, A. H., Skiada, A., Lass-Flörl, C., Calandra, T., Viscoli, C., & Herbrecht, R. (2017) · Haematologica · doi:10.3324/haematol.2016.152900 · Cited by 682 · see citing works
Echinocandin resistance: an emerging clinical problem?
Arendrup, M. C., & Perlin, D. S. (2014) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000111 · Cited by 299 · see citing works
McCarty, T. P., & Pappas, P. G. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.013 · Cited by 285 · see citing works
Self-citationCandidemia and Invasive Candidiasis
McCarty, T. P., White, C. M., & Pappas, P. G. (2021) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2021.03.007 · Cited by 260 · see citing works
Self-citationCandidemia and invasive candidiasis in adults: A narrative review
Antinori, S., Milazzo, L., Sollima, S., Galli, M., & Corbellino, M. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.06.029 · Cited by 259 · see citing works
ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients
Martín‐Loeches, I., Antonelli, M. M., Cuenca‐Estrella, M., Dimοpoulos, G., Einav, S., Waele, J. J. D., Garnacho‐Montero, J., Kanj, S. S., Machado, F. R., Montravers, P., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05599-w · Cited by 234 · see citing works
Groll, A. H., Pana, D., Lanternier, F., Mesini, A., Ammann, R. A., Averbuch, D., Castagnola, E., Cesaro, S., Engelhard, D., García‐Vidal, C., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(20)30723-3 · Cited by 231 · see citing works
Tabah, A., Bassetti, M., Kollef, M. H., Zahar, J.-R., Paiva, J.-A., Timsit, J.-F., Roberts, J. A., Schouten, J., Giamarellou, H., Rello, J., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05866-w · Cited by 191 · see citing works
Intensive care medicine research agenda on invasive fungal infection in critically ill patients
Bassetti, M., Garnacho‐Montero, J., Calandra, T., Kullberg, B. J., Dimοpoulos, G., Azoulay, É., Chakrabarti, A., Kett, D., León, C., Ostrosky‐Zeichner, L., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4731-2 · Cited by 185 · see citing works
Self-citationDiagnosis and Treatment of Invasive Candidiasis
Barantsevich, N. E., & Barantsevich, E. P. (2022) · Antibiotics · doi:10.3390/antibiotics11060718 · Cited by 193 · see citing works
Invasive candidiasis in critical care: challenges and future directions
Logan, C., Martin-Loeches, I., & Bicanic, T. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06240-x · Cited by 180 · see citing works
Cháves, F., Garnacho‐Montero, J., del Pozo, J. L., Bouza, E., Capdevila, J. A., de Cueto, M., Domínguez, M. Á., Esteban, J., Fernández‐Hidalgo, N., Sampedro, M. F., et al. (2018) · Medicina Intensiva · doi:10.1016/j.medin.2017.09.012 · Cited by 174 · see citing works
Treatment of Invasive Candidiasis: A Narrative Review
Ben-Ami, R. (2018) · Journal of Fungi · doi:10.3390/jof4030097 · Cited by 111 · see citing works
Antifungal stewardship in daily practice and health economic implications
Muñóz, P., Valerio, M., Vena, A., & Bouza, E. (2015) · Mycoses · doi:10.1111/myc.12329 · Cited by 101 · see citing works
What has changed in the treatment of invasive candidiasis? A look at the past 10 years and ahead
Bassetti, M., Righi, E., Montravers, P., & Cornely, O. A. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx445 · Cited by 101 · see citing works
Chen, S. C., Sorrell, T. C., Chang, C. C., Paige, E. K., Bryant, P. A., & Slavin, M. A. (2014) · Internal Medicine Journal · doi:10.1111/imj.12597 · Cited by 78 · see citing works
Ruhnke, M., Cornely, O. A., Schmidt‐Hieber, M., Alakel, N., Boell, B., Buchheidt, D., Christopeit, M., Hasenkamp, J., Heinz, W., Hentrich, M., et al. (2020) · Mycoses · doi:10.1111/myc.13082 · Cited by 76 · see citing works
Management bundles for candidaemia: the impact of compliance on clinical outcomes
Takesue, Y., Ueda, T., Mikamo, H., Oda, S., Takakura, S., Kitagawa, Y., KOHNO, S., on behalf of the ACTIONs Project, Masuda, A., Yoshida, C., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku414 · Cited by 69 · see citing works
Bailly, S., Leroy, O., Montravers, P., Constantin, J., Dupont, H., Guillemot, D., Lortholary, O., Mira, J. P., Pérrigault, P.-F., Gangneux, J., et al. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-4053-1 · Cited by 64 · see citing works
Keighley, C., Cooley, L., Morris, A. J., Ritchie, D., Clark, J. E., Boan, P., & Worth, L. J. (2021) · Internal Medicine Journal · doi:10.1111/imj.15589 · Cited by 65 · see citing works
Candidemia in the Intensive Care Unit
Epelbaum, O., & Chasan, R. (2017) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2017.04.010 · Cited by 65 · see citing works
Garnacho‐Montero, J., Díaz‐Martín, A., Cantón‐Bulnes, M. L., Ramírez, P., Sierra, R., Arias-Verdú, D., Rodríguez-Delgado, M., Loza-Vázquez, A., Rodriguez-Gomez, J., Gordón, M., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002867 · Cited by 64 · see citing works
The current treatment landscape: the need for antifungal stewardship programmes
Muñóz, P., & Bouza, E. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw391 · Cited by 58 · see citing works
Invasive fungal infections in acute and chronic liver impairment: A systematic review
Lahmer, T., Pietrobom, P. M. P., Schmid, R. M., & Colombo, A. L. (2021) · Mycoses · doi:10.1111/myc.13403 · Cited by 56 · see citing works
Attributable mortality of candidemia after introduction of echinocandins
Cornely, F. B., Cornely, O. A., Salmanton‐García, J., Koehler, F. C., Koehler, P. A., Seifert, H., Wingen-Heimann, S. M., & Mellinghoff, S. C. (2020) · Mycoses · doi:10.1111/myc.13177 · Cited by 54 · see citing works
Diagnosis and Treatment of Candidemia in the Intensive Care Unit
Bassetti, M., Giacobbe, D. R., Vena, A., & Wolff, M. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1693704 · Cited by 55 · see citing works
Fungal infections in children with haematologic malignancies and stem cell transplant recipients
Otto, W. R., & Green, A. M. (2020) · British Journal of Haematology · doi:10.1111/bjh.16452 · Cited by 54 · see citing works
Al‐Hasan, M. N., & Winders, H. R. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.05.012 · Cited by 52 · see citing works
Rahi, M. S., Jindal, V., Pednekar, P., Parekh, J., Gunasekaran, K., Sharma, S., Stender, M., & Jaiyesimi, I. A. (2021) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361211039050 · Cited by 48 · see citing works
Bader, J. C., Lakota, E. A., Flanagan, S., Ong, V. S., Sandison, T., Rubino, C. M., Bhavnani, S. M., & Ambrose, P. G. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02614-17 · Cited by 44 · see citing works
López-Cortés, L. E., Almirante, B., Cuenca‐Estrella, M., Garnacho‐Montero, J., Padilla, B., Puig‐Asensio, M., Ruíz-Camps, I., Rodríguez‐Baño, J., Padilla, B., Muñóz, P., et al. (2016) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2016.05.008 · Cited by 40 · see citing works
Oliva, A., Rosa, F. G. D., Mikulska, M., Pea, F., Sanguinetti, M., Tascini, C., & Venditti, M. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2240956 · Cited by 40 · see citing works
Ruhnke, M., & Schwartz, S. (2016) · Therapeutic Advances in Hematology · doi:10.1177/2040620716656381 · Cited by 37 · see citing works
Efficacy and safety of antimicrobial de-escalation as a clinical strategy
Mathieu, C., Pastène, B., Cassir, N., Martín‐Loeches, I., & Léone, M. (2018) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2019.1561275 · Cited by 34 · see citing works
Boonstra, J. M., Märtson, A., Sandaradura, I., Kosterink, J. G. W., van der Werf, T. S., Marriott, D. J. E., Zijlstra, J. G., Touw, D. J., & Alffenaar, J. C. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01554-20 · Cited by 36 · see citing works
Dudiuk, C., Macedo, D., Leonardelli, F., Theill, L., Cabeza, M. S., Gamarra, S. P., & García‐Effrón, G. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02644-16 · Cited by 33 · see citing works
An evidence-based bundle improves the quality of care and outcomes of patients with candidaemia
Cardozo, C., Cuervo, G., Salavert, M., Merino, P., Gioia, F., Fernández‐Ruiz, M., López-Cortés, L. E., Escolà‐Vergé, L., Montejo, M., Muñóz, P., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz491 · Cited by 29 · see citing works
Invasive fungal infections in liver diseases
Barros, N., Rosenblatt, R. E., Phipps, M. M., Fomin, V. G., & Mansour, M. K. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000216 · Cited by 30 · see citing works
Is Fluconazole or an Echinocandin the Agent of Choice for Candidemia
Eschenauer, G. A., Nguyen, M.-H., & Clancy, C. J. (2015) · Annals of Pharmacotherapy · doi:10.1177/1060028015590838 · Cited by 28 · see citing works
Kullberg, B. J., Vasquez, J., Mootsikapun, P., Nucci, M., Paiva, J.-A., Garbino, J., Yan, J. L., Aram, J. A., Capparella, M. R., Conte, U., et al. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx116 · Cited by 27 · see citing works
Self-citationAntifungal stewardship with an emphasis on candidaemia
Capoor, M. R., Subudhi, C. P. K., Collier, A., & Bal, A. M. (2019) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2019.05.030 · Cited by 27 · see citing works
Singh, A., Singh, K., Sharma, A., Joshi, K., Singh, B., Sharma, S., Batra, K., Kaur, K., Singh, D., Chadha, R., et al. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202300024 · Cited by 27 · see citing works
Moreno-García, E., Puerta‐Alcalde, P., Gariup, G., Fernández‐Ruiz, M., López-Cortés, L. E., Cuervo, G., Salavert, M., Merino, P., Machado, M., Guinea, J., et al. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab250 · Cited by 23 · see citing works
Invasive Candidiasis in the Intensive Care Unit: Where Are We Now?
Vázquez, J. A., Whitaker, L., & Zubovskaia, A. (2025) · Journal of Fungi · doi:10.3390/jof11040258 · Cited by 24 · see citing works
Sganga, G., Wang, M., Capparella, M. R., Tawadrous, M., Yan, J. L., Aram, J. A., & Montravers, P. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03617-9 · Cited by 23 · see citing works
Vena, A., Bovis, F., Tutino, S., Barbone, A. S., Mezzogori, L., Ponzano, M., Taramasso, L., Baldi, F., Dettori, S., Labate, L., et al. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac656 · Cited by 22 · see citing works
Kontoyiannis, D. P., Bassetti, M., Nucci, M., Capparella, M. R., Yan, J. L., Aram, J. A., & Hogan, P. A. (2017) · Mycoses · doi:10.1111/myc.12641 · Cited by 22 · see citing works
Jaffal, K., Poissy, J., Rouzé, A., Préau, S., Sendid, B., Cornu, M., & Nseir, S. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0392-8 · Cited by 22 · see citing works
Schroeder, J. A., Wilson, C. M., & Pappas, P. G. (2024) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2024.11.007 · Cited by 24 · see citing works
Self-citationTiraboschi, I. N., Pozzi, N. C., Farías, L., García, S., & Fernández, N. (2017) · Revista chilena de infectología · doi:10.4067/s0716-10182017000500431 · Cited by 20 · see citing works
Abdelhamed, A. M., Zhang, S. X., Watkins, T., Morgan, M. A., Wu, F., Buckner, R. J., Fuller, D., Davis, T. E., Salimnia, H., Fairfax, M. R., et al. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.00549-15 · Cited by 18 · see citing works
Zhang, P., Yang, X., He, Y., Chen, Z., Liu, B., Emesto, C. S., Yang, G., Wang, W., Zhang, J., & Lin, R. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8463-6 · Cited by 18 · see citing works
Antifungal Clinical Trials and Guidelines: What We Know and Do Not KnowPreprint
Pappas, P. G. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019745 · Cited by 17 · see citing works
Self-citationTowards shorter therapy for candidaemia: defining uncomplicated candidaemia in adults
Reinhold, I., Picardi, S., Liss, B., Seidel, D., Stemler, J., Koehler, P. A., Ruegamer, T., Sprute, R., & Cornely, O. A. (2025) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(25)00409-8 · Cited by 16 · see citing works
Bal, A. M., Pana, Z. D., Carlesse, F. A. D. M. C., Marek, A., Seidel, D., Mehler, K., Butzer, S., Sprute, R., Stemler, J., Ludwig-Bettin, D., et al. (2025) · Mycoses · doi:10.1111/myc.70041 · Cited by 15 · see citing works
van der Geest, P. J., Rijnders, B. J. A., Vonk, A. G., & Groeneveld, A. B. J. (2015) · Mycoses · doi:10.1111/myc.12450 · Cited by 15 · see citing works
Wang, Y., McGuire, T., Hollingworth, S., Dong, Y., & van Driel, M. (2019) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2019.10.016 · Cited by 14 · see citing works
Opportunistic and Systemic Fungi
Kosmidis, C., & Denning, D. W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-7020-6285-8.00189-1 · Cited by 14 · see citing works
The Impact of Rapid Species Identification on Management of Bloodstream Infections
Wu, S., Huang, G., Maurice, A. D. S., Lehman, D. L., Graber, C. J., Goetz, M. B., & Haake, D. A. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.02.011 · Cited by 12 · see citing works
Genomic epidemiology of human candidaemia isolates in a tertiary hospital
Chew, K. L., Achik, R., Osman, N. H., Octavia, S., & Teo, J. W. P. (2023) · Microbial Genomics · doi:10.1099/mgen.0.001047 · Cited by 11 · see citing works
van der Geest, P. J., Hunfeld, N., Ladage, S. E., & Groeneveld, A. B. J. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-1825-3 · Cited by 11 · see citing works
Husni, R., Chrabieh, R., Dib, R. W., Vázquez, J. A., Guimarães, T., Fernandez, A. R., Khoury, R., Asmar, L., Khazen, G., Samaha, N. L., et al. (2021) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2021.031 · Cited by 10 · see citing works
Chastain, D. B., White, B. P., Tu, P. J., Chan, S., Jackson, B., Kubbs, K. A., Bandali, A., McDougal, S., Henao‐Martínez, A. F., & Cluck, D. B. (2023) · Annals of Pharmacotherapy · doi:10.1177/10600280231175201 · Cited by 10 · see citing works
Cháves, F., Garnacho‐Montero, J., del Pozo, J. L., Bouza, E., Capdevila, J. A., de Cueto, M., Domínguez, M. Á., Esteban, J., Fernández‐Hidalgo, N., Sampedro, M. F., et al. (2018) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2017.09.001 · Cited by 9 · see citing works
Rosa, F. G. D., Busca, A., Capparella, M. R., Yan, J. L., & Aram, J. A. (2021) · Clinical Drug Investigation · doi:10.1007/s40261-021-01024-7 · Cited by 8 · see citing works
Dib, R. W., Hachem, R. Y., Chaftari, A., & RAAD, I. I. (2018) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2018.028 · Cited by 7 · see citing works
De-escalation from Echinocandins to Azole Treatment in Critically Ill Patients with Candidemia
Lin, J., Zhou, M., Chen, J., Zhang, L., Lu, M., & Liu, Z. (2022) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2022.04.044 · Cited by 6 · see citing works
Oñate, J., Pallares, C., Esparza, G., Jiménez, A., Berrío, I., Osorio-Pinzón, J., Cataño, J. C., Álvarez, C., Rodríguez, J. E., Guevara, F. O., et al. (2021) · Infectio · doi:10.22354/in.v25i4.954 · Cited by 5 · see citing works
Nguyen, T. N. T., Bui, Q. T. H., Tran, V. T., Tran, N. Q., Nguyen, N. T. Y., Nguyen, H. T., Pham, C. T. L., Phạm, H. T. T., Tran, M. T. P., Dau, H. T. T., et al. (2023) · Tropical Medicine & International Health · doi:10.1111/tmi.13911 · Cited by 4 · see citing works
Albanell‐Fernández, M., González, F. S., Pérez, O. M., Aniyar, V., Carrera‐Hueso, F. J., Soriano, À., García‐Vidal, C., Puerta‐Alcalde, P., Martínez, J. A., & Vazquez‐Ferreiro, P. (2024) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2024.107020 · Cited by 4 · see citing works
Droney, M., Reed, E. E., Sarwar, S., Coe, K. E., & Tran, N. N. (2025) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaf026 · Cited by 4 · see citing works
Management of invasive fungal infections in the pediatric intensive care unit
Fisher, B. T., Zaoutis, T. E., & Chiotos, K. (2015) · Journal of Pediatric Intensive Care · doi:10.3233/pic-14108 · Cited by 4 · see citing works
Role of Antifungal Therapy in Complicated Intra-abdominal Infections
Bassetti, M., Vena, A., Pincino, R., Briano, F., & Giacobbe, D. R. (2020) · Current Infectious Disease Reports · doi:10.1007/s11908-020-00731-0 · Cited by 4 · see citing works
Saavedra‐Lozano, J., Slöcker-Barrio, M., Fresán‐Ruiz, E., Grasa, C. D., Pedraz, L. M., Menasalvas, A. I., & Sebastián, M. D. M. S. (2024) · Anales de Pediatría · doi:10.1016/j.anpedi.2024.04.011 · Cited by 3 · see citing works
Bucayu, R., Boge, C. L. K., Yildirim, I. B., Avilés-Robles, M. J., Vora, S. B., Berman, D. M., Sharma, T. S., Sung, L., Castagnola, E., Palazzi, D. L., et al. (2024) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piae116 · Cited by 3 · see citing works
Fungal Infections in Cancer Patients
Granwehr, B. P., & Kontoyiannis, D. P. (2021) · Springer eBooks · doi:10.1007/978-3-319-74698-2_121-2 · Cited by 3 · see citing works
Enfermedades invasoras por hongos levaduriformes en pacientes neutropénicos
Ruíz-Camps, I., & Jarque, I. (2016) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2015.11.001 · Cited by 3 · see citing works
Saavedra‐Lozano, J., Slöcker-Barrio, M., Fresán‐Ruiz, E., Grasa, C. D., Pedraz, L. M., Menasalvas, A. I., & Sebastián, M. D. M. S. (2024) · Anales de Pediatría (English Edition) · doi:10.1016/j.anpede.2024.05.012 · Cited by 2 · see citing works
Muñóz, P., & Fernández‐Cruz, A. (2020) · Hematologic malignancies · doi:10.1007/978-3-030-57317-1_9 · Cited by 2 · see citing works
Colombo, A. L., Magri, M. M. C., Carlesse, F. A. D. M. C., Falci, D. R., Garnica, M., Santos, D. W. D. C. L., Queiroz‐Telles, F., & Pasqualotto, A. C. (2026) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2026.105946 · Cited by 1 · see citing works
Fungal Infections in Cancer Patients
Granwehr, B. P., Sipsas, N. V., & Kontoyiannis, D. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-74588-6_121 · Cited by 1 · see citing works
Treating Common Fungal Infections in Children
Campbell, A. J., McLeod, C., & Blyth, C. C. (2016) · Current Pediatrics Reports · doi:10.1007/s40124-016-0110-7
Serious Infections in the Intensive Care Unit: diagnosis and management
van der Geest, P. J. (2016) · EUR Research Repository (Erasmus University Rotterdam)
Candidemia: New Directions for Management and Treatment
Theppote, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-64774-6_3
Treatment of Invasive Fungal Infections in Haematology-Oncology Patients
Tekin, S. (2020) · Klimik Dergisi/Klimik Journal · doi:10.5152/kd.2019.62
Fungal Infections in Cancer Patients
Granwehr, B. P., Sipsas, N. V., & Kontoyiannis, D. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-74698-2_121-1
Altun, G., Akbaş, T., & YEKENKURUL, D. (2023) · Sağlık Bilimlerinde Değer · doi:10.33631/sabd.1133488
تباين الكورتيزول اللعابي عند نقل الترشيحات مراجعة الأدبيات
اسميو, س. ا. م. (2023) · Journal of the Academic Forum · doi:10.59743/jaf.v7i2.329
Jordan, V. S., Perera, M., Unsworth, A., Basile, K., Halliday, C., & Chen, S. C.-A. (2026) · Future Microbiology · doi:10.1080/17460913.2026.2634539
Fongémies : épidémiologie, diagnostic et conduite à tenir
Dellière, S., Chantelot, L., Garnaud, C., & Cornet, M. (2026) · EMC - Biologie Médicale · doi:10.1016/s2211-9698(25)48322-8
Interactions hôte-candida au cours des péritonites fongiques graves de réanimation
Novy, E. (2024) · theses.fr (ABES) · doi:10.70675/bb875beazbffcz45cdz85b2z2ac1b68c7226
Traitement des infections fongiques invasives
Danion, F. (2026) · EMC-Maladies infectieuses/Encyclopédie médico-chirurgicale. Maladies infectieuses · doi:10.1016/s1166-8598(25)83033-3
Clinical controversies in the management of candidemia in adults and children
Cluck, D. B., White, B. P., Hilzendager, S. A., Ryder, J. H., Tu, P. J., McPherson, A. Z., Rogers, D. J., & Chastain, D. B. (2026) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxag212
Albanell‐Fernández, M., Tuset, M., Vergara, A., Villanueva, M., Barrantes-González, M., Bodro, M., Soriano, À., & Herrera, S. (2026) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkag252
Jaffal, K., Bayon, C., Kreitmann, L., Rouzé, A., Labruyère, M., Stoclin, A., Jean, R., Guillaume, B., Dartevel, A., Sendid, B., et al. (2026) · Annals of Intensive Care · doi:10.1016/j.aicoj.2026.100139
Martín‐Loeches, I., & Yu, Y. (2026) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2026.2726965
- Authors
- Vazquez, J., Reboli, A. C., Pappas, P. G., Patterson, T. F., Reinhardt, J., Chin-Hong, P., Tobin, E., Kett, D. H., Biswas, P., & Swanson, R.
- Affiliations
- Cooper Medical School of Rowan University (US)
- University of Alabama at Birmingham (US)
- South Texas Veterans Health Care System (US)
- University of California, San Francisco (US)
- Albany Medical Center Hospital (US)
- University of Miami (US)
- Pfizer (United States) (US)
- Corresponding author
- Swanson, Robert
- Venue
- BMC Infectious Diseases
- Published
- 2014-02-21
- Volume
- 14
- Issue
- 1
- Pages
- 97-97
- ISSN
- 1471-2334 (ISSN-L)
- PMC
- PMC3944438
- OpenAlex
- W2043992568
- Cited by
- 101
- References
- 22
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 3 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 4
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Infectious Diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- candidemia, invasive candidiasis, anidulafungin, step-down therapy, fluconazole, voriconazole, antifungal therapy, Candida albicans, Candida glabrata, Candida parapsilosis, treatment-related adverse events
- MeSH terms
- Anidulafungin, Administration, Oral, Adult, Aged, Aged, 80 and over, Antifungal Agents, Candida, Candidiasis, Female, Humans, Male, Middle Aged, Research Design, Risk, United States, Fluconazole, Treatment Outcome, Echinocandins, Young Adult, Republic of Korea, Candidiasis, Invasive, Candidemia, Administration, Intravenous, Voriconazole
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